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You searched for id:"oai:d-scholarship.pitt.edu:34185". One record found.

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University of Pittsburgh

1. Lang, Feng. Enantioenriched Oxazolidinones as Synthesis Scaffolds and Efforts towards the Total Synthesis of Marineosin A.

Degree: 2018, University of Pittsburgh

Enantioenriched Oxazolidinones as Synthesis Scaffolds and Efforts towards the Total Synthesis of Marineosin Feng Lang, PhD University of Pittsburgh, 2018 The utility of enantioenriched oxazolidinones in the preparation of small chiral building blocks has been investigated. Hard nucleophile induced ring opening reactions of oxazolidinones provided a series of enantioenriched α-hydroxy carbonyl compounds. Soft nucleophile induced ring opening reactions of oxazolidinones have been attempted. Aldol reactions and Mannich reactions of oxazolidinones afforded the addition products with good results. Additionally, the aldol addition products were able to be converted to enantioenriched α,β-dihydroxy carbonyl compounds with a quaternary chirality center at the α position. In addition, chiral diol was also obtained through the reductive ring opening reaction of oxazolidinone. The synthesis of marineosin A, a structurally unique natural product exhibiting acute cytotoxicity, has been under investigation in our laboratory. The previously unreported spiroaminal structure consisting of tetrahydropyrrole ring and dihydropyran ring has been synthesized through a radical cyclization in model study. The 12-membered macrocyclic pyrrole core synthesis has been accomplished by Stetter reaction in model study. It is worth noting that this is the first time that Stetter reaction was used in macrocyclization reaction. Both the diene fragment and the dienophile fragment have been prepared successfully towards the synthesis of the densely functionalized tetrahydropyran ring in marineosin A.

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APA (6th Edition):

Lang, F. (2018). Enantioenriched Oxazolidinones as Synthesis Scaffolds and Efforts towards the Total Synthesis of Marineosin A. (Thesis). University of Pittsburgh. Retrieved from http://d-scholarship.pitt.edu/34185/1/Lang_Feng_ETD2.pdf ; http://d-scholarship.pitt.edu/34185/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lang, Feng. “Enantioenriched Oxazolidinones as Synthesis Scaffolds and Efforts towards the Total Synthesis of Marineosin A.” 2018. Thesis, University of Pittsburgh. Accessed December 16, 2018. http://d-scholarship.pitt.edu/34185/1/Lang_Feng_ETD2.pdf ; http://d-scholarship.pitt.edu/34185/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lang, Feng. “Enantioenriched Oxazolidinones as Synthesis Scaffolds and Efforts towards the Total Synthesis of Marineosin A.” 2018. Web. 16 Dec 2018.

Vancouver:

Lang F. Enantioenriched Oxazolidinones as Synthesis Scaffolds and Efforts towards the Total Synthesis of Marineosin A. [Internet] [Thesis]. University of Pittsburgh; 2018. [cited 2018 Dec 16]. Available from: http://d-scholarship.pitt.edu/34185/1/Lang_Feng_ETD2.pdf ; http://d-scholarship.pitt.edu/34185/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lang F. Enantioenriched Oxazolidinones as Synthesis Scaffolds and Efforts towards the Total Synthesis of Marineosin A. [Thesis]. University of Pittsburgh; 2018. Available from: http://d-scholarship.pitt.edu/34185/1/Lang_Feng_ETD2.pdf ; http://d-scholarship.pitt.edu/34185/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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