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University of Western Ontario

1. Siraj, Sadia. A cross- sectional study of stress biomarkers and their associations with post-trauma complaints, and how those associations are moderated by early life adversity.

Degree: 2017, University of Western Ontario

Chronic musculoskeletal pain results in significant personal, economic, and social burden. Early identification and intervention in those people with acute pain that are likely to transition into a state of chronicity can prevent the onset of chronic pain before it emerges and becomes resistant to treatment. This study investigated the potential stress biomarkers associated with acute pain and disability and how those associations are influenced by early life adversities. Stress level was determined according to the plasma level of stress biomarkers (cortisol, BDNF, TGFB1) and self-report measures of stress following musculoskeletal traumatic events. The magnitude and direction of associations of cortisol and BDNF with self-reported stress markers provided supportive evidence for further exploration of cortisol and BDNF as acute stress biomarkers. The results of the study also supported the moderating role of adverse childhood experiences on the associations between self-reported distress and stress biomarkers.

Subjects/Keywords: Chronic pain; acute musculoskeletal trauma; Hypothalamic-Pituitary-Adrenal axis (HPA axis); stress biomarkers; Cortisol; Brain-derived neurotrophic factor (BDNF); Transforming growth factor beta1 (TGFB1); early life adversity.; Physical Therapy; Preventive Medicine; Rehabilitation and Therapy; Trauma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Siraj, S. (2017). A cross- sectional study of stress biomarkers and their associations with post-trauma complaints, and how those associations are moderated by early life adversity. (Thesis). University of Western Ontario. Retrieved from http://ir.lib.uwo.ca/etd/4856

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Siraj, Sadia. “A cross- sectional study of stress biomarkers and their associations with post-trauma complaints, and how those associations are moderated by early life adversity.” 2017. Thesis, University of Western Ontario. Accessed September 20, 2017. http://ir.lib.uwo.ca/etd/4856.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Siraj, Sadia. “A cross- sectional study of stress biomarkers and their associations with post-trauma complaints, and how those associations are moderated by early life adversity.” 2017. Web. 20 Sep 2017.

Vancouver:

Siraj S. A cross- sectional study of stress biomarkers and their associations with post-trauma complaints, and how those associations are moderated by early life adversity. [Internet] [Thesis]. University of Western Ontario; 2017. [cited 2017 Sep 20]. Available from: http://ir.lib.uwo.ca/etd/4856.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Siraj S. A cross- sectional study of stress biomarkers and their associations with post-trauma complaints, and how those associations are moderated by early life adversity. [Thesis]. University of Western Ontario; 2017. Available from: http://ir.lib.uwo.ca/etd/4856

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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