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Karolinska Institute

1. Schollin Ask, Lina. The introduction of rotavirus vaccine in Sweden : setting the scene and short term outcomes .

Degree: 2019, Karolinska Institute

Background: The rotavirus causes the most severe cases of viral gastroenteritis in small children worldwide, resulting in both high morbidity and mortality. The World Health Organization has recommended vaccination against the rotavirus since 2009 and the vaccine had been introduced by more than 90 countries in 2017. Since 2014, the vaccine has been offered to all newborn infants in Stockholm and Jönköping counties and it will be introduced into the national Swedish immunization program in September 2019. The aim of this thesis is to create a platform for the national implementation of the rotavirus vaccine in Sweden. It studies parental attitudes to the vaccine, examines the rare, but serious, adverse event of intussusception and looks at how the vaccine affects the burden of disease. The thesis also looks at social disparities in hospital use due to gastroenteritis. Methods and Results: Different methods have been used to illustrate different aspects of the introduction of the rotavirus vaccine in Sweden in the five studies included in this thesis. The thesis highlights the importance of good relationships between child health care nurses and parents, sets the scene for safety surveillance, shows how paediatric care for gastroenteritis has been reduced by the rotavirus vaccine and also shows social differences in the utilization of paediatric care for gastroenteritis in small children. Studies I and II focused on parental attitudes, conceptions and knowledge of the rotavirus vaccine during the implementation of the vaccine in Stockholm. Both studies included parents of newborn infants before the first dose of the rotavirus vaccine was offered. Study I was a cross-sectional questionnaire study of 1,063 parents. The analyses were carried out using Pearson´s chi-square test and stepwise logistic regression in order to find the main predictors for vaccination or not. Most parents (81%) intended to vaccinate their child, 8% did not want to vaccinate and 11% were uncertain. Poor knowledge about the vaccine and the rotavirus infection, less trust in the child health care nurse, lower levels of education and having a child of up to five weeks of age were associated with being hesitant or unwilling to vaccinate. Study II was a qualitative study of 10 in-depth interviews with parents. We identified four main categories that showed different conceptions of the rotavirus vaccine: to vaccinate without doubt, hesitant to vaccinate, risky to vaccinate and unnecessary to vaccinate. Study III was a validation study of the diagnosis of intussusception in children under three years of age and it used data from the Swedish National Patient Register for the period 1987-2013. The aim of this study was to create a platform for further register-based follow-up studies of this rare, but serious, adverse event of the rotavirus vaccine. We manually reviewed 392 medical records that were randomly selected by The National Board of Health and Welfare from both pediatric and surgery care in Sweden, by using accepted…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Schollin Ask, L. (2019). The introduction of rotavirus vaccine in Sweden : setting the scene and short term outcomes . (Thesis). Karolinska Institute. Retrieved from http://hdl.handle.net/10616/46656

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Schollin Ask, Lina. “The introduction of rotavirus vaccine in Sweden : setting the scene and short term outcomes .” 2019. Thesis, Karolinska Institute. Accessed April 22, 2019. http://hdl.handle.net/10616/46656.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Schollin Ask, Lina. “The introduction of rotavirus vaccine in Sweden : setting the scene and short term outcomes .” 2019. Web. 22 Apr 2019.

Vancouver:

Schollin Ask L. The introduction of rotavirus vaccine in Sweden : setting the scene and short term outcomes . [Internet] [Thesis]. Karolinska Institute; 2019. [cited 2019 Apr 22]. Available from: http://hdl.handle.net/10616/46656.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schollin Ask L. The introduction of rotavirus vaccine in Sweden : setting the scene and short term outcomes . [Thesis]. Karolinska Institute; 2019. Available from: http://hdl.handle.net/10616/46656

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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