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University of Guelph

1. Yiew, Xiu Ting. Evaluation of Volume Kinetic Modelling and Analysis for the Assessment of Acute Fluid Shifts in Cats .

Degree: 2019, University of Guelph

Fluid therapy is a rapidly evolving yet imprecise clinical practice based upon broad assumptions, species-to-species extrapolations, outdated experimental evidence, and individual preferences. Fluid therapy can cause significant harm through fluid overload which increases morbidity and mortality. With limited evidence to support our current fluid administration practices in cats, greater understanding of the volume kinetics (pharmacokinetics) of intravenous fluid and body water physiology in this species would provide valuable data to support safer effective fluid therapy practices. This research project explored the potential of volume kinetic modelling analysis as determined by hemoglobin dilution and estimated urine output in unveiling the distribution, elimination, plasma volume expansion, half-life, and comparative potency of three commonly prescribed intravenous fluids in healthy cats. The feasibility of a novel non-invasive 3-dimensional bladder volume estimation method utilizing bladder circumference tracings obtained from point-of-care bladder ultrasonographic images was also investigated. Approximately equipotent doses of blinded balanced crystalloid solution (Plasma-Lyte A, 20 mL/kg), hypertonic saline solution (5% sodium chloride, 3.3 mL/kg), and synthetic colloid solution (6% tetrastarch 130/0.4, 5 mL/kg) infused over 15 minutes on separate random occasions revealed similar peak plasma volume expansion. The half-life and potency of these solutions were consistent with reports from human and canine studies. Intriguingly, the distribution of all infusions from the central compartment was rapid while the elimination was slow in comparison to other species; suggesting that cats may have different physiological responses to intravenous fluid infusion, which may explain their susceptibility to fluid overload. Computer simulations of hypothetical fluid infusions to achieve and maintain plasma volume expansion at steady state revealed the need for substantial reduction in the infusion rate following initial fluid bolus. Lastly, non-invasive 3-dimensional bladder volume estimation was achieved and showed promising potential in terms of feasibility and agreement with a recently published feline geometric linear bladder dimension formula. Bladder circumference tracings were easy to perform, reliable, and reproducible among individuals with limited point-of-care ultrasonography experience and remained robust when dealing with images of various diagnostic qualities. Additional work on volume kinetics and non-invasive bladder volume estimation are warranted for further investigation of acute fluid shifts in cats. Advisors/Committee Members: Bateman, Shane (advisor).

Subjects/Keywords: volume kinetics; intravenous fluid therapy; body water physiology; healthy cats; hemoglobin dilution; estimated urine output; distribution; elimination; plasma volume expansion; half-life; comparative potency; steady state; balanced crystalloid; hypertonic saline; synthetic colloid; 3D bladder volume estimation; bladder circumference tracings

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Yiew, X. T. (2019). Evaluation of Volume Kinetic Modelling and Analysis for the Assessment of Acute Fluid Shifts in Cats . (Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/16846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Yiew, Xiu Ting. “Evaluation of Volume Kinetic Modelling and Analysis for the Assessment of Acute Fluid Shifts in Cats .” 2019. Thesis, University of Guelph. Accessed August 24, 2019. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/16846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Yiew, Xiu Ting. “Evaluation of Volume Kinetic Modelling and Analysis for the Assessment of Acute Fluid Shifts in Cats .” 2019. Web. 24 Aug 2019.

Vancouver:

Yiew XT. Evaluation of Volume Kinetic Modelling and Analysis for the Assessment of Acute Fluid Shifts in Cats . [Internet] [Thesis]. University of Guelph; 2019. [cited 2019 Aug 24]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/16846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yiew XT. Evaluation of Volume Kinetic Modelling and Analysis for the Assessment of Acute Fluid Shifts in Cats . [Thesis]. University of Guelph; 2019. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/16846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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