+publisher:"Western Sydney University" +contributor:("Western Sydney University. School of Science and Health")

1. Hedges, Kevin. Assessment and control of respirable crystalline silica in quarries and dimension stone mines.

Degree: 2016, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:36593

► The health risk of breathing very fine particles of respirable crystalline silica (RCS) dust, resulting in poor lung health is not well defined in Australia,… (more)

▼ The health risk of breathing very fine particles of respirable crystalline silica (RCS) dust, resulting in poor lung health is not well defined in Australia, even though many hundreds of thousands of workers are exposed to uncontrolled dusty activities daily. It is now clear from international studies that lung health of workers continues to be affected at relatively low exposures to RCS, even at occupational exposure limits (OEL) including the current Safe Work Australia Exposure Standard (SWA-ES). This has prompted the United States to reduce their permissible exposure limit (PEL) to one half of the Australian SWA-ES, to 0.05 mg/m3, and challenges the adequacy of the current Australian SWA-ES, which is 0.1 mg/m3. In terms of numbers of workers affected, the mining industry employs approximately 267,000 workers, which is 2.3 percent of the total workforce, and accounts for about 10.2 % of Australia’s Gross Domestic Product (GDP). Approximately 55,000 workers are employed in Queensland mining, many of whom work in quarries and dimension stone mines where exposure to RCS is known to be elevated. A recent assessment estimated that about 440,000 deaths from cancer attributable to RCS exposure will occur throughout Europe from 2010 to 2069. Unless exposure to RCS is well controlled, many hundreds of thousands of lives will also be cut short from silicosis and chronic obstructive pulmonary disease (COPD). As the weight of evidence grows in Australia, the disease risks attributable to RCS will increasingly become more obvious. This study evaluated the health risk from exposure to RCS for 47 quarry and dimension stone mine workers throughout Queensland, Australia. Personal exposures to RCS were measured across a range of exposures, and lung function testing was carried out in parallel. Findings revealed that about one in four workers were exposed to RCS above the SWA-ES, and more than one in ten were being exposed at a concentration of more than twice this limit. A major finding for those workers exposed to RCS at the SWA-ES was loss of lung function greater than 20%. The increased loss of lung function was positively correlated with jobs associated with increased RCS exposure. When similar exposure groups were combined into three RCS exposure ranges categorised as high (≥ 0.09 - ≤ 0.20 mg/m3), medium (≥ 0.04 - ≤ 0.08 mg/m3) and low (< 0.04 mg/m3), analysis of variance (ANOVA) confirmed that the loss of lung function below the lower limit of normal (LLN) at the current SWA-ES, is significant (p < 0.05). Abnormal lung function patterns were also more pronounced for smokers who were exposed to RCS ≥ 0.04 mg/m3 and not as obvious for smokers exposed to RCS < 0.04 mg/m3. This demonstrated that both smoking and RCS had a combined impact resulting in poor lung health. In this study, vehicles fitted with standard heating, ventilation and air-conditioning systems (HVAC) were tested for ingress of respirable dust into the operator’s cabin, and compared with more recent technology. Evaluation of the effectiveness of newer… Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: silica dust; mineral industries; dust control; silica; carcinogenicity; quarries and quarrying; Australia; Thesis (Ph.D.) – Western Sydney University, 2016

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APA (6^th Edition):

Hedges, K. (2016). Assessment and control of respirable crystalline silica in quarries and dimension stone mines. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:36593

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hedges, Kevin. “Assessment and control of respirable crystalline silica in quarries and dimension stone mines.” 2016. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:36593.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hedges, Kevin. “Assessment and control of respirable crystalline silica in quarries and dimension stone mines.” 2016. Web. 06 Mar 2021.

Vancouver:

Hedges K. Assessment and control of respirable crystalline silica in quarries and dimension stone mines. [Internet] [Thesis]. Western Sydney University; 2016. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:36593.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hedges K. Assessment and control of respirable crystalline silica in quarries and dimension stone mines. [Thesis]. Western Sydney University; 2016. Available from: http://hdl.handle.net/1959.7/uws:36593

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Bonaccordo, Emma. Evaluation of an automated panoramic imaging system for the photographic recording and analysis of blood spatter in crime scenes.

Degree: 2018, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:51827

► Crime scene photography plays a fundamental role in forensic investigations. The primary purpose of crime scene photography is the recording of the entire crime scene,… (more)

▼ Crime scene photography plays a fundamental role in forensic investigations. The primary purpose of crime scene photography is the recording of the entire crime scene, both the context and specific details relevant to the scene, for later recollection and analysis. The aim of this research was to design and verify a new, rapid and easy to use method for the recording of blood spatter at crime scenes to support the off-site determination of area of origin and/or other visually-based interpretive processes. This research determined the optimum operating conditions required for the successful high-resolution photographic documentation of blood spatter. This entailed creating a single panoramic image from a set of images, captured automatically without user input, in which both detail and context are provided as required for ex situ blood spatter analysis. The development of this research method was based on the GigaPan® system, a robotised tripod-mounted hardware platform designed to interface with a digital camera and automate the panoramic image capture process. The GigaPan® system was employed to capture a series of high-resolution images of various test targets to assist the investigation and evaluation of a range of hardware and software parameters that played a role in the creation of forensically useful panoramic images of blood spatter patterns. Investigated parameters included GigaPan® hardware settings, digital image stitching software selection, subject to camera distance, picture overlap percentage, picture order setting and enhancement processes for improving the dimensional integrity of panoramas. Once optimal parameters had been determined the effectiveness of the method was evaluated. This was carried out by establishing the accuracy with which area of origin calculations could be conducted from the established panoramic blood spatter images. The results of this research demonstrate that the developed method can be employed to effectively capture a panoramic image of a scene containing blood spatter in which enough detail is present to conduct off-site area of origin determination of blood spatter. This method might allow blood spatter pattern experts to process spatter information off-site, resulting in a more streamlined investigative process. Advisors/Committee Members: Western Sydney University. School of Science and Health.

Subjects/Keywords: legal photography; photography, panoramic; crime scenes; evidence, criminal; bloodstains; Thesis (M.Res.) – Western Sydney University, 2018

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APA (6^th Edition):

Bonaccordo, E. (2018). Evaluation of an automated panoramic imaging system for the photographic recording and analysis of blood spatter in crime scenes. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:51827

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bonaccordo, Emma. “Evaluation of an automated panoramic imaging system for the photographic recording and analysis of blood spatter in crime scenes.” 2018. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:51827.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bonaccordo, Emma. “Evaluation of an automated panoramic imaging system for the photographic recording and analysis of blood spatter in crime scenes.” 2018. Web. 06 Mar 2021.

Vancouver:

Bonaccordo E. Evaluation of an automated panoramic imaging system for the photographic recording and analysis of blood spatter in crime scenes. [Internet] [Thesis]. Western Sydney University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:51827.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bonaccordo E. Evaluation of an automated panoramic imaging system for the photographic recording and analysis of blood spatter in crime scenes. [Thesis]. Western Sydney University; 2018. Available from: http://hdl.handle.net/1959.7/uws:51827

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Carter, kate. Foot involvement among people with psoriatic arthritis.

Degree: 2020, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:58726

► Despite recognition that hallmark features of psoriatic arthritis (PsA) are predominant and persistent in the foot and ankle, limited foot-specific research exists and there are… (more)

Subjects/Keywords: psoriatic arthritis; foot diseases; health surveys; methodology; Thesis (Ph.D.) – Western Sydney University, 2020

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APA (6^th Edition):

Carter, k. (2020). Foot involvement among people with psoriatic arthritis. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:58726

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carter, kate. “Foot involvement among people with psoriatic arthritis.” 2020. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:58726.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carter, kate. “Foot involvement among people with psoriatic arthritis.” 2020. Web. 06 Mar 2021.

Vancouver:

Carter k. Foot involvement among people with psoriatic arthritis. [Internet] [Thesis]. Western Sydney University; 2020. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:58726.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carter k. Foot involvement among people with psoriatic arthritis. [Thesis]. Western Sydney University; 2020. Available from: http://hdl.handle.net/1959.7/uws:58726

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Low, Mitchell. A chemical and pharmacological study of a commercial Andrographis paniculata extract and andrographolide, to determine their anti-inflammatory drug potential.

Degree: 2015, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:36545

► There is increasing evidence that chronic inflammation is a contributing factor to many prevalent ageing-related diseases, such as acute and chronic neurodegenerative diseases, degenerative musculoskeletal… (more)

▼ There is increasing evidence that chronic inflammation is a contributing factor to many prevalent ageing-related diseases, such as acute and chronic neurodegenerative diseases, degenerative musculoskeletal diseases, cardiovascular diseases, diabetes, and cancer. To date, pharmacotherapy of inflammatory conditions is based mainly on the use of non-steroidal anti-inflammatory drugs (NSAIDs). However, the prolonged use of NSAIDs can cause serious side effects. There is a need to develop novel and safe anti-inflammatory medicines. Andrographis paniculata (Acanthaceae), has been used as an herbal medicine in both traditional Indian and Chinese medicine for inflammation related ailments. A. paniculata anti-inflammatory activity is commonly attributed to the ent-labdane diterpenoid andrographolide, A. paniculata’s characteristic and main secondary metabolite. This compound may be suitable as an alternative treatment for inflammation, with alternate pharmacological targets to that of NSAIDs with reduced side effects. The commercial A. paniculata extract was fractionated based on polarity (by chloroform-aqueous partitioning), and characterised by HPLC-PDA to quantify the andrographolide. A sulphonation metabolite of andrographolide was synthesised, purified by preparative HPLC and characterised by MS and 1HNMR. The commercial A. paniculata extract, andrographolide, sulphonation metabolite and NSAIDs (Diclofenac, Ibuprofen, Aspirin, Paracetamol) were tested in a number of anti-inflammatory in vitro cell based assays, nitric oxide (Griess reagent) , TNF-α and PGE2 (ELISA), 27 simultaneous cytokines (bead based ELISA) and NF-κB activation (flow cytometry). The andrographolide content accounted for the in vitro anti-inflammatory activity of A. paniculata. Andrographolide is a potent inhibitor of many mediators of inflammation. NSAIDs were not effective inhibitors of any of the mediators tested except PGE2. Andrographolide showed comparable inhibition of PGE2 release to that of the weak NSAIDs aspirin and paracetamol. Andrographolide’s IC50 for most mediators was below the highest reported Cmax’s in rats, but above those achieve in humans. The sulphonation metabolite of andrographolide had comparable activity to andrographolide against most inflammatory mediators and has greater activity against TNF-α and IL-6. The sulphonation metabolite’s IC50 for the majority of mediators was well below (47 times) which had the only reported Cmax in rats. The sulphonation metabolite shows promise as a treatment for inflammation as it inhibited a wide range of inflammatory mediators below the reported in vivo levels. Pharmacokinetics studies in humans are needed to determine its pharmacokinetics. Further animal studies should be conducted to assess its safety. Advisors/Committee Members: Western Sydney University. School of Science and Health, Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: Thesis (Ph.D.) – Western Sydney University, 2015; Acanthaceae; therapeutic use; anti-inflammatory agents; analysis; materia medica, vegetable

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APA (6^th Edition):

Low, M. (2015). A chemical and pharmacological study of a commercial Andrographis paniculata extract and andrographolide, to determine their anti-inflammatory drug potential. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:36545

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Low, Mitchell. “A chemical and pharmacological study of a commercial Andrographis paniculata extract and andrographolide, to determine their anti-inflammatory drug potential.” 2015. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:36545.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Low, Mitchell. “A chemical and pharmacological study of a commercial Andrographis paniculata extract and andrographolide, to determine their anti-inflammatory drug potential.” 2015. Web. 06 Mar 2021.

