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University of Western Ontario

1. Win, Phyo. Beta-cell β1 Integrin Deficiency During Second Transition Stage Of Fetal Pancreas Development On Islet Growth.

Degree: 2018, University of Western Ontario

β1 integrin has been shown to be important for pancreatic beta-cell growth and functioning. Congenital and postnatal studies have shown beta-cell mass reduction with β1 integrin knockout (β1KO). Using an inducible cre recombinase (CreERT) expressed from the mouse insulin promoter (MIP) crossed to a line in which Itgb1 (β1 integrin encoding gene) was flanked by loxP sites (MIP-CreERT+; β1itg designated as MIPβ1KO), we examined the in vivo temporal role of beta-cell β1 integrin effect on islet growth during the second transition stage of pancreas development. Prenatal MIPβ1KO mice displayed decreased beta-cell area, mass, density and proliferation. In addition, a decrease in phosphorylated-ERK activity, islet vascularization and nascent endocrine cells in the ductal region was observed. However, normal levels of transcription factors needed for beta-cell development was seen. This study may suggest that β1 integrin plays an important role in prenatal beta-cell development during the second transition stage.

Subjects/Keywords: β1 integrin; mouse insulin promoter (MIP); tamoxifen-inducible; beta-cell mass; pancreas development; Cellular and Molecular Physiology; Endocrinology

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APA (6th Edition):

Win, P. (2018). Beta-cell β1 Integrin Deficiency During Second Transition Stage Of Fetal Pancreas Development On Islet Growth. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/5627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Win, Phyo. “Beta-cell β1 Integrin Deficiency During Second Transition Stage Of Fetal Pancreas Development On Islet Growth.” 2018. Thesis, University of Western Ontario. Accessed September 21, 2018. https://ir.lib.uwo.ca/etd/5627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Win, Phyo. “Beta-cell β1 Integrin Deficiency During Second Transition Stage Of Fetal Pancreas Development On Islet Growth.” 2018. Web. 21 Sep 2018.

Vancouver:

Win P. Beta-cell β1 Integrin Deficiency During Second Transition Stage Of Fetal Pancreas Development On Islet Growth. [Internet] [Thesis]. University of Western Ontario; 2018. [cited 2018 Sep 21]. Available from: https://ir.lib.uwo.ca/etd/5627.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Win P. Beta-cell β1 Integrin Deficiency During Second Transition Stage Of Fetal Pancreas Development On Islet Growth. [Thesis]. University of Western Ontario; 2018. Available from: https://ir.lib.uwo.ca/etd/5627

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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