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1.
Duty, Lindsay.
A detailed look at the familial, social, and clinical contexts for children after the identification of maltreatment.
Degree: MA, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1092
► In 2007, Child Protective Services received 3.2 million child abuse and neglect referrals that involved 5.8 million children. According to Health and Human Services, these…
(more)
▼ In 2007, Child Protective Services received 3.2 million child abuse and neglect
referrals that involved 5.8 million children. According to Health and Human Services,
these reports resulted in nearly 796,000 cases of confirmed maltreatment, requiring
271,000 children to enter foster care. Research indicates children in care have a higher
prevalence of medical, emotional, behavioral, and developmental disorders or concerns.
Despite this increased prevalence, foster care children have a heightened risk for their
mental health needs going unmet. By review of CPS records, this paper intends to
examine the mental health assessments, service utilization, provider characteristics, and
placement decisions for a sample of maltreated children. This history is then compared
to findings and recommendations resulting from a multidisciplinary mental health
evaluation. Results indicate that 50% of children were diagnosed with AD/HD prior to
the interdisciplinary evaluation and those evaluations performed by medical practitioners
resulted in AD/HD in 70% of cases. Inventory and assessment methods were unknown
or not given in the records from every MD evaluation and the resultant recommendation
always included medication. Psychologists and Masters-level professionals used 4.5
diagnostic inventories on average to determine clinical impairments and offered therapy,
skills training, and academic considerations as recommendations. They diagnosed fewer
cases of AD/HD and more mood disorders and developmental delays. In contrast, the
interdisciplinary evaluation used 9 inventories on average, recommended a form of therapy for every child, and more often included recommendations specific to the home,
school, and social environments of each child. Diagnoses included fewer behavioral
disorders and highlighted more emotional and developmental concerns. The decline in
AD/HD diagnoses from previous evaluations is a significant finding due to the use of
stimulant medication as the primary means for mediating symptoms. In addition,
discrepant diagnostic findings, especially in regards to learning disorders and
developmental delays, may have kept some children from receiving educational
interventions permitted to them by law. Given the vulnerability of maltreated children, it
is paramount that evaluations incorporate valid means of identifying familial, social,
emotional, and behavioral concerns in order to guide effective service decisions, which
can only result from the highest clinical accuracy in determining diagnoses.
M.A.
1 online resource (vi, 60 p.)
Psychology
College of Arts and Sciences
Professional credentials Mental health assessments Clinical methods Diagnoses Child maltreatment
UNRESTRICTED
Advisors/Committee Members: Biasini, Fred J., Marullo, Daniel S. <br>, Perumean-Chaney, Suzanne E..
Subjects/Keywords: Abused children – Mental health services – United States <; br>; Child mental health services – United States <; br>; Psychic trauma in children <; br>; Abused children – Mental health <; br>; Community mental health services – United States <; br>; Foster children – United States
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APA (6th Edition):
Duty, L. (2009). A detailed look at the familial, social, and clinical contexts for children after the identification of maltreatment. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1092
Chicago Manual of Style (16th Edition):
Duty, Lindsay. “A detailed look at the familial, social, and clinical contexts for children after the identification of maltreatment.” 2009. Masters Thesis, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1092.
MLA Handbook (7th Edition):
Duty, Lindsay. “A detailed look at the familial, social, and clinical contexts for children after the identification of maltreatment.” 2009. Web. 22 Jan 2021.
Vancouver:
Duty L. A detailed look at the familial, social, and clinical contexts for children after the identification of maltreatment. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1092.
Council of Science Editors:
Duty L. A detailed look at the familial, social, and clinical contexts for children after the identification of maltreatment. [Masters Thesis]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1092
2.
Larson, Matthew Rodney.
Elucidation of the elongated fibrillar structure of Streptococcus mutans antigen I/II.
Degree: PhD, 2011, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1093
► Streptococcus mutans (S. mutans) is the causative agent behind dental caries, an infectious disease also known as tooth decay or dental cavities. S. mutans has…
(more)
▼ Streptococcus mutans (S. mutans) is the causative agent behind dental caries, an infectious
disease also known as tooth decay or dental cavities. S. mutans has a cell wall-attached
protein known as Antigen I/II (AgI/II) utilized for bacterial adhesion to the tooth surface.
Here we have solved the structures of both amino- and carboxy-terminal regions of the
AgI/II molecule using X-ray crystallography. Using this structural information we have
now built a tertiary model for AgI/II as a fibrillar protein. Further, we have functionally
characterized AgI/II and determined minimal regions of AgI/II that are implicated in its
adherence to the salivary agglutinin found on the tooth surface.
The following results are presented in this thesis work:
1. We report the high resolution structure (1.8 A° ) of an amino-terminal fragment of
AgI/II. This fragment reveals that AgI/II is an elongated molecule with a stalk comprised
of - and polyproline type-II (PPII)-helices. The hybrid structure formed from
- and PPII helices represents the first example of a new structural class of fibrillar
proteins.
2. We report the (2.5 A° ) crystal structure of the complete carboxy-terminus of AgI/II.
This structure now shows that the AgI/II carboxy-terminus has three domains that
each each adopt the DE-variant immunoglobulin-like fold.
3. Using the amino- and carboxy- terminal structures of AgI/II, biophysical characterizations,
and electron microscopic imaging, we have now created an overall tertiary
model for AgI/II family of proteins.
4. Adherence studies for AgI/II revealed that AgI/II contains two distinct regions that
adhered to human salivary agglutinin (SAG). These regions of AgI/II also adhered
non-competitively to SAG. These results now suggest possible models for the S.
mutans bacterial adherence to SAG.
AgI/II can now be described as an elongated fibrillar protein with globular domains at
its termini. The V-region is distal to the cell surface, while three carboxy-terminal domains
are close to the cell surface. These globular regions are separated by the alanine-rich and
proline-rich repeats of AgI/II that form a unique - and PPII helical hybrid fibril which is
revealed for the first time by these structures. This research now provides the first overall
structural model for AgI/II as a fibrillar protein.
1 online resource (xiv, 119 p.) : ill., digital, PDF file.
Physiology and Biophysics
Joint Health Sciences;
Streptococcus mutans
Antigen I/II
fibrillar
structure
UNRESTRICTED
Advisors/Committee Members: Deivanayagam, Champion, Delucas, Lawrence<br>, Fuller, Catherine<br>, Michalek, Suzanne<br>, Smith, Peter.
Subjects/Keywords: Adhesins, Bacterial – chemistry<; br>;
Agglutinins – chemistry<; br>;
Antigens, Bacterial – chemistry<; br>;
Saliva – metabolism<; br>;
Streptococcus mutans – chemistry<; br>;
Streptococcus mutans – metabolism<; br>
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Larson, M. R. (2011). Elucidation of the elongated fibrillar structure of Streptococcus mutans antigen I/II. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1093
Chicago Manual of Style (16th Edition):
Larson, Matthew Rodney. “Elucidation of the elongated fibrillar structure of Streptococcus mutans antigen I/II.” 2011. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1093.
MLA Handbook (7th Edition):
Larson, Matthew Rodney. “Elucidation of the elongated fibrillar structure of Streptococcus mutans antigen I/II.” 2011. Web. 22 Jan 2021.
Vancouver:
Larson MR. Elucidation of the elongated fibrillar structure of Streptococcus mutans antigen I/II. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2011. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1093.
Council of Science Editors:
Larson MR. Elucidation of the elongated fibrillar structure of Streptococcus mutans antigen I/II. [Doctoral Dissertation]. University of Alabama – Birmingham; 2011. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1093
3.
Kimble, Steven James Andrew.
Community structure of Caribbean mangrove root sponges.
Degree: MS, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1094
► Tropical mangrove root communities are some of the most productive and biodiverse on the plant. Sponge mangrove communities inhabit the peat banks and roots of…
(more)
▼ Tropical mangrove root communities are some of the most productive and
biodiverse on the plant. Sponge mangrove communities inhabit the peat banks and roots
of mangroves, often accounting for much of their biomass. Mangroves are threatened
worldwide by coastal development, aquaculture, and increased storm intensity.
Understanding the population dynamics of these communities is essential to management
of this habitat.
This thesis compares traditional and taxonomically-sensitive biodiversity indices
in comparisons of 1.) mangrove and coral reef sponge communities in Caribbean
Panama, 2.) how mangrove sponge communities vary at varying spatial scales across the
Caribbean, and 3.) how mangrove sponge communities vary with mangrove islands size.
It also makes inferences from incidence functions concerning species-specific dispersal
ability, life history strategies, competition, predation, resources, metapopulation stability,
and effects of patch removal.
The comparisons of traditional and taxonomically-sensitive indices showed mixed
performance. Only an analysis of similarity and the most recent taxonomic metric
detected a difference between mangrove and reef sponge communities in close proximity
to each other. Most of the indices, traditional and modern, showed a significant difference
between the mangrove sponges faunas of Panama and Belize. Within Belize, one island
was identified by one taxonomic index as having a mangrove sponge fauna significantly different than the rest. Within Panama, the same index identified two islands as
significantly different. Incidence functions models identified a putative bimodal
relationship between incidence and dispersal ability, with both high and low dispersers
present on many islands, and medium dispersers present on few islands. Population
simulations demonstrated a range of population fates: extinction, stability, and spreading
to all islands. Metapopulation calculations likewise demonstrated a range of islands
necessary for each species to maximize their populations.
No strong trends were identified that could directly point to trends in the ways
sponges may compete with each other and communities assemble. Full ranges were
identified for dispersal ability, metapopulation capacities, and population simulations,
suggesting a community constantly in flux as species are concurrently remaining stable,
going extinct, spreading their ranges, even trading habitats.
M.S.
1 online resource (xi, 132 p.) : ill. (some col.), maps.
Biology
College of Arts and Sciences
UNRESTRICTED
Advisors/Committee Members: Thacker, Robert W., Bej, Asim K. <br>, Halancyh, Kenneth M..
Subjects/Keywords: Sponges – Population viability analysis – Caribbean Area <; br>; Sponges – Dispersal – Caribbean Area <; br>; Mangrove animals – Caribbean Area <; br>; Coral reef animals – Caribbean Area <; br>; Mangrove ecology – Caribbean Area <; br>; Coral reef ecology – Caribbean Area <; br>; Numbers of species – Caribbean Area
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kimble, S. J. A. (2009). Community structure of Caribbean mangrove root sponges. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1094
Chicago Manual of Style (16th Edition):
Kimble, Steven James Andrew. “Community structure of Caribbean mangrove root sponges.” 2009. Masters Thesis, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1094.
MLA Handbook (7th Edition):
Kimble, Steven James Andrew. “Community structure of Caribbean mangrove root sponges.” 2009. Web. 22 Jan 2021.
Vancouver:
Kimble SJA. Community structure of Caribbean mangrove root sponges. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1094.
Council of Science Editors:
Kimble SJA. Community structure of Caribbean mangrove root sponges. [Masters Thesis]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1094
4.
Momeni, Stephanie Stahlbuhk.
Genotyping of Streptococcus mutans using multilocus sequence typing.
Degree: MS, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1095
► The role of Streptococcus mutans has been extensively studied using a variety of genotyping techniques. Repetitive extragenic palindromic polymerase chain reaction (rep-PCR) is an effective…
(more)
▼ The role of Streptococcus mutans has been extensively studied using a
variety of genotyping techniques. Repetitive extragenic palindromic polymerase
chain reaction (rep-PCR) is an effective tool for screening large-scale
epidemiological studies with high discriminatory power and reproducibility. For this
study, multilocus sequence typing (MLST) analysis is used to evaluate genotypes
previously identified as unique using rep-PCR. Twenty-two unique S. mutans rep-
PCR genotypes were selected from a longitudinal study. Four additional isolates
were selected from each genotype group of the 6 most commonly occurring
genotypes (n=30) for further analysis. Real-time PCR was performed using eight
housekeeping S. mutans gene loci and products sequenced. Sequence data
analysis was performed using CLC DNA Workbench with MLST module.
Concatenated sequences (3366 bp) were evaluated with MEGA using minimum
evolution method with bootstrap. All 22 rep-PCR genotypes were unique by MLST
analysis. For rep-PCR genotype groups, MLST groups matched rep-PCR for 3/6
(50%); three groups were further distinguished with MLST analysis. Rep-PCR
results were consistent with those found using MLST, although MLST can provide
further discrimination for some isolates. Rep-PCR is an effective tool for screening
large-scale populations studies of S. mutans for subsequent MLST analysis.
M.S.
1 online resource (xi, 57 p.) : ǂb ill., digital, PDF file.
Dentistry
Dentistry;
MLST
rep-PCR
genotyping
Streptococcus mutans
DiversiLab
UNRESTRICTED
Advisors/Committee Members: Childers, Noel K., Hollinghead, Susan<br>, Moser, Stephen A.<br>, Ruby, John D..