Vancouver:

Low M. A chemical and pharmacological study of a commercial Andrographis paniculata extract and andrographolide, to determine their anti-inflammatory drug potential. [Internet] [Thesis]. Western Sydney University; 2015. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:36545.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Low M. A chemical and pharmacological study of a commercial Andrographis paniculata extract and andrographolide, to determine their anti-inflammatory drug potential. [Thesis]. Western Sydney University; 2015. Available from: http://hdl.handle.net/1959.7/uws:36545

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Salib, Alice. Regulation of TGFB2 expression during EMT in lung epithelial cells.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:45813

► The epithelial to mesenchymal transition (EMT) process is the driving mechanism behind epithelial-derived tumor metastasis but also plays an important role in developmental and wound… (more)

▼ The epithelial to mesenchymal transition (EMT) process is the driving mechanism behind epithelial-derived tumor metastasis but also plays an important role in developmental and wound healing programs. The EMT programs in these different cellular contexts have very different outcomes but rely on TGF-β signalling pathways to induce the EMT process. In recent years, a number of genome wide association studies (GWAS) of lung function have identified the TGFB2 locus as an important determinant of lung function. Using publicly available GWAS and ChIP-sequencing data from the UCSC genome browser, a cluster of SNPs were found to localize to transcription regulatory epigenetic signatures in A549 lung epithelial cancer cells. In this study we aimed to determine if a regulatory element corresponds with the location of GWAS genetic variants, and if such a regulatory element is responsive to EMT signals. Using ChIP-QPCR to assess the occupancy of H3K4me1 relative to H3K4me3 we identified a novel TGFB2 enhancer. Functional analysis of the enhancer region using a luciferase reporter assay revealed that the enhancer is activated upon TGF-β1-induced EMT in the cancerous A549 cell line but not in normal lung epithelial BEAS-2B cells. Using the online 3DSNP database, which annotates the regulatory function of SNPs by exploring their 3D interactions with genes mediated by chromatin looping, the TGFB2 enhancer region was identified to interact with the promoter of TGFB2. QPCR analysis of A549 and BEAS-2B cells revealed that the mRNA expression of TGFB2 increased in response to TGF-β1 in A549 cells but not BEAS-2B cells. We observed increased invasiveness of A549 and BEAS-2B cells in response to TGF-β2 and using immunohistochemistry we visualized TGF-β2 aggregation in A549 cells during TGF-β1-induced EMT. These results indicate that the aberrant activation of the TGFB2 enhancer increases TGFB2 expression, leading to increased invasiveness of lung epithelial cells. The TGFB2 enhancer could serve as a potential target for therapeutic agents for lung cancer. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: Thesis (M.Res.) – Western Sydney University, 2017; lungs; cancer; epithelial cells; diseases; cancer cells; growth; regulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Salib, A. (2017). Regulation of TGFB2 expression during EMT in lung epithelial cells. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:45813

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Salib, Alice. “Regulation of TGFB2 expression during EMT in lung epithelial cells.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:45813.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Salib, Alice. “Regulation of TGFB2 expression during EMT in lung epithelial cells.” 2017. Web. 06 Mar 2021.

Vancouver:

Salib A. Regulation of TGFB2 expression during EMT in lung epithelial cells. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:45813.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Salib A. Regulation of TGFB2 expression during EMT in lung epithelial cells. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:45813

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Dhiman, Ankita. Developing effective copper(II) based antimicrobial agents.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:45779

► Antimicrobial drug resistance is increasing at an alarming rate while the availability of new and effective antibiotics for treating microbial infections is reducing and will… (more)

▼ Antimicrobial drug resistance is increasing at an alarming rate while the availability of new and effective antibiotics for treating microbial infections is reducing and will eventually be exhausted. It is estimated that by the year 2050, the death rates will increase to about 10 million people a year due to antimicrobial resistance and the Gross Domestic Product of countries will be reduced by 2-3.5%. In efforts attempt to address this problem, copper(II) complexes with a structural formula of [Cu(PL)2(H2O)n]2+ (where n = 0 or 1) or [Cu(N4-TL)(H2O)]2+ new complexes include: PL = derivatives of 1,10-phenanthroline and 2,2´-bipyridine, N4-TL = N,N-bis(2-pyridyl)-1,2-diiminoethane (picen) and its derivatives, were synthesised and their antibacterial activity investigated against Gram-positive bacteria Staphylococcus aureus, Gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli and yeast Candida krusei, were determined. Characterisation was accomplished using techniques such as UV-Vis spectroscopy, electrospray ionisation mass spectroscopy (ESI-MS), X-ray crystallography and elemental analysis. Antimicrobial activities of the synthesised species were determined using Minimum Inhibitory Concentration (MIC90) and anti-biofilm assay. Complexes based on derivatives of phenanthroline and bipyridine ligands demonstrated significant activity against S. aureus. [Cu(29Me2phen)] was demonstrated to be the most active against S. aureus, E. coli and C. krusei at considerably low concentrations with a starting concentration of 4 μM. N4-Tetradentates based copper complexes exhibited no significant activity against any microbial species. Preliminary anti-biofilm studies were performed on S. aureus biofilms against Cu1, Cu4 and Cu7, with ampicillin as control. Cu4 demonstrated maximum eradication as compared to Cu1, Cu7 and ampicillin at concentration of 59 μM, whereas ampicillin eradicated only 5% biomass at 91 μM. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: copper; Thesis (M.Res.) – Western Sydney University, 2017; anti-infective agents; drug resistance in microorganisms; metal complexes

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APA (6^th Edition):

Dhiman, A. (2017). Developing effective copper(II) based antimicrobial agents. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:45779

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dhiman, Ankita. “Developing effective copper(II) based antimicrobial agents.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:45779.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dhiman, Ankita. “Developing effective copper(II) based antimicrobial agents.” 2017. Web. 06 Mar 2021.

Vancouver:

Dhiman A. Developing effective copper(II) based antimicrobial agents. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:45779.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dhiman A. Developing effective copper(II) based antimicrobial agents. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:45779

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Dizon, Kevin. The characterisation of ultrafiltration membranes used in water purification.

Degree: 2018, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:48583

► The increase of urbanisation has caused water scarcity concerns in developed nations. Natural sources of freshwater (ground water, river water, rain fall) are becoming insufficient,… (more)

▼ The increase of urbanisation has caused water scarcity concerns in developed nations. Natural sources of freshwater (ground water, river water, rain fall) are becoming insufficient, requiring man-made technologies for the purification of water. Ultrafiltration membranes are currently becoming more relied upon for water purification due to their selectivity and applicability in different environments. Fabrication of some ultrafiltration membranes require the mixing of two (binary blend) or three (ternary blend) synthetic polymers to form an amphiphilic polymer blend. Overall properties of the blend are dependent on the chemical nature of the precursors; however, chemical incompatibilities between polymers causes incomplete mixing, thereby forming a partially miscible system. The presence of different domains of varying miscibility creates a complex matrix where minimal changes in local chemical composition can drastically change the membranes properties. The material becomes increasingly complex with a ternary blend. Hence, the understanding of function and composition relationship is important to the development of design and functionality. This project aims to characterise a number of properties of ultrafiltration membranes at various stages, from fabrication to production. In this work, industrial membranes (both binary and ternary) and their respective precursors were studied. Difference in end groups within the system affects solubility of the precursor leading. This can lead to undissolved poly(N-vinyl pyrrolidone) (PVP) affecting the properties of the membrane produced. Free solution Capillary Electrophoresis (CE) was employed for the separation of PVP via end groups. Representative electrophoretic mobility distributions of different PVP samples were obtained showing the presence of different populations. The membranes were characterised through solid-state Nuclear Magnetic Resonance (NMR) spectroscopy, providing a means to determine the molecular structure and molecular mobility within the membranes. NMR measurements identified that polymer A is extracted out of the membrane during production and the ternary membrane is a miscible system. Deductions made contributed to interpretations on functionality Relationships between the surface composition and the functionality of the membrane were established. Functional properties were determined through tensile strength tests and tensiometry tests. The surface composition was determined through Scanning electron microscopy / energy dispersive x-ray spectroscopy and 1H NMR spectroscopy. Surface localisation of polymer A and polymer C affected the hydrophilicity of the membranes. It was also found the formation of macrovoids affect the tensile strength of the membrane. In conclusion, methods were developed to determine the chemical structures of the membrane, at various stages of production, and relating it to functionality. Analysis of structure-function relationships allowed for the improvement of design to optimise membrane properties. The AB membrane was… Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: water; purification; membrane filtration; ultrafiltration; membranes (technology); water-supply; Australia; Thesis (M.Res.) – Western Sydney University, 2018

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APA (6^th Edition):

Dizon, K. (2018). The characterisation of ultrafiltration membranes used in water purification. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:48583

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dizon, Kevin. “The characterisation of ultrafiltration membranes used in water purification.” 2018. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:48583.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dizon, Kevin. “The characterisation of ultrafiltration membranes used in water purification.” 2018. Web. 06 Mar 2021.

