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University of Western Ontario

1. Horne, Justine Rochelle. The NOW Trial: A Pragmatic Randomized Controlled Trial of Personalized, Genetic-Based Lifestyle Advice.

Degree: 2020, University of Western Ontario

Background: The impact of nutrigenomics and lifestyle genomics interventions on health outcomes and behaviours remains controversial and under-explored. Objectives: To determine the short-term (3-month), moderate-term (6-month) and long-term (12-month) impact of providing personalized, genetic-based lifestyle information and advice on anthropometric measures, as well as dietary intake and adherence. Methods: The nutrigenomics, overweight/obesity and weight management trial (NOW Trial) is a pragmatic randomized controlled trial that was incorporated into the Group Lifestyle Balance™ (GLB) program (N=140). Inclusion criteria: overweight or obesity (BMI ≥ 25 kg/m2), ≥ 18 years of age, English-speaking, having access to internet at least one day per week, willing to undergo genetic testing, and not seeing another healthcare provider outside of the study for weight-loss advice. Exclusion criteria: Pregnancy and lactation. Twelve-month GLB weight management program groups were randomized 1:1 to receive either the standard GLB program or a modified nutrigenomics-based GLB program (GLB+NGx). Data collection occurred at baseline, 3-, 6- and 12-month follow-up. The predetermined primary outcome was change in body fat percentage (BFP). Dietary intake and adherence were secondary outcome measures. Statistical Analysis: Statistical tests conducted using SPSS (version 26.0) included: repeated measures analyses of variance (ANOVAs), split-plot ANOVAs, two-way ANOVAs, chi-square and Fisher’s exact tests and logistic regression. Key components of the Theory of Planned Behaviour were considered in the dietary intake analyses. Results: After 3- and 6-month follow-up, the GLB+NGx group improved (reduced) their BFP to a significantly greater extent (pp Conclusion: Genetically-tailored lifestyle advice can lead to improvements in body composition over the short-term and moderate-term, and motivate long-term dietary changes and adherence to nutrition recommendations. Biological mechanisms may challenge long-term weight loss, even with genetically-tailored advice that motivates long-term dietary changes.

Subjects/Keywords: nutrigenomics; nutritional genomics; nutrigenetics; lifestyle genomics; genetics; nutrition; overweight; obesity; Theory of Planned Behaviour; Theory of Planned Behavior; Dietetics and Clinical Nutrition; Other Genetics and Genomics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Horne, J. R. (2020). The NOW Trial: A Pragmatic Randomized Controlled Trial of Personalized, Genetic-Based Lifestyle Advice. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Horne, Justine Rochelle. “The NOW Trial: A Pragmatic Randomized Controlled Trial of Personalized, Genetic-Based Lifestyle Advice.” 2020. Thesis, University of Western Ontario. Accessed April 09, 2020. https://ir.lib.uwo.ca/etd/6839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Horne, Justine Rochelle. “The NOW Trial: A Pragmatic Randomized Controlled Trial of Personalized, Genetic-Based Lifestyle Advice.” 2020. Web. 09 Apr 2020.

Vancouver:

Horne JR. The NOW Trial: A Pragmatic Randomized Controlled Trial of Personalized, Genetic-Based Lifestyle Advice. [Internet] [Thesis]. University of Western Ontario; 2020. [cited 2020 Apr 09]. Available from: https://ir.lib.uwo.ca/etd/6839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Horne JR. The NOW Trial: A Pragmatic Randomized Controlled Trial of Personalized, Genetic-Based Lifestyle Advice. [Thesis]. University of Western Ontario; 2020. Available from: https://ir.lib.uwo.ca/etd/6839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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