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You searched for id:"oai:minds.wisconsin.edu:1793/76896". One record found.

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University of Wisconsin – La Cross

1. Lin, Xingxing. Mechanism of microtubule rod formation in 13-lined ground squirrel (Ictidomys tridecemlineatus) platelets.

Degree: 2017, University of Wisconsin – La Cross

Blood platelets play a critical role in blood clotting, or hemostasis. Platelets from human, baboon, and mouse are sensitive to cold, resulting in rapid removal from blood circulation by macrophages in the liver. Short shelf life at room temperature has led to a worldwide shortage of platelets. An understanding of how to prolong platelet shelf life is a high priority of platelet research. 13-lined ground squirrel (Ictidomys tridecemlineatus) platelets undergo significant morphological changes, forming rod shapes, when exposed to cold temperature. However, to date, little research has been done to uncover the correlation between the morphological changes and ground squirrel platelets' survival during hibernation. In this study, we confirmed that microtubules are responsible for ground squirrel platelet shape changes when exposed to different temperatures. Microtubules from ground squirrel platelets are maintained in equilibrium between rod and ring conformations. Microtubule polymerizations leads platelets to form rods. Microtubule depolymerization leads platelets to form rings. Low temperature acts as an inhibitor of microtubule depolymerization shifting platelet equilibrium to rod shapes. Advisors/Committee Members: Cooper, Scott.

Subjects/Keywords: Cold  – Physiological effect; Blood platelets; Thirteen-lined ground squirrel

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lin, X. (2017). Mechanism of microtubule rod formation in 13-lined ground squirrel (Ictidomys tridecemlineatus) platelets. (Thesis). University of Wisconsin – La Cross. Retrieved from http://digital.library.wisc.edu/1793/76896

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lin, Xingxing. “Mechanism of microtubule rod formation in 13-lined ground squirrel (Ictidomys tridecemlineatus) platelets.” 2017. Thesis, University of Wisconsin – La Cross. Accessed December 18, 2017. http://digital.library.wisc.edu/1793/76896.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lin, Xingxing. “Mechanism of microtubule rod formation in 13-lined ground squirrel (Ictidomys tridecemlineatus) platelets.” 2017. Web. 18 Dec 2017.

Vancouver:

Lin X. Mechanism of microtubule rod formation in 13-lined ground squirrel (Ictidomys tridecemlineatus) platelets. [Internet] [Thesis]. University of Wisconsin – La Cross; 2017. [cited 2017 Dec 18]. Available from: http://digital.library.wisc.edu/1793/76896.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin X. Mechanism of microtubule rod formation in 13-lined ground squirrel (Ictidomys tridecemlineatus) platelets. [Thesis]. University of Wisconsin – La Cross; 2017. Available from: http://digital.library.wisc.edu/1793/76896

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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