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University of Rochester

1. Xu, Mengchen; Yoon, Geunyoung. Investigation of corneal biomechanical and optical behaviors by developing individualized finite element model.

Degree: PhD, 2019, University of Rochester

The biomechanics of the cornea has a significant impact on its optical behavior. Alterations in corneal biomechanics lead to abnormalities in the surface topography and affect ocular aberrations that degrade retinal image quality. The goal of this thesis work is aimed towards investigating the interaction of corneal biomechanical and optical behaviors through development of an individualized corneal model based on the finite element method that accounts for the large variations in corneal geometry and material properties. The goal of the thesis can be divided into four specific aims. First, we investigated the biomechanical and optical behaviors of a healthy normal cornea at various IOPs through numerical simulations based on a widely accepted anisotropic hyperelastic FE model. We conducted a sensitivity analysis based on a powerful experimental/statistical technique, the DOE method. The biomechanical and optical responses of the cornea to IOP elevation as well as the relative contribution of multiple geometrical and material parameters to corneal biomechanical and optical behaviors were evaluated. We found that the radius of curvature of the cornea was the most important geometric parameter that contributes to both biomechanical and optical behaviors of the cornea. For material parameters, corneal apical displacement was influenced nearly evenly by matrix stiffness, fiber stiffness and nonlinearity. However, the corneal optical aberrations were primarily affected by the matrix stiffness and the distribution of collagen fibril dispersion. These findings have important implications for future theoretical and experimental studies of the cornea, especially for the development of an individualized cornea model. Second, we proposed new methods for material characterization of individual corneas. We aimed to characterize a complete set of material parameters for developing an individualized 3-D anisotropic hyperelastic corneal model, which provides accurate prediction of the interrelation between corneal biomechanics and optics of a specific cornea. We proposed novel methods mainly focusing on the individual quantification of three challenging material parameters, including collagen fiber stiffness, collagen fiber nonlinearity and collagen fibril dispersion using optical information of the cornea to overcome the traditional challenges in corneal material characterization. The new material characterization method could also be beneficial for future development of an in vivo individualized biomechanical model of the cornea and the investigation of the impact of corneal biomechanics on patient’s visual performance for clinical applications. Third, we evaluated the clinical significance of corneal biomechanical modeling in one of the important clinical applications, laser refractive surgery. An accurate prediction of the biomechanical response of the cornea to tissue ablation would help to predict postoperative surgical outcomes, which can be taken into account in developing new surgical…

Subjects/Keywords: Cornea; Biomechanics; Optics; Finite element model; Optical aberrations

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Xu, Mengchen; Yoon, G. (2019). Investigation of corneal biomechanical and optical behaviors by developing individualized finite element model. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/34992

Chicago Manual of Style (16th Edition):

Xu, Mengchen; Yoon, Geunyoung. “Investigation of corneal biomechanical and optical behaviors by developing individualized finite element model.” 2019. Doctoral Dissertation, University of Rochester. Accessed June 24, 2019. http://hdl.handle.net/1802/34992.

MLA Handbook (7th Edition):

Xu, Mengchen; Yoon, Geunyoung. “Investigation of corneal biomechanical and optical behaviors by developing individualized finite element model.” 2019. Web. 24 Jun 2019.

Vancouver:

Xu, Mengchen; Yoon G. Investigation of corneal biomechanical and optical behaviors by developing individualized finite element model. [Internet] [Doctoral dissertation]. University of Rochester; 2019. [cited 2019 Jun 24]. Available from: http://hdl.handle.net/1802/34992.

Council of Science Editors:

Xu, Mengchen; Yoon G. Investigation of corneal biomechanical and optical behaviors by developing individualized finite element model. [Doctoral Dissertation]. University of Rochester; 2019. Available from: http://hdl.handle.net/1802/34992

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