Vancouver:

Dizon K. The characterisation of ultrafiltration membranes used in water purification. [Internet] [Thesis]. Western Sydney University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:48583.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dizon K. The characterisation of ultrafiltration membranes used in water purification. [Thesis]. Western Sydney University; 2018. Available from: http://hdl.handle.net/1959.7/uws:48583

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Redman, Kellyanne. The effects of fatigue on decision-making in Junior Rugby League.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:45566

► During the later stages of sporting competition, a decrease in performance is regularly observed and is often attributed to fatigue. Although, it is unclear if… (more)

▼ During the later stages of sporting competition, a decrease in performance is regularly observed and is often attributed to fatigue. Although, it is unclear if the decrement of performance is exclusively due to physiological fatigue or an indicator of a decline in decision-making (DM) performance. Rugby league (RL) is a highly physical and tactical team sport wherein players are required to make decisions under time and fatigued based constraints. The aim of this study was to determine the effects of match-related fatigue on DM in junior RL players. A secondary aim of this study was to compare positional playing groups, forwards and backs, and determine if fatigue differentially effects DM performance. Twenty male junior RL players (mean ± standard deviation: age 15.9 ± 0.9 years, body mass 87.3 ± 14.3 kg, height 1.82 ± 0.07 m, playing experience 10.2 ± 2.4 years, predicted VO2max 47.42 ± 3.69 mL.kg-1.min-1) completed a match simulation protocol (MSP) that replicated the physiological demands of an elite junior RL match. DM performance was measured pre, mid and post match simulation via a reactive agility test and video-based temporal occlusion task. Upper and lower body neuromuscular measures (countermovement jump and plyometric push up) were also applied prior to DM assessments to quantify fatigue. Ratings of perceived exertion were obtained immediately post exercise at mid and post MSP. Two-way mixed ANOVA was utilised to assess any changes in temporal occlusion, reactive agility test and neuromuscular fatigue (countermovement jump etc.) at the time points of pre, mid and post MSP and to compare positional playing groups (forwards and backs). Paired T tests for rating of perceived exertion measures, as they were only taken mid and post MSP. In the event of a significant main effect, post hoc comparisons were made using a Bonferroni correction. Significance was accepted at p < 0.05. The main finding of this study was despite observing a decline in neuromuscular function during the MSP, this decline did not significantly affect DM performance. Additionally, there was no significant difference between forwards and backs DM performance throughout the MSP. These results suggest elite junior RL players are capable of processing information during a progressively fatiguing match simulation. The results of this study are beneficial for elite level junior RL coaching staff as it highlights DM practice during fatiguing conditions is not an aspect of training that requires attention. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: Rugby League football; fatigue; decision making; Thesis (M.Res.) – Western Sydney University, 2017

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APA (6^th Edition):

Redman, K. (2017). The effects of fatigue on decision-making in Junior Rugby League. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:45566

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Redman, Kellyanne. “The effects of fatigue on decision-making in Junior Rugby League.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:45566.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Redman, Kellyanne. “The effects of fatigue on decision-making in Junior Rugby League.” 2017. Web. 06 Mar 2021.

Vancouver:

Redman K. The effects of fatigue on decision-making in Junior Rugby League. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:45566.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Redman K. The effects of fatigue on decision-making in Junior Rugby League. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:45566

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Power, Declan. Determination of marker compounds to assess the quality of green tea.

Degree: 2018, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:51883

► Green tea, as a commonly consumed beverage worldwide, has a long history of use as a dietary supplement for various conditions. Green tea products have… (more)

Subjects/Keywords: green tea; antioxidants; therapeutic use; catechin; Thesis (M.Res.) – Western Sydney University, 2018; analysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Power, D. (2018). Determination of marker compounds to assess the quality of green tea. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:51883

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Power, Declan. “Determination of marker compounds to assess the quality of green tea.” 2018. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:51883.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Power, Declan. “Determination of marker compounds to assess the quality of green tea.” 2018. Web. 06 Mar 2021.

Vancouver:

Power D. Determination of marker compounds to assess the quality of green tea. [Internet] [Thesis]. Western Sydney University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:51883.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Power D. Determination of marker compounds to assess the quality of green tea. [Thesis]. Western Sydney University; 2018. Available from: http://hdl.handle.net/1959.7/uws:51883

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Buscemi, Valentina. Exploring stress in low back pain : from patient perspectives to neurophysiology.

Degree: 2018, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:52112

► Musculoskeletal pain disorders (MDs) are common health problems and a leading cause of disability worldwide. Of these, low back pain (LBP) is the most common… (more)

Subjects/Keywords: backache; musculoskeletal system; diseases; Thesis (Ph.D.) – Western Sydney University, 2018.; pain; stress (psychology); neurophysiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Buscemi, V. (2018). Exploring stress in low back pain : from patient perspectives to neurophysiology. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:52112

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Buscemi, Valentina. “Exploring stress in low back pain : from patient perspectives to neurophysiology.” 2018. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:52112.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Buscemi, Valentina. “Exploring stress in low back pain : from patient perspectives to neurophysiology.” 2018. Web. 06 Mar 2021.

Vancouver:

Buscemi V. Exploring stress in low back pain : from patient perspectives to neurophysiology. [Internet] [Thesis]. Western Sydney University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:52112.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Buscemi V. Exploring stress in low back pain : from patient perspectives to neurophysiology. [Thesis]. Western Sydney University; 2018. Available from: http://hdl.handle.net/1959.7/uws:52112

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Carroll, Rani. The effects of urban geochemical modification on endangered Blue Mountains Upland Swamps.

Degree: 2018, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:52102

► Catchment urbanisation is associated with the global degradation of freshwater ecosystems, including poor water quality, sediment contamination and exotic weed invasions. Urban ecosystems are identified… (more)

▼ Catchment urbanisation is associated with the global degradation of freshwater ecosystems, including poor water quality, sediment contamination and exotic weed invasions. Urban ecosystems are identified as exhibiting distinct patterns of elevated major ions (including calcium, potassium and bicarbonate) and metals, referred to as the ‘urban geochemical signature’. However, the implications of this modified urban fingerprint on physical, chemical and biological attributes of sensitive freshwater systems is not well-known. Blue Mountains Upland Swamps are listed as an ‘endangered ecological community’ under State and Federal legislation and are home to a range of endangered flora and fauna. These ecosystems provide a unique case study to examine the effects of catchment urbanisation on a fragile freshwater environment with high conservation value. This study investigated whether urban Blue Mountains Upland Swamps exhibit altered elemental composition compared to naturally vegetated swamp catchments. Water, sediment and foliage chemistry was assessed within four urban and four naturally vegetated Blue Mountains Upland Swamp catchments, through field monitoring and a range of routine and innovative laboratory techniques (including scanning electron microscopy, x-ray diffraction and acid digestion methods). Urban swamps exhibited a distinct elemental signature compared to naturally vegetated swamps. Water in urban swamps displayed higher pH, ionic strength and had elevated concentrations of major ions (particularly calcium and bicarbonate) and metals (including strontium, barium, manganese and iron). Sediment from urban swamps had higher concentrations of calcium, with calcium hydroxide detected at two of the urban sites. Analysis of foliage tissue suggested the potential for foliage from urban catchments to exhibit higher concentrations of calcium, bicarbonate and potassium compared to non-urban catchments, however there was variability between sites and exotic and native species. Urban development alters natural hydrology and channels surface runoff into concrete drainage infrastructure, which can modify water chemistry. Findings from this study suggest that urbanisation remains a potential source of chemical modification within BMUS. Understanding the impacts of urban development is key to guiding management and promoting conservation within fragile environments. In an increasingly urban world, this research can be applied at local and international scales, assisting to identify the ecological consequences of urbanisation and shape management approaches within fragile freshwater environments. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: swamps; effect of chemicals on; urbanisation; Blue Mountains (N.S.W.); Thesis (M.Res.) – Western Sydney University, 2018

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carroll, R. (2018). The effects of urban geochemical modification on endangered Blue Mountains Upland Swamps. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:52102

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carroll, Rani. “The effects of urban geochemical modification on endangered Blue Mountains Upland Swamps.” 2018. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:52102.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carroll, Rani. “The effects of urban geochemical modification on endangered Blue Mountains Upland Swamps.” 2018. Web. 06 Mar 2021.

Vancouver:

Carroll R. The effects of urban geochemical modification on endangered Blue Mountains Upland Swamps. [Internet] [Thesis]. Western Sydney University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:52102.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carroll R. The effects of urban geochemical modification on endangered Blue Mountains Upland Swamps. [Thesis]. Western Sydney University; 2018. Available from: http://hdl.handle.net/1959.7/uws:52102

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Chang, Weiju. The role of the brain in the transition from acute to chronic musculoskeletal pain : an investigation of neuroplastic mechanisms and novel treatments.

Degree: 2018, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:52106

► Musculoskeletal pain is a leading health problem globally. Its prevalence and associated socioeconomic costs have increased exponentially and this trend is expected to continue in… (more)

▼ Musculoskeletal pain is a leading health problem globally. Its prevalence and associated socioeconomic costs have increased exponentially and this trend is expected to continue in the coming decades. While all stages of musculoskeletal pain contribute to the burden of disease, the costs attributed to chronic pain (pain lasting > 3 months) are most significant. Effective treatment would substantially reduce the impact of chronic musculoskeletal pain at both the individual and societal level. Yet, the effects of current treatments are, at best, moderate for pain and function. One explanation for the limited success of current treatments is an inadequate understanding of the neurophysiological mechanisms that underpin musculoskeletal pain. Addressing the evidence gap surrounding our mechanistic understanding of musculoskeletal pain is essential to guide the development of effective treatments. Maladaptive neuroplasticity, manifesting as altered sensorimotor cortex organisation and impaired central pain processing, is the prevailing theory used to explain the development and maintenance of chronic musculoskeletal pain. Cross sectional evidence derived from individual studies suggests maladaptive neuroplasticity in the primary motor cortex (M1) is present in chronic musculoskeletal pain and is associated with symptoms of pain and movement dysfunction. Yet, a systematic evaluation of the evidence for altered M1 plasticity in chronic pain is absent. Further, no study has characterised neuroplasticity in the acute stage of clinical musculoskeletal pain. This information is critical to better understand the time course of neuroplasticity in musculoskeletal pain. Finally, few treatments exist that specifically target altered neuroplasticity in chronic musculoskeletal pain conditions. Thus, the overarching aim of this thesis was to investigate and target specific mechanisms of neuroplasticity (sensorimotor cortex organisation and central pain processing) in musculoskeletal pain. This aim was achieved through four studies. This thesis provides original and novel insight into our understanding of neuroplasticity in musculoskeletal pain and provides a foundation for the development and testing of novel interventions to reduce pain and disability. Specifically, this thesis demonstrates that: (1) evidence for M1 structural, organisational and functional changes in chronic pain conditions is inconsistent, (2) neuroplasticity in acute LBP is characterised by lower sensorimotor and cingulate cortex excitability and impaired descending inhibitory pain control when compared with pain-free individuals, although inter-individual variability is high and (3) adding tDCS to strengthening exercise may improve pain, function and pain mechanisms in knee osteoarthritis beyond that of exercise applied alone. Notably, subgroups distinguished by high or low S2 and ACC excitability may represent individual adaptation of different cortical strategies that relate to the processing of non-noxious input in acute… Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: musculoskeletal system; chronic pain; therapeutics; neurophysiology; neuroplasticity; Thesis (Ph.D.) – Western Sydney University, 2018

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chang, W. (2018). The role of the brain in the transition from acute to chronic musculoskeletal pain : an investigation of neuroplastic mechanisms and novel treatments. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:52106

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chang, Weiju. “The role of the brain in the transition from acute to chronic musculoskeletal pain : an investigation of neuroplastic mechanisms and novel treatments.” 2018. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:52106.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chang, Weiju. “The role of the brain in the transition from acute to chronic musculoskeletal pain : an investigation of neuroplastic mechanisms and novel treatments.” 2018. Web. 06 Mar 2021.

