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University of Guelph

1. Collett, Heather. Effect of Early-life Enrichment on the Development of “Cognitive Reserve” in Mice.

Degree: MS, Department of Psychology, 2020, University of Guelph

Resilience to Alzheimer’s disease (AD) pathology has been attributed to the development of cognitive reserve (CR) through life experiences. These experiences can be modeled with environmental enrichment (EE) in rodents. To determine the role of EE in the development of CR, we validated a novel enrichment protocol. Mice were exposed to enrichment on an obstacle-filled running track. Track-enriched mice used object representations more flexibly, enabling them to perform complex variations of the object recognition task over longer retention delays than non-enriched and home cage enriched animals. We then evaluated the potential for CR-type outcomes in the 3xTg model of AD. We longitudinally evaluated performance on an object recognition and category recognition task after early-life EE. 3xTg mice were progressively impaired on both tasks and EE ameliorated these deficits. This research supports the validation of a novel enrichment protocol and adds to the understanding of how early-life circumstances contribute to CR. Advisors/Committee Members: Winters, Boyer (advisor).

Subjects/Keywords: Environmental Enrichment; Cognitive reserve; Enrichment; 3xTg; Alzheimer's Disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Collett, H. (2020). Effect of Early-life Enrichment on the Development of “Cognitive Reserve” in Mice. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/21176

Chicago Manual of Style (16th Edition):

Collett, Heather. “Effect of Early-life Enrichment on the Development of “Cognitive Reserve” in Mice.” 2020. Masters Thesis, University of Guelph. Accessed September 20, 2020. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/21176.

MLA Handbook (7th Edition):

Collett, Heather. “Effect of Early-life Enrichment on the Development of “Cognitive Reserve” in Mice.” 2020. Web. 20 Sep 2020.

Vancouver:

Collett H. Effect of Early-life Enrichment on the Development of “Cognitive Reserve” in Mice. [Internet] [Masters thesis]. University of Guelph; 2020. [cited 2020 Sep 20]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/21176.

Council of Science Editors:

Collett H. Effect of Early-life Enrichment on the Development of “Cognitive Reserve” in Mice. [Masters Thesis]. University of Guelph; 2020. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/21176

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