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IUPUI

1. Davis, Kymeri Elizabeth. Detection of Illicit Drugs in Various Matrices Via Total Vaporization Solid-Phase Microextraction.

Degree: 2019, IUPUI

Indiana University-Purdue University Indianapolis (IUPUI)

In Headspace Solid-Phase Microextraction (Headspace SPME), a sample is heated to encourage a portion of the analyte into the headspace of a vial. A coated fiber is introduced into the sample headspace and the analyte is adsorbed onto the fiber coating. Total Vaporization Solid-Phase Microextraction (TV-SPME) is a technique that is derived from this technique. In TV-SPME, liquid samples are completely vaporized allowing for better adsorption and fewer matrix effects. This method does not require any sample preparation, utilizes minimal supplies and can be automated, making it both an efficient and cost-effective method. Chapter 1 will discuss the theory of SPME and TV-SPME. In Chapter 2, the detection of ɣ-hydroxybutyric acid (GHB) and ɣ-butyrolactone (GBL) in beverages is discussed. The detection of these compounds in beverages is of importance because these drugs may be used to facilitate sexual assault. This crime utilizes substances that cause sedation and memory loss. The derivatization of GHB as well as the properties that make GHB difficult to detect will be discussed. Chapter 3 will discuss the detection of methamphetamine and amphetamine (as their trifluoroacetyl derivatives), GBL, and the trimethylsilyl derivative of GHB in human urine. Amphetamine is a metabolite of methamphetamine, therefore, both drugs should be identified within biological samples. GHB and GBL are metabolites of one another and interconvert when in aqueous solution. This interconversion will be discussed. Chapter 4 will cover method optimization of the Total Vaporization Solid-Phase Microextraction method. Analytes of interest for these analyses were methamphetamine, amphetamine, GHB, and GBL. The optimal extraction temperature ranging from 60-160°C of each drug will be discussed as well as why higher temperatures may not be suitable for this method. A limit of detection study for methamphetamine and amphetamine will also be covered. Chapter 5, the future work chapter, will discuss future analyses using the Total Vaporization Solid-Phase Microextraction method including the analysis of powder materials, plant material, and toxicological samples. Powder material will include the analysis of individual powdered drugs as well as realistic drug mixtures. Some analyses on individual powder samples has already been completed and will be shown. Plant material will include the analysis of naturally occurring compounds found in marijuana plants as well as synthetic cannabinoids. Toxicological samples will expand on previously mentioned urine samples to include drugs such as benzoylecgonine and THC-COOH.

Advisors/Committee Members: Goodpaster, John, Manicke, Nicholas, Deiss, Frédérique.

Subjects/Keywords: Gas Chromatography-Mass Spectrometry; Solid-Phase Microextraction; Drugs

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Davis, K. E. (2019). Detection of Illicit Drugs in Various Matrices Via Total Vaporization Solid-Phase Microextraction. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/19903

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Davis, Kymeri Elizabeth. “Detection of Illicit Drugs in Various Matrices Via Total Vaporization Solid-Phase Microextraction.” 2019. Thesis, IUPUI. Accessed August 24, 2019. http://hdl.handle.net/1805/19903.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Davis, Kymeri Elizabeth. “Detection of Illicit Drugs in Various Matrices Via Total Vaporization Solid-Phase Microextraction.” 2019. Web. 24 Aug 2019.

Vancouver:

Davis KE. Detection of Illicit Drugs in Various Matrices Via Total Vaporization Solid-Phase Microextraction. [Internet] [Thesis]. IUPUI; 2019. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/1805/19903.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Davis KE. Detection of Illicit Drugs in Various Matrices Via Total Vaporization Solid-Phase Microextraction. [Thesis]. IUPUI; 2019. Available from: http://hdl.handle.net/1805/19903

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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