Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for id:"oai:etd.ohiolink.edu:osu1492631647528424". One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters

1. Ciamacca, Marisa Lynn. Foveal Phase Retardation Correlation with Henle Fiber Layer Thickness.

Degree: MS, Vision Science, 2017, The Ohio State University

The Henle fiber layer (HFL) is comprised of cone photoreceptor axons in the central fovea which undergo lateral displacement along with the inner retinal layers throughout early development to give rise to the foveal pit. The close relationship between the photoreceptor axons and the cone photoreceptors within the fovea allows the HFL to be studied and imaged as an indirect measure of photoreceptor viability. Due to the optical transparency of the HFL, traditional reflectance based imaging modalities, such as optical coherence tomography (OCT), have struggled to accurately delineate this retinal layer from the adjacent outer nuclear layer. By employing directional OCT imaging, which utilizes offset of the imaging beam, maximization of the primary scattering angle of the HFL can be achieved allowing the tissue to be more readily visualized and quantified in thickness. Additionally, the HFL is one of various ocular tissues which exhibit form birefringence attributed to the production and organization of microtubules within the axonal cell walls. This birefringence acts as a potential biomarker for density and integrity changes to the foveal cone photoreceptors and can be measured and quantified using polarization sensitive technology such as scanning laser polarimetry (SLP). In this study, we examine two optical properties associated with the Henle fiber layer using directional OCT and SLP to compare the HFL thickness measurements obtained using these two techniques.Directional OCT imaging was performed using the Heidelberg Spectralis spectral domain OCT in both the horizontal and vertical meridians to achieve measurements for the superior, inferior, nasal and temporal retina. Manual segmentation using Adobe Photoshop was performed and thickness values for the four meridians were averaged. Henle fiber layer phase retardation was measured using the GDx scanning laser polarimeter which generated a characteristic and expected macular cross pattern due to the radial symmetry of the tissue. Custom curve fitting analysis was used to generate intensity profiles in the phase retardation maps. Henle fiber layer thickness values and the amplitude of the phase retardation signal were plotted against each other at 0.25 degree intervals from 0 to 3 degrees eccentricity. The average thickness profiles and phase retardation amplitudes correlated closely at the eccentricities evaluated (r2 = 0.981). Overall, HFL thickness and phase retardation were minimal centrally, increased until reaching a maximum at 2 degrees eccentricity, and declined at greater eccentricities. In this study, we measured HFL thickness using directional OCT imaging and found a significant correlation with macular phase retardation distribution using SLP in normal subjects. The strong correlation between phase retardation distribution and HFL thickness in the central macula provides supporting evidence that the macular phase retardation signal results from the birefringent HFL in healthy normal subjects. Understanding this correlation becomes important, as the… Advisors/Committee Members: VanNasdale, Dean (Advisor).

Subjects/Keywords: Ophthalmology; Henle fiber layer; scanning laser polarimetry; directional optical coherence tomography; fovea

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Ciamacca, M. L. (2017). Foveal Phase Retardation Correlation with Henle Fiber Layer Thickness. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1492631647528424

Chicago Manual of Style (16th Edition):

Ciamacca, Marisa Lynn. “Foveal Phase Retardation Correlation with Henle Fiber Layer Thickness.” 2017. Masters Thesis, The Ohio State University. Accessed November 19, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492631647528424.

MLA Handbook (7th Edition):

Ciamacca, Marisa Lynn. “Foveal Phase Retardation Correlation with Henle Fiber Layer Thickness.” 2017. Web. 19 Nov 2017.

Vancouver:

Ciamacca ML. Foveal Phase Retardation Correlation with Henle Fiber Layer Thickness. [Internet] [Masters thesis]. The Ohio State University; 2017. [cited 2017 Nov 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1492631647528424.

Council of Science Editors:

Ciamacca ML. Foveal Phase Retardation Correlation with Henle Fiber Layer Thickness. [Masters Thesis]. The Ohio State University; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1492631647528424

.