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You searched for id:"handle:1805/19901". One record found.

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IUPUI

1. Bills, Brandon John. Studying and Modifying Paper to Lower Detection Limits for Paper Spray Mass Spectrometry.

Degree: 2019, IUPUI

Indiana University-Purdue University Indianapolis (IUPUI)

In this work we developed paper spray mass spectrometry methods to obtain lower detection limits for pharmaceuticals and drugs of abuse. The second chapter investigates blood fractionation membranes for their ability to obtain lysis free plasma from whole blood without changing the drug concentration relative to centrifugation. We presented a device capable of obtaining and analyzing plasma samples from whole blood and obtaining quantitative results similar to traditional methods. In the third chapter the properties of the paper substrate are investigated systematically for their impacts on ionization efficiency and recovery in combination with the solvent choice. The fourth and fifth chapters detail a simple method for lowering detection limits using a method called paper strip extraction. In this method biofluids are wicked through either sesame seed oil or solid phase extraction powder on a paper strip to concentrate and preserve (in the case of THC) analytes out of biofluids. The use of 3D printing for rapid prototyping and how it potentially impacts paper spray MS sensitivity is outlined in the final chapter.

Advisors/Committee Members: Manicke, Nicholas, Goodpaster, John, Laulhé, Sébastien, Rusyniak, Daniel.

Subjects/Keywords: Paper Spray; Mass Spectrometry; 3D printing; Tetrahydrocannabinol; New psychoactive substances

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bills, B. J. (2019). Studying and Modifying Paper to Lower Detection Limits for Paper Spray Mass Spectrometry. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/19901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Bills, Brandon John. “Studying and Modifying Paper to Lower Detection Limits for Paper Spray Mass Spectrometry.” 2019. Thesis, IUPUI. Accessed August 24, 2019. http://hdl.handle.net/1805/19901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Bills, Brandon John. “Studying and Modifying Paper to Lower Detection Limits for Paper Spray Mass Spectrometry.” 2019. Web. 24 Aug 2019.

Vancouver:

Bills BJ. Studying and Modifying Paper to Lower Detection Limits for Paper Spray Mass Spectrometry. [Internet] [Thesis]. IUPUI; 2019. [cited 2019 Aug 24]. Available from: http://hdl.handle.net/1805/19901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bills BJ. Studying and Modifying Paper to Lower Detection Limits for Paper Spray Mass Spectrometry. [Thesis]. IUPUI; 2019. Available from: http://hdl.handle.net/1805/19901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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