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University of Saskatchewan

1. Ostad Ali Dehaghi, Razieh 1983-. D-Lactate and its related metabolic intermediates: Potential biomarkers for diabetic vascular complications.

Degree: 2019, University of Saskatchewan

Micro- and macrovascular diseases are the main causes of mortality and morbidity among patients with Type 2 Diabetes Mellitus (DM2). Routine surveillance for vascular complications in these individuals is important to optimize their health outcomes. Endothelial dysfunction is one of the known root causes of micro- and macrovascular problems of all patients including diabetic patients, yet endothelial function is not directly tested in diabetic individuals. Intracellular Adhesion Molecule (ICAM), Vascular Adhesion Molecule (VCAM), and E-selectin are three important research biomarkers of endothelial function. D- and L-Lactate and methylglyoxal are three natural glucose metabolites and have known toxicity to the endothelium. We aimed to explore the correlation of these three key glucose metabolites in diabetic patients with the biomarkers of endothelial dysfunction to determine if glucose control is reflective of endothelial health. Metformin, a common oral diabetic medication, may increase D-lactate levels in serum and may directly damage endothelium, which was also explored in this study. The study involved an open label randomized design with four unique groups of participants. Two groups were patients with a DM2 diagnosis who either were prescribed metformin (DM2 plus MET) or were not treated with metformin (DM2 no MET). The remaining two control groups did not have DM2, but one group was prescribed metformin for unrelated indications (i.e. women with PCOS) (NonDM plus MET) and the other group was not prescribed metformin (NonDM no MET). Multiple fasting blood samples were collected from each individual over the 1-year study at the Royal University Hospital in Saskatoon. In total 76 persons participated in the study, 6 in DM2 plus MET, 1 in DM2 no MET, 39 in NonDM plus MET and 30 in NonDM no MET groups. In the non-DM2 groups, 35 of 39 participants were women treated for >6 months with metformin for polycystic ovarian syndrome (PCOS) and were originally recruited as part of another study. We hypothesized that the hyperglycemia associated with DM2 correlates with relatively high levels of glucose metabolites and endothelial damage markers. To test this correlation, fasting glucose, hemoglobin A1C, and fasting insulin levels of all participants were measured. All these measurements revealed that levels of these factors among diabetic patients are higher than non-diabetic patients consistent with their underlying hyperglycemia. The mean for fasting glucose levels was 9.4 mmol/L for diabetic participants and 5.0 mmol/L in non-diabetic participants over three independent testing times. The mean levels for HbA1C were 7.2% in the diabetic groups and 5.2% for non-diabetic participants (normal <7%). These findings revealed suboptimal long- (reflected by HbA1c) and short-term (fasting glucose) glucose control among diabetic participants. As predicted, the levels of three glucose metabolites, D-lactate, L-lactate, and methylglyoxal, were higher in the diabetic population than in non-diabetic participants. We did not detect… Advisors/Committee Members: Alcorn, Jane, Arnason, Terra, Zello, Gord, Alcorn, Jane, Arnason, Terra, Zello, Gord, Badea, Ildiko [email protected], Baerwald, Angela.

Subjects/Keywords: D-Lactate; biomarkers; vascular complications

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APA (6th Edition):

Ostad Ali Dehaghi, R. 1. (2019). D-Lactate and its related metabolic intermediates: Potential biomarkers for diabetic vascular complications. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Ostad Ali Dehaghi, Razieh 1983-. “D-Lactate and its related metabolic intermediates: Potential biomarkers for diabetic vascular complications.” 2019. Thesis, University of Saskatchewan. Accessed September 19, 2019. http://hdl.handle.net/10388/12273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Ostad Ali Dehaghi, Razieh 1983-. “D-Lactate and its related metabolic intermediates: Potential biomarkers for diabetic vascular complications.” 2019. Web. 19 Sep 2019.

Vancouver:

Ostad Ali Dehaghi R1. D-Lactate and its related metabolic intermediates: Potential biomarkers for diabetic vascular complications. [Internet] [Thesis]. University of Saskatchewan; 2019. [cited 2019 Sep 19]. Available from: http://hdl.handle.net/10388/12273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ostad Ali Dehaghi R1. D-Lactate and its related metabolic intermediates: Potential biomarkers for diabetic vascular complications. [Thesis]. University of Saskatchewan; 2019. Available from: http://hdl.handle.net/10388/12273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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