Subjects/Keywords: Bacterial Typing Techniques – methods<; br>;
Genotype<; br>;
Genotyping Techniques<; br>;
Polymerase Chain Reaction – methods<; br>;
Streptococcus mutans – genetics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Momeni, S. S. (2010). Genotyping of Streptococcus mutans using multilocus sequence typing. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1095
Chicago Manual of Style (16th Edition):
Momeni, Stephanie Stahlbuhk. “Genotyping of Streptococcus mutans using multilocus sequence typing.” 2010. Masters Thesis, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1095.
MLA Handbook (7th Edition):
Momeni, Stephanie Stahlbuhk. “Genotyping of Streptococcus mutans using multilocus sequence typing.” 2010. Web. 22 Jan 2021.
Vancouver:
Momeni SS. Genotyping of Streptococcus mutans using multilocus sequence typing. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1095.
Council of Science Editors:
Momeni SS. Genotyping of Streptococcus mutans using multilocus sequence typing. [Masters Thesis]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1095
5.
Markwardt, Sean J.
GABAergic signaling to adult-generated neurons in hippocampus.
Degree: PhD, 2011, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1096
► In the central nervous system of adult mammals, new neurons are produced throughout life in at least two regions, the subventricular zone and dentate gyrus…
(more)
▼ In the central nervous system of adult mammals, new neurons are produced
throughout life in at least two regions, the subventricular zone and dentate gyrus of the
hippocampus. New neurons in the SVZ migrate via the rostral migratory stream and
eventually participate in adaptive olfactory processes. In the dentate gyrus, a variety of
physiological functions for continued addition of neurons have been proposed, but its role
in normal or pathological conditions remains largely unclear. Neurogenesis in the dentate
gyrus consists of the stepwise process of generating fully functional granule cells (GCs)
from adult neural stem cells. Regulation of neurogenesis can occur at multiple stages by a
wide range of physiological or pathological stimuli. Although many factors can influence
the differentiation, maturation, and integration of newborn neurons, considerable evidence
suggests γ-aminobutyric acid (GABA) signaling is a key regulator. Newborn neurons
initially receive synaptic input that is exclusively GABAergic, and normal maturation
and synaptic integration is profoundly disrupted when GABA signaling is altered.
Hippocampal interneurons are a diverse population of GABA-releasing cells that serve
specific inhibitory functions and modulate local circuitry. In the following work, I demonstrate
that newborn neurons of the dentate gyrus receive GABAA receptor-mediated
input with particularly slow kinetics that result from dedicated presynaptic inputs that also
generate slow responses in mature GCs. This characteristically slow GABA signaling
in newborn GCs arises from a unique subset of late-spiking hippocampal interneurons of the neurogliaform (NG) cell family. During synchronous activity in the dentate network, late-spiking cells provide robust depolarization to newborn cells while inhibiting other interneurons. Collectively, these data suggest that late-spiking interneurons coordinate local circuitry among new and preexisting GCs, and are poised to manipulate activity-dependent GABAergic regulation of neurogenesis.
1 online resource (viii, 114 p.) : ill., digital, PDF file.
Neurobiology;
Joint Health Sciences;
dentate gyrus
GABA
granule cell
interneuron
neurogenesis
synapse
UNRESTRICTED
Advisors/Committee Members: Overstreet-Wadiche, Linda, Floyd, Candace L.<br>, Lester, Robin A.<br>, McMahon, Lori L.<br>, Wadiche, Jacques I..
Subjects/Keywords: Adult Stem Cells – physiology<; br>;
Dentate Gyrus – cytology<; br>;
gamma-Aminobutyric Acid – metabolism<; br>;
Neurons – physiology<; br>;
Receptors, GABA – metabolism<; br>;
Signal Transduction – physiology
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Markwardt, S. J. (2011). GABAergic signaling to adult-generated neurons in hippocampus. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1096
Chicago Manual of Style (16th Edition):
Markwardt, Sean J. “GABAergic signaling to adult-generated neurons in hippocampus.” 2011. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1096.
MLA Handbook (7th Edition):
Markwardt, Sean J. “GABAergic signaling to adult-generated neurons in hippocampus.” 2011. Web. 22 Jan 2021.
Vancouver:
Markwardt SJ. GABAergic signaling to adult-generated neurons in hippocampus. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2011. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1096.
Council of Science Editors:
Markwardt SJ. GABAergic signaling to adult-generated neurons in hippocampus. [Doctoral Dissertation]. University of Alabama – Birmingham; 2011. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1096
6.
Luther, Rita Jeanne.
Development and implementation of knock-in and BAC-in IL-2 reporter mouse models to characterize IL2 gene regulation in CD4 T cells.
Degree: PhD, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1097
► Maintenance of immune homeostasis involves a balance between T cell effector responses to antigen stimulus and reciprocal downregulation of this response through peripheral tolerance mechanisms.…
(more)
▼ Maintenance of immune homeostasis involves a balance between T cell effector
responses to antigen stimulus and reciprocal downregulation of this response through
peripheral tolerance mechanisms. Upon exposure to pathogen, cytokine production and
signaling serve to tightly coordinate cell-mediated clearance of antigen followed by
contraction of the immune response. Interkeukin-2 (IL-2) is a type I family cytokine
critical for expansion of activated T cells in vitro and enhancement of T cell memory
responses in vivo. Deficiency of IL-2 in vivo also revealed a critical role for IL-2 in
immune tolerance through the maintenance of T regulatory cell populations (Treg) in
peripheral lymphoid tissues. Thus, regulation of Il2 gene expression and autocrine
signaling are central to the balance of immune homeostasis.
Defining the regulatory mechanisms associated with Il2 gene expression is crucial
for defining the integral role for IL-2 in tolerance and effector immunity. In order to
evaluate the role of IL-2 production during the immune response we have engineered a
BAC transgenic as well as a gene-targeted knock-in reporter mouse model system to
mark Il2 gene activation. Our studies indicate that both mouse models exhibit reporter
expression with high fidelity to endogenous Il2 expression patterns while stably marking
IL-2-producing cells. Using our Il2 BAC transgenic system (2BiT) system to model
inhibition of IL-2 production in responder CD4 T cells by Tregs we describe a model in
which Tregs prevent initial activation of Il2 transcription that also subsequently
associates with increased responder cell death of non-IL-2 producers. Suppression of
naïve activated CD4 T cells by Tregs followed a mechanism consistent with competition
for co-stimulation and preventing a threshold of activation rather than cytokine
deprivation. Utilizing an Il2 GFP knock-in model we show evidence that IL-21 enhances
proliferation and the frequency of IL-2-producing cells in activated naïve CD4 T cells.
These results are suggestive of a coordinate relationship between Il2 expression and IL-
21 production and signaling in effector T cell function and fate. Future Il2 expression
studies using our novel mouse reporter systems will enable a more in-depth
understanding of the role of this cytokine in effector function and immune tolerance.
1 online resource (xvi, 141 p.) : ill., digital, PDF file.
Microbiology;
Joint Health Sciences;
Interleukin-2
T regulatory cells
immune tolerance
T cell activation
gene transcription
BAC transgenic and knock-in reporter mice
UNRESTRICTED
Advisors/Committee Members: Weaver, Casey T., Burrows, Peter D.<br>, Chaplin, David D.<br>, Hatton, Robin D.<br>, Raman, Chander<br>, Ryan, Thomas M..
Subjects/Keywords: Immune Tolerance<; br>;
Interleukin-2<; br>;
Mice<; br>;
T-Lymphocytes, Regulatory<; br>;
Transcription, Genetic
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Luther, R. J. (2009). Development and implementation of knock-in and BAC-in IL-2 reporter mouse models to characterize IL2 gene regulation in CD4 T cells. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1097
Chicago Manual of Style (16th Edition):
Luther, Rita Jeanne. “Development and implementation of knock-in and BAC-in IL-2 reporter mouse models to characterize IL2 gene regulation in CD4 T cells.” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1097.
MLA Handbook (7th Edition):
Luther, Rita Jeanne. “Development and implementation of knock-in and BAC-in IL-2 reporter mouse models to characterize IL2 gene regulation in CD4 T cells.” 2009. Web. 22 Jan 2021.
Vancouver:
Luther RJ. Development and implementation of knock-in and BAC-in IL-2 reporter mouse models to characterize IL2 gene regulation in CD4 T cells. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1097.
Council of Science Editors:
Luther RJ. Development and implementation of knock-in and BAC-in IL-2 reporter mouse models to characterize IL2 gene regulation in CD4 T cells. [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1097
7.
Hosch, Ian E.
Design of highway overhead cantilever-type sign support structures for fatigue loads.
Degree: PhD, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1098
► The 2001 edition of the American Association of State Highway and Transportation Officials (AASHTO) Standard Specifications for Structural Supports for Highway Signs, Luminaires and Traffic…
(more)
▼ The 2001 edition of the American Association of State Highway and Transportation Officials (AASHTO) Standard Specifications for Structural Supports for Highway
Signs, Luminaires and Traffic Signals has been revised in its entirety through a major research project conducted under the auspices of the National Cooperative Highway Research Program (NCHRP 17-10). A major part of the revision included updated provisions and criteria for extreme wind loads and new provisions and criteria on fatigue design. These provisions differ considerably from those in previous editions of the specifications, and have remained relatively unchanged in the 2009 edition.
The impact of the fatigue criteria on the design of overhead sign structures has not
been fully evaluated. The fatigue design loads do not adequately reflect the stresses generated on these structures from wind-induced fatigue loading. In addition, the provisions
do not account for the variety of support structures in design, each with different configuration, sizes, shapes, and material properties that influence vibration behavior. As a result, the vulnerability of sign support structures to wind-induced fatigue loading is not
fully realized.
The main goal of the project was to conduct theoretical and experimental programs of study to evaluate the performance of cantilever-type highway overhead sign
support structures subjected to wind induced fatigue loads. A theoretical program was developed that took into account the variety of sign supports structures in design, as well
as addressed the vulnerability of these structures to wind-induced fatigue loading. The
experimental program was developed to evaluate the accuracy of the theoretical study. A
finite element analysis program was conducted to simulate the wind-induced loading environment and the response of sign support structures to this environment. Alterations
were made to the model that could not be done experimentally due to costs and time restraints. The results of the finite element analysis were compared to the theoretical and
experimental programs of study.
The developed information and criteria on fatigue design of sign support structures were used to develop fatigue design loads to provide an improved and more reliable
design method. Recommendations are made to update the current specifications to include more reliable fatigue loads.
1 online resource (xxvii, 399 p.) : ill. (some col.)
Civil, Construction and Environmental Engineering
Engineering
Cantilever-type sign support structures Fatigue design Fatigue load Natural wind Truck-induced wind Vibration
UNRESTRICTED
Advisors/Committee Members: Fouad, Fouad H., Salama, Talat <br>, Sisiopiku, Virginia <br>, Toutanji, Houssam <br>Uddin, Nasim.
Subjects/Keywords: Traffic signs and signals – Supports – Design and construction <; br>; Traffic signs and signals – Supports – Materials – Fatigue <; br>; Wind-pressure <; br>; Live loads
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hosch, I. E. (2009). Design of highway overhead cantilever-type sign support structures for fatigue loads. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1098
Chicago Manual of Style (16th Edition):
Hosch, Ian E. “Design of highway overhead cantilever-type sign support structures for fatigue loads.” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1098.
MLA Handbook (7th Edition):
Hosch, Ian E. “Design of highway overhead cantilever-type sign support structures for fatigue loads.” 2009. Web. 22 Jan 2021.
Vancouver:
Hosch IE. Design of highway overhead cantilever-type sign support structures for fatigue loads. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1098.
Council of Science Editors:
Hosch IE. Design of highway overhead cantilever-type sign support structures for fatigue loads. [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1098
8.
Huff, Kayci R.
The intestinal extracellular matrix as an innate regulator of effector T-cell responses.
Degree: PhD, 2011, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1099
► Extracellular matrix (stroma) regulation of mucosal T‐cell function is incompletely understood. Here we uncovered a role for intestinal stromal products in the innate regulation of…
(more)
▼ Extracellular matrix (stroma) regulation of mucosal T‐cell function is
incompletely understood. Here we uncovered a role for intestinal stromal products
in the innate regulation of effector T‐cells. Stroma‐conditioned media (S‐CM)
derived from normal human intestinal stroma (TGF‐βhi/IL‐6lo/IL‐1βlo) significantly
down‐regulated T‐cell proliferation and IFN‐γ production compared to S‐CM derived
from inflamed Crohn’s mucosa (TGF‐βhi/IL‐6hi/IL‐1βhi). Antibody neutralization
studies showed that TGF‐β in normal S‐CM inhibited T‐cell proliferation and IFN‐γ
production, whereas IL‐6 plus IL‐1β in Crohn’s S‐CM promoted T‐cell proliferation,
and the IL‐1β alone promoted IFN‐γ and IL‐17 release. Importantly, stromal cells in
normal tissue produce TGF‐β and contribute to mucosal homeostasis and tolerance
to antigenic stimulation. In contrast, stromal cells in Crohn’s mucosa produce high
levels of IL‐6 and IL‐1β in addition to TGF‐β and are hyper‐responsive to antigenic
stimulation. These findings implicate an important role for stromal regulation of
immune responses in normal mucosa through the production of TGF‐β and in
promoting inflammatory responses in Crohn’s disease through the production of IL‐
6 and IL‐1β and TGF‐β.
