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Nanyang Technological University

1. Luis Adiwati, Guntur Eric. 3-D direct printing of silicone meniscus using a novel heat-curing extrusion based silicone printer .

Degree: 2019, Nanyang Technological University

Silicone implants have been widely used as treatment for osteoarthritis of the knee with meniscal pathologies. Silicone products have conventionally been manufactured by direct or indirect molding methods which are expensive and time-consuming. The geometrical precision and aesthetic parameters of the end-products are also highly operator-dependent. Silicone 3D printing provides immediate benefits of customization, time and cost savings for patients. Typical non-printable meniscal substitutes lack the customizability of 3D printable implants and are mechanically weak for instantaneous weight bearing. Currently, 3D printed scaffolds, using hydrogels, suffer from the common major drawbacks of being mechanically weak and patients are unable to execute immediate post-surgical weight-bearing, ambulation and rehabilitation. To solve this problem, a 3D silicone meniscus implant which is 1) biocompatible, 2) mechanically similar to native meniscus and resistant to cyclic loading, and 3) directly 3D printable, has been developed. The main objectives of this research are: 1)To design, manufacture and optimize a novel extrusion-based 3D silicone printer with unique heating processes. The optimization of various printing parameters and printing processes will be studied by conducting design of experiments (DOE). This silicone printer will be able to perform Liquid Additive Manufacturing with different ranges of medical and non-medical grade silicones. 2) To 3D print a customized meniscus which has comparable biomechanical properties as those of the native meniscus. In a future design to the 3D printed meniscus, micro-channels and reservoirs will be incorporated into the meniscus to provide slow release mechanism for drugs, lubricants and growth factors. 3) To incorporate shape memory properties into currently commercially available liquid silicone rubber. This work reports the first demonstration of direct extrusion of heat-cured silicone using a two-part Ecoflex silicone rubber. The results provide a better understanding on the fabrication and workings of a heat-cured extrusion-based printer in the direct 3D printing of a silicone meniscus. For subsequent experimental purposes, Ecoflex silicone rubbers are used for their costs and biocompatibility. Their rheological, mechanical and biological properties are first characterized and these form the basis for the design and fabrication of the silicone printer. All hardwares and softwares used are open-sourced materials. The printer developed contains a pre-mixing station to ensure homogenous mixing of silicone prior to dispensing. The printing volume is demonstrated with the printing of an 8 cm3 cube. Secondly, printer parameters such as print velocities, nozzle diameters, nozzle-platform distance, flow-rates, nozzle temperatures and bed temperatures were selected for characterization and testing. The optimal processing window was established for each parameter. Overall, it was found that nozzle diameter and bed temperature were the major determinants on the accuracy and…

Subjects/Keywords: Engineering::Mechanical engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Luis Adiwati, G. E. (2019). 3-D direct printing of silicone meniscus using a novel heat-curing extrusion based silicone printer . (Thesis). Nanyang Technological University. Retrieved from http://hdl.handle.net/10220/50265

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Luis Adiwati, Guntur Eric. “3-D direct printing of silicone meniscus using a novel heat-curing extrusion based silicone printer .” 2019. Thesis, Nanyang Technological University. Accessed November 17, 2019. http://hdl.handle.net/10220/50265.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Luis Adiwati, Guntur Eric. “3-D direct printing of silicone meniscus using a novel heat-curing extrusion based silicone printer .” 2019. Web. 17 Nov 2019.

Vancouver:

Luis Adiwati GE. 3-D direct printing of silicone meniscus using a novel heat-curing extrusion based silicone printer . [Internet] [Thesis]. Nanyang Technological University; 2019. [cited 2019 Nov 17]. Available from: http://hdl.handle.net/10220/50265.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Luis Adiwati GE. 3-D direct printing of silicone meniscus using a novel heat-curing extrusion based silicone printer . [Thesis]. Nanyang Technological University; 2019. Available from: http://hdl.handle.net/10220/50265

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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