Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for id:"handle:2077/56912". One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


University of Gothenburg / Göteborgs Universitet

1. Sjöberg Jabbar, Karolina. Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis.

Degree: 2018, University of Gothenburg / Göteborgs Universitet

Mucus covers our inner interfaces towards the environment, providing protection while enabling vital interaction with the outside world. The mucus is built around mucin proteins, which are important for our defences against infection and inflammation, but may also contribute to carcinogenesis and tumour progression. These divergent aspects of mucin biology are exemplified in the different studies in this thesis, which are all based on mass spectrometry. The topics covered range from mucin biomarkers for the early diagnosis of pancreatic cancer, to the discovery of a link between a mucus-associated bacterial genus and irritable bowel syndrome. Pancreatic cancer is a relatively rare tumour form, but is postulated to become the second leading cause of cancer deaths in the United States by 2030. The poor prognosis is largely explained by late detection. With advances in imaging, cystic precursors of pancreatic cancer are detected with increasing frequency, offering an unprecedented opportunity for prevention and cure. Unfortunately, available diagnostic tools are not sufficiently robust to enable targeted intervention against high-risk cystic lesions. Here, we describe the development and evaluation of a mass spectrometry based method for quantification of mucins and other biomarkers in pancreatic cyst fluid samples. In a prospective validation cohort, the analysis identified cystic precursors of pancreatic cancer with 97% accuracy. This result represented a significant improvement upon state-of-the-art diagnostic methods. Thus, clinical implementation of the analysis may facilitate early detection of pancreatic cancer, which is a prerequisite for increasing survival rates. Ulcerative colitis is an inflammatory bowel disease with a chronic and relapsing course. According to the current view, ulcerative colitis results from inappropriate interactions between colonic microbiota and host immunity, against a background of genetic susceptibility. Normally, the abundant luminal microbes are segregated from the colonic epithelium, through an impervious mucus barrier. Here, abnormalities in mucus protein composition were detected in ulcerative colitis patients, also in samples from non-inflamed areas. This implies that structural weakening of the colonic mucus barrier could be important for the development of the disease. The natural history of ulcerative colitis varies considerably between patients. Prognostic markers for the disease course could reduce relapses and colectomies, as well as the unnecessary use of medication. Herein, we identified a ratio of two proteins in colonic mucus as a powerful predictor of the requirement for intensified medication or surgery during a five year period. Interestingly, these two proteins differentially regulate the sensing of specific microbial ligands. An altered equilibrium of these proteins was tentatively associated with infiltration of bacterial endospores in the colonic lamina propria. Thus, intermittent activation of endospores may conceivably contribute to relapses in patients with…

Subjects/Keywords: Mucus; Mass spectrometry; MUC2; MUC5AC; IPMN; Pancreatic cysts; Ulcerative colitis; IBS; Brachyspira

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Sjöberg Jabbar, K. (2018). Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/56912

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Sjöberg Jabbar, Karolina. “Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis.” 2018. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed November 19, 2018. http://hdl.handle.net/2077/56912.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Sjöberg Jabbar, Karolina. “Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis.” 2018. Web. 19 Nov 2018.

Vancouver:

Sjöberg Jabbar K. Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2018. [cited 2018 Nov 19]. Available from: http://hdl.handle.net/2077/56912.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sjöberg Jabbar K. Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition: implications for diagnosis, prognosis and pathogenesis. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2018. Available from: http://hdl.handle.net/2077/56912

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.