1 online resource (x, 100 p.) : ill., digital, PDF file.
Microbiology;
Joint Health Sciences;
intestine
Immune regulation
T-cell
Stroma
Human
Crohn's disease
UNRESTRICTED
Advisors/Committee Members: Smith, Phillip D., Elson, Charles O.<br>, Justement, Louis B.<br>, Lorenz, Robinna G.<br>, Mestecky, Jiri.
Subjects/Keywords: CD4-Positive T-Lymphocytes – immunology<; br>;
Crohn Disease<; br>;
Cytokines – immunology<; br>;
Extracellular Matrix – immunology<; br>;
Intestinal Mucosa – immunology<; br>;
Stromal Cells<; br>;
T-Lymphocytes
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Huff, K. R. (2011). The intestinal extracellular matrix as an innate regulator of effector T-cell responses. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1099
Chicago Manual of Style (16th Edition):
Huff, Kayci R. “The intestinal extracellular matrix as an innate regulator of effector T-cell responses.” 2011. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1099.
MLA Handbook (7th Edition):
Huff, Kayci R. “The intestinal extracellular matrix as an innate regulator of effector T-cell responses.” 2011. Web. 22 Jan 2021.
Vancouver:
Huff KR. The intestinal extracellular matrix as an innate regulator of effector T-cell responses. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2011. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1099.
Council of Science Editors:
Huff KR. The intestinal extracellular matrix as an innate regulator of effector T-cell responses. [Doctoral Dissertation]. University of Alabama – Birmingham; 2011. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1099
9.
Kim, Junghyun.
Transcriptional regulation of the human heme oxygenase-1 via chromatin looping in renal cells.
Degree: PhD, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1100
► Heme oxygenase-1 (HO-1) is a critical enzyme catalyzing the degradation of heme and generating carbon monoxide, iron, and biliverdin. In addition to heme degradation, HO-1…
(more)
▼ Heme oxygenase-1 (HO-1) is a critical enzyme catalyzing the degradation of
heme and generating carbon monoxide, iron, and biliverdin. In addition to heme
degradation, HO-1 expression is known to protect against various cellular insults and
disease states including acute kidney injury, atherosclerosis, vascular restenosis, and
others. Human HO-1 gene expression is tightly regulated at the level of transcription. The
main goal of this study is to explore the transcriptional regulation of the human HO-1
gene in renal epithelial cells. Chromosome Conformation Capture (3C) demonstrates that
multiple regulatory regions within the HO-1 promoter and enhancer regions are
physically interacting with each other by forming chromatin loops and this looping is
required for the initiation of the human HO-1 gene transcription. ChIP-Loop assay
reveals that these regions share several common transcription factors such as Sp1, USF-1,
and JunB. Sp1 binds to the intronic enhancer which interacts with the -4.5kb promoter
region by chromatin looping. Inhibition of Sp1 by siRNA abolishes this interaction and
reduces HO-1 transcription. To study human HO-1 transcription in vivo, a HO-1 bacterial
artificial chromosome (BAC) transgenic mouse was generated by integrating a 87 kb
BAC DNA (a portion of the human chromosome 22 including HO-1 gene and its
regulatory regions) into the mouse genome. Global overexpression of HO-1 mRNA and
protein in tissues of HO-1 BAC transgenic mice were detected. Moreover, using this HO-
1 BAC transgenic mouse, a “humanized” HO-1 BAC transgenic mouse (hHO-1 BAC)
was generated by crossing HO-1 BAC mice with HO-1 knockout (HO-1-/-) mice. In
addition to the overexpression of human-specific HO-1 mRNA and protein expression,
the human HO-1 gene in hHO-1 BAC mice rescued the abnormal phenotype observed in
the HO-1-/- mice such as increased incidence of abortion and embryonic lethality,
heightened sensitivity to acute kidney injury, iron overload, anemia, and splenomegaly.
These studies provide not only functional insights for the regulation of the human HO-1
gene but also the molecular architecture of the human chromosome containing the HO-1
gene and promoter in renal epithelial cells.
1 online resource (xiv, 136 p.) : ill., digital, PDF file.
Joint Health Sciences;
Heme oxygenase-1
Chromatin looping
Transgenic mice
Acute kidney injury
rhabdomyolysis
chromosome conformation capture
UNRESTRICTED
Advisors/Committee Members: McDonald, Jay M., Agarwal, Anupam<br>, Chugh, Sumant S.<br>, Hardy, Robert W.<br>, Ponnazhagan, Selvaragan<br>, Ryan, Thomas.
Subjects/Keywords: Acute Kidney Injury<; br>;
Chromatin – chemistry<; br>;
Gene Expression Regulation, Enzymologic<; br>;
Heme Oxygenase-1 – biosynthesis<; br>;
Kidney – enzymology<; br>;
Mice<; br>;
Sp1 Transcription Factor – physiology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kim, J. (2010). Transcriptional regulation of the human heme oxygenase-1 via chromatin looping in renal cells. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1100
Chicago Manual of Style (16th Edition):
Kim, Junghyun. “Transcriptional regulation of the human heme oxygenase-1 via chromatin looping in renal cells.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1100.
MLA Handbook (7th Edition):
Kim, Junghyun. “Transcriptional regulation of the human heme oxygenase-1 via chromatin looping in renal cells.” 2010. Web. 22 Jan 2021.
Vancouver:
Kim J. Transcriptional regulation of the human heme oxygenase-1 via chromatin looping in renal cells. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1100.
Council of Science Editors:
Kim J. Transcriptional regulation of the human heme oxygenase-1 via chromatin looping in renal cells. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1100
10.
Joo, Heui Yun.
Understanding the regulatory mechanisms of UBP-M and H2A deubiquitination in chromatin and cellular functions.
Degree: PhD, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1101
► Posttranslational modifications of histones regulate important chromatin and cellular functions. Among them, ubiquitination of histone H2A is correlated to transcriptional repression, such as HOX gene…
(more)
▼ Posttranslational modifications of histones regulate important chromatin and
cellular functions. Among them, ubiquitination of histone H2A is correlated to
transcriptional repression, such as HOX gene silencing and X chromosome inactiviation.
Little was known about the removal of ubiquitin from histones, the enzyme(s) involved
and its function in chromatin dynamics. We have identified the protein Ubp-M (USP16)
to be the H2A- and nucleosome-specific deubiquitinase. We also demonstrated that Ubp-
M-mediated H2A deubiquitination is involved in cell cycle progression to M-phase, HOX
gene expression, and posterior development in Xenopus laevis. Furthermore, we have
also purified USP12 and USP46 which contain an Ubp-M independent deubiquitinase
activity for both uH2A and uH2B. USP12 and USP46 each form a complex with the
WD40 repeat-containing protein WDR48, which is required for the deubiquitinase
activity. USP12 and USP46 regulate HOX gene expression and gastrulation during
Xenopus laevis development. These studies will contribute to the understanding of the
regulatory mechanisms of H2A and H2B ubiquitination and deubiquitination, and their
biological functions.
1 online resource (x, 90 p.) : ill., digital, PDF file.
Biochemistry and Molecular Genetics;
Joint Health Sciences;
histone H2A
ubiquitination
deubiquitination
Ubp-M
UNRESTRICTED
Advisors/Committee Members: Wang, Hengbin, Chang, Chenbei<br>, Chow, Louise<br>, Ruppert, J. Michael<br>, Townes, Tim M..
Subjects/Keywords: Chromatin – physiology<; br>;
Endopeptidases – metabolism<; br>;
Histones – metabolism<; br>;
Ubiquitin Thiolesterase – metabolism<; br>;
Xenopus Proteins – metabolism<; br>;
Xenopus laevis – embryology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Joo, H. Y. (2009). Understanding the regulatory mechanisms of UBP-M and H2A deubiquitination in chromatin and cellular functions. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1101
Chicago Manual of Style (16th Edition):
Joo, Heui Yun. “Understanding the regulatory mechanisms of UBP-M and H2A deubiquitination in chromatin and cellular functions.” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1101.
MLA Handbook (7th Edition):
Joo, Heui Yun. “Understanding the regulatory mechanisms of UBP-M and H2A deubiquitination in chromatin and cellular functions.” 2009. Web. 22 Jan 2021.
Vancouver:
Joo HY. Understanding the regulatory mechanisms of UBP-M and H2A deubiquitination in chromatin and cellular functions. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1101.
Council of Science Editors:
Joo HY. Understanding the regulatory mechanisms of UBP-M and H2A deubiquitination in chromatin and cellular functions. [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1101
11.
Jampani, Prabhavathi.
Development and application of a technique to measure soft tissue changes following noncarious cervical lesion restorations.
Degree: MS, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1102
► Non-carious Cervical lesions (NCCL) often encountered in clinical practice, is tooth structure loss at the cemento-enamel junction unrelated to dental caries. NCCL is mostly associated…
(more)
▼ Non-carious Cervical lesions (NCCL) often encountered in clinical practice, is tooth structure loss at the cemento-enamel junction unrelated to dental caries. NCCL is mostly associated with gingival recession. Restoration of NCCL is challenging due to close periodontal relationship.
OBJECTIVE: To develop a non invasive, highly reproducible technique to measure the soft tissue changes and apply the technique to measure the gingival margin position changes after restoration of NCCL.
MATERIALS & METHODS: Forty one patients participated in the study. 3 resin composite (Filtek Supreme Plus) restorations were done per patient. GI(Loe & Sillness), PI (Loe & Sillness) , digital images and elastomeric impressions (Aquasil heavy & extra low viscosity) were collected from the three visits ( restoration, 10-15 days first recall, 6 month recall).Gingival phenotype is classified as thick or thin from the photographs. Casts (Fuji Rock type IV die stone) were prepared and a mold was made with putty impression material to hold the cast for imaging. Linear measurements (VHX 600 Keyence digital microscope) were recorded. Follow up visits were also recorded using the same molds as position guides.
RESULTS: Intraclass correlation of 0.9963 was seen for the reproducibility of the technique done on 40 samples repeated 8 times. Generalized mixed model analysis of variance was used to evaluate the gingival margin position changes over time and by phenotype. Generalized estimating equations were used to account the GI and the PI. No statistically significant difference in gingival height (p=0.6993), gingival height by phenotype (p=0.9102), and in plaque index (p=0.3092) was noted at the three time intervals. A significant difference was seen in the mean length between the phenotypes (p=0.0211), with thick phenotype having shorter mean length than thin phenotype and in GI (p<0.0001) between GI 1and GI 2 and between GI 1 and GI 3.
CONCLUSION: Within the limits of this study it can be concluded that placement of restoration in a NCCL restoration would not change the gingival margin position by time and by phenotype. Resin Composite restoration did not have an effect on plaque accumulation but, it would cause inflammation of the gingiva.
M.S.
1 online resource (xi, 80 p.) : ill., digital, PDF file.
Prosthodontics
Dentistry;
Non-carious cervical lesions
linear gingival margin position change measurement
UNRESTRICTED
Advisors/Committee Members: Burgess, John O., Reddy, Michael S.<br>, Litaker, Mark S.<br>, Javed, Amjad.
Subjects/Keywords: Dental Marginal Adaptation<; br>;
Dental Restoration, Permanent – methods<; br>;
Gingival Recession<; br>;
Tooth Cervix<; br>;
Tooth Wear – therapy<; br>;
Treatment Outcome
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jampani, P. (2009). Development and application of a technique to measure soft tissue changes following noncarious cervical lesion restorations. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1102
Chicago Manual of Style (16th Edition):
Jampani, Prabhavathi. “Development and application of a technique to measure soft tissue changes following noncarious cervical lesion restorations.” 2009. Masters Thesis, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1102.
MLA Handbook (7th Edition):
Jampani, Prabhavathi. “Development and application of a technique to measure soft tissue changes following noncarious cervical lesion restorations.” 2009. Web. 22 Jan 2021.
Vancouver:
Jampani P. Development and application of a technique to measure soft tissue changes following noncarious cervical lesion restorations. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1102.
Council of Science Editors:
Jampani P. Development and application of a technique to measure soft tissue changes following noncarious cervical lesion restorations. [Masters Thesis]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1102
12.
Mavalli, Mahendra D.
Mechanisms of growth hormone action in skeletal muscle.
