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University of Western Ontario

1. Gupta, Sarah. PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking.

Degree: 2016, University of Western Ontario

β-arrestins are versatile adaptor proteins that play a vital role in regulation of G protein coupled receptor (GPCR) trafficking and signalling properties. PDZ proteins have previously been shown to modulate β-arrestin2 recruitment and receptor internalization for many GPCRs including Corticotropin-Releasing Factor Receptor 1 (CRFR1), a receptor whose antagonists have been shown to demonstrate both anxiolytic- and antidepressant-like effects. Further characterization of the interplay between β-arrestins and PDZ proteins may aid in determining a potential mechanism for PDZ protein regulation of GPCR trafficking. Our findings suggest that PDZ proteins PSD-95, MAGI1, and PDZK1 complex with β-arrestin2 by interacting via the PDZ domain. Using a proteomic approach, mutational analyses were used to reveal that the β-arrestin2 A175F mutant impairs interaction with PSD-95. Additionally, this mutant form of β-arrestin2 shows decreased CRF-stimulated recruitment to CRFR1. Thus, investigating how β-arrestins and PDZ proteins interact could provide further insight into GPCR trafficking properties and the development of novel therapeutics.

Subjects/Keywords: Molecular and Cellular Neuroscience

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gupta, S. (2016). PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking. (Thesis). University of Western Ontario. Retrieved from http://ir.lib.uwo.ca/etd/4374

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Gupta, Sarah. “PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking.” 2016. Thesis, University of Western Ontario. Accessed November 17, 2017. http://ir.lib.uwo.ca/etd/4374.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Gupta, Sarah. “PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking.” 2016. Web. 17 Nov 2017.

Vancouver:

Gupta S. PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking. [Internet] [Thesis]. University of Western Ontario; 2016. [cited 2017 Nov 17]. Available from: http://ir.lib.uwo.ca/etd/4374.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gupta S. PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking. [Thesis]. University of Western Ontario; 2016. Available from: http://ir.lib.uwo.ca/etd/4374

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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