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University of Cincinnati

1. Unser, Sarah A. Improving the Sensitivity and Selectivity of Localized Surface Plasmon Resonance Biosensors Toward Novel Point-of-Care Diagnostics.

Degree: PhD, Arts and Sciences: Chemistry, 2019, University of Cincinnati

This thesis contains work that has been done in order to improve the sensitivity and selectivity of localized surface plasmon resonance sensors, specifically in regards to medical and point-of-care diagnostics. For centuries the vivid optical properties of gold nanoparticles have captured the attention of both artists and scientists. Today, due to the bold colorimetric properties that are highly tunable, plasmonic nanoparticles have been key to their widespread popularity and incorporation into medical diagnostics. As diagnostics become more readily available for self-monitoring of human health, it is imperative that new devices are produced that are highly accurate, precise, and affordable for consumer use. Applying the colorimetric properties of plasmonic nanoparticles, their colorimetric readout helps create a response that is either a simple yes or no, or a quantitative colorimetric readout. The contents of this thesis highlight efforts to enhance the surface chemistry to improve the sensitivity of nanoparticle substrates for improved detection of health relevant biomolecules. In addition, integration of these nanoparticles into extracellular matrix and lipid membrane systems help improve the selectivity of these model schemes. These strategies applied in this thesis are aimed toward improving medical diagnostics to make them affordable for point-of-care scenarios to improve the quality of human health. Advisors/Committee Members: Sagle, Laura (Committee Chair).

Subjects/Keywords: Chemistry; Localized Surface Plasmon Resonance; Biosensors; Point-of-Care; Nanoparticles; Colorimetric Sensing; Diagnostics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Unser, S. A. (2019). Improving the Sensitivity and Selectivity of Localized Surface Plasmon Resonance Biosensors Toward Novel Point-of-Care Diagnostics. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1561997005551383

Chicago Manual of Style (16th Edition):

Unser, Sarah A. “Improving the Sensitivity and Selectivity of Localized Surface Plasmon Resonance Biosensors Toward Novel Point-of-Care Diagnostics.” 2019. Doctoral Dissertation, University of Cincinnati. Accessed December 08, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1561997005551383.

MLA Handbook (7th Edition):

Unser, Sarah A. “Improving the Sensitivity and Selectivity of Localized Surface Plasmon Resonance Biosensors Toward Novel Point-of-Care Diagnostics.” 2019. Web. 08 Dec 2019.

Vancouver:

Unser SA. Improving the Sensitivity and Selectivity of Localized Surface Plasmon Resonance Biosensors Toward Novel Point-of-Care Diagnostics. [Internet] [Doctoral dissertation]. University of Cincinnati; 2019. [cited 2019 Dec 08]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1561997005551383.

Council of Science Editors:

Unser SA. Improving the Sensitivity and Selectivity of Localized Surface Plasmon Resonance Biosensors Toward Novel Point-of-Care Diagnostics. [Doctoral Dissertation]. University of Cincinnati; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1561997005551383

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