Degree: PhD, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1103
► Growth hormone (GH) and insulin like growth factor-1 (IGF-1) exert profound growth promoting actions during pre and postnatal skeletal muscle development. GH and IGF-1 seem…
(more)
▼ Growth hormone (GH) and insulin like growth factor-1 (IGF-1) exert profound
growth promoting actions during pre and postnatal skeletal muscle development. GH and
IGF-1 seem to promote their anabolic actions by influencing skeletal muscle cell proliferation
and fusion. However, because GH stimulates the production of IGF-1 from the
liver and other GH-responsive peripheral tissues, including skeletal muscle, the individual
contributions of these two growth factors to anabolic responses in skeletal muscle remains
poorly defined. In this dissertation research, I sought to distinguish the mechanisms
responsible for growth hormone’s (GH) anabolic actions in skeletal muscle. To
accomplish this, I analyzed the impact of selected genetic alterations in the GH-IGF-1
pathway on skeletal muscle development and function in mice. With the results from
these studies, I demonstrate that GH mediates skeletal muscle development by enhancing
myoblast fusion in an IGF-1 dependent manner. In addition, I also demonstrate that disruption
of the GHR in skeletal muscle leads to alterations in global energy utilization and
insulin resistance in an IGF-1 independent manner.
1 online resource (vi, 85 p.) : ill., digital, PDF file.
Pathology
Joint Health Sciences;
GH
IGF-1
myoblast fusion
insulin sensitivity
insulin resistance
energy expenditure
UNRESTRICTED
Advisors/Committee Members: Gladson, Candece L., Bamman, Marcas M.<br>, Bellis, Susan L.<br>, Clemens, Thomas L.<br>, Frank, Stuart J..
Subjects/Keywords: Growth Hormone – metabolism<; br>;
Insulin – metabolism<; br>;
Insulin Resistance<; br>;
Muscle, Skeletal – growth & development<; br>;
Muscle, Skeletal – metabolism<; br>;
Receptor, IGF Type 1 – metabolism<; br>;
Receptors, Somatotropin – metabolism<; br>;
Sarcopenia
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mavalli, M. D. (2009). Mechanisms of growth hormone action in skeletal muscle. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1103
Chicago Manual of Style (16th Edition):
Mavalli, Mahendra D. “Mechanisms of growth hormone action in skeletal muscle.” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1103.
MLA Handbook (7th Edition):
Mavalli, Mahendra D. “Mechanisms of growth hormone action in skeletal muscle.” 2009. Web. 22 Jan 2021.
Vancouver:
Mavalli MD. Mechanisms of growth hormone action in skeletal muscle. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1103.
Council of Science Editors:
Mavalli MD. Mechanisms of growth hormone action in skeletal muscle. [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1103
13.
Hamilton, Kiya R.
Design of the predictive power method with two endpoints.
Degree: PhD, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1104
► Three reasons to review accumulating data in clinical trials include: ethical issues, financial concerns and administrative concerns. Interim analysis is a good way to monitor…
(more)
▼ Three reasons to review accumulating data in clinical trials include: ethical issues,
financial concerns and administrative concerns. Interim analysis is a good way to monitor
accumulating data in clinical trials. Interim analysis allows for the possibility that a study
may be terminated early; that is, if the currently observed data convincingly favor the null
or the alternative hypothesis then the study ends early. In addition, many clinical trials are
conducted to compare a treatment group to a standard group on multiple endpoints. Combining
interim analyses with multiple endpoints allows for more information to be provided
from the trial than either testing a single endpoint alone or testing multiple endpoints
without interim looks.
Stochastic curtailment procedures are frequently used in interim monitoring of
clinical trials. These methods allow for the possibility of early termination of a study at
any interim time point if a significant result (or null result) is highly likely given the current
data. One such stochastic curtailment method is conditional power. Conditional
power gives the probability of rejecting the null hypothesis at the end of the study given
the current data and some fixed parameter of interest. One criticism of conditional power
is that it is computed under values of the parameter of interest which may not be supported
by the current data. The predictive power method, a mixed Bayesian-frequentist
method, is another stochastic curtailment procedure for which this is no longer a concern.
The predictive power method extends conditional power to assume that the parameter of interest is random. The conditional power function is averaged with respect to the posterior
distribution of the parameter of interest given the observed data. We present an extension
of the univariate predictive power method to allow for two correlated endpoints.
We assess the properties of the extended predictive power under a variety of conditions,
and compare the performance of the extended predictive power method to other commonly
used methods for assessing data at interim time points. Finally, we illustrate our
extended predictive power method by applying it to data from the Inhaled Nitric Oxide
Study.
1 online resource (xiii, 182 p.) : ill., digital, PDF file.
Biostatistics;
Public Health;
predictive power
conditional power
multiple endpoints
interim monitoring
clinical trials
UNRESTRICTED
Advisors/Committee Members: McClure, Leslie A., Cutter, Gary<br>, Glasser, Stephen<br>, Redden, David T.<br>, Voeks, Jenifer.
Subjects/Keywords: Analysis of Variance<; br>;
Bayes Theorem<; br>;
Clinical Trials as Topic<; br>;
Data Interpretation, Statistical<; br>;
Endpoint Determination – methods<; br>;
Research Design<; br>;
Stochastic Processes
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hamilton, K. R. (2009). Design of the predictive power method with two endpoints. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1104
Chicago Manual of Style (16th Edition):
Hamilton, Kiya R. “Design of the predictive power method with two endpoints.” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1104.
MLA Handbook (7th Edition):
Hamilton, Kiya R. “Design of the predictive power method with two endpoints.” 2009. Web. 22 Jan 2021.
Vancouver:
Hamilton KR. Design of the predictive power method with two endpoints. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1104.
Council of Science Editors:
Hamilton KR. Design of the predictive power method with two endpoints. [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1104
14.
Nguyen, Tonga T.
Analysis and design of innovative composite storm shelter againt wind hazards.
Degree: MS, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1105
► Every year extreme windstorms such as tornadoes and hurricanes have imposed disastrous consequences to the United States community, economy and population. Having a community shelter…
(more)
▼ Every year extreme windstorms such as tornadoes and hurricanes have imposed
disastrous consequences to the United States community, economy and population.
Having a community shelter can protect civilians from these dangerous events. This
study focused on providing detailed design guidance in addition to demonstrating the
design and analysis of a safe, on-ground, stand-alone community shelter to resist extreme
wind forces. The storm shelter must be able to resist 300 mile per hour wind gusts and
flying debris impacts of such storms. The primary objective was to develop an innovative
and cost-effective Fiber Reinforced Polymer (FRP) panelized construction system. The
technique allows the shelter to be sub-divided into basic elements that can be prefabricated and shipped to the construction site, where they can be assembled into the
finished structure. The design must meet the requirements recommended by the Federal
Emergency Management Agency (FEMA) with life safety as the primary consideration.
The design wind pressures for the community shelter were calculated per the
American Society of Civil Engineering (ASCE) 7-05 code provision and modeled in the
Computational Fluid Dynamic (CFD) software named HYBRID3D. Comparison was
made between the ASCE 7-05 and CFD wind pressures to validate the accuracy of the
ASCE 7-05 design methodology.
Two different FRP materials were proposed for the design and analysis of the
FRP panels. The design of FRP panels was based on the performance and minimum wind load design criteria of the ASCE 7-05. The finite element analysis (FEA) software
package called ANSYS 11.0 was used to carry out the design of the FRP panels under the
wind pressure loading. In addition, the FEA was conducted on the bolted joint
connections of the shelter. Further analysis was carried out on the bolted joint
connections per the Load Resistance Factor Design (LRFD) code to determine if the bolts
had sufficient strength to resist the applied external loadings.
M.S.
1 online resource (xvii, 202 p.) : ill. (chiefly col.), maps.
Civil, Construction and Environmental Engineering
Engineering
Extreme wind FRP ASCE 7-05 FEA Connection Community shelter
UNRESTRICTED
Advisors/Committee Members: Uddin, Nasim, Kirby, Jason T. <br>, Du, Lianxiang.
Subjects/Keywords: Building, Stormproof – Materials – Mechanical properties – Computer simulation <; br>; Composite construction – Materials – Mechanical properties – Computer simulation <; br>; Public shelters – Computer-aided design <; br>; Fiber-reinforced plastics – Mechanical properties – Computer simulation <; br>; Buildings – Aerodynamics – Computer simulation <; br>; Wind-pressure – Computer simulation <; br>; Bolted joints – Testing – Computer simulation
Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nguyen, T. T. (2009). Analysis and design of innovative composite storm shelter againt wind hazards. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1105
Chicago Manual of Style (16th Edition):
Nguyen, Tonga T. “Analysis and design of innovative composite storm shelter againt wind hazards.” 2009. Masters Thesis, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1105.
MLA Handbook (7th Edition):
Nguyen, Tonga T. “Analysis and design of innovative composite storm shelter againt wind hazards.” 2009. Web. 22 Jan 2021.
Vancouver:
Nguyen TT. Analysis and design of innovative composite storm shelter againt wind hazards. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1105.
Council of Science Editors:
Nguyen TT. Analysis and design of innovative composite storm shelter againt wind hazards. [Masters Thesis]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1105
15.
Pyle, Louise Clare.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their mechanistic basis: relevance to emerging therapies for cystic fibrosis.
Degree: PhD, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1106
► Cystic fibrosis (CF) is a lethal genetic disorder leading to pulmonary decline and premature death. The gene responsible for CF, the cystic fibrosis transmembrane conductance…
(more)
▼ Cystic fibrosis (CF) is a lethal genetic disorder leading to pulmonary decline and
premature death. The gene responsible for CF, the cystic fibrosis transmembrane conductance
regulator (CFTR), serves as a chloride and bicarbonate channel situated at the
apical cell surface of epithelia. The discovery of small molecules that augment channel
gating of mutant CFTR (so-called ‘potentiators’) represents a major theme of CF research,
and offers hope for new therapeutic interventions. High-throughput screening
(HTS) provides a means to test millions of agents in an unbiased manner for CFTR potentiating
properties. New agents identified by HTS have undergone extensive preclinical
and clinical testing in CF individuals, and shown substantial progress toward
clinical advancement. However, novel strategies are required to better understand CFTR
potentiators and their applicability in the clinic.
In this thesis, we pursued a detailed understanding of emerging CFTR potentiators
with high relevance to therapeutic intervention. We describe a set of mechanistic experiments
intended to functionally categorize CFTR potentiators based on their biochemical
effects on the CFTR regulatory domain (RD), and their activity profiles in cell
systems representative of the in vivo environment. Our findings indicate that CFTR potentiators
acting independently of RD phosphorylation may be best tailored to rescue
cAMP regulation of CFTR carrying the common ΔF508 mutation. In another series of
experiments, we show that quercetin, a novel flavonoid, potentiates CFTR mediated anion
transport in respiratory epithelia in vitro and in vivo, and may be useful to optimally
detect rescue of ΔF508-CFTR.
The present project therefore addresses two questions fundamental to both CFTR
biology and CF therapeutic intervention:
1. How can knowledge of CFTR modulator mechanism aid in optimization of
emerging CFTR potentiators and advance basic understanding of CFTR biology?
2. How can knowledge of a robust class of CFTR activators, the flavonoids, be used
to identify compounds best able to activate and detect surface localized and functional
CFTR in human subjects with cystic fibrosis?
These findings address the increasingly recognized gap between identification of new
therapeutic compounds for CF, and a better understanding of agents most suitable for basic
and translational cystic fibrosis research.
1 online resource (xv, 115 p.) : ill., digital, PDF file.
Genetics
Joint Health Sciences;
CFTR
Cystic Fibrosis
potentiators
quercetin
regulatory-domain
cAMP
UNRESTRICTED
Advisors/Committee Members: Sorscher, Eric J., Bedwell, David M.<br>, Dobrunz, Lynn E.<br>, Rowe, Steven M.<br>, Yoder, Bradley K..
Subjects/Keywords: Biological Markers – metabolism<; br>;
Cystic Fibrosis – metabolism<; br>;
Cystic Fibrosis Transmembrane Conductance Regulator<; br>;
High-Throughput Screening Assays<; br>;
Ion Channel Gating – drug effects<; br>;
Membrane Transport Modulators – pharmacology<; br>;
Mutant Proteins – metabolism<; br>;
Protein Structure, Tertiary – genetics<; br>;
Quercetin – pharmacology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pyle, L. C. (2009). Cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their mechanistic basis: relevance to emerging therapies for cystic fibrosis. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1106
Chicago Manual of Style (16th Edition):
Pyle, Louise Clare. “Cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their mechanistic basis: relevance to emerging therapies for cystic fibrosis.” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1106.
MLA Handbook (7th Edition):
Pyle, Louise Clare. “Cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their mechanistic basis: relevance to emerging therapies for cystic fibrosis.” 2009. Web. 22 Jan 2021.
Vancouver:
Pyle LC. Cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their mechanistic basis: relevance to emerging therapies for cystic fibrosis. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1106.
