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Leiden University

1. Brinck, ten, R.M. Comprehending the symptomatic phase preceding rheumatoid arthritis: Clinically suspect arthralgia.

Degree: 2020, Leiden University

This thesis focused on investigating the early identification of Rheumatoid Arthritis (RA), assessing the burden of disease, and enhancing understanding of disease mechanisms in the earliest disease phases. Many of the studies in this thesis focused on data from the Leiden Clinically Suspect Arthralgia (CSA) cohort. The CSA cohort is an inception cohort at the rheumatology outpatient clinic of the Leiden University Medical Centre, in Leiden, the Netherlands. CSA patients had recent-onset (We showed that although early identification is increasingly improving, there remains a large proportion of patients that cannot be accurately identified despite a suspect pattern of signs and symptoms, as well as information on autoantibodies. Furthermore, the burden of disease is already substantial during the symptomatic pre-arthritis phase of CSA. Future studies will have to provide evidence for the effectiveness of preventing persistent RA and functional disability with prescribing Disease-modifying antirheumatic drugs (DMARD) treatment in the phase of CSA. Advisors/Committee Members: Supervisor: Helm-van Mil A.H.M. van der, Huizinga T.W.J..

Subjects/Keywords: Rheumatoid Arthritis; Clinically Suspect Arthralgia; Early Inflammatory Arthritis; Autoantibodies; Subclinical Joint Inflammation; Magnetic Resonance Imaging; Rheumatoid Arthritis; Clinically Suspect Arthralgia; Early Inflammatory Arthritis; Autoantibodies; Subclinical Joint Inflammation; Magnetic Resonance Imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Brinck, ten, R. M. (2020). Comprehending the symptomatic phase preceding rheumatoid arthritis: Clinically suspect arthralgia. (Doctoral Dissertation). Leiden University. Retrieved from http://hdl.handle.net/1887/136529

Chicago Manual of Style (16th Edition):

Brinck, ten, R M. “Comprehending the symptomatic phase preceding rheumatoid arthritis: Clinically suspect arthralgia.” 2020. Doctoral Dissertation, Leiden University. Accessed September 20, 2020. http://hdl.handle.net/1887/136529.

MLA Handbook (7th Edition):

Brinck, ten, R M. “Comprehending the symptomatic phase preceding rheumatoid arthritis: Clinically suspect arthralgia.” 2020. Web. 20 Sep 2020.

Vancouver:

Brinck, ten RM. Comprehending the symptomatic phase preceding rheumatoid arthritis: Clinically suspect arthralgia. [Internet] [Doctoral dissertation]. Leiden University; 2020. [cited 2020 Sep 20]. Available from: http://hdl.handle.net/1887/136529.

Council of Science Editors:

Brinck, ten RM. Comprehending the symptomatic phase preceding rheumatoid arthritis: Clinically suspect arthralgia. [Doctoral Dissertation]. Leiden University; 2020. Available from: http://hdl.handle.net/1887/136529

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