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You searched for id:"oai:ir.lib.uwo.ca:etd-7031". One record found.

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University of Western Ontario

1. Solo, Karla. Antithrombotic Therapy in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Network Meta-Analysis.

Degree: 2017, University of Western Ontario

Comprehensive evidence on the comparative effects of various oral antithrombotic agents on the prevention of saphenous vein graft failure (SVGF) for patients undergoing coronary artery bypass is lacking. A systematic review and frequentist random-effects network meta-analysis of 18 RCTs (n=3,413 patients) comparing the effect of antithrombotic agents on SVGF and clinical outcomes was performed. Based on moderate quality evidence, among the six eligible interventions, dual-antiplatelet therapy with aspirin and clopidogrel was superior to aspirin monotherapy in reducing SVGF (OR: 0.63; 95% CI: 0.41-0.97). No statistical differences were found for major bleeding, mortality, and myocardial infarction between antithrombotic agents, owing to low number of events for most comparisons. Though significant heterogeneity or incoherence was not found, the quality of network evidence for these outcomes ranged from very low to moderate. Adequately-powered multi-arm RCTs are needed to ascertain the effects of antithrombotic therapies to help clinicians and patients achieve optimal treatment decisions.

Subjects/Keywords: Coronary artery bypass; saphenous vein graft failure; antithrombotic therapy; network meta-analysis; Cardiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Solo, K. (2017). Antithrombotic Therapy in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Network Meta-Analysis. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/5094

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Solo, Karla. “Antithrombotic Therapy in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Network Meta-Analysis.” 2017. Thesis, University of Western Ontario. Accessed January 18, 2018. https://ir.lib.uwo.ca/etd/5094.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Solo, Karla. “Antithrombotic Therapy in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Network Meta-Analysis.” 2017. Web. 18 Jan 2018.

Vancouver:

Solo K. Antithrombotic Therapy in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Network Meta-Analysis. [Internet] [Thesis]. University of Western Ontario; 2017. [cited 2018 Jan 18]. Available from: https://ir.lib.uwo.ca/etd/5094.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Solo K. Antithrombotic Therapy in Patients Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Network Meta-Analysis. [Thesis]. University of Western Ontario; 2017. Available from: https://ir.lib.uwo.ca/etd/5094

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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