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1. Garcia Casado, Francisco Javier. Identificación de la Señal Mioeléctrica del Intestino Delgado Registrada en Superficie Externa Abdominal. Comparativa con Registros Internos.

Degree: 2020, Universitat Politècnica de València

[EN] Intestinal motility is responsible for the functions of segmentation, mixing and transport of the chime poured from the stomach. These functions are of main importance in the processes of nutrients digestion and absorption. Intestinal contractile activity is determined by the myoelectrical activity of intestinal muscular layers. Precisely, intestinal myoelectrical activity, which is also called electroenterogram (EEnG), is the result of two components: a low frequency component (slow wave, SW) that is always present and a high frequency component (spike bursts, SB) which is associated with bowel contractions. Despite of the diagnostic significance of internal recordings of EEnG, clinical application of this technique is limited due to its invasiveness. Thus, surface recording of EEnG could be a solution for non-invasive monitoring of intestinal motility. The aim of this Ph.D. Thesis is the recording of surface electroenterogram and the identification of slow wave and spike bursts activity in order to quantify bowel motor activity in dogs. We conducted simultaneous recordings of IMA in bowel serosa and on abdominal surface of Beagle dogs in fast state. Both signals were analyzed in spectral domain and a frequency band for slow wave and spike bursts energy were determined. Likewise, the effects of abdominal layers and of possible interferences on surface recording of EEnG were also studied. For this purpose it was necessary to define new signal-to-interference and attenuation functions. We calculated different spectral parameters of surface EEnG that quantify presence and intensity of SB taking into consideration the attenuation behavior of abdominal layers and interference effects. These parameters have shown a strong correlation with bowel contractile activity. The research about surface EEnG is complemented with an analysis of signal dynamics throughout the pattern of bowel motor activity in fast state. Stationarity of the signal was evaluated in every period of contractile activity with different window-lengths. The study finishes with the definition of an algorithm that provides a variable window-length, adapting EEnG analysis to the spectral content of signal at every moment. This permits the generation of a fast non-invasive index of bowel contractile activity for future real-time applications. Three main conclusions can be deduced out of the obtained results: - It is possible to identify both bowel’s slow wave and spike bursts activity on surface recordings of EEnG. - Quantification of SB activity on surface EEnG allows non-invasive monitoring of small bowel mechanical activity. - It has been developed a new adaptive analysis method that improves intestinal motility indexes based in traditional techniques as it considers non-stationarity of EEnG. Advisors/Committee Members: Martínez De Juan, José Luís (advisor), Ponce Marco, Jose Luis (advisor).

Subjects/Keywords: Mioeléctrico; Motilidad intestinal; Electroenterograma; Perro; Espectral; Adaptativo; No invasivo

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APA (6th Edition):

Garcia Casado, F. J. (2020). Identificación de la Señal Mioeléctrica del Intestino Delgado Registrada en Superficie Externa Abdominal. Comparativa con Registros Internos. (Doctoral Dissertation). Universitat Politècnica de València. Retrieved from http://hdl.handle.net/10251/135956

Chicago Manual of Style (16th Edition):

Garcia Casado, Francisco Javier. “Identificación de la Señal Mioeléctrica del Intestino Delgado Registrada en Superficie Externa Abdominal. Comparativa con Registros Internos. ” 2020. Doctoral Dissertation, Universitat Politècnica de València. Accessed February 28, 2020. http://hdl.handle.net/10251/135956.

MLA Handbook (7th Edition):

Garcia Casado, Francisco Javier. “Identificación de la Señal Mioeléctrica del Intestino Delgado Registrada en Superficie Externa Abdominal. Comparativa con Registros Internos. ” 2020. Web. 28 Feb 2020.

Vancouver:

Garcia Casado FJ. Identificación de la Señal Mioeléctrica del Intestino Delgado Registrada en Superficie Externa Abdominal. Comparativa con Registros Internos. [Internet] [Doctoral dissertation]. Universitat Politècnica de València; 2020. [cited 2020 Feb 28]. Available from: http://hdl.handle.net/10251/135956.

Council of Science Editors:

Garcia Casado FJ. Identificación de la Señal Mioeléctrica del Intestino Delgado Registrada en Superficie Externa Abdominal. Comparativa con Registros Internos. [Doctoral Dissertation]. Universitat Politècnica de València; 2020. Available from: http://hdl.handle.net/10251/135956

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