Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for id:"handle:10900/86236". One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters

1. Rosenbaum, David. Aberrant brain activation and coupling in Depression – Links between Psychopathology and Neurophysiology .

Degree: 2019, Universität Tübingen

Major Depressive Disorder (MDD) is the most common mental disorder and ranging under the top three of the most disabling diseases worldwide. Although various treatments exist for MDD, about 30 to 40 % of the patients don’t respond. A better understanding of the neurobiological correlates of MDD might lead to the development of new and the improvement of existing treatments. The dissertation at hand is dedicated to the aim of a better understanding of aberrant brain functioning and coupling in MDD. Further, we sought to investigate the behavioral and cognitive-affective underpinnings that lead to aberrant brain functioning and coupling in MDD, in terms of depressive rumination. In total this work comprises four studies. In our first study, we investigated the functional connectivity (FC) during resting state (rsFC) and task performance of the Trail Making Test (TMT) in subjects with late-life depression (LLD) and healthy controls (HC). FC was assessed via functional near-infrared spectroscopy (fNIRS) in areas of the cognitive control network (CCN). While we observed an expected pattern of change in FC in the healthy controls with relatively low FC during resting-state and an increase during task-performance, subjects with LLD showed an opposite pattern, with relatively high FC during resting-state and decreases during task-performance. Further, depressed and non-depressed subjects differed significantly during resting-state (LLD>HC) and the executive demanding condition of the TMT (HC>LLD). While these results were interesting from a standpoint of pathophysiological changes in FC, we couldn’t give a final explanation for the observed FC patterns in LLD. As a possible explanation, we assumed that some kind of depressive cognitive process could lead to hyper-connectivity within the CCN during resting-state that further disturbs cortical coupling during task performance. As depressive rumination is such a cognitive process that is common in depression, we developed a resting-state questionnaire to assess state rumination for subsequent studies. In study two, we investigated rsFC within subjects with MDD and HC with a parietal probeset covering parts of the default mode network (DMN), CCN and dorsal attention network (DAN). Further, we investigated in how far state- and trait rumination explained the differences between depressed and non-depressed subjects in rsFC. In contrast to our first study, we observed an opposite pattern of FC differences between the groups: within the parietal cortex, depressed subjects showed reduced FC in comparison to HC in a widespread bilateral network. While state rumination showed rather restricted effects, the measures of trait rumination showed wide-spread effects. Further, FC was negatively correlated with state- and trait rumination. Since our results so far were restricted to non-experimental between-subject associations, that don’t allow the investigation of causal relationships, we further designed a study in which we sought to induce rumination with the Trier Social Stress… Advisors/Committee Members: Fallgatter, Andreas (Prof. Dr.) (advisor).

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rosenbaum, D. (2019). Aberrant brain activation and coupling in Depression – Links between Psychopathology and Neurophysiology . (Thesis). Universität Tübingen. Retrieved from http://hdl.handle.net/10900/86236

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Rosenbaum, David. “Aberrant brain activation and coupling in Depression – Links between Psychopathology and Neurophysiology .” 2019. Thesis, Universität Tübingen. Accessed February 22, 2019. http://hdl.handle.net/10900/86236.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Rosenbaum, David. “Aberrant brain activation and coupling in Depression – Links between Psychopathology and Neurophysiology .” 2019. Web. 22 Feb 2019.

Vancouver:

Rosenbaum D. Aberrant brain activation and coupling in Depression – Links between Psychopathology and Neurophysiology . [Internet] [Thesis]. Universität Tübingen; 2019. [cited 2019 Feb 22]. Available from: http://hdl.handle.net/10900/86236.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rosenbaum D. Aberrant brain activation and coupling in Depression – Links between Psychopathology and Neurophysiology . [Thesis]. Universität Tübingen; 2019. Available from: http://hdl.handle.net/10900/86236

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.