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You searched for id:"oai:openscholarship.wustl.edu:art_sci_etds-2646". One record found.

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Washington University in St. Louis

1. Chai, Jiani. CD4 T Cell Interaction with Intestinal Microbes under Homeostasis and Inflammation.

Degree: PhD, Biology & Biomedical Sciences (Immunology), 2018, Washington University in St. Louis

Specific gut commensal bacteria improve host health by eliciting mutualistic regulatory T (Treg) cells responses. However, the bacteria that induce effector T (Teff) cells during inflammation are unclear. Here, we addressed this by analyzing bacterial-reactive T cell receptor (TCR) transgenic cells and TCR repertoires in a murine colitis model. Unexpectedly, we found that mucosal-associated Helicobacter species triggered both Treg responses during homeostasis and Teff responses during colitis, as suggested by an increased overlap between the Teff/Treg TCR repertoires with colitis. In fact, 4/6 Treg TCRs tested recognized mucosal-associated Helicobacter species in vitro and in vivo. By contrast, the marked expansion of luminal Bacteroides species seen during colitis did not trigger a commensurate Teff response. Unlike other Treg cell-inducing bacteria, Helicobacter species are known pathobionts and cause disease in immunodeficient mice. Thus, our study suggests a model in which mucosal bacteria elicit context-dependent Treg or effector cell responses to facilitate intestinal tolerance or inflammation. Advisors/Committee Members: Chyi-Song Hsieh, Paul Allen, Marco Colonna, Takeshi Egawa, Thaddeus Stappenbeck.

Subjects/Keywords: colitis, colon, Helicobacter, microbiota, T cell, Treg; Allergy and Immunology; Immunology and Infectious Disease; Medical Immunology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chai, J. (2018). CD4 T Cell Interaction with Intestinal Microbes under Homeostasis and Inflammation. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/art_sci_etds/1613

Chicago Manual of Style (16th Edition):

Chai, Jiani. “CD4 T Cell Interaction with Intestinal Microbes under Homeostasis and Inflammation.” 2018. Doctoral Dissertation, Washington University in St. Louis. Accessed November 20, 2018. https://openscholarship.wustl.edu/art_sci_etds/1613.

MLA Handbook (7th Edition):

Chai, Jiani. “CD4 T Cell Interaction with Intestinal Microbes under Homeostasis and Inflammation.” 2018. Web. 20 Nov 2018.

Vancouver:

Chai J. CD4 T Cell Interaction with Intestinal Microbes under Homeostasis and Inflammation. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2018. [cited 2018 Nov 20]. Available from: https://openscholarship.wustl.edu/art_sci_etds/1613.

Council of Science Editors:

Chai J. CD4 T Cell Interaction with Intestinal Microbes under Homeostasis and Inflammation. [Doctoral Dissertation]. Washington University in St. Louis; 2018. Available from: https://openscholarship.wustl.edu/art_sci_etds/1613

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