Council of Science Editors:
Pyle LC. Cystic fibrosis transmembrane conductance regulator (CFTR) modulators and their mechanistic basis: relevance to emerging therapies for cystic fibrosis. [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1106
16.
Panjamapirom, Anantachai.
The impact of EHR systems on physician productivity and performance.
Degree: PhD, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1107
► This study examines the relationship between electronic health record (EHR) adoption and physicians’ operational productivity and financial performance. The resource-based view of the firm (RBV)…
(more)
▼ This study examines the relationship between electronic health record (EHR) adoption and physicians’ operational productivity and financial performance. The resource-based view of the firm (RBV) was utilized as a theoretical framework to develop and address four hypotheses. Specifically, the first two hypotheses address the impact of EHR adoption status (i.e., electronic- vs. paper-based medical records), and the other two hypotheses focus on the length of EHR adoption (i.e., years of EHR adoption). This cross- sectional study used secondary data from the 2008 physician compensation and production survey conducted by the Medical Group Management Association (MGMA). Multiple linear regression analysis was used to test the hypothesized relationships.
The results showed that there was partial evidence that EHR adoption and the length of adoption were negatively related to physicians’ operational productivity. Particularly, while EHR adoption was not related to physician RVU, it was negatively related to the number of encounters. The length of EHR adoption was negatively related to physician RVU. Although EHR adoption and length of adoption were not associated with overall financial performance, the adoption was associated with significantly higher charges.
An important implication for scholars is that IT infrastructure might serve as a source of competitive advantage for specific tasks. This suggests that when conducting an
IT-performance study, researchers should consider task-specific outcome measures. In addition, managers of ambulatory physician practices can use the findings from this current study to facilitate their decision-making process in EHR adoption. Even though partial evidence suggests that EHR adoption is associated with decreased physicians’ productivity, it is not negatively associated with financial performance. Coupled with the meaningful incentive program currently being offered as part of the HITECH Act, the ability of EHR to improve charge captures should encourage managers to adopt EHR.
3.58MB
Health Services Administration
Health Professions;
electronic health record
resource-based view
physician practice setting
operational productivity
financial performance
RVU
UNRESTRICTED
Advisors/Committee Members: Shewchuk, Richard M., Menachemi, Nir<br>, Hernandez, S. Robert<br>, Ginter, Peter M.<br>, Burkhardt, Jeffrey H..
Subjects/Keywords: Efficiency, Organizational – economics<; br>;
Electronic Health Records – utilization<; br>;
Medical Records Systems, Computerized<; br>;
Physician's Practice Patterns – statistics & numerical data<; br>;
Practice Management, Medical – economics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Panjamapirom, A. (2010). The impact of EHR systems on physician productivity and performance. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1107
Chicago Manual of Style (16th Edition):
Panjamapirom, Anantachai. “The impact of EHR systems on physician productivity and performance.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1107.
MLA Handbook (7th Edition):
Panjamapirom, Anantachai. “The impact of EHR systems on physician productivity and performance.” 2010. Web. 22 Jan 2021.
Vancouver:
Panjamapirom A. The impact of EHR systems on physician productivity and performance. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1107.
Council of Science Editors:
Panjamapirom A. The impact of EHR systems on physician productivity and performance. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1107
17.
Polter, Abigail Marie.
Regulation of GSK3 in the pathophysiology and treatment of mood disorders.
Degree: PhD, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1108
► Mood disorders are devastating psychiatric illnesses that will affect as many as one in every five persons worldwide over the course of their lifetime. Significant…
(more)
▼ Mood disorders are devastating psychiatric illnesses that will affect as many as one in
every five persons worldwide over the course of their lifetime. Significant gaps still remain
in our understanding of these illnesses and outcomes for many patients are far from optimal.
Glycogen Synthase Kinase 3 (GSK3) is a protein kinase that is increasingly recognized as
playing an important role in a number of neuronal functions, as well as in pathological states
such as mood disorders. GSK3 is inhibited in the brain by phosphorylation on an N-terminal
serine. Several treatments for mood disorders, including lithium, antidepressants, and
atypical antipsychotics increase this inhibitory phosphorylation, suggesting that it may be an
important mechanism for the regulation of mood. In these studies, we investigate the role of
serine phosphorylation of GSK3 in the treatment and pathophysiology of mood disorders.
To investigate the mechanisms of mood disorder treatment, we first examined
activation of Akt, an upstream regulating kinase of GSK3, in response to serotonin. Both an
acute increase in serotonin and chronic antidepressant treatment result in a functional
activation of the Akt signaling pathway. Similarly, activation of 5-HT1A receptors were
found to increase phosphorylation of GSK3 through activation of the PI3K/Akt pathway, and
phosphorylation of GSK3 was found to be necessary for 5-HT1A receptor-mediated
inhibition of conditioned fear memories. Antagonism of 5-HT2A receptors was found to
inhibit GSK3 through activation of Akt, while activation of 5-HT2A receptors was found to
increase inhibitory phosphorylation of GSK3 only in the absence of β-arrestin2.
Furthermore, loss of β-arrestin2 potentiates the antidepressant-induced increase in
phosphorylated GSK3 as well as the behavioral response to antidepressants. Finally, we
investigated the behavioral effects of decreased serine-phosphorylation of GSK3 using
knock-in mice with GSK3 that is immune to serine phosphorylation. We found that loss of
this phosphorylation resulted in increased behavioral susceptibility to induction of both
manic- and depressive-like states.
The studies presented here demonstrate that serine phosphorylation of GSK3 plays a
critical role in mood disorder pathology. This gives us novel insights into the regulation of
mood, and may provide avenues for the development of more effective treatments for mood disorders.
1 online resource (x, 250 p.) : ill., digital, PDF file.
Neurobiology;
Joint Health Sciences;
GSK3
Akt
Mood Disorders
Serotonin
Antidepressants
Behavior
UNRESTRICTED
Advisors/Committee Members: Li. Xiaohua, Hablitz, John<br>, Jope, Richard<br>, Theibert, Anne<br>, Wilson, Scott.
Subjects/Keywords: Behavior, Animal – physiology<; br>;
Brain – metabolism<; br>;
Exploratory Behavior – physiology<; br>;
Forkhead Transcription Factors – metabolism<; br>;
Glycogen Synthase Kinase 3<; br>;
Mood Disorders<; br>;
Receptor, Serotonin, 5-HT1A – metabolism<; br>;
Serine – metabolism<; br>;
Serotonin – metabolism<; br>;
Signal Transduction
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Polter, A. M. (2010). Regulation of GSK3 in the pathophysiology and treatment of mood disorders. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1108
Chicago Manual of Style (16th Edition):
Polter, Abigail Marie. “Regulation of GSK3 in the pathophysiology and treatment of mood disorders.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1108.
MLA Handbook (7th Edition):
Polter, Abigail Marie. “Regulation of GSK3 in the pathophysiology and treatment of mood disorders.” 2010. Web. 22 Jan 2021.
Vancouver:
Polter AM. Regulation of GSK3 in the pathophysiology and treatment of mood disorders. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1108.
Council of Science Editors:
Polter AM. Regulation of GSK3 in the pathophysiology and treatment of mood disorders. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1108
18.
Richey, Christina R.
Near-infrared spectroscopy of ices under conditions relevant to interstellar and planetary environments.
Degree: PhD, 2011, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1109
► The abundances of ices in planetary environments are obtained through measurements of near-infrared absorption features (˜ν=10,000-4,000 cm−1 , λ=1-2.5 µm), and nearIR measurements of materials…
(more)
▼ The abundances of ices in planetary environments are obtained through measurements
of near-infrared absorption features (˜ν=10,000-4,000 cm−1
, λ=1-2.5 µm), and nearIR measurements of materials present in the interstellar medium are increasingly
common. In the studies presented here, the near-IR band strengths for molecules are
determined through correlations to their better-known mid-IR characteristics. These
strengths are used to determine the column densities of molecules in interstellar dense
clouds or other environments from observed data. The first set of experiments focused
on the near-IR features of molecules relevant to the study of interstellar icy grain
mantles and planetary bodies: CO, CO2, C3O2, CH4, H2O, CH3OH, and NH3. The
spectra of these species were studied in the near-IR region from 10,000-4,000 cm−1
and in the mid-IR region from 4,000-400 cm−1
after the slow growth of films at ∼5 K.
The results were then used the results to determine the near-IR band strengths of each
molecule. Many icy satellites have surfaces that are dominated by either N2 or H2O,
and ices in the ISM are primarily composed of H2O. The second set of experiments
is focused on the near-IR absorption features of CO, CO2, CH4, and NH3 diluted in
H2O and diluted in N2. Since the compositions of icy planetary bodies and interstellar
ices are affected by processing due to UV light and proton bombardment, spectra of
UV photolyzed and proton irradiated ices of N2 + CO2 and H2O + CO2 have been
collected to determine the extent of energetic processing on icy bodies in the outer
solar system. These studies have shown that planetary ices are best represented by
laboratory analogs comprised of mixed, energetically processed ices.
1 online resource (xix, 154 p.) : ill. (some col.)
Physics
College of Arts and Sciences
UNRESTRICTED
Advisors/Committee Members: Gerakines, Perry A., Camata, Renato P. <br>, Hilton, David J. <br>, Hudson, Reggie L. <br>, Watkins, Charles L..
Subjects/Keywords: Ice – Spectra <; br>; Interstellar molecules – Spectra <; br>;
Infrared spectroscopy <; br>; Cosmic dust – Spectra <; br>; Interstellar hydrogen – Spectra <; br>; Cosmic physics
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Richey, C. R. (2011). Near-infrared spectroscopy of ices under conditions relevant to interstellar and planetary environments. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1109
Chicago Manual of Style (16th Edition):
Richey, Christina R. “Near-infrared spectroscopy of ices under conditions relevant to interstellar and planetary environments.” 2011. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1109.
MLA Handbook (7th Edition):
Richey, Christina R. “Near-infrared spectroscopy of ices under conditions relevant to interstellar and planetary environments.” 2011. Web. 22 Jan 2021.
Vancouver:
Richey CR. Near-infrared spectroscopy of ices under conditions relevant to interstellar and planetary environments. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2011. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1109.
Council of Science Editors:
Richey CR. Near-infrared spectroscopy of ices under conditions relevant to interstellar and planetary environments. [Doctoral Dissertation]. University of Alabama – Birmingham; 2011. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1109
19.
Sullivan, Kathryn Amanda.
Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara.
Degree: MA, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1110
► In our present day, the term “chivalry” is understood to define the gentlemanly conduct of a man with respects to a female counterpart. In the…
(more)
▼ In our present day, the term “chivalry” is understood to define the gentlemanly
conduct of a man with respects to a female counterpart. In the fifteenth century, the term
“chivalry” is applied in a broader sense, referring to the inter-dynamics of a grouping of
knights. “Chivalry” thus examines the bachelorhood of the knight and the magnanimous
and egalitarian nature of his position.
Italians have been aware of Arthurian legends since at least the eleventh century.
In fifteenth century Northern Italy, chivalric literature enjoyed refreshed interest due to
an outpouring of Italian and French translations.
Borso d’Este (1413-1471), although illegitimate, was the second sovereign son of
Niccolò III d’Este of Ferrara. Borso’s illegitimacy and lifestyle made it advantageous for
him to embody a knightly persona. In doing so, he employed a variety of artistic campaigns that hyperbolized his pedigree. This thesis focuses on one of these campaigns, the
Hall of the Months, in the Palazzo Schifanoia, an Este hunting retreat on the outskirts of
Ferrara.
Francesco del Cossa and Cosmè Tura painted the Hall of the Months. The program for the fresco cycle is complex. The twelve calendar months run clockwise around
the room. Horizontally, the hall is divided into three registers, from bottom to top: earth,
corresponding zodiacal signs, and corresponding deities. Considering the 1:1 scaling and expansive proportions of the Hall of the Months
(24 m long, 11 m long, and 7.5 m high), the earthly tier illusionistically places viewers
outdoors and serve as a reminder of Borso’s place among sovereigns. Themes of civic
harmony abated any fear of discord or aggression.
Previous scholarship has tended to focus on the astrological aspects of the Hall of
the Months. However, its chivalric imagery has either been neglected or not fully explored. Thus, this thesis focuses only on the “earthly” register, whose chivalric imagery
promulgates Borso’s carefully crafted persona. By providing a new focus of interest for
the Hall of the Months, I hope to open the field to further research about Borso’s biography as well as the importance of chivalric literature in fifteenth-century Italy and in fifteenth-century Italian art.
M.A.
1 online resource (xi, 76 p.) : ill. (chiefly col.), geneal. table, map, plans.
Art and Art History
College of Arts and Sciences
Borso d’Este Chivalry Ferrara Hall of the Months Italian Renaissance Schifanoia
UNRESTRICTED
Advisors/Committee Members: McIver, Katherine A., Dallow, Jessica <br>, Nancarrow, Mindy.
