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University of Western Ontario

1. Fournier, Dale Edward. Tomographic and Histological Analyses of Ectopic Calcification Associated With Diffuse Idiopathic Skeletal Hyperostosis (DISH).

Degree: 2018, University of Western Ontario

Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory spondyloarthropathy characterised by the formation of ectopic calcifications of the ligaments/enthuses along the anterolateral aspect of the vertebral column. Despite affecting 15-25% of North Americans over the age of 50, the aetiology of DISH is poorly understood and there are no disease modifying treatments. Our discovery-based approach implemented a transdisciplinary research team to study the basic biology, imaging science, clinical anatomy and significance of DISH in humans. Our novel characterisation defined distinct morphological presentations of ectopic calcifications associated with DISH in cadaveric specimens using micro-computed tomography imaging. Subsequent histopathological analyses demonstrated that flowing bridges characteristic of DISH are composed of both ectopic ossifications and discrete regions of amorphous calcifications within fibrocartilage structures. These findings provide newfound insight into the pathogenesis of DISH and that the current diagnostic criteria captures a heterogenous population of presentations, or distinct pathologies that must be further defined.

Subjects/Keywords: diffuse idiopathic skeletal hyperostosis (DISH); spine[vertebral column]; calcification[ossification]; micro-computed tomography; human[cadaver].; Musculoskeletal Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Fournier, D. E. (2018). Tomographic and Histological Analyses of Ectopic Calcification Associated With Diffuse Idiopathic Skeletal Hyperostosis (DISH). (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/5606

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Fournier, Dale Edward. “Tomographic and Histological Analyses of Ectopic Calcification Associated With Diffuse Idiopathic Skeletal Hyperostosis (DISH).” 2018. Thesis, University of Western Ontario. Accessed September 21, 2018. https://ir.lib.uwo.ca/etd/5606.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Fournier, Dale Edward. “Tomographic and Histological Analyses of Ectopic Calcification Associated With Diffuse Idiopathic Skeletal Hyperostosis (DISH).” 2018. Web. 21 Sep 2018.

Vancouver:

Fournier DE. Tomographic and Histological Analyses of Ectopic Calcification Associated With Diffuse Idiopathic Skeletal Hyperostosis (DISH). [Internet] [Thesis]. University of Western Ontario; 2018. [cited 2018 Sep 21]. Available from: https://ir.lib.uwo.ca/etd/5606.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fournier DE. Tomographic and Histological Analyses of Ectopic Calcification Associated With Diffuse Idiopathic Skeletal Hyperostosis (DISH). [Thesis]. University of Western Ontario; 2018. Available from: https://ir.lib.uwo.ca/etd/5606

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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