Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for id:"oai:d-scholarship.pitt.edu:33081". One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


University of Pittsburgh

1. Wegener, Meredyth. Impact of Learning and Diet on Two Distinct Populations of Midbrain Dopamine Neurons.

Degree: 2017, University of Pittsburgh

Dopamine is a crucial component of the neural mechanisms underlying motivation and reward learning, both of which are disrupted in psychiatric disorders. Much of the research in this field has focused on the role of ventral tegmental area (VTA) and its influence on the nucleus accumbens, but there is also evidence that the substantia nigra pars compacta (SNc), a separate dopaminergic region with its own efferent and afferent projections, contributes to guiding motivated behavior. Environmental insults, such as insufficient dietary nutrition, are thought to negatively impact the dopamine system and possibly promote the development of mental illness. These issues have not yet been investigated in the context of dopamine neuronal function during reward-mediated behavior. This dissertation sought to address this gap in our knowledge through two primary objectives. Using electrophysiology in awake-behaving animals, the first aim was to simultaneously record neuronal activity in the VTA and SNc during two reward-related associative learning paradigms to understand the role each region plays in motivated behavior. The second aim was to evaluate the impact of dietary deficiency on dopamine neuronal function and identify any region-specific effects in the VTA and SNc. In our comparison of VTA and SNc, we employed an instrumental conditioning task, in which the animal executed a nose poke to earn a sugar pellet reward, and a Pavlovian conditioning task, which pairs a previously meaningless cue with a sugar pellet reward. We found that VTA and SNc may play similar roles in both forms of reward learning, possibly driven by common excitatory inputs between the two regions. We then measured correlations in activity of simultaneously recorded neurons within each region and found that how these correlations fluctuate in response to associative learning differed between regions. In our dietary manipulation experiment, we observed that event-evoked neuronal activity was reduced in animals lacking essential fatty acids, and this reduction is more pronounced in the SNc. Our findings suggest that the SNc may be more vulnerable to environmental insult and its role in reward learning and dysfunction in psychiatric disorders warrant further investigation.

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Wegener, M. (2017). Impact of Learning and Diet on Two Distinct Populations of Midbrain Dopamine Neurons. (Thesis). University of Pittsburgh. Retrieved from http://d-scholarship.pitt.edu/33081/1/WegenerETD_Final.pdf ; http://d-scholarship.pitt.edu/33081/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Wegener, Meredyth. “Impact of Learning and Diet on Two Distinct Populations of Midbrain Dopamine Neurons.” 2017. Thesis, University of Pittsburgh. Accessed December 18, 2017. http://d-scholarship.pitt.edu/33081/1/WegenerETD_Final.pdf ; http://d-scholarship.pitt.edu/33081/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Wegener, Meredyth. “Impact of Learning and Diet on Two Distinct Populations of Midbrain Dopamine Neurons.” 2017. Web. 18 Dec 2017.

Vancouver:

Wegener M. Impact of Learning and Diet on Two Distinct Populations of Midbrain Dopamine Neurons. [Internet] [Thesis]. University of Pittsburgh; 2017. [cited 2017 Dec 18]. Available from: http://d-scholarship.pitt.edu/33081/1/WegenerETD_Final.pdf ; http://d-scholarship.pitt.edu/33081/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wegener M. Impact of Learning and Diet on Two Distinct Populations of Midbrain Dopamine Neurons. [Thesis]. University of Pittsburgh; 2017. Available from: http://d-scholarship.pitt.edu/33081/1/WegenerETD_Final.pdf ; http://d-scholarship.pitt.edu/33081/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.