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Virginia Tech

1. O'Neal, Scott Thomas. The role of ATP-sensitive inwardly rectifying potassium channels in the honey bee (Apis mellifera L.).

Degree: PhD, Entomology, 2017, Virginia Tech

Honey bees are economically important pollinators of a wide variety of crops that have attracted the attention of both researchers and the public alike due to unusual declines in the numbers of managed colonies in some parts of the world. Viral infections are thought to be a significant factor contributing to these declines, along with exposure to agricultural and apicultural pesticides, but viruses have proven a challenging pathogen to study in a bee model and interactions between viruses and the bee antiviral immune response remain poorly understood. Recent studies have demonstrated an important role for inwardly-rectifying ATP-sensitive potassium (KATP) channels in the cardiac regulation of the fruit fly antiviral immune response, but no information is available on their role in the heart-specific regulation of bee immunity. The results of this work demonstrate that KATP channel modulators have an observable effect on honey bee heart rate that supports their expected physiological role in bee cardiac function. Here, it is also reported that the entomopathogenic flock house virus (FHV) infects adult bees, causing rapid onset of mortality and accumulation of viral RNA. Furthermore, infection-mediated mortality can be altered by pre-exposure to KATP channel modulators. Finally, this work shows that exposure to environmental stressors such as commonly used in-hive acaricides can impact bee cardiac physiology and tolerance to viral infection. These results suggest that KATP channels provide a significant link between cellular metabolism and the antiviral immune response in bees and highlight the significant impact of environmental stressors on pollinator health. Advisors/Committee Members: Anderson, Troy D (committeechair), Brewster, Carlyle C (committeechair), Bloomquist, Jeffrey R (committee member), Swale, Daniel Robert (committee member), Kuhar, Thomas P (committee member).

Subjects/Keywords: Honey bee; cardiac function; ion channel; virus; antiviral immunity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

O'Neal, S. T. (2017). The role of ATP-sensitive inwardly rectifying potassium channels in the honey bee (Apis mellifera L.). (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/78344

Chicago Manual of Style (16th Edition):

O'Neal, Scott Thomas. “The role of ATP-sensitive inwardly rectifying potassium channels in the honey bee (Apis mellifera L.).” 2017. Doctoral Dissertation, Virginia Tech. Accessed October 24, 2017. http://hdl.handle.net/10919/78344.

MLA Handbook (7th Edition):

O'Neal, Scott Thomas. “The role of ATP-sensitive inwardly rectifying potassium channels in the honey bee (Apis mellifera L.).” 2017. Web. 24 Oct 2017.

Vancouver:

O'Neal ST. The role of ATP-sensitive inwardly rectifying potassium channels in the honey bee (Apis mellifera L.). [Internet] [Doctoral dissertation]. Virginia Tech; 2017. [cited 2017 Oct 24]. Available from: http://hdl.handle.net/10919/78344.

Council of Science Editors:

O'Neal ST. The role of ATP-sensitive inwardly rectifying potassium channels in the honey bee (Apis mellifera L.). [Doctoral Dissertation]. Virginia Tech; 2017. Available from: http://hdl.handle.net/10919/78344

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