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University of Texas – Austin

1. -9119-8176. Cysteine responsive copper(II) based ¹⁹F MRI probes.

Degree: Chemistry, 2018, University of Texas – Austin

Cysteine plays an important role upholding cellular homeostasis by maintaining a proper redox environment. Perturbations in cysteine concentration may lead to cardiovascular and liver disease, and cancer, making cysteine an important amino acid to detect and monitor. In order to detect cysteine in vitro and in vivo it is advantageous to choose an imaging tool with high tissue penetration, low background noise, and less radiation, which led us to ¹⁹F MRI. Herein we report a series of copper complexes with fluorine moieties appended to the macrocycle cyclam for use of ¹⁹F MRI detection of cysteine. In this study, an efficient “turn-on” response was observed upon reduction of the Cu(II) complexes by cysteine. This response was characterized using UV/Vis absorption spectroscopy, NMR, EPR, and ¹⁹F MRI. Early biological results suggest that these probes can detect cysteine in red blood cells, opening the doors for further animal studies. Advisors/Committee Members: Que, Emily (advisor).

Subjects/Keywords: ¹⁹F; MRI; Cysteine; Cyclam; Copper

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

-9119-8176. (2018). Cysteine responsive copper(II) based ¹⁹F MRI probes. (Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/63548

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

-9119-8176. “Cysteine responsive copper(II) based ¹⁹F MRI probes.” 2018. Thesis, University of Texas – Austin. Accessed December 18, 2018. http://hdl.handle.net/2152/63548.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

-9119-8176. “Cysteine responsive copper(II) based ¹⁹F MRI probes.” 2018. Web. 18 Dec 2018.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-9119-8176. Cysteine responsive copper(II) based ¹⁹F MRI probes. [Internet] [Thesis]. University of Texas – Austin; 2018. [cited 2018 Dec 18]. Available from: http://hdl.handle.net/2152/63548.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

-9119-8176. Cysteine responsive copper(II) based ¹⁹F MRI probes. [Thesis]. University of Texas – Austin; 2018. Available from: http://hdl.handle.net/2152/63548

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

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