Subjects/Keywords: Mural painting and decoration – Italy – Ferrara <; br>; Arthurian romances in art <; br>; Chivalry in art <; br>; Salone dei Mesi (Museo civico d'arte antica di Palazzo Schifanoia) <; br>; Borso d'Este, Duke of Ferrara, Modena, and Reggio, 1413-1471 – Art patronage <; br>; Este family – Art patronage <; br>; Cossa, Francesco del, ca. 1435-ca. 1477 – Criticism and interpretation <; br>; Tura, Cosmè, ca. 1430-1495 – Criticism and interpretation
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sullivan, K. A. (2009). Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1110
Chicago Manual of Style (16th Edition):
Sullivan, Kathryn Amanda. “Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara.” 2009. Masters Thesis, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1110.
MLA Handbook (7th Edition):
Sullivan, Kathryn Amanda. “Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara.” 2009. Web. 22 Jan 2021.
Vancouver:
Sullivan KA. Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1110.
Council of Science Editors:
Sullivan KA. Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara. [Masters Thesis]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1110
20.
Sheppard, Kathryn Anne Jackson.
Parental separation anxiety and shared responsibility for diabetes-related tasks in adolescents diagnosed with type 1 diabetes mellitus.
Degree: PhD, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1111
► Type 1 diabetes mellitus (T1D) is most commonly diagnosed in children and young adults, and complications may be life-long as well as life threatening. Management…
(more)
▼ Type 1 diabetes mellitus (T1D) is most commonly diagnosed in children and
young adults, and complications may be life-long as well as life threatening.
Management of T1D has proven to be very challenging during adolescence, and parental
involvement in diabetes management has been shown to improve adherence and
glycemic control in children and adolescents. Middle adolescents should become
increasingly responsible for diabetes-related tasks under the supervision and guidance of
parents (shared management). However, adolescents spend less time with their family as
they get older, resulting in parents’ being unable to validate effective self-management;
this inability may lead to anxiety about being separated from their adolescent (parental
separation anxiety) and to retention of diabetes task responsibility that would interfere
with an effective transfer of responsibility. The purpose of this study was to examine
separation anxiety in parents and couples who were parents of adolescents 15 to 17 years
of age who had T1D. Specifically, the relationship investigated was that of parental
separation anxiety to parental responsibility for diabetes-related tasks and glycemic
control. Secondary data analysis was used to examine 61 adolescents and their parents
from a larger longitudinal study. Maternal separation anxiety was associated with and
was a predictor for maternal responsibility only in 2-parent and 2-parent biological
families (p = .008). Maternal separation anxiety was associated with glycemic control in
the total sample (p = .042). Findings from multiple regression revealed that maternal
separation anxiety was not a significant predictor for maternal responsibility once
significant covariates were controlled in the model. Paternal separation anxiety was
neither significantly associated with nor a predictor for paternal responsibility or
glycemic control. Paired, samples t-tests indicated that maternal separation anxiety and
paternal separation anxiety were significantly different in 2-parent biological families
(p = .019) but not in 2-parent stepfamilies. Parental separation anxiety was not
significantly associated with parental responsibility or glycemic control in the total
sample. Bivariate correlations indicated that shared responsibility was not significantly
related to glycemic control. Shared responsibility has been associated with improved
glycemic control in younger adolescents; however, it does not appear to have the same
impact in middle adolescents.
1 online resource (xv, 225 p.) : ill., digital, PDF file.
Nursing;
Nursing;
adolescents
diabetes responsibility
shared responsibility
shared management
maternal separation anxiety
paternal separation anxiety
UNRESTRICTED
Advisors/Committee Members: Dashiff, Carol J., Bevill, J. Thomas<br>, Guest, Kristi C.<br>, Ivey, Jean B.<br>, Pryor, Erica R..
Subjects/Keywords: Adolescent<; br>;
Anxiety, Separation – psychology<; br>;
Diabetes Mellitus, Type 1 – psychology<; br>;
Father-Child Relations<; br>;
Mother-Child Relations<; br>;
Parenting – psychology<; br>;
Self Care – psychology
Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sheppard, K. A. J. (2010). Parental separation anxiety and shared responsibility for diabetes-related tasks in adolescents diagnosed with type 1 diabetes mellitus. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1111
Chicago Manual of Style (16th Edition):
Sheppard, Kathryn Anne Jackson. “Parental separation anxiety and shared responsibility for diabetes-related tasks in adolescents diagnosed with type 1 diabetes mellitus.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1111.
MLA Handbook (7th Edition):
Sheppard, Kathryn Anne Jackson. “Parental separation anxiety and shared responsibility for diabetes-related tasks in adolescents diagnosed with type 1 diabetes mellitus.” 2010. Web. 22 Jan 2021.
Vancouver:
Sheppard KAJ. Parental separation anxiety and shared responsibility for diabetes-related tasks in adolescents diagnosed with type 1 diabetes mellitus. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1111.
Council of Science Editors:
Sheppard KAJ. Parental separation anxiety and shared responsibility for diabetes-related tasks in adolescents diagnosed with type 1 diabetes mellitus. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1111
21.
Schreeder, Daniel M.
Biological characterization of Fc receptor-like 6 (FCRL6).
Degree: PhD, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1112
► Members of the Fc receptor-like (FCRL) family are cell-surface proteins with ancient conservation, distinct lymphocyte expression patterns, and tyrosine-based signaling capabilities that imply a fundamental…
(more)
▼ Members of the Fc receptor-like (FCRL) family are cell-surface proteins with ancient
conservation, distinct lymphocyte expression patterns, and tyrosine-based signaling capabilities
that imply a fundamental role for them in modulating immune responses. Though
they share many features with the Fc receptors (FCR) for IgG and IgE, FCRLs have not
been found to bind immunoglobulin. In these studies, we sought to characterize the cellular
expression pattern, binding partner, and function of a recently identified FCRL family
member, human FCRL6.
By developing specific monoclonal antibodies (mAbs) we determined that FCRL6 is distinctly
expressed by cytotoxic lymphocytes, namely NK cells, CD8+ T cells, γδ T cells,
and rare cytotoxic CD4+ T cells. To elucidate its extracellular ligand(s), a cell-based GFP
reporter system was developed to assay FCRL6 surface receptor engagement. These studies
revealed that FCRL6 binds to HLA-DR, an MHC class II molecule. This interaction
was confirmed by generating a panel of HLA-DR-reactive mAbs that blocked the
FCRL6/HLA-DR association and by demonstrating that soluble recombinant FCRL6-Fc
molecules specifically bind to HLA-DR transductants. The functional relevance of this
discovery was also examined. First, by blocking the FCRL6/HLA-DR interaction, CD8+
T cell functions could be enhanced in response to antigenic peptide stimulation. Second,
forced expression of FCRL6 in a human NK cell line inhibited its killing of HLA-DR
expressing cells. Collectively, these studies demonstrate that FCRL6, a molecule distinctly
expressed by cytotoxic lymphocytes, inhibits their effector function upon engagement
of its ligand, MHC class II. These findings reveal an intriguing evolutionary relationship
between receptors for immunoglobulin and MHC and demonstrate that NK cells
and CD8+ T cells, whose activities are traditionally considered to be governed by MHC
class I interactions, are also functionally regulated by MHC class II. This newfound interface
may have important implications for better understanding HLA class II disease association
and its manipulation could be of therapeutic benefit to patients with disorders of
cell-mediated immunity.
1 online resource (v, 86 p.) : ill., digital, PDF file.
Microbiology;
Joint Health Sciences;
FCR
FCRL
FCRL6
MHC class II
NK cells
CD8+ T cells
UNRESTRICTED
Advisors/Committee Members: Davis, Randall S., Burrows, Peter D.<br>, Justement, Louis B.<br>, Lorenz, Robinna G.<br>, Zajac, Allan J..
Subjects/Keywords: CD8-Positive T-Lymphocytes – immunology<; br>;
HLA-DR Antigens – metabolism<; br>;
Killer Cells, Natural – immunology<; br>;
Leukemia, Lymphocytic, Chronic, B-Cell – immunology<; br>;
Receptors, Cell Surface – physiology<; br>;
Receptors, Fc – metabolism
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MLA ·
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APA (6th Edition):
Schreeder, D. M. (2009). Biological characterization of Fc receptor-like 6 (FCRL6). (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1112
Chicago Manual of Style (16th Edition):
Schreeder, Daniel M. “Biological characterization of Fc receptor-like 6 (FCRL6).” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1112.
MLA Handbook (7th Edition):
Schreeder, Daniel M. “Biological characterization of Fc receptor-like 6 (FCRL6).” 2009. Web. 22 Jan 2021.
Vancouver:
Schreeder DM. Biological characterization of Fc receptor-like 6 (FCRL6). [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1112.
Council of Science Editors:
Schreeder DM. Biological characterization of Fc receptor-like 6 (FCRL6). [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1112
22.
Thomas, Donna Gossom.
Gossom Switch, and, The Zearn master.
Degree: MA, 2011, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1113
► Gossom Switch is a creative nonfiction piece which traces my paternal roots. This narrative explores the family bond, racial segregation, slavery, and civil rights. Although…
(more)
▼ Gossom Switch is a creative nonfiction piece which traces my paternal roots. This
narrative explores the family bond, racial segregation, slavery, and civil rights. Although
Gossom Switch is a personal journey, my story is also universal and historical.
The Zearn Master is a middle-grade fiction novel. While the main purpose of this
novel is to entertain, like my creative nonfiction it focuses on family, especially the bond
between siblings. This piece is also universal in that it centers around the sport of
basketball.
M.A.
1 online resource (vii, 38, 83 p.)
English
College of Arts and Sciences
Fiction Creative nonfiction Middle-grade Basketball Slavery Freedom
UNRESTRICTED
Advisors/Committee Members: Madden, Kerry, Kim, Sue <br>, Wharton, Larry <br>, Wood, Jacqueline.
Subjects/Keywords: African Americans – Alabama – Elmore County – Fiction <; br>; Alabama – Social conditions – 19th century – Fiction <; br>; Elmore County (Ala.) – Fiction <; br>; Slaves – Alabama – Fiction <; br>; Basketball stories <; br>; Brothers and sisters – Juvenile fiction
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Thomas, D. G. (2011). Gossom Switch, and, The Zearn master. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1113
Chicago Manual of Style (16th Edition):
Thomas, Donna Gossom. “Gossom Switch, and, The Zearn master.” 2011. Masters Thesis, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1113.
MLA Handbook (7th Edition):
Thomas, Donna Gossom. “Gossom Switch, and, The Zearn master.” 2011. Web. 22 Jan 2021.
Vancouver:
Thomas DG. Gossom Switch, and, The Zearn master. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2011. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1113.
Council of Science Editors:
Thomas DG. Gossom Switch, and, The Zearn master. [Masters Thesis]. University of Alabama – Birmingham; 2011. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1113
23.
Walters, John Brandon.
USP14: a link between the proteasome and synaptic function.
Degree: PhD, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1114
► The ubiquitin proteasome system (UPS) is a coordinated process by which the cell can control protein distribution and abundance. Proteins are marked for turnover by…
(more)
▼ The ubiquitin proteasome system (UPS) is a coordinated process by
which the cell can control protein distribution and abundance. Proteins are
marked for turnover by the construction of a polyubiquitin chain on the protein
substrate. Once engaged by the proteasome, the ubiquitin side-chain is
disassembled by proteasomal deubiquitinating enzymes (DUBs), preventing
entry of ubiquitin into the proteasome and recycling it for use in future reactions.
One of the DUBs that resides on the proteasome is Ubiquitin Specific Protease
14 (Usp14), which is mutated in the ataxia (axJ) mice. This mutation results in
pronounced physical deficits and, unexpectedly, a deficit in hippocampal synaptic
function. This deficit in the hippocampus was primarily characterized as a
reduction in paired pulse facilitation (PPF), a form of synaptic short-term
plasticity. The purpose of this project was to understand how the proteasome is
able to modulate PPF. To this end we found that the deficit in PPF is due to an
increase in the rate of degradation at the proteasome. This change results from
the loss of Usp14’s ability to regulate the proteasome, independent of Usp14’s
ability to process ubiquitin chains. Surprisingly, the deficit in PPF is not caused
by a change in the initial synaptic release probability. Instead, an increased rate
of proteasomal degradation results in a significant reduction in the number of
docked vesicles at the synaptic terminal. This deficit, combined with a
hypothesized homeostatic increase in the release probability per vesicle, accounts for the observed deficit in PPF of the axJ mice.
1 online resource (ix, 144 p.) : ill., digital, PDF file.
Neurobiology;
Joint Health Sciences;
Usp14
Short term plasticity
Proteasome
PPF
UPS
UNRESTRICTED
Advisors/Committee Members: Dobrunz, Lynn, Wilson, Scott<br>, Floyd, Candace<br>, Lester, Robin<br>, McMahon, Lori.
