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Erasmus University Rotterdam

1. Knuth, Callie. Towards Improved Bone Regeneration: Naar verbeterde botregeneratie.

Degree: 2019, Erasmus University Rotterdam

textabstractThe aim of the thesis, “Towards improved bone regeneration,” was to investigate ways to improve tissue engineered endochondral bone grafts. In this thesis we improve the construction of these grafts by identifying a more stable cell source with more favorable in vitro expansion characteristics compared to current gold standard cells, and expand upon our understanding of how such constructs form bone in vivo by investigating the importance of collagen type X during this process. By creating an easily injectable micropellet construct, an injectable endochondral bone forming construct was developed which could be used in combinational therapies with compounds, such as Emdogain, to perhaps further improve the effectiveness of graft outcomes which are described in more detail below. Together the studies in this thesis move our understanding and possible clinical applications for endochondral bone grafts forward.

Subjects/Keywords: Endochondral ossification; bone tissue engineering; mesenchymal stem cells; paediatric MSCs; collagen type x; micropellets; bone regeneration; msc expansion; chondrogenic differentiation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Knuth, C. (2019). Towards Improved Bone Regeneration: Naar verbeterde botregeneratie. (Doctoral Dissertation). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/117367

Chicago Manual of Style (16th Edition):

Knuth, Callie. “Towards Improved Bone Regeneration: Naar verbeterde botregeneratie.” 2019. Doctoral Dissertation, Erasmus University Rotterdam. Accessed July 20, 2019. http://hdl.handle.net/1765/117367.

MLA Handbook (7th Edition):

Knuth, Callie. “Towards Improved Bone Regeneration: Naar verbeterde botregeneratie.” 2019. Web. 20 Jul 2019.

Vancouver:

Knuth C. Towards Improved Bone Regeneration: Naar verbeterde botregeneratie. [Internet] [Doctoral dissertation]. Erasmus University Rotterdam; 2019. [cited 2019 Jul 20]. Available from: http://hdl.handle.net/1765/117367.

Council of Science Editors:

Knuth C. Towards Improved Bone Regeneration: Naar verbeterde botregeneratie. [Doctoral Dissertation]. Erasmus University Rotterdam; 2019. Available from: http://hdl.handle.net/1765/117367

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