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You searched for id:"oai:NSYSU:etd-0806117-173323". One record found.

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NSYSU

1. Jhung, Jheng-Yan. Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway.

Degree: Master, Institute of Biomedical Sciences, 2017, NSYSU

Bladder cancer is derived from urothelial, called urothelial carcinoma. It√Ęs the most top ten cancer in Taiwan. In addition, the cancer with high mortality rate and cost of treatment. In past report, the BCL6 induced cell cycle progression and cell proliferation when the BCL6 highly expression in bladder cancer. According to the analysis of whole gene array (HumanHT-12v4 Expression BeadChip) find that 2900 genes regulated by the BCL6. Further analysis of intersection gets 1310 genes. Using the KEGG mapper analysis finds that cell cycle pathway and the FOXO pathway regulated by the BCL6. The BCL6 through the FOXO pathway effects the FOXO3 (Forkhead box O3) expression. To prove the BCL6 how to effect the FOXO3 expression level and nuclear/cytosol distribution, and then affect the cell cycle progression and cell proliferation. The FOXO3 regulates cell function and expression level through the phosphorylation site. For the reason that, to up regulates the BCL6 and add to LY294002 (PI3K inhibitor), AZD6244 (MEK inhibitor), Gefitinib (EGFR inhibitor) to observed the change of phosphorylation site and nuclear/cytosol distribution and cell cycle progression of the FOXO3. Understanding BCL6 effects the downstream genes and cell function through the MEK/ERK in T24 and BFTC905 bladder cancer cell lines. Therefore, to control the activity of BCL6 is a potential therapy. Advisors/Committee Members: Chien-Feng Li (chair), Yow-Ling Shiue (committee member), Cheng-Tang Pan (chair), Hung-Wen Huang (chair).

Subjects/Keywords: FOXO3; BCL6; Urothelial; Cell cycle; bladder cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Jhung, J. (2017). Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806117-173323

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Jhung, Jheng-Yan. “Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway.” 2017. Thesis, NSYSU. Accessed September 20, 2017. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806117-173323.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Jhung, Jheng-Yan. “Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway.” 2017. Web. 20 Sep 2017.

Vancouver:

Jhung J. Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway. [Internet] [Thesis]. NSYSU; 2017. [cited 2017 Sep 20]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806117-173323.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jhung J. Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806117-173323

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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