Subjects/Keywords: Neuronal Plasticity – physiology<; br>;
Proteasome Endopeptidase Complex – metabolism<; br>;
Synapses – metabolism<; br>;
Synaptic Transmission – physiology<; br>;
Ubiquitin – metabolism<; br>;
Ubiquitin Thiolesterase – metabolism
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Walters, J. B. (2010). USP14: a link between the proteasome and synaptic function. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1114
Chicago Manual of Style (16th Edition):
Walters, John Brandon. “USP14: a link between the proteasome and synaptic function.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1114.
MLA Handbook (7th Edition):
Walters, John Brandon. “USP14: a link between the proteasome and synaptic function.” 2010. Web. 22 Jan 2021.
Vancouver:
Walters JB. USP14: a link between the proteasome and synaptic function. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1114.
Council of Science Editors:
Walters JB. USP14: a link between the proteasome and synaptic function. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1114
24.
Yan, Ming.
The structural and functional studies of yeast nucleotide exchange factor Sil1P and its complex with Bip.
Degree: PhD, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1115
► Sil1 is an Endoplasmic Reticulum (ER) localized protein. SIL1 was initially identified as a UPR-regulated gene. Later studies show Sil1 functions as the nucleotide exchange…
(more)
▼ Sil1 is an Endoplasmic Reticulum (ER) localized protein. SIL1 was initially
identified as a UPR-regulated gene. Later studies show Sil1 functions as the nucleotide
exchange factor of ER lumenal Hsp70—Bip by directly interacting with the ATPase
domain of Bip. Currently, the molecular mechanism how Sil1 catalyzes nucleotide
exchange of Bip is still elusive. In this study we determine the complex structure of yeast
S.cerevisia Sil1 and Bip (also called Kar2) ATPase domain at 2.3Å resolution by
Single-anomalous dispersion (SAD) methods. The Sil1-Bip complex structure reveals
that one sil1 molecule interacts with one Bip ATPase domain molecule to form the
complex. Sil1 forms an elongated shape which is entirely comprised of α-helices
including four Armadillo-like repeats. In the complex structure, Sil1 wraps around the
subdomain IIb of the Bip ATPase domain and acts in a “clamp” model. The binding of
Sil1 forces a ~13.5° outward rotation of subdomain IIb away from the nucleotide-binding
cleft. The complex formation also induces a ~3.7° rotation of subdomain Ib to the
opposite direction. These conformational changes open up the nucleotide-binding cleft of
Bip ATPase domain, disrupt the hydrogen bonds between Bip ATPase domain and bound
ADP, and eventually promote the ADP release and the subsequent ATP binding.
A group of interface residues from Sil1 are mutated. Two single mutants H163A and
E390A result in complete loss of Sil1-Bip interaction. All the other mutants compromise
binding between two proteins to various extents. The ATPase activity assay results show
all the Sil1 mutants lose the ability to stimulate the ATPase activity of Bip. The results
are consistent with that of the reduced binding affinities between Sil1 mutants and Bip
ATPase domain.
Utilizing the structural and functional data, a reasonable mechanism for Sil1
functioning as the nucleotide exchange factor of Bip has been proposed.
1 online resource (xi, 78 p.) : ill., digital, PDF file.
Cell Biology;
Joint Health Sciences;
Sil1
Bip
ATPase activity
UNRESTRICTED
Advisors/Committee Members: Sha, Bingdong, Chang, Chenbei<br>, Deivanayagam, Champion<br>, Lin, Fang-Tsyr<br>, Sthanam, Narayana.
Subjects/Keywords: Fungal Proteins – chemistry<; br>;
HSP70 Heat-Shock Proteins – chemistry<; br>;
Membrane Transport Proteins – chemistry<; br>;
Saccharomyces cerevisiae – metabolism<; br>;
Saccharomyces cerevisiae Proteins – chemistry
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Yan, M. (2010). The structural and functional studies of yeast nucleotide exchange factor Sil1P and its complex with Bip. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1115
Chicago Manual of Style (16th Edition):
Yan, Ming. “The structural and functional studies of yeast nucleotide exchange factor Sil1P and its complex with Bip.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1115.
MLA Handbook (7th Edition):
Yan, Ming. “The structural and functional studies of yeast nucleotide exchange factor Sil1P and its complex with Bip.” 2010. Web. 22 Jan 2021.
Vancouver:
Yan M. The structural and functional studies of yeast nucleotide exchange factor Sil1P and its complex with Bip. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1115.
Council of Science Editors:
Yan M. The structural and functional studies of yeast nucleotide exchange factor Sil1P and its complex with Bip. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1115
25.
Yang, Sherry W. (Sherry Wei).
A TIMP2-armed conditionally-replicating adenovirus for the treatment of ovarian cancer.
Degree: PhD, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1116
► Ovarian cancer remains the most lethal gynecological malignancy in the U.S. Conventional therapies have limited therapeutic value due to advanced stage of the dis-ease at…
(more)
▼ Ovarian cancer remains the most lethal gynecological malignancy in the U.S. Conventional therapies have limited therapeutic value due to advanced stage of the dis-ease at diagnosis. Conditionally-replicating adenoviruses (CRAds) are promising, novel anti-cancer agents that are designed to selectively replicate in and lyse tumor cells. In clinical trials, CRAds exhibited limited efficacy thus far. Second generation CRAds are being developed to express a therapeutic protein to further enhance antitumor efficacy. One attractive target in ovarian tumor microenvironment is the matrix metalloproteinases (MMPs) that degrade the extracellular matrix. Thus, tissue inhibitor of metalloproteinase 2 (TIMP2), an endogenous inhibitor of MMPs, is a promising candidate to arm a CRAd intended to treat ovarian cancer. We hypothesize that a CRAD armed with TIMP2 will inhibit ovarian cancer progression through two distinct mechanisms. First, specific repli-cation in tumor cells should lead to oncolysis. Second, secretion of TIMP2 into the tu-mor microenvironment should inhibit excess extracellular MMPs and activate other MMP-independent signaling pathways to inhibit tumor growth, angiogenesis and metas-tasis.
A targeted and armed CRAd, Ad5/3-CXCR4-TIMP2 was developed using the CXCR4 promoter for enhanced replication, expressing the TIMP2 transgene. First, we confirmed the secretion and functional activity of TIMP2, as demonstrated by the inhibi-
tion of gelatin degradation by MMPs. In addition, arming with TIMP2 did not inhibit viral replication nor oncolytic potency, as the TIMP2 armed viruses showed enhanced killing of cancer cells when compared to the unarmed viruses. Examination of viral rep-lication in primary stage III and IV ovarian cancer samples revealed a consistent high level of viral replication with Ad5/3-CXCR4-TIMP2. The therapeutic efficacy of the TIMP2-armed CRAd was then evaluated in an orthotropic model of ovarian cancer, in which athymic mice were intraperitoneally injected with human ovarian cancer cells. The results demonstrated that the Ad5/3-CXCR4-TIMP2 delayed tumor growth and sig-nificantly increased survival when compared to the unarmed CRAd. This effect was me-diated through inhibition of MMPs. Collectively, the present study demonstrated the en-hanced therapeutic efficacy of the dual-action, TIMP2-armed CRAd in vivo and the trans-lational potential of using Ad5/3-CXCR4-TIMP2 for treatment in patients with advanced ovarian cancer.
1 online resource (xiv, 113 p.) : ill., digital, PDF file.
Pathology;
Joint Health Sciences;
CRAds
CXCR4
TIMP2
ovarian cancer
UNRESTRICTED
Advisors/Committee Members: Ponnazhagan, Selvarangan, Alvarez, Ronald D.<br>, Bedwell, David M.<br>, Lorenz, Robin<br>, Siegal, Gene P.<br>, Strong, Theresa V..
Subjects/Keywords: Adenoviridae – genetics<; br>;
Adenoviridae – physiology<; br>;
DNA, Viral – metabolism<; br>;
Oncolytic Virotherapy – methods<; br>;
Ovarian Neoplasms – pathology<; br>;
Tissue Inhibitor of Metalloproteinase-2 – metabolism<; br>;
Virus Replication – physiology
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Yang, S. W. (. W. (2010). A TIMP2-armed conditionally-replicating adenovirus for the treatment of ovarian cancer. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1116
Chicago Manual of Style (16th Edition):
Yang, Sherry W (Sherry Wei). “A TIMP2-armed conditionally-replicating adenovirus for the treatment of ovarian cancer.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1116.
MLA Handbook (7th Edition):
Yang, Sherry W (Sherry Wei). “A TIMP2-armed conditionally-replicating adenovirus for the treatment of ovarian cancer.” 2010. Web. 22 Jan 2021.
Vancouver:
Yang SW(W. A TIMP2-armed conditionally-replicating adenovirus for the treatment of ovarian cancer. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1116.
Council of Science Editors:
Yang SW(W. A TIMP2-armed conditionally-replicating adenovirus for the treatment of ovarian cancer. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1116
26.
Zhu, Xiaolin.
Roles of NR4A3 in insulin sensitivity in skeletal muscle.
Degree: PhD, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1117
► For the past several decades, the prevalence of Type 2 Diabetes and the metabolic syndrome has been increasing. Insulin resistance is the central pathogenic event…
(more)
▼ For the past several decades, the prevalence of Type 2 Diabetes and the metabolic
syndrome has been increasing. Insulin resistance is the central pathogenic event for these
diseases. We previously reported that the NR4A family of orphan nuclear receptors
augments insulin sensitivity in adipocytes. We now found that lentiviral mediated
NR4A3 hyper-expression increased insulin stimulated glucose transport (ISGT) in
C2C12 myocytes while NR4A3 knock-down exhibited opposite effect. We also
examined the effects of prostaglandin A2 (PGA2) on insulin action and NR4A3 transactivation
in C2C12 myocytes. PGA2 augmented ISGT and insulin stimulated AKT
phosphorylation in C2C12 myocytes. Importantly, PGA2 treatment led to increased ISGT
in NR4A3 over-expressing C2C12 myocytes while the sensitizing effect of PGA2 was
diminished in NR4A3 knock-down myocytes. These novel results suggest that a working
model that PGA2 augments insulin action in myocytes via a mechanism involving
NR4A3, which provides a proof of principle for future anti-diabetic medication
development.
Exercise is used therapeutically to reverse insulin resistance. Interestingly,
exercise was also reported to induce NR4A mRNA expression. Given the established role
of NR4As in insulin sensitivity modulation, it was imperative to explore whether exercise
regulates NR4A protein expression. Therefore, we measured muscle NR4A protein in 16
healthy young and 11 old males following acute (AE) and chronic (CE) resistance
exercise. Muscle biopsies were performed at baseline and 24 hr after both AE and CE. NR4A1 levels are similar in young and old at baseline, increased by AE in young only, and reduced in young and old following chronic resistance training. NR4A3 protein levels are diminished in elderly subjects but are not affected by AE or CE. Our data indicate differential effects of age and exercise on muscle NR4A protein expression, which may shed a light to address whether NR4As are involved in the beneficiary effects of exercise.
1 online resource (viii, 131 p.) : ill., digital, PDF file.
Cell Biology;
Joint Health Sciences;
NR4A3
MINOR
insulin sensitivity
prostaglandin A2
glucose transport
skeletal muscle
C2C12 cells
insulin action
exercise
NR4A1
UNRESTRICTED
Advisors/Committee Members: Garvey, W. Timothy, Cowell, Rita<br>, Frank, Stuart J.<br>, Fu, Yuchang<br>, Nagy, Timothy R..
Subjects/Keywords: Adipocytes – drug effects<; br>;
DNA-Binding Proteins – metabolism<; br>;
Hypoglycemic Agents – pharmacology<; br>;
Insulin – pharmacology<; br>;
Insulin Resistance<; br>;
Muscle, Skeletal<; br>;
Nuclear Receptor Subfamily 4, Group A, Member 3<; br>;
Receptors, Steroid – metabolism
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zhu, X. (2010). Roles of NR4A3 in insulin sensitivity in skeletal muscle. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1117
Chicago Manual of Style (16th Edition):
Zhu, Xiaolin. “Roles of NR4A3 in insulin sensitivity in skeletal muscle.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1117.
MLA Handbook (7th Edition):
Zhu, Xiaolin. “Roles of NR4A3 in insulin sensitivity in skeletal muscle.” 2010. Web. 22 Jan 2021.
Vancouver:
Zhu X. Roles of NR4A3 in insulin sensitivity in skeletal muscle. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1117.
Council of Science Editors:
Zhu X. Roles of NR4A3 in insulin sensitivity in skeletal muscle. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1117
27.
Van Duyn, Lauren B.
Calrecticulin and its role in collagen regulation.
