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Karolinska Institute

1. Pettersson, Henrik. Physical function, physical activity and quality of life in systemic sclerosis .

Degree: 2019, Karolinska Institute

Background and aims. Systemic sclerosis (SSc) is a multisystem rheumatic disease characterized by fibrosis, vasculopathy and immune system activation. There is a dearth of knowledge how different subphenotypes such as patients with no–mild and moderate–end-stage lung disease differs in physical function and activity, muscle function and active range of motion. Likewise, no study has yet investigated what experiences patients with SSc have of physical activity and exercise. Although it is known that many patients with SSc have physical disabilities, reduced health-related quality of life (HRQoL) and have anxiety and depression symptoms, little is known about differences between patients with no-mild and moderate-end-stage lung disease respectively. The overarching aim of this thesis was to increase the knowledge of physical function, physical activity and HRQoL in patients with SSc and different degrees of lung disease. The specific aims were to investigate the differences in physical capacity, physical activity, muscle function and range of motion in comparison with population-based controls or reference values. Further, a specific aim was to explore patients’ own experiences of physical activity and exercise. Participants and methods. Three Cross-sectional studies were performed. In paper 1, 106 patients with SSc and 106 age- and gender-matched population-based controls were involved. In paper II, 205 patients with SSc were compared with reference values and in a paper III, 279 patients were involved. Further, a qualitative study with interviews of 16 individuals with SSc were performed and underwent a content analysis. Results. Paper I: Patients with SSc reported overall lower physical capacity for walking, jogging, and running, and more limiting factors for physical capacity than controls. Patients with no–mild lung disease reported pain more often than their controls, whereas moderate–severe lung disease patients reported cardiopulmonary disease and reduced muscle strength as limiting factors for physical capacity more often than their controls. More patients than controls had ‘never exercised’ for at least 30 min per occasion within the past year; however, there were no differences overall between patients and controls in frequency of exercise, physical activity, nor time spent sitting. Paper II: Shoulder- and hip flexion muscle endurance were lower in relation to reference values, median [53% and 40% of predicted], respectively. Patients with moderate–end-stage lung disease had lower endur- ance in shoulder- and hip flexion [39% and 35%] than patients with no-mild lung disease [57% and 48%]. All patients, regardless subtype/grouping, needed longer time to complete the Timed-Stands Test (TST) [21 s] compared to reference values [17 s], and patients with moderate–end-stage lung disease needed longer time to complete TST than patients with no-mild lung involvement, [25 s vs 19 s]. Active range of motion in shoulder-arm were lower compared with reference values, and patients with dcSSc had…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Pettersson, H. (2019). Physical function, physical activity and quality of life in systemic sclerosis . (Thesis). Karolinska Institute. Retrieved from http://hdl.handle.net/10616/46685

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Pettersson, Henrik. “Physical function, physical activity and quality of life in systemic sclerosis .” 2019. Thesis, Karolinska Institute. Accessed April 22, 2019. http://hdl.handle.net/10616/46685.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Pettersson, Henrik. “Physical function, physical activity and quality of life in systemic sclerosis .” 2019. Web. 22 Apr 2019.

Vancouver:

Pettersson H. Physical function, physical activity and quality of life in systemic sclerosis . [Internet] [Thesis]. Karolinska Institute; 2019. [cited 2019 Apr 22]. Available from: http://hdl.handle.net/10616/46685.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pettersson H. Physical function, physical activity and quality of life in systemic sclerosis . [Thesis]. Karolinska Institute; 2019. Available from: http://hdl.handle.net/10616/46685

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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