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Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

1. Savvoulidis, Panagiotis. Συσχέτιση των επιπέδων της πρωτεΐνης a-Klotho με το βαθμό επασβέστωσης της αορτικής βαλβίδας και των στεφανιαίων αγγείων σε ασθενείς με χρόνια νεφρική ανεπάρκεια.

Degree: 2021, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)

Our study was a cross-sectional observational study with 60 enrolled patients with chronic kidney disease (CKD) stage III and stage V evenly distributed between the two groups. We explored the association between the levels of a-klotho and the calcification of the coronary arteries and the aortic valve. Serum levels of a-klotho were statistically significantly lower in the CKD stage V on hemodialysis sub-group compared with the CKD stage III sub-group. No difference was found in the severity of vascular calcification of the coronary arteries and the aortic valve between the two groups. In multivariate regression analysis calcitonin, parathyroid hormone and phosphorus levels were associated with serum concentration of a-klotho while hyperlipidemia was the only factor associated with calcification of the coronary arteries. No variable was identified as associated factor for calcification of the aortic valve. In summary, no association between the levels of a-klotho protein and the severity of calcification of the coronary arteries and the aortic valve was identified in our study population. This study confirms previous studies where a-klotho levels decrease with the progression of CKD severity. Furthermore, multivariate analysis confirmed associated factors of a-klotho levels and vascular calcification as previously documented in other studies. A-klotho has a pivotal role in the regulation and homeostasis of minerals and therefore, is part of the regulatory factors of the levels of calcium and phosphorus, among others like parathyroid hormone (regulates levels of calcium and phosphorus) and calcitonin (regulates calcium levels) which were identified as associated factors for the levels of a-klotho. By contrast, no significant difference in the level of calcification in the coronary arteries and the aortic valve was identified between the two study groups. A potential explanation for this finding is that the majority of the patients enrolled in our study sub-group CKD stage III were actually in stage IIIb (73% of this group) and hence, the severity of CKD was closer to the more advanced stages of CKD stage IV and V implying possible advanced vascular calcification as a consequence. Therefore, the size of the studied population possibly has been small to depict statistically significant differences. Our study has some limitations. This was a cross-sectional study and as such can not identify the temporal progression of calcification which may have been different between the two study groups and may be a point to be evaluated in future studies. Furthermore, as a cross-sectional observational study can not infer causality which is an inherent limitation of studies of this sort. One other limitation of our study is that all participants were of Caucasian race and therefore our findings can not be extrapolated to patients of different race. In conclusion, in our study we confirmed that the levels of serum a-klotho decrease as the severity of CKD progresses and that there is at least moderate vascular calcification in the…

Subjects/Keywords: Χρόνια νεφρική ανεπάρκεια (ΧΝΑ) τελικού σταδίου; Αγγειακή επασβέστωση; Ασβέστωση στεφανιαίων αρτηριών; Αορτική ασβέστωση; End stage chronic kidney disease; Vascular calcification; Coronary artery calcification; Aortic valve calcification

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APA (6th Edition):

Savvoulidis, P. (2021). Συσχέτιση των επιπέδων της πρωτεΐνης a-Klotho με το βαθμό επασβέστωσης της αορτικής βαλβίδας και των στεφανιαίων αγγείων σε ασθενείς με χρόνια νεφρική ανεπάρκεια. (Thesis). Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/48824

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Savvoulidis, Panagiotis. “Συσχέτιση των επιπέδων της πρωτεΐνης a-Klotho με το βαθμό επασβέστωσης της αορτικής βαλβίδας και των στεφανιαίων αγγείων σε ασθενείς με χρόνια νεφρική ανεπάρκεια.” 2021. Thesis, Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Accessed March 01, 2021. http://hdl.handle.net/10442/hedi/48824.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Savvoulidis, Panagiotis. “Συσχέτιση των επιπέδων της πρωτεΐνης a-Klotho με το βαθμό επασβέστωσης της αορτικής βαλβίδας και των στεφανιαίων αγγείων σε ασθενείς με χρόνια νεφρική ανεπάρκεια.” 2021. Web. 01 Mar 2021.

Vancouver:

Savvoulidis P. Συσχέτιση των επιπέδων της πρωτεΐνης a-Klotho με το βαθμό επασβέστωσης της αορτικής βαλβίδας και των στεφανιαίων αγγείων σε ασθενείς με χρόνια νεφρική ανεπάρκεια. [Internet] [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2021. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10442/hedi/48824.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Savvoulidis P. Συσχέτιση των επιπέδων της πρωτεΐνης a-Klotho με το βαθμό επασβέστωσης της αορτικής βαλβίδας και των στεφανιαίων αγγείων σε ασθενείς με χρόνια νεφρική ανεπάρκεια. [Thesis]. Aristotle University Of Thessaloniki (AUTH); Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ); 2021. Available from: http://hdl.handle.net/10442/hedi/48824

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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