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Leiden University

1. Doornbos, M.L.J. Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor.

Degree: 2018, Leiden University

During the course of drug discovery translational steps are made. The translation from in vitro to in vivo experiments is not as predictive as one would desire, resulting in selection of inefficacious compounds but also in overlooking of promising drug candidates. This is not different for the mGlu2 receptor for which no drugs are available on the market so far despite enormous drug discovery efforts. Therefore, there is a need to improve the molecular understanding of key in vitro parameters that drive in vivo efficacy. Hence, this thesis focuses on the concepts of target binding kinetics and functional efficacy of both allosteric and orthosteric ligands of the mGlu2 receptor. Advisors/Committee Members: Supervisor: IJzerman A.P. Co-Supervisor: Heitman L.H..

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Doornbos, M. L. J. (2018). Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor. (Doctoral Dissertation). Leiden University. Retrieved from http://hdl.handle.net/1887/65384

Chicago Manual of Style (16th Edition):

Doornbos, M L J. “Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor.” 2018. Doctoral Dissertation, Leiden University. Accessed December 17, 2018. http://hdl.handle.net/1887/65384.

MLA Handbook (7th Edition):

Doornbos, M L J. “Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor.” 2018. Web. 17 Dec 2018.

Vancouver:

Doornbos MLJ. Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor. [Internet] [Doctoral dissertation]. Leiden University; 2018. [cited 2018 Dec 17]. Available from: http://hdl.handle.net/1887/65384.

Council of Science Editors:

Doornbos MLJ. Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor. [Doctoral Dissertation]. Leiden University; 2018. Available from: http://hdl.handle.net/1887/65384

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