Degree: PhD, 2009, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1118
► Calreticulin (CRT), classically known for its chaperone functions in the endoplasmic reticulum and as a Ca2+ regulator, also is found on the cell surface and…
(more)
▼ Calreticulin (CRT), classically known for its chaperone functions in the endoplasmic reticulum and as a Ca2+ regulator, also is found on the cell surface and in the extracellular matrix. It is involved in many cellular processes including signaling, adhesion, migration, apoptotic cell clearance, gene regulation, and production of a fibronectin matrix. CRT has been suggested to play a role in wound healing and fibrosis. Therefore, these studies investigated the role of CRT in collagen production, an important extracellular matrix molecule in wounding and fibrosis. We demonstrated that CRT regulates collagen through transcription, secretion, and processing. We also investigated the role of cell surface CRT on signaling through its co-receptor, low density lipoprotein receptor-related protein-1 (LRP1), in response to thrombospondin 1 (TSP1). TSP1 signaling through CRT and LRP1 causes focal adhesion disassembly, cell migration, and anoikis resistance. We found that TSP1 causes LRP1 phosphorylation, which may contribute to its cell signaling capabilities. TSP1, CRT, and LRP1 also have been implicated in cancer development. Therefore, we explored the role of TSP1 binding to CRT and signaling through LRP1 in breast cancer invasion. Our findings do not support a role for TSP1 signaling through CRT and LRP1 in breast cancer invasion. In conclusion, these studies demonstrate that CRT regulates fibrillar collagens. In addition, TSP1 signaling through cell surface CRT and LRP1 induces tyrosine phosphorylation of LRP1.
1 online resource (xvi, 154 p.) : ill., digital, PDF file.
Pathology
Joint Health Sciences;
calreticulin
collagen
low density lipoprotein receptor-related protein-1
thrombospondin 1
UNRESTRICTED
Advisors/Committee Members: Murphy-Ullrich, Joanne, Frost, Andra<br>, Hagood, James<br>, Justement, Louis<br>, Welch, Danny<br>, Woods, Anne.
Subjects/Keywords: Calreticulin – physiology<; br>;
Collagen<; br>;
Endoplasmic Reticulum – metabolism<; br>;
LDL-Receptor Related Protein-Associated<; br>;
Protein – metabolism<; br>;
Thrombospondin 1
Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Van Duyn, L. B. (2009). Calrecticulin and its role in collagen regulation. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1118
Chicago Manual of Style (16th Edition):
Van Duyn, Lauren B. “Calrecticulin and its role in collagen regulation.” 2009. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1118.
MLA Handbook (7th Edition):
Van Duyn, Lauren B. “Calrecticulin and its role in collagen regulation.” 2009. Web. 22 Jan 2021.
Vancouver:
Van Duyn LB. Calrecticulin and its role in collagen regulation. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2009. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1118.
Council of Science Editors:
Van Duyn LB. Calrecticulin and its role in collagen regulation. [Doctoral Dissertation]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1118
28.
Prentice, Tyler E.
Linear evaluation and comparison of traditional orthodontic plaster models versus digital models obtained through intraoral scanning.
Degree: MS, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1124
► Introduction: The digital revolution has arrived and is propelling the field of orthodontics into a new age of continually evolving technology. Digital impression technology is…
(more)
▼ Introduction: The digital revolution has arrived and is propelling the field of
orthodontics into a new age of continually evolving technology. Digital impression
technology is now available to produce digital replications directly from a patient’s
mouth through laser scanning. The purpose of this preliminary study of the Cadent iTero
digital impression system was to determine how the accuracy and reliability of linear
measurements made using digital models compare with measurements obtained from
control and plaster models.
Methods: Nine different polyurethane typodonts
demonstrating common occlusal conditions were used as control models through which
traditional plaster models and digital models were reproduced and compared. Twentyfour
linear measurements were recorded for each typodont (1-9) and model type (control,
digital, plaster). Measurements were repeated by the same operator at three separate timepoints
(intervals at least one week apart).
Results: Mean linear measurements differed
significantly by model type – p <0.0001. Tukey’s test demonstrated the mean value for
digital models differed significantly from those of control and plaster models while
means of control and plaster models were not significantly different. Measurements
obtained from each model type were highly correlated and repeatable based on intraclass
correlation evaluation (>0.99).
Conclusions: Linear measurements obtained from digital models produced through the iTero digital impression system appear to be both accurate and reliable. Though statistically significant differences were demonstrated in this study, the magnitude of the differences was 0.06mm and is considered clinically insignificant by current orthodontic literature standards. The iTero digital impression system for creating digital models therefore appears to be an acceptable digital model development technique.
M.S.
1 online resource (viii, 57 p.) : ill., digital, PDF file.
Orthodontics;
Dentistry;
UNRESTRICTED
Advisors/Committee Members: Javed, Amjad, Cakir, Deniz<br>, Burgess, John<br>, Ferreira, Andre.
Subjects/Keywords: Dental Impression Technique<; br>;
Dental Models<; br>;
Image Processing, Computer-Assisted – methods<; br>;
Imaging, Three-Dimensional – methods<; br>;
Lasers<; br>;
Reproducibility of Results
Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Prentice, T. E. (2010). Linear evaluation and comparison of traditional orthodontic plaster models versus digital models obtained through intraoral scanning. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1124
Chicago Manual of Style (16th Edition):
Prentice, Tyler E. “Linear evaluation and comparison of traditional orthodontic plaster models versus digital models obtained through intraoral scanning.” 2010. Masters Thesis, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1124.
MLA Handbook (7th Edition):
Prentice, Tyler E. “Linear evaluation and comparison of traditional orthodontic plaster models versus digital models obtained through intraoral scanning.” 2010. Web. 22 Jan 2021.
Vancouver:
Prentice TE. Linear evaluation and comparison of traditional orthodontic plaster models versus digital models obtained through intraoral scanning. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1124.
Council of Science Editors:
Prentice TE. Linear evaluation and comparison of traditional orthodontic plaster models versus digital models obtained through intraoral scanning. [Masters Thesis]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1124
29.
Naisbitt, Mark A.
The effect of bracket base design on shear bond strength : at the bracket base-cement interface.
Degree: MS, 2010, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1128
► Provided that a good enamel bonding procedure has taken place, in vitro and in vivo failure of orthodontic brackets most often takes place at the…
(more)
▼ Provided that a good enamel bonding procedure has taken place, in vitro and in
vivo failure of orthodontic brackets most often takes place at the bracket base-cement
interface.1 Current innovations in metal bracket base designs, therefore, most often have
focused on improving bond strengths at this interface. Manufacturers claim their particular
bracket base design will provide better bond strengths with less bracket failure than their
competitors’ design. The purpose of this study was to evaluate the effect bracket base
design on mean shear bond strength (SBS) at the bracket base-cement interface. The
following four types of metal brackets were compared, ie, 20 Smart Clip brackets (80-
gauge single-mesh base), 20 In-Ovation R brackets (SuperMesh, 81.50-gauge doublemesh
base), 20 Quick brackets (machined, integral, microetched 3D hook base), and 20 T3
brackets (machined, integral, microetched base with mechanical undercuts). Ten bracketcylinders
of each type were debonded after 30 minutes, to simulate initial arch wire
engagement. The remaining bracket-cylinders (10 of each type) were debonded after 24
hours and 2,500 rounds of thermocycling. The mean SBS for 30 minute and 24 hour time
intervals were as follows: SmartClip, 14.66 ± 2.0 MPa and 25.55 ± 3.6 MPa; In-Ovation
R, 14.56 ± 5.0 MPa and 24.94 ± 2.3 MPa; Quick, 11.82 ± 3.9 MPa and 26.82 ± 4.2 MPa;
and T3, 24.24 ± 3.8 MPa and 36.86 ± 3.7 MPa. Debonded specimens were examined using
10X magnification to determine adhesive remnants on the acrylic cylinders and bracket
bases. The modified adhesive remnant index (MARI) comparisons indicated that three of
the bracket types (SmartClip, In-Ovation R, Quick) had similar bracket failure modes, ie, higher frequencies of MARI score 3 (more than half of the adhesive remained on the cylinders and was removed from the bracket). However, the T3 bracket had higher incidence of MARI score 2 (more than half of the adhesive remained on the bracket and was removed from the cylinder). Bracket base design variations were found to significantly influence SBS. The T3 bracket had significantly higher bond strengths than the other bracket types (1-way ANOVA, P ≤ .05) at both 30 minutes and 24 hours. The Quick bracket had significantly lower SBS than the other bracket types at 30 minutes, but SBS values were not significantly different from the mesh-based brackets at 24 hours (P ≤ .05). All four bracket types showed a significant increase in SBS from 30 minutes to 24 hours (2-way ANOVA, P ≤ .05).
M.S.
1 online resource (vii, 34 p.) : ill., digital, PDF file.
Clinical Dentistry;
Dentistry;
UNRESTRICTED
Advisors/Committee Members: Burgess, John O., Cakir, Deniz<br>, Vlachos, Christos.
Subjects/Keywords: Dental Bonding<; br>;
Equipment Failure<; br>;
Orthodontic Appliance Design<; br>;
Orthodontic Brackets<; br>;
Shear Strength
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Naisbitt, M. A. (2010). The effect of bracket base design on shear bond strength : at the bracket base-cement interface. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1128
Chicago Manual of Style (16th Edition):
Naisbitt, Mark A. “The effect of bracket base design on shear bond strength : at the bracket base-cement interface.” 2010. Masters Thesis, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1128.
MLA Handbook (7th Edition):
Naisbitt, Mark A. “The effect of bracket base design on shear bond strength : at the bracket base-cement interface.” 2010. Web. 22 Jan 2021.
Vancouver:
Naisbitt MA. The effect of bracket base design on shear bond strength : at the bracket base-cement interface. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2010. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1128.
Council of Science Editors:
Naisbitt MA. The effect of bracket base design on shear bond strength : at the bracket base-cement interface. [Masters Thesis]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1128
30.
Dearborn, Altaira D.
Scaffold-mediated size determination of bacteriophage capsids by mobile genetic elements.
Degree: PhD, 2012, University of Alabama – Birmingham
URL: http://contentdm.mhsl.uab.edu/u?/etd,1131
► Bacteriophage can mediate the transfer of unrelated mobile genetic elements (MGE) from a carrier bacterial cell to the susceptible population around it. This transfer results…
(more)
▼ Bacteriophage can mediate the transfer of unrelated mobile genetic elements
(MGE) from a carrier bacterial cell to the susceptible population around it. This transfer
results in the spread of virulence or other accessory genes encoded on the MGE. During
viral particle assembly, the MGE can discourage the formation of viable bacteriophage
progeny by limiting the size of the particles to those large enough to encapsidate the
MGE, but too small to fit the complete bacteriophage genome which is three times larger.
Here, I present models for size determination by an external scaffolding protein which is
independent of and dominant over the native bacteriophage scaffold, and for size
determination by a pair of internal scaffolding proteins which function in combination
with each other and with the native bacteriophage scaffold. Finally, I show distinct
patterns of size determination in closely related paradigms.
PhD
1 online resource (ix, 113 p.) :ill., digital, PDF file.
Microbiology;
Joint Health Sciences;
bacteriophage, pathogenicity island, horizontal gene transfer, size
determination, scaffold
UNRESTRICTED
Advisors/Committee Members: Terje Dokland, Christie, Gail E.<br>, Prevelige, Peter E.<br>, Saad, Jamil S.<br>, Yother, Janet.
Subjects/Keywords: Capsid – physiology<; br>;
Capsid Proteins – physiology<; br>;
Genomic Islands – genetics<; br>;
Organelle Size – genetics<; br>;
Staphylococcus aureus – genetics<; br>;
Virus Assembly – genetics
Record Details
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Share »
Record Details
Similar Records
Cite
« Share





❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dearborn, A. D. (2012). Scaffold-mediated size determination of bacteriophage capsids by mobile genetic elements. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1131
Chicago Manual of Style (16th Edition):
Dearborn, Altaira D. “Scaffold-mediated size determination of bacteriophage capsids by mobile genetic elements.” 2012. Doctoral Dissertation, University of Alabama – Birmingham. Accessed January 22, 2021.
http://contentdm.mhsl.uab.edu/u?/etd,1131.
MLA Handbook (7th Edition):
Dearborn, Altaira D. “Scaffold-mediated size determination of bacteriophage capsids by mobile genetic elements.” 2012. Web. 22 Jan 2021.
Vancouver:
Dearborn AD. Scaffold-mediated size determination of bacteriophage capsids by mobile genetic elements. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2012. [cited 2021 Jan 22].
Available from: http://contentdm.mhsl.uab.edu/u?/etd,1131.
Council of Science Editors:
Dearborn AD. Scaffold-mediated size determination of bacteriophage capsids by mobile genetic elements. [Doctoral Dissertation]. University of Alabama – Birmingham; 2012. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1131
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