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University of Gothenburg / Göteborgs Universitet

1. Jesper, Magnusson. On viral infections in lung transplant recipients.

Degree: 2017, University of Gothenburg / Göteborgs Universitet

Viral infections are the most common type of infection in humans. Lung transplantation (LTx) recipients are exceptionally susceptible to infections in general, and the short- and long- term effects tend to be more detrimental. It is important to better determine the effects and outcomes of viral infections to improve survival and long-term quality of life after LTx. The following hypotheses were tested: that early viral respiratory tract infection (VRTI) has long term effect on outcome after lung transplantation (Papers I and III); that hepatitis E (HEV) antibodies are common in Swedish lung transplant recipients (Paper II); and that torque teno Virus (TTV) and Epstein-Barr virus (EBV) may be potential biomarkers for monitoring of the net state of immunosuppression after LTx. Methods: Bronchiolar lavage (BAL) samples from a retrospective cohort (Paper I) and from a prospective cohort, together with nasopharyngeal (NPH) samples. (PaperIII) were analyzed with a multiplex PCR for respiratory viruses. Prospectively collected blood samples were analyzed for HEV antibodies using two ELISA methods (Paper III) and for TTV and EBV using PCR (paper IV). Results: VRTI during the first year was associated with a shortened time to chronic rejection but not to death in both the retrospective cohort and the prospective cohort (Paper I and III). Thirteen per cent of the patients had anti -HEV antibodies during follow-up. No association between TTV DNA nor EBV DNA and immunosuppression-related events could be found. Conclusions: VRTI during the first year is an independent risk factor for chronic rejection. HEV antibodies are equally common in the LTx population and the general Swedish population. EBV DNA and TTV DNA has limited usefulness as biomarkers for monitoring of immunosuppression after lung transplantation. Keywords: Lung transplantation, respiratory infection, Respriatory virus, Hepatitis E, Torque Teno Virus, EBV.

Subjects/Keywords: Pulmonary Medicine; Lung Transplantation; Virology; Respiratory infections; PCR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Jesper, M. (2017). On viral infections in lung transplant recipients. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/53913

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Jesper, Magnusson. “On viral infections in lung transplant recipients.” 2017. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed July 21, 2018. http://hdl.handle.net/2077/53913.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Jesper, Magnusson. “On viral infections in lung transplant recipients.” 2017. Web. 21 Jul 2018.

Vancouver:

Jesper M. On viral infections in lung transplant recipients. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. [cited 2018 Jul 21]. Available from: http://hdl.handle.net/2077/53913.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jesper M. On viral infections in lung transplant recipients. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. Available from: http://hdl.handle.net/2077/53913

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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