Vancouver:

Chang W. The role of the brain in the transition from acute to chronic musculoskeletal pain : an investigation of neuroplastic mechanisms and novel treatments. [Internet] [Thesis]. Western Sydney University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:52106.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chang W. The role of the brain in the transition from acute to chronic musculoskeletal pain : an investigation of neuroplastic mechanisms and novel treatments. [Thesis]. Western Sydney University; 2018. Available from: http://hdl.handle.net/1959.7/uws:52106

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Wijesekera, Nadeeja. Evaluating hypoxia-targeting vectors for MRI applications.

Degree: 2018, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:52103

► Tissue hypoxia, or oxygen deficiency in tissue, is usually the result of a locally restricted oxygen supply or an abnormal increase in oxygen consumption, or… (more)

▼ Tissue hypoxia, or oxygen deficiency in tissue, is usually the result of a locally restricted oxygen supply or an abnormal increase in oxygen consumption, or both. Hypoxia is related to a variety of pathological conditions including cancer, stroke and ischemic heart disease. In locally advanced solid tumors, hypoxic and anoxic regions are often distributed heterogeneously due to structurally and functionally abnormal vasculature. Tumor hypoxia has been closely associated with poor cancer prognosis after radiation and chemotherapy, and is known to encourage tumor proliferation factors, such as growth, apoptosis, angiogenesis and metastasis. In radiotherapy, dosage (i.e., the amount of radiation required to kill a tumorous tissue) is determined by the intrinsic radiosensitivity of the cancer cell population and the tumor microenvironment, in particular the oxygen level of the tissue. Therefore, hypoxic tissues are known to be resistant to the lethal effects of radiation. The ability to accurately identify the hypoxic levels of tumors, and regions within a tumor, can allow clinicians to alter radiotherapy treatment planning to improve treatment outcomes. Consequently, considerable efforts have been made to identify hypoxia within tumors. Of particularly interest at present is to develop chemicals, incorporating hypoxiatargeting vectors, which specifically accumulate in hypoxic tissue when injected and can then be traced/imaged by an imaging modality, thus allowing delineation of hypoxic parts of a tumor. The potential of these compounds as markers for hypoxic tumors has long been realised, and have been extensively exploited in positron-emission tomography imaging, but less so in magnetic resonance imaging. However, developing such compounds for MRI first requires determining which of the several available hypoxia-targeting vectors is most favourable. As these targeting vectors bind to macromolecular structures, a suitable model for such determinations is to probe the binding interactions of these vectors in albumin. Probing such interactions has been studied by nuclear magnetic resonance spectroscopy due to its general applicability and non-invasive nature. NMR diffusion measurements allow binding ligands to be easily differentiated from non-binding molecules by significant differences in the diffusion coefficients. The mathematical framework for analysing such data is provided by the Kärger equations. To understand limits of these equations, such as the short gradient pulse approximation, and thus the conditions under which these equations are valid, a detailed derivation of these equations for the case of two freely diffusing exchanging species is presented along with the simplifications that result in the slow and fast exchange limits. This leads to the population weighted diffusion equation, which is then used to quantitatively characterise the binding properties of the hypoxia-targeting vectors in albumin by the number of binding sites, n and the association constant, K. The binding properties of three… Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: oxygen; physiological transport; impaired oxygen delivery; blood-vessels; tumors; radiation; dosage; drug development.; Thesis (Ph.D.) – Western Sydney University, 2018

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wijesekera, N. (2018). Evaluating hypoxia-targeting vectors for MRI applications. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:52103

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wijesekera, Nadeeja. “Evaluating hypoxia-targeting vectors for MRI applications.” 2018. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:52103.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wijesekera, Nadeeja. “Evaluating hypoxia-targeting vectors for MRI applications.” 2018. Web. 06 Mar 2021.

Vancouver:

Wijesekera N. Evaluating hypoxia-targeting vectors for MRI applications. [Internet] [Thesis]. Western Sydney University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:52103.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wijesekera N. Evaluating hypoxia-targeting vectors for MRI applications. [Thesis]. Western Sydney University; 2018. Available from: http://hdl.handle.net/1959.7/uws:52103

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Hissen, Sarah L. Interactions between sympathetic baroreflex sensitivity and vascular transduction in males and females.

Degree: 2019, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:52362

► The control of muscle sympathetic nerve activity (MSNA) via the baroreflex is an important mechanism of blood pressure control. Spontaneous sympathetic baroreflex sensitivity (BRS) is… (more)

▼ The control of muscle sympathetic nerve activity (MSNA) via the baroreflex is an important mechanism of blood pressure control. Spontaneous sympathetic baroreflex sensitivity (BRS) is a tool used to examine how well the baroreflex buffers beat-to-beat changes in arterial pressure. Due to the lack of research around the baroreflex control of MSNA, it is unknown if an individual's sympathetic BRS reflects the end organ response and thus is indicative of how effective they are at regulating their blood pressure. It was hypothesised that poor baroreflex sensitivity was compensated for by enhanced vascular transduction, and vice versa. Given that sex differences are known to exist in regulatory mechanisms involved in cardiovascular control, these interactions were explored and contrasted in young males and females. In order to further our understanding of the regulatory mechanism of the sympathetic baroreflex, MSNA, blood pressure and superficial femoral artery (SFA) blood flow were measured to i) examine the stability and repeatability of measures of spontaneous sympathetic BRS, ii) examine whether vascular transduction, quantified on a beat-to-beat basis using two different approaches, were different between males and females, iii) examine the relationship between sympathetic BRS and vascular transduction, and iv) examine sympathetic BRS and vascular transduction during physiological stressors that drive increases in MSNA. Here I present evidence of sex differences in sympathetic baroreflex function in healthy young adults. Spontaneous sympathetic BRS was moderately stable in the same recording period and also when examined on different days. Recording periods of at least 5 min should be used when quantifying BRS as shorter durations can overestimate BRS values. Using the Fairfax method, sympathetic vascular transduction was significantly lower in males when compared with females. In contrast, the Briant method did not reveal sex differences in vascular transduction between males and females. Sympathetic BRS and vascular transduction was negatively correlated under resting conditions. This means that individuals with high sympathetic BRS have less effective vascular transduction during spontaneous changes in blood pressure. However, this was only apparent in young males; there was no relationship observed in females. Furthermore, resting MSNA did not predict sympathetic BRS or vascular transduction in either males or females. Finally, vascular transduction was significantly greater in males when quantified as the relationship between MSNA and leg vascular conductance during isometric handgrip and the cold pressor test. Sympathetic BRS was not different between males and females during the cold pressor test but was reset to a higher blood pressure range. Collectively, the studies conducted in this thesis provide insight into the dynamic nature of the baroreflex control of arterial pressure at rest, and during increases in muscle vasoconstrictor drive. Whilst this thesis provides evidence of sex differences in sympathetic… Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: sympathetic nervous system; cardiovascular system; physiology; baroreflexes; signal transduction; blood pressure; regulation; Thesis (Ph.D.) – Western Sydney University, 2019; sex differences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hissen, S. L. (2019). Interactions between sympathetic baroreflex sensitivity and vascular transduction in males and females. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:52362

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hissen, Sarah L. “Interactions between sympathetic baroreflex sensitivity and vascular transduction in males and females.” 2019. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:52362.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hissen, Sarah L. “Interactions between sympathetic baroreflex sensitivity and vascular transduction in males and females.” 2019. Web. 06 Mar 2021.

Vancouver:

Hissen SL. Interactions between sympathetic baroreflex sensitivity and vascular transduction in males and females. [Internet] [Thesis]. Western Sydney University; 2019. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:52362.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hissen SL. Interactions between sympathetic baroreflex sensitivity and vascular transduction in males and females. [Thesis]. Western Sydney University; 2019. Available from: http://hdl.handle.net/1959.7/uws:52362

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Peel, Nicole. Young people in foster care and their leisure : tools for living independently.

Degree: 2019, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:52999

► This thesis utilises a case study method with a small cohort of young people in foster care to generate an explanation of how leisure can… (more)

▼ This thesis utilises a case study method with a small cohort of young people in foster care to generate an explanation of how leisure can be used beneficially to move to and through their transition from care to independent living at 18 years of age. The foster care environment, as a sub-set of Out-of-Home Care (OOHC), has been described as complex, regulated and one in which those in care have at times little or no control over important aspects of their lives. Indeed, it has been reported that young people in foster care are sometimes told by those in authority such as teachers that they need not concern themselves with ambition or aspiration because their life choices are already limited by their situation and their environment. Nevertheless, there are two sides to foster care and the second side involves supportive birth families, foster families, teachers, counsellors, case workers and friendships. As well, there is an inherent optimism among those in care reported by some authors. This inherent optimism, frequently expressed through leisure, was found to be well established in the great majority of the twelve case studies undertaken. This optimism is evident in the study as an underpinning of the willingness of participants to look to the future, to plan, to understand their leisure environment, to actively apply personally held cognitive skills and to generate outcomes and experiences that were useful to them. A number of interesting factors relevant to the use of leisure by young people in foster care have been articulated in the study. It is noted, for example, that the participants were using a range of cognitive resources to date unreported in the literature on foster care or OOHC and only reported as a limited allied concept in the leisure literature. However, the small amount of work in the leisure literature was not undertaken in regards to foster care. The use of personal cognitive resources was found to be widespread and multifaceted within the cohort studied. These resources were not leisure specific and while their application was, it does not need be. In effect then, participants were using, or creating and using, and practicing the use of sets of cognitive resources applicable to independent living after transition from care at the age of 18. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: foster children; attitudes; leisure; social aspects; youth; conduct of life; adulthood; psychological aspects; Australia; Thesis (Ph.D.) – Western Sydney University, 2019

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Peel, N. (2019). Young people in foster care and their leisure : tools for living independently. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:52999

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Peel, Nicole. “Young people in foster care and their leisure : tools for living independently.” 2019. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:52999.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Peel, Nicole. “Young people in foster care and their leisure : tools for living independently.” 2019. Web. 06 Mar 2021.

