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University of Ottawa

1. Noblett, Nathaniel. A Role for the Caenorhabditis Elegans Adenylate Gorming Domain Protein Disco-Interacting Protein 2 (DIP-2) in the Maintenance of Neuron Morphology .

Degree: 2018, University of Ottawa

Post-developmentally, neurons are very long lived and, while shown to be capable of plasticity-promoting remodeling of dendritic structures, are thought to maintain relatively stable morphologies over long animal lifespans. The molecular mechanisms that maintain neuronal morphology remain poorly understood. Members of the highly conserved DIP2 protein family contain an N-terminal DNA methyltransferase-associated protein 1 (DMAP1) binding domain and two adenylate-forming (AFD) domains. Using two loss-of-function alleles, we show that DIP-2 acts to maintain neuronal morphology in C. elegans. dip-2 mutants display a progressive increase in ectopic neurite sprouting and branching post-development. DIP-2 acts in a DMAP1 binding-domain-independent manner to maintain neuronal morphology post-developmentally and DIP-2 overexpression can suppress the normal increase in neuronal sprouting defects observed in aging worms. Endogenous DIP-2 is widely expressed in neuronal and epithelial tissue but acts cell-autonomously in neurons. Finally, dip-2 neuronal defects are modified by loss of insulin/IGF-1 signalling (IIS) and DIP-2 acts in parallel with the SAX-2/Furry-SAX-1/NDR kinase pathway to regulate neuronal morphology.

Subjects/Keywords: Neuroscience; Genetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Noblett, N. (2018). A Role for the Caenorhabditis Elegans Adenylate Gorming Domain Protein Disco-Interacting Protein 2 (DIP-2) in the Maintenance of Neuron Morphology . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/38083

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Noblett, Nathaniel. “A Role for the Caenorhabditis Elegans Adenylate Gorming Domain Protein Disco-Interacting Protein 2 (DIP-2) in the Maintenance of Neuron Morphology .” 2018. Thesis, University of Ottawa. Accessed September 23, 2018. http://hdl.handle.net/10393/38083.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Noblett, Nathaniel. “A Role for the Caenorhabditis Elegans Adenylate Gorming Domain Protein Disco-Interacting Protein 2 (DIP-2) in the Maintenance of Neuron Morphology .” 2018. Web. 23 Sep 2018.

Vancouver:

Noblett N. A Role for the Caenorhabditis Elegans Adenylate Gorming Domain Protein Disco-Interacting Protein 2 (DIP-2) in the Maintenance of Neuron Morphology . [Internet] [Thesis]. University of Ottawa; 2018. [cited 2018 Sep 23]. Available from: http://hdl.handle.net/10393/38083.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Noblett N. A Role for the Caenorhabditis Elegans Adenylate Gorming Domain Protein Disco-Interacting Protein 2 (DIP-2) in the Maintenance of Neuron Morphology . [Thesis]. University of Ottawa; 2018. Available from: http://hdl.handle.net/10393/38083

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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