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You searched for id:"handle:10211.3/199815". One record found.

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California State University – Northridge

1. CHEN, GE. Models of understanding virus-host dynamics of EIAV infection with free-virus and cell-to-cell transmission in SCID horses.

Degree: MS, Department of Mathematics, 2018, California State University – Northridge

We develop three models of Equine Infectious Anemia Virus infection with free-virus and cell-to-cell transmission in Severe Combined Immunodeficiency Disease horses. Since such horses do not have immune responses, we will conduct studies for EIAV infection with two possible immune responses: the Antibody neutralization and the Cytotoxic T Lymphocyte (CTL) immune response. The first model is the basic model which does not contain immune response. And based on the first model we add the cytotoxic T Lymphocyte immune response to the second model. Thereafter, in the third model we combine both CTL and antibody immune responses. There are two strains of viruses in our models, one is sensitive to the antibody neutralization and the other one is neutralization resistant. For each model there are three types of equilibria: Infection-free equilibrium, single resistant strain equilibrium and both strains coexist equilibrium. We study the values of the basic reproduction number R0 to find how the endemic status changes when R0 changes. Then we examine how the antibody immune response controls the infection by comparing the effects of different impulsive infusion dosages. We also test the minimum dosage of the impulsive antibody that may eradicate the infection. Last we study the sensitivity of R0 on the model parameters. We do the sensitivity analysis by using the Latin hypercube sampling method and the partial rank correlation coefficients method. Then we get the most sensitive parameters of R0 which will change R0 greatly even if they themselves move just a little. We find that the transmission rates of free-virus and the proportion of virions released for free viral transmission of both strains will enlarge R0 if they become larger, the clearance rates of both viral strains will make R0 smaller if they grow. Advisors/Committee Members: Li, Jing (advisor), Sprouse, Chadwick (committee member).

Subjects/Keywords: EIAV; Dissertations, Academic  – CSUN  – Mathematics.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

CHEN, G. (2018). Models of understanding virus-host dynamics of EIAV infection with free-virus and cell-to-cell transmission in SCID horses. (Masters Thesis). California State University – Northridge. Retrieved from http://hdl.handle.net/10211.3/199815

Chicago Manual of Style (16th Edition):

CHEN, GE. “Models of understanding virus-host dynamics of EIAV infection with free-virus and cell-to-cell transmission in SCID horses.” 2018. Masters Thesis, California State University – Northridge. Accessed February 18, 2018. http://hdl.handle.net/10211.3/199815.

MLA Handbook (7th Edition):

CHEN, GE. “Models of understanding virus-host dynamics of EIAV infection with free-virus and cell-to-cell transmission in SCID horses.” 2018. Web. 18 Feb 2018.

Vancouver:

CHEN G. Models of understanding virus-host dynamics of EIAV infection with free-virus and cell-to-cell transmission in SCID horses. [Internet] [Masters thesis]. California State University – Northridge; 2018. [cited 2018 Feb 18]. Available from: http://hdl.handle.net/10211.3/199815.

Council of Science Editors:

CHEN G. Models of understanding virus-host dynamics of EIAV infection with free-virus and cell-to-cell transmission in SCID horses. [Masters Thesis]. California State University – Northridge; 2018. Available from: http://hdl.handle.net/10211.3/199815

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