Vancouver:

Peel N. Young people in foster care and their leisure : tools for living independently. [Internet] [Thesis]. Western Sydney University; 2019. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:52999.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peel N. Young people in foster care and their leisure : tools for living independently. [Thesis]. Western Sydney University; 2019. Available from: http://hdl.handle.net/1959.7/uws:52999

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Ghimire, Pramesh R. Modelling perinatal and child mortality in Nepal.

Degree: 2019, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:52996

► South Asia has the second largest burden of perinatal and childhood mortality in the world and Nepal has been reported as a significant contributor to… (more)

▼ South Asia has the second largest burden of perinatal and childhood mortality in the world and Nepal has been reported as a significant contributor to this burden within the region. The main aim of this thesis was to statistically model perinatal and childhood mortality in Nepal. Specifically, this thesis will first conduct a systematic review of factors associated with perinatal mortality in South Asia including Nepal. Second, socioeconomic predictors of stillbirths in Nepal will be examined. Third, Factors associated with perinatal mortality in Nepal will be identified. Finally, this thesis will examine factors associated with under-5 mortality in Nepal. Chapter 2 identifies the factors associated with perinatal and childhood mortality through literature review. The systematic literature review revealed the most common factors associated with perinatal mortality were: low socioeconomic status, lack of quality health care services, pregnancy/obstetric complications and lack of antenatal care. Similarly, poor socio economic status, rural residence, higher birth order and lower birth interval, use of contraceptives, polluted fuel for cooking at home, and antenatal care were found to be associated with under-5 mortality. Chapter 4 examined the socio-economic predictors of stillbirth in Nepal. Multivariable analysis and found maternal age (>25years), ecological zone (mountains or hills), religion (Hindu, Muslim, Christian and others), low maternal education, mother’s occupation (farming) and the use of open defecation system are associated with stillbirth. Chapter 5 presents the factors associated with Perinatal Mortality (PM) and Extended Perinatal Mortality (EPM) in Nepal. In this study, PM rate was 42 [95% Confidence Interval (CI): 39, 44] per 1000 births and the corresponding EPM rate was 49 [95% CI: 46, 51] for the five-year prior each survey (2001-2016). Multivariable analysis revealed that ecological zone, household wealth index, birth order and birth interval; maternal age, use of contraceptives, and types of cooking fuel were associated with PM and EPM. Chapter 6 assesses the common factors associated with neonatal, post-neonatal, infant, child, and under-5 mortality in Nepal, and the study found that the death of the previous child, non usage of contraceptives and non-receipt of TT vaccination during pregnancy were associated with inder-5 mortality. In summary, household with poor socio-economic status, and non-use of contraceptives among mothers were strongly associated with perinatal, and under-5 mortality in Nepal. Hence, future intervention to reduce perinatal and under-5 mortality should focus on family planning and these intervention should target mothers from socioeconomically disadvantaged groups. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: Nepal; perinatal death; children; mortality; statistics; mathematical models; Thesis (Ph.D.) – Western Sydney University, 2019

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ghimire, P. R. (2019). Modelling perinatal and child mortality in Nepal. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:52996

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ghimire, Pramesh R. “Modelling perinatal and child mortality in Nepal.” 2019. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:52996.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ghimire, Pramesh R. “Modelling perinatal and child mortality in Nepal.” 2019. Web. 06 Mar 2021.

Vancouver:

Ghimire PR. Modelling perinatal and child mortality in Nepal. [Internet] [Thesis]. Western Sydney University; 2019. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:52996.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ghimire PR. Modelling perinatal and child mortality in Nepal. [Thesis]. Western Sydney University; 2019. Available from: http://hdl.handle.net/1959.7/uws:52996

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Zhang, Lin. Biological activities and structural characterisation of anticancer herbal polysaccharides.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:45024

► In recent years, medicinal plants have become popular for the treatment of several diseases due to their efficacy and cost effectiveness. Plant derived therapeutic agents… (more)

▼ In recent years, medicinal plants have become popular for the treatment of several diseases due to their efficacy and cost effectiveness. Plant derived therapeutic agents are increasingly sought out as pharmaceuticals for the treatment of life-threatening illnesses. Important contributions have already been made in the recent years to the drug market by the compounds isolated from natural sources or from their derivatives. There is no doubt that, novel lifesaving drugs could be discovered by a systematic evaluation of ethno medicinal information using modern scientific tools. This thesis attempts to systematically combine ethnomedicinal knowledge together with the contemporary scientific methods to evaluate immunomodulatory and anticancer properties of sixteen traditional medicinal herbs with an aim to discover anticancer formulations. The major objective of this project is to isolate and characterise potent anticancer polysaccharides from Traditional Chinese Medicinal (TCM) herbs. In order to achieve these objectives, sixteen Chinese Medicinal herbs have been successfully screened for their antioxidant, immunomodulatory and anticancer activities. Based on their immunomodulatory and anticancer activities, three traditional anticancer TCM herbs, namely, Amauroderma rugosum, Lobelia chinensis and Artemisia annua have been selected for further studies. Isolation and characterisation of polysaccharides from these three medicinal herbs has been carried out. The structural characterization employing FT-IR and NMR spectroscopy has been carried out and presented in Chapters 5 to 7. A total of eight potent immuno-therepuritic polysaccharides have been discovered for the first time from the three important anticancer TCM herbs (A. annua, L. chinensis and A. rugosum). The structure of three of them have been determined. The MRI contrast potentials of Gd(III) complexes of three of the herbal polysaccharides have also been studied. Low molecular weight polysacchro-proteins were found to be T1 agents and high molecular weight polysacchro-proteins were T2 agents. Findings of this thesis have contributed significant scientific knowledge that has offered some suggestions for designing new immuno-therepeutic formulations based on the eight polysaccharides discovered in this thesis. However, further research is required in order to design such formulations. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: medicine, Chinese; herbs; therapeutic use; polysaccharides; cancer; alternative treatment; Thesis (Ph.D.) – Western Sydney University, 2017

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhang, L. (2017). Biological activities and structural characterisation of anticancer herbal polysaccharides. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:45024

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhang, Lin. “Biological activities and structural characterisation of anticancer herbal polysaccharides.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:45024.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhang, Lin. “Biological activities and structural characterisation of anticancer herbal polysaccharides.” 2017. Web. 06 Mar 2021.

Vancouver:

Zhang L. Biological activities and structural characterisation of anticancer herbal polysaccharides. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:45024.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhang L. Biological activities and structural characterisation of anticancer herbal polysaccharides. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:45024

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Singh, Ravikash. The relationship between workplace injuries and youth employment in the QSR industry in NSW.

Degree: 2016, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:44091

► Occupational Health and Safety [OHS] forms an integral part of the employment relationship between an employee and employer. The intention of this research was to… (more)

Subjects/Keywords: industrial accidents; youth; employment; industrial safety; fast food restaurants; New South Wales; Thesis (M.Res.) – Western Sydney University, 2016

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Singh, R. (2016). The relationship between workplace injuries and youth employment in the QSR industry in NSW. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:44091

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Singh, Ravikash. “The relationship between workplace injuries and youth employment in the QSR industry in NSW.” 2016. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:44091.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Singh, Ravikash. “The relationship between workplace injuries and youth employment in the QSR industry in NSW.” 2016. Web. 06 Mar 2021.

Vancouver:

Singh R. The relationship between workplace injuries and youth employment in the QSR industry in NSW. [Internet] [Thesis]. Western Sydney University; 2016. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:44091.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Singh R. The relationship between workplace injuries and youth employment in the QSR industry in NSW. [Thesis]. Western Sydney University; 2016. Available from: http://hdl.handle.net/1959.7/uws:44091

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Moroney, Benjamin F. Advanced numerical modelling of NMR diffusion experiments.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:47377

► Pulsed gradient spin-echo nuclear magnetic resonance (PGSE NMR) diffusion measurements provide a powerful technique for measuring the translational motion of molecules. PGSE measurements can be… (more)

▼ Pulsed gradient spin-echo nuclear magnetic resonance (PGSE NMR) diffusion measurements provide a powerful technique for measuring the translational motion of molecules. PGSE measurements can be made with a minimum of sample preparation, applied to a large variety of substances, and used to either acquire diffusion coefficients from multiple species in a single sample or isolate a single species from a complex mixture. Consequently, PGSE NMR has tremendous utility in a large variety of disciplines, and is capable of elucidating information on chemical structure, kinetics, and binding in a non-invasive manner. It has particular utility in probing the structure of microscale porous media. By using the diffusion of fluid molecules in the void space of porous materials as a molecular probe, PGSE NMR experiments can reveal detailed information on the structure, size and internal properties of porous systems on a variety of length scales. Such experiments are non-destructive to the porous material, allowing the characterisation of materials in vivo as well as in vitro, meaning they are of benefit to medical diagnostics and treatment as they can safely and accurately probe the properties of biological structures in the human body. Such experiments require mathematical models to describe the relationship between the measured spin-echo signal and the properties of the probe molecule and its interactions with the restricting porous system in which it is contained. However, the derivation of analytical mathematical models for analysing such experiments is only straightforward for ideal restricting geometries and rapidly becomes intractable as the geometrical complexity increases. This is especially true when these models must take into account certain experimental limitations, particularly in clinical NMR spectrometers which do not have hardware as effective as research instruments. Consequently, when attempting to analyse diffusion experiments in complex geometries or including effects such as long magnetic gradient pulses, relaxing boundaries or internal magnetic gradients arising from external magnetic fields, numerical methods become an attractive method for generating these models. In this thesis, a variety of numerical techniques are examined in relation to the diffusion equation, the Bloch equations which describe nuclear magnetism and induction and the Bloch-Torrey equations which combine the two to describe the evolution of nuclear magnetism in a diffusing system. A highly flexible method for calculating the results of PGSE NMR experiments in porous systems based on the finite element method is presented. The efficiency and accuracy of the method is verified by comparison with the known solutions to simple pore geometries in the short gradient pulse limit (parallel planes, a cylindrical pore, and a spherical pore) and outside this limit (parallel planes, a circular pore and a spherical pore). The approach is then applied to modelling the more complicated cases of diffusion in parallel semipermeable planes, an array of… Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: nuclear magnetic resonance, pulsed; translational motion; porous materials; Thesis (M.Phil.) – Western Sydney University, 2017; diffusion; nuclear magnetic resonance spectroscopy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moroney, B. F. (2017). Advanced numerical modelling of NMR diffusion experiments. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:47377

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moroney, Benjamin F. “Advanced numerical modelling of NMR diffusion experiments.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:47377.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moroney, Benjamin F. “Advanced numerical modelling of NMR diffusion experiments.” 2017. Web. 06 Mar 2021.

