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University of Western Ontario

1. Fuhrmann, Benjamin B. Inhibition of NK cell-mediated Cytotoxicity by Tubular Epithelial Cell Expression of Clr Proteins.

Degree: 2018, University of Western Ontario

Cytotoxic effector cells can target and kill parenchymal cells of the kidney which results in injury and loss of function. Endogenous regulatory systems may exist to attenuate Natural Killer (NK) and other effector cell activation and cytotoxicity in diverse conditions, including ischemia-reperfusion injury associated with kidney transplantation. Understanding these mechanisms will direct new therapeutic strategies. Kidney tubular epithelial cells (TEC), the predominant cell type in kidneys, may negatively regulate NK cell activation by surface expression of C-type lectin-related proteins (Clr). Clr-b and -f were found to be expressed by wild type (WT) TEC. Clr-b was upregulated by TNFα+IFNγ in vitro. Elimination of both Clr-b and Clr-f expression with siRNA resulted in increased NK killing of TEC compared to individual silencing of Clr-b or Clr-f TEC (p<0.01), or WT control TEC (p<0.001). NK cells treated in vitro with soluble Clr-b and Clr-f reduced their capacity to kill Clr-b/-f -/- TEC as compared to untreated NK cells (p<0.05). NK cells therefore are regulated by proteins expressed by TEC and thus may represent an important endogenous regulatory system in the kidney to limit organ injury. As no current drugs exist to specifically target NK cells, Clr-b and Clr-f soluble proteins that bind to NK cells may represent a novel and clinically feasible strategy to protect organs from NK cell-mediated inflammation during ischemia-reperfusion and other kidney injury models.

Subjects/Keywords: Tubular epithelial cell; Natural Killer cell; Clr-b; Clr-f; Ischemia Reperfusion Injury; Biological Phenomena, Cell Phenomena, and Immunity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Fuhrmann, B. B. (2018). Inhibition of NK cell-mediated Cytotoxicity by Tubular Epithelial Cell Expression of Clr Proteins. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/5631

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Fuhrmann, Benjamin B. “Inhibition of NK cell-mediated Cytotoxicity by Tubular Epithelial Cell Expression of Clr Proteins.” 2018. Thesis, University of Western Ontario. Accessed September 24, 2018. https://ir.lib.uwo.ca/etd/5631.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Fuhrmann, Benjamin B. “Inhibition of NK cell-mediated Cytotoxicity by Tubular Epithelial Cell Expression of Clr Proteins.” 2018. Web. 24 Sep 2018.

Vancouver:

Fuhrmann BB. Inhibition of NK cell-mediated Cytotoxicity by Tubular Epithelial Cell Expression of Clr Proteins. [Internet] [Thesis]. University of Western Ontario; 2018. [cited 2018 Sep 24]. Available from: https://ir.lib.uwo.ca/etd/5631.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fuhrmann BB. Inhibition of NK cell-mediated Cytotoxicity by Tubular Epithelial Cell Expression of Clr Proteins. [Thesis]. University of Western Ontario; 2018. Available from: https://ir.lib.uwo.ca/etd/5631

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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