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Brno University of Technology

1. Klobušiaková, Patrícia. Hodnocení strukturální a funkční konektivity u pacientů s Parkinsonovou nemocí: Structural and functional connectivity assessment in patients with Parkinson's disease.

Degree: 2020, Brno University of Technology

Early changes in visuospatial functions predict dementia in Parkinson’s disease (PD). The aim of this work is to assess both structural and functional connectivity of the fasciculus longitudinalis inferior (ILF), which is engaged in visuospatial processing, in PD patients in comparison to healthy controls, and to find associations between connectivity changes and cognitive performance in the patient groups with or without mild cognitive impairment (MCI). To achieve our goal we recruited PD patients with normal cognition (PD-NC, n = 23) and PD with MCI (PD-MCI, n = 21) as well as healthy controls (HC, n = 48). Bidirectional iterative parcellation was used to isolate ILF tracts and their respective endpoints (occipital lobe and anterior temporal lobe) in each subject. The endpoints then served as regions of interest for functional connectivity calculation. We found ILF microstructural connectivity impairment in PD-MCI group, as measured by mean diffusivity, fractional anisotropy and radial diffusivity. In addition, the functional connectivity of ILF tracts was decreased already in the PD-NC. Both structural and functional connectivity deterioration was associated with visuospatial dysfunction in PD-MCI. These changes could serve as potential markers of disease progression or treatment effects monitoring. Advisors/Committee Members: Mekyska, Jiří (advisor), Keller, Jiří (referee).

Subjects/Keywords: Parkinsonova choroba; fMRI; obojsmerná iteratívna parcelácia; konektivita; fasciculus longitudinalis inferior; Parkinson’s disease; fMRI; Bidirectional Iterative Parcellation; connectivity; inferior longitudinal fasciculus

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APA (6th Edition):

Klobušiaková, P. (2020). Hodnocení strukturální a funkční konektivity u pacientů s Parkinsonovou nemocí: Structural and functional connectivity assessment in patients with Parkinson's disease. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/190461

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Klobušiaková, Patrícia. “Hodnocení strukturální a funkční konektivity u pacientů s Parkinsonovou nemocí: Structural and functional connectivity assessment in patients with Parkinson's disease.” 2020. Thesis, Brno University of Technology. Accessed August 11, 2020. http://hdl.handle.net/11012/190461.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Klobušiaková, Patrícia. “Hodnocení strukturální a funkční konektivity u pacientů s Parkinsonovou nemocí: Structural and functional connectivity assessment in patients with Parkinson's disease.” 2020. Web. 11 Aug 2020.

Vancouver:

Klobušiaková P. Hodnocení strukturální a funkční konektivity u pacientů s Parkinsonovou nemocí: Structural and functional connectivity assessment in patients with Parkinson's disease. [Internet] [Thesis]. Brno University of Technology; 2020. [cited 2020 Aug 11]. Available from: http://hdl.handle.net/11012/190461.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Klobušiaková P. Hodnocení strukturální a funkční konektivity u pacientů s Parkinsonovou nemocí: Structural and functional connectivity assessment in patients with Parkinson's disease. [Thesis]. Brno University of Technology; 2020. Available from: http://hdl.handle.net/11012/190461

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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