Vancouver:

Moroney BF. Advanced numerical modelling of NMR diffusion experiments. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:47377.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moroney BF. Advanced numerical modelling of NMR diffusion experiments. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:47377

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Gall, Mailie L. Patterns of dispersal in the Tasman Sea and the South Pacific Ocean : population genetics and the role of environmental constraints.

Degree: 2016, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:40543

► The interconnected nature of the oceans, the small size and passive nature of larvae has resulted in the presumption that marine populations are large and… (more)

▼ The interconnected nature of the oceans, the small size and passive nature of larvae has resulted in the presumption that marine populations are large and open. However, this paradigm has been challenged in the last few of decades, where genetic studies have found significant structure at very fine-scales (of the order of 10 km). Given that many sedentary marine organisms can only disperse via a larval phase, it is intuitive that the duration of this phase (pelagic larval duration, PLD) should correspond with a species dispersal capacity and hence predict population genetic structure. Furthermore, if PLD predicts dispersal capacity then PLD should correlate with a species distribution. In this thesis, the population genetic structure of three sedentary marine organisms, endemic to the south-east Australia Pacific region, was examined to explore the relationships between dispersal capacity, life-history and geographical distribution. In chapter 2 the influence of an oceanic frontal system, the Subtropical Front (STF), on the genetic structure (mitochondrial region cytochrome c oxidase subunit I), trophic status (stable isotopes δ15N and δ13C) and condition (RNA:DNA, protein:DNA, DNA:dry weight) of the benthic gastropod Fusitriton magellanicus was examined across the Chatham Rise, New Zealand. The front acted as barrier to the transport of material between flanks, such that populations of F. magellanicus from the northern flank were in poorer condition than those from the southern flank. In addition, δ15N signatures were different between flanks, the northern flank being more enriched than the southern flank, indicating that F. magellanicus on the north flank where either starving or occupying a higher trophic level. Despite the STF shaping the trophic ecology of F. magellanicus, no differences in genetic structure were found. This indicates that there is larval exchange between or around the STF and hence larval biology may override environmental factors. To explore if a limited dispersal capacity, in contrast to its PLD (~30 days), was responsible for driving the unusual and abbreviated distribution of the sea urchin Heliocidaris tuberculata, its population genetic structure was characterised in chapter 3. Examination of the genetic structure using three different genetic markers (COI, 16S and 12 microsatellites) across the geographical distribution of the species (New South Wales coast and across the Tasman Sea to Lord Howe, Norfolk and the Kermadec Islands) was made, revealing a complete absence of structure (microsatellites FST = 0.003, COI PhiPT = 0.0021, and 16S PhiPT = 0.029). To elucidate the role of other important environmental factors in shaping genetic patterns, correlations between genetic measures and key environmental variables were explored, but no significant relationships were found. Therefore, H. tuberculata is panmictic across its range and its unusual restricted latitudinal distribution, despite it wide longitudinal distribution, is not explained by a limited dispersal capacity. The population… Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: marine animals; population genetics; larvae; oceanography; Tasman Sea; South Pacific Ocean; Thesis (Ph.D) – Western Sydney University, 2016

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gall, M. L. (2016). Patterns of dispersal in the Tasman Sea and the South Pacific Ocean : population genetics and the role of environmental constraints. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:40543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gall, Mailie L. “Patterns of dispersal in the Tasman Sea and the South Pacific Ocean : population genetics and the role of environmental constraints.” 2016. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:40543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gall, Mailie L. “Patterns of dispersal in the Tasman Sea and the South Pacific Ocean : population genetics and the role of environmental constraints.” 2016. Web. 06 Mar 2021.

Vancouver:

Gall ML. Patterns of dispersal in the Tasman Sea and the South Pacific Ocean : population genetics and the role of environmental constraints. [Internet] [Thesis]. Western Sydney University; 2016. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:40543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gall ML. Patterns of dispersal in the Tasman Sea and the South Pacific Ocean : population genetics and the role of environmental constraints. [Thesis]. Western Sydney University; 2016. Available from: http://hdl.handle.net/1959.7/uws:40543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Zhou, Xian. Synergistic behaviour of Salvia and Notoginseng species in vascular diseases.

Degree: 2016, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:41152

► As the mainstay and principal form of traditional Chinese medicine (TCM), Chinese herbal medicine (CHM) has been the subject of growing interest and popular use… (more)

▼ As the mainstay and principal form of traditional Chinese medicine (TCM), Chinese herbal medicine (CHM) has been the subject of growing interest and popular use worldwide. However, its unique philosophy, diagnosis and prescription are completely different from Western Medicine (WM), which has brought great challenges for the quality standardisation, safety control, and efficacy evaluation confronting its development in a modernised scientific manner. This PhD project aims to address challenges that revolve around the efficacy research of CHM. Based on CHM theory, the key mechanism of the efficacy of CHM is the synergistic interactions among multiple herbal ingredients in a formula to reach an optimised therapeutic effect, multi-target mode of actions and reduced potential side effects. Several rigorous analytical methods such as combination index (CI), isobolographic analysis and systems biology are designed for the quantitative evaluations of synergistic effects in pharmaceutical combination therapy, and have also been utilised for the study of CHM. Among them, CI and isobologram models are applied for studying the interactions of a small number of active components or herbal extracts on the same target or receptor in which their chemical and pharmacological properties are well defined. A systems biology model may also be used to analyse multi-component, multi-target actions in combinational therapy. However, following a systematic review, it is apparent that the current literature on synergistic study of CHM is still at an early stage. Based on previous studies, we hypothesised that a platform to systematically analyse synergistic interactions of herbal compounds can be established by modern bioassays and scientific models (e.g., CI and isobologram approaches). Herb-pairs are the basic unit for the Chinese herbal formulae. Salvia Miltiorrhiza Radix et Rhizoma and Notoginseng Radix et Rhizome (known as Danshen [DS] and Sanqi [SQ] in TCM) has been one of the most frequently prescribed herb pairs in TCM clinics for cardiovascular disease management for over 30 years in Asian countries. However, very limited mechanistic studies on the combinational benefits on the complex pathological mechanisms of vascular diseases are available, despite the fact that the bioactivities for a single extract have been well studied. Therefore, the DS-SQ herb-pair was selected as a case study to address the issue of synergistic activities in CHM. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: Salvia miltiorrhiza; Notoginseng; medicine, Chinese; herbs; vascular diseases; therapeutics; Thesis (Ph.D.) – Western Sydney University, 2016

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhou, X. (2016). Synergistic behaviour of Salvia and Notoginseng species in vascular diseases. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:41152

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhou, Xian. “Synergistic behaviour of Salvia and Notoginseng species in vascular diseases.” 2016. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:41152.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhou, Xian. “Synergistic behaviour of Salvia and Notoginseng species in vascular diseases.” 2016. Web. 06 Mar 2021.

Vancouver:

Zhou X. Synergistic behaviour of Salvia and Notoginseng species in vascular diseases. [Internet] [Thesis]. Western Sydney University; 2016. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:41152.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhou X. Synergistic behaviour of Salvia and Notoginseng species in vascular diseases. [Thesis]. Western Sydney University; 2016. Available from: http://hdl.handle.net/1959.7/uws:41152

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Wright, Belinda K. Lifetime and hyperspectral analyses of stem cell nuclei during differentiation.

Degree: 2018, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:46248

► Nicotinamide Adenine Dinucleotide (NADH), is an endogenous regulatory metabolite localised in various cellular compartments including but not limited the nucleus, mitochondria and cytoplasm. The endogenous… (more)

▼ Nicotinamide Adenine Dinucleotide (NADH), is an endogenous regulatory metabolite localised in various cellular compartments including but not limited the nucleus, mitochondria and cytoplasm. The endogenous biological molecule plays a key role in a variety of processes including cellular respiration, transcriptional regulation and differentiation. Through understanding the unique chemical properties and the localisation of NADH in various cellular compartments, can enhance the understanding in determining a cell’s metabolic status and molecular activity. The endogenous properties of NADH are often hard to examine due to their near infrared excitation, transient state within cellular compartments and often uncharacterised binding properties. This leads to difficulty in monitoring real time dynamics in live cells. Described in this thesis are two models, phasor fluorescence lifetime imaging microscopy and spectral phasor analysis which enables the real-time analysis of endogenous NADH inside developing zebrafish embryo somites and living cells. Little is known about the energy metabolite NADHs behaviour in embryology, particularly during somitogenesis, and how the analysis of its spatial location in individual somites may aid in the understanding of the somites metabolic status. Here we describe the use of the phasor FLIM and spectral phasor techniques to spatially map NADH’s lifetime and spectral emissions in developing zebrafish somites and discrete microenvironments in the nucleus of live cells under normal culture conditions and those stimulated to differentiate. Detecting the spectral differences of free and bound NADH in developing tissues and live cells, is currently limited due to the very small differences in emission. The Spectral phasor technique enables not only the examination of small shifts in spectral emissions but also provides the spatial location of spectrally different components in live cells without any prior knowledge of the species being analysed. The phasor representation enables direct comparison of either optical sections (i.e. different focal planes) of one cell or multiple cells for global analysis. A comparison of undifferentiated stem cells and those stimulated to differentiate demonstrate differing spatial distributions of emission spectral associated with NADH. Undifferentiated stem cells displayed shorter emissions centred in the nucleus, while longer wavelengths were localised around the perinuclear boarder. Stem cells stimulated into the early stages of differentiation displayed a redirection of the shorter emissions to regional clustering predominately in one area close to the nuclear/cytoplasmic broader, while the longer wavelengths were localised throughout the remainder of the nucleus. Here we show the application of the spectral phasor technique to identify discrete wavelength shifts associated with endogenous NADH fluorescence in the nucleus, and observed changes in their spatial distribution in live cells and tissues during the early stages of differentiation. For the first… Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: Thesis (Ph.D. (Sc.)) – Western Sydney University, 2018; NAD (coenzyme); embryology; cell differentiation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wright, B. K. (2018). Lifetime and hyperspectral analyses of stem cell nuclei during differentiation. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:46248

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wright, Belinda K. “Lifetime and hyperspectral analyses of stem cell nuclei during differentiation.” 2018. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:46248.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wright, Belinda K. “Lifetime and hyperspectral analyses of stem cell nuclei during differentiation.” 2018. Web. 06 Mar 2021.

Vancouver:

Wright BK. Lifetime and hyperspectral analyses of stem cell nuclei during differentiation. [Internet] [Thesis]. Western Sydney University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:46248.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wright BK. Lifetime and hyperspectral analyses of stem cell nuclei during differentiation. [Thesis]. Western Sydney University; 2018. Available from: http://hdl.handle.net/1959.7/uws:46248

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Tadros, Joseph. Flow chemistry approaches to access norcantharidin inspired cytotoxic agents.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:45758

► This project focused on the development of flow chemistry methodologies to access norcantharidin inspired analogues as potential cytotoxic agents, accessed via a convergent mixed batch-flow… (more)

Subjects/Keywords: flow chemistry; antineoplastic agents; chemical synthesis; Thesis (M.Res.) – Western Sydney University, 2017

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APA (6^th Edition):

Tadros, J. (2017). Flow chemistry approaches to access norcantharidin inspired cytotoxic agents. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:45758

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tadros, Joseph. “Flow chemistry approaches to access norcantharidin inspired cytotoxic agents.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:45758.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tadros, Joseph. “Flow chemistry approaches to access norcantharidin inspired cytotoxic agents.” 2017. Web. 06 Mar 2021.

Vancouver:

Tadros J. Flow chemistry approaches to access norcantharidin inspired cytotoxic agents. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:45758.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tadros J. Flow chemistry approaches to access norcantharidin inspired cytotoxic agents. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:45758

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Sohail, Iman. Targeting the FACT complex in understanding the regulation of quiescent cancer cells.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:45777

► a Prostate cancer (PCa) is the most commonly diagnosed cancer among Australian males and the third most common cancer-related mortality in Australia. The heterogeneous nature… (more)

▼ a Prostate cancer (PCa) is the most commonly diagnosed cancer among Australian males and the third most common cancer-related mortality in Australia. The heterogeneous nature of PCa as well as the increased clinical use of prostate-specific antigen (PSA) testing has led to a dramatic shift towards the diagnosis of low-risk and low-grade PCa. Nearly 30% of low-risk PCa patients subsequently experience cancer progression after active surveillance or primary treatments such as radiation or surgery. The presence of quiescent cancer cells, which are defined as Ki-67 negative and at a reversible arrest at the G0 phase, has been observed in PCa. Additionally, the proportion of quiescent cancer cells is low in low-risk PCa but increases in high-risk or metastatic PCa. Therefore, PCa progression may be potentially influenced by the cell’s transition from a quiescent to proliferative state. However, an understanding of the biological mechanisms involved in an increased proportion of quiescent over proliferative cells is currently elusive. The Facilitates Chromatin Transcription (FACT) complex is a highly conserved histone chaperone that is known to play major roles in ordered nucleosome assembly and reassembly, chromatin integrity, DNA replication and repair. FACT’s role in transcription regulation is also selective to a subset of genes involved in cell maintenance and cell growth function. As a higher level of FACT is documented in cancer cells, FACT has recently been implicated in cancer progression and associated with the poor prognosis of aggressive cancers. Moreover, an increased expression of FACT was evident in metastatic PCa and lower levels of FACT facilitated a G1 arrest to reduce cell proliferation. However, what is currently undetermined is the potential role or mechanism FACT may facilitate in the distribution of PCa cells in the cell cycle. Additionally, research on FACT and its effect on the G0 population is vastly ambiguous. Thus, the aim of this project was to define the effect of FACT expression on the proportion of quiescent cells at the G0 phase in PCa cells. Additionally, the project aimed to investigate the mechanism underlying FACT action on the increased proportion of quiescent PCa cells. Using a doxycycline-controlled shRNA to silence each of FACT’s subunits, SPT16 and SSRP1, my study indicated that the silencing of FACT decreased cell proliferation and led to an accumulation of PCa cells at the G0 phase. Decreased levels of SKP2 and PIRH2 and increased levels of p27, all of which are G0 regulatory proteins, was revealed through immunoblotting. Concomitantly, a similar pattern by the G0 regulatory proteins was determined at the mRNA level through RT-qPCR. Overall, this project has revealed that FACT may potentially play an important role in the regulation of G0 cells, which could be important in disease progression and future treatment. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: prostate; cancer; prostate-specific antigen; Thesis (M.Res.) – Western Sydney University, 2017; cell proliferation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sohail, I. (2017). Targeting the FACT complex in understanding the regulation of quiescent cancer cells. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:45777

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sohail, Iman. “Targeting the FACT complex in understanding the regulation of quiescent cancer cells.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:45777.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sohail, Iman. “Targeting the FACT complex in understanding the regulation of quiescent cancer cells.” 2017. Web. 06 Mar 2021.

Vancouver:

Sohail I. Targeting the FACT complex in understanding the regulation of quiescent cancer cells. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:45777.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sohail I. Targeting the FACT complex in understanding the regulation of quiescent cancer cells. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:45777

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Philp, Joshua N. Improving small ruminant productivity in Western China through the management of diet digestibility and feed use efficiency.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:45432

► Increasing the productivity of mixed forage and livestock farming systems is an important pathway for the improvement of rural livelihoods in developing economies, however production… (more)

▼ Increasing the productivity of mixed forage and livestock farming systems is an important pathway for the improvement of rural livelihoods in developing economies, however production is limited by seasonal fluctuations in feed quantity and quality. In the Loess Plateau of north-western China, regular feed deficits often occur during winter and early spring, despite government programmes aiming to increase the area of lucerne grown as high-quality feed. This thesis explores how changes in the provisioning of lucerne can increase the productivity of sheep in the Loess Plateau, in accordance with the administrative aims of the region. Feeding practices and their consequences for animal production were reviewed, revealing that livestock producers who grow lucerne typically offer it in greater proportions during the growing season but seldom conserve any for use during winter. Instead, protein deficient grain-crop residues are relied upon for feeding animals during winter, resulting in severe production losses. A review of previous research into feeding practices typical in the region found that negative protein balance is a factor in digestibility decline during underfeeding. Given that lucerne is available, protein-rich and presently underutilised, it was hypothesised that animal performance in these systems could be improved by modifying the timing with which lucerne is incorporated into rations. The benefits of storing enough lucerne to meet the minimum nitrogen requirements for rumen function during winter deficits were explored with a series of investigations in Qingyang Prefecture, Gansu Province, People’s Republic of China. First, Tan weaner sheep (mean weight 15.4 kg) were fed corn straw, corn grain and lucerne hay in respective ratios of 80:20:0 (metabolisable energy = 7.4 MJ/kg dry matter, crude protein = 40 g/kg dry matter; “S1”) or 55:20:25 (metabolisable energy = 8.2 MJ/kg dry matter, crude protein = 65 g/kg dry matter; “S2”). Rations were offered daily in a constant quantity supplying approximately 80% maintenance energy requirements estimated at the start of the experiment. Sheep fed S2 retained more weight on average than those fed S1 after 20 days of experimental conditions. Sheep fed S1 experienced a sustained decrease in ration digestibility and metabolisable energy intake per kg dry matter ingested. The mean dry matter digestibility and metabolisable energy observed in S2 fed animals remained stable, with no statistically significant differences between starting and finishing values. The results indicate that the capability for underfed Tan weaner sheep to absorb energy from low protein rations typical of winter rapidly decreases and that the lucerne hay in the diet prevented this decrease. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: feeding and feeds; sheep; sheep farming; Thesis (Ph.D.) – Western Sydney University, 2017; sustainable agriculture; Loess Plateau (China)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Philp, J. N. (2017). Improving small ruminant productivity in Western China through the management of diet digestibility and feed use efficiency. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:45432

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Philp, Joshua N. “Improving small ruminant productivity in Western China through the management of diet digestibility and feed use efficiency.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:45432.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Philp, Joshua N. “Improving small ruminant productivity in Western China through the management of diet digestibility and feed use efficiency.” 2017. Web. 06 Mar 2021.

Vancouver:

Philp JN. Improving small ruminant productivity in Western China through the management of diet digestibility and feed use efficiency. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:45432.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Philp JN. Improving small ruminant productivity in Western China through the management of diet digestibility and feed use efficiency. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:45432

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Kariawasam, Ruvini. Determining the structural mechanism of how single-stranded DNA binding proteins bind DNA.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:47195

► Single stranded DNA binding proteins (SSB) play a major role in cellular DNA processing events such as replication, recombination and repair and are central to… (more)

▼ Single stranded DNA binding proteins (SSB) play a major role in cellular DNA processing events such as replication, recombination and repair and are central to maintaining the integrity of our genome. These processes require the DNA double helix to unwind, exposing less stable and highly vulnerable regions of single stranded DNA (ssDNA). SSB proteins bind ssDNA via a highly conserved oligonucleotide-binding (OB) domain and function to temporarily bind and protect exposed ssDNA generated during these events. The vital role of SSBs is evident from their ubiquitous presence in all forms of life. In the recent years, high resolution DNA-bound structures of bacterial SSBs and the eukaryotic Replication Protein A (RPA) were published, significantly enhancing our understanding of the molecular mechanism of DNA binding by SSBs. Although the structure of the archaeal SSB from Sulfolobus solfataricus (SsoSSB) has been solved, the DNA binding details of this protein have not been elucidated until now. This thesis reveals the structural basis of ssDNA recognition by SsoSSB and provides the first look into how archaeal SSBs bind ssDNA at the structural level. Two novel human SSBs, hSSB1 and hSSB2 were recently discovered. Prior to this, RPA was the only known SSB in humans, therefore this discovery has provided a new dimension to our understanding of DNA processing events in our cells and is now a prevailing topic of interest. The main function of the hSSBs appears to be central to a range of DNA repair pathways. However, irrespective of their precise function in DNA repair, both homologs are primarily involved in binding ssDNA, and act very early in the damage response. This has provided us with the opportunity to study hSSB1 and hSSB2 as suitable targets to shut down highly active DNA repair processes in tumour cells. In this thesis, I present the structural basis of DNA binding by hSSB1 and hSSB2 which will ultimately complement the development of hSSB inhibitors for the use in novel anti-cancer therapeutics. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: antioncogenes; DNA-binding proteins; DNA-protein interactions; Thesis (Ph.D.) – University of Western Sydney, 2017

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kariawasam, R. (2017). Determining the structural mechanism of how single-stranded DNA binding proteins bind DNA. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:47195

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kariawasam, Ruvini. “Determining the structural mechanism of how single-stranded DNA binding proteins bind DNA.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:47195.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kariawasam, Ruvini. “Determining the structural mechanism of how single-stranded DNA binding proteins bind DNA.” 2017. Web. 06 Mar 2021.

Vancouver:

Kariawasam R. Determining the structural mechanism of how single-stranded DNA binding proteins bind DNA. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:47195.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kariawasam R. Determining the structural mechanism of how single-stranded DNA binding proteins bind DNA. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:47195

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Kapoor, Navya. Investigating metallo-peptides as antibacterial agents.

Degree: 2018, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:50421

► Increasing bacterial drug resistance and the emergence of dangerous resistant pathogens like methicillin-resistant Staphylococcus aureus is driving an urgent need to develop new antibiotics. Antimicrobial… (more)

▼ Increasing bacterial drug resistance and the emergence of dangerous resistant pathogens like methicillin-resistant Staphylococcus aureus is driving an urgent need to develop new antibiotics. Antimicrobial peptides (AMPs) and metals are two classes of antibacterial agents being explored as novel therapeutics. AMPs are produced as a part of innate immune system of living organisms and have broad spectrum activity and a bactericidal effect making bacteria less able to develop resistance., Metals are one of the oldest antibacterial agents known to humans. Notably, silver is very effective, and although its exact mode of action/s is unclear its ability to bind to a variety of enzymes is likely important. This project aims to investigate whether the coordination of silver to AMPs can create a synergistic antibacterial agent. To achieve this, AMPs, based on their potential to bind Ag(I), were selected from large AMP databases available online. Three AMPs, latarcin 3b, pleurain R1, tigerinin1, were selected. Further two Ag(I)-binding neuropeptides having properties consistent with antibacterial activity were also investigated. These were the tachykinins Neurokinin B, Substance P. Finally, Substance P was modified to include a methionine at its N-terminus (M1 Substance P) to generate a predicted high-affinity Ag(I)-binding site. The physiochemical properties of all the peptides were assessed using the R computational tool and these were related to potential antibacterial potential. Neurokinin B and Substance P have previously been shown to bind Ag(I), and the ability of the remaining peptides to coordinate Ag(I) was assessed using NMR and electronic spectroscopy. All but pleurain R1 and tigerinin1 could coordinate Ag(I), and further investigation of pleurain indicated that the lack of Ag(I)-binding was due to disulphide-bond formation. The Peptide-Ag(I) complexes were then studied for their antibacterial properties against gram negative bacteria using percentage inhibition and time-kill analysis. The results of this analysis showed that two complexes, latarcin 3b-Ag(I), and M1SP-Ag(I) displayed synergistic activity. Finally, the cellular location of silver after cultures were treated with these complexes was determined. These results show that silver alone is located mainly in the periplasm, but coordination to the peptides traps the metal in the membrane. This suggests that the synergistic effect is due to improved membrane-lytic activity. It can be concluded that the Peptide-Ag(I) complex can hold potential as next-generation antibacterial agents. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: peptide antibiotics; silver; therapeutic use; anti-infective agents; development; Thesis (M.Res.) – Western Sydney University, 2018

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kapoor, N. (2018). Investigating metallo-peptides as antibacterial agents. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:50421

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kapoor, Navya. “Investigating metallo-peptides as antibacterial agents.” 2018. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:50421.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kapoor, Navya. “Investigating metallo-peptides as antibacterial agents.” 2018. Web. 06 Mar 2021.

Vancouver:

Kapoor N. Investigating metallo-peptides as antibacterial agents. [Internet] [Thesis]. Western Sydney University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:50421.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kapoor N. Investigating metallo-peptides as antibacterial agents. [Thesis]. Western Sydney University; 2018. Available from: http://hdl.handle.net/1959.7/uws:50421

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Sayed, Reem. The regulation of FAM13A, a chronic obstructive pulmonary disease risk gene.

Degree: 2018, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:49560

► Chronic Obstructive Pulmonary Disease (COPD) is an incurable disease characterized by ongoing processes of inflammation and repair of the pulmonary epithelium. The dysregulation of the… (more)

Subjects/Keywords: lungs; diseases, obstructive; cancer genes; medical genetics; Thesis (M.Res.) – Western Sydney University, 2018

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sayed, R. (2018). The regulation of FAM13A, a chronic obstructive pulmonary disease risk gene. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:49560

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sayed, Reem. “The regulation of FAM13A, a chronic obstructive pulmonary disease risk gene.” 2018. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:49560.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sayed, Reem. “The regulation of FAM13A, a chronic obstructive pulmonary disease risk gene.” 2018. Web. 06 Mar 2021.

Vancouver:

Sayed R. The regulation of FAM13A, a chronic obstructive pulmonary disease risk gene. [Internet] [Thesis]. Western Sydney University; 2018. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:49560.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sayed R. The regulation of FAM13A, a chronic obstructive pulmonary disease risk gene. [Thesis]. Western Sydney University; 2018. Available from: http://hdl.handle.net/1959.7/uws:49560

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Cockrell, Krista R. Exploration of rural paramedics' capacity for utilising a salutogenic approach to healthcare delivery : a mixed methods study.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:49930

► The evolving profession of Paramedicine has been recognised as a potential solution to disparities in healthcare access in rural communities. With many rural paramedics highlighting… (more)

Subjects/Keywords: paramedics; allied health personnel; training of; clinical health psychology; salutogenesis; social medicine; health education; rural areas; mixed methods research; Australia; Canada; New Zealand; United States; Great Britain; Thesis (M.H.Sc.) – Western Sydney University, 2017

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cockrell, K. R. (2017). Exploration of rural paramedics' capacity for utilising a salutogenic approach to healthcare delivery : a mixed methods study. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:49930

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cockrell, Krista R. “Exploration of rural paramedics' capacity for utilising a salutogenic approach to healthcare delivery : a mixed methods study.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:49930.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cockrell, Krista R. “Exploration of rural paramedics' capacity for utilising a salutogenic approach to healthcare delivery : a mixed methods study.” 2017. Web. 06 Mar 2021.

Vancouver:

Cockrell KR. Exploration of rural paramedics' capacity for utilising a salutogenic approach to healthcare delivery : a mixed methods study. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:49930.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cockrell KR. Exploration of rural paramedics' capacity for utilising a salutogenic approach to healthcare delivery : a mixed methods study. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:49930

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Abir, Tanvir. Stillbirth, perinatal mortality, and the effect of prenatal care services on child mortality in Bangladesh.

Degree: 2017, Western Sydney University

URL: http://hdl.handle.net/1959.7/uws:47355

► Stillbirth, neonatal mortality and child mortality have remained a public health concern in low income and middle income countries, including Bangladesh. Steps taken to minimise… (more)

▼ Stillbirth, neonatal mortality and child mortality have remained a public health concern in low income and middle income countries, including Bangladesh. Steps taken to minimise this burden include antenatal care, and offering of drugs such as iron and folic acid supplements and tetanus toxoid vaccinations. This thesis utilises data from the 2004, 2007, 2011 and 2014 Bangladesh Demographic and Health Surveys, and carried out multilevel modelling for all analyses. This thesis first examines the factors associated with stillbirth in Bangladesh. It then explores the factors associated with perinatal mortality in the country. The thesis further examines the impact of antenatal care, iron folic acid supplementation and tetanus toxoid vaccination during pregnancy on child mortality in Bangladesh. Finally, the factors associated with under-5 mortality are examined. Chapter 5 presents the results of analysis of factors associated with stillbirth in Bangladesh. Findings in this chapter identifies some of the determinants of stillbirth to include low levels of maternal education, lack of husbands for mothers, household poverty, number of children per mother, and mother’s limited access to newspapers. Chapter 6 identifies factors associated with perinatal mortality in Bangladesh, and identified high body mass index of mothers, male infants, mother’s delivery complications and non-use of contraceptives as significant determinants. Chapter 7 identifies that mothers who were given no iron and folic acid (IFA) supplements and had less than two tetanus toxoid (TT) vaccinations, mothers who received no IFA supplements and had less than two TT vaccinations, and mothers who did not have any antenatal care, visits and did not receive any IFA supplements were significantly associated with under-5 mortality in Bangladesh. Chapter 8 identifies mothers from the Sylhet region, older mothers, and mothers’ low level of education as some of the factors associated with neonatal deaths. Non-working mothers and those with no schooling were some of factors associated with post-neonatal deaths. Almost similar factors were identified to be associated with infant, child, and under-5 deaths. Advisors/Committee Members: Western Sydney University. School of Science and Health (Host institution).

Subjects/Keywords: children; mortality; stillbirth; perinatal death; prenatal care; Bangladesh; Thesis (Ph.D.) – Western Sydney University, 2017

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Abir, T. (2017). Stillbirth, perinatal mortality, and the effect of prenatal care services on child mortality in Bangladesh. (Thesis). Western Sydney University. Retrieved from http://hdl.handle.net/1959.7/uws:47355

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abir, Tanvir. “Stillbirth, perinatal mortality, and the effect of prenatal care services on child mortality in Bangladesh.” 2017. Thesis, Western Sydney University. Accessed March 06, 2021. http://hdl.handle.net/1959.7/uws:47355.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abir, Tanvir. “Stillbirth, perinatal mortality, and the effect of prenatal care services on child mortality in Bangladesh.” 2017. Web. 06 Mar 2021.

Vancouver:

Abir T. Stillbirth, perinatal mortality, and the effect of prenatal care services on child mortality in Bangladesh. [Internet] [Thesis]. Western Sydney University; 2017. [cited 2021 Mar 06]. Available from: http://hdl.handle.net/1959.7/uws:47355.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abir T. Stillbirth, perinatal mortality, and the effect of prenatal care services on child mortality in Bangladesh. [Thesis]. Western Sydney University; 2017. Available from: http://hdl.handle.net/1959.7/uws:47355

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations