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You searched for +publisher:"Wayne State University" +contributor:("Patrick M. Woster"). One record found.

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Wayne State University

1. Crowley, Michael. Novel inhibitors of lysine specific demethylase 1 as epigenetic modulators.

Degree: MS, Pharmaceutical Sciences, 2011, Wayne State University

The recently discovered enzyme lysine-specific demethylase 1 (LSD1) plays an important role in the epigenetic control of gene expression, and aberrant gene silencing secondary to LSD1 over expression is thought to contribute to the development of cancer. We recently reported a series of (bis)guanidines and (bis)biguanides that are potent inhibitors of LSD1, and induce the re-expression of aberrantly silenced tumor suppressor genes in tumor cells in vitro. We now report a new series of isosteres that are also potent inhibitors of LSD1. These compounds induce increases in methylation at the histone 3 lysine 4 (H3K4) chromatin mark, a specific target of LSD1, in Calu-6 lung carcinoma cells. In addition, these analogues increase cellular levels of secreted frizzle-related proteins (SFRP) 2 and 5, and transcription factor GATA4. These compounds represent an important new series of epigenetic modulators with the potential for use as antitumor agents. Advisors/Committee Members: Patrick M. Woster, Timothy L. Stemmler.

Subjects/Keywords: Antitumor; Demethylase; Design; Discovery; Epigenetics; LSD1; Medicinal Chemistry and Pharmaceutics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Crowley, M. (2011). Novel inhibitors of lysine specific demethylase 1 as epigenetic modulators. (Masters Thesis). Wayne State University. Retrieved from https://digitalcommons.wayne.edu/oa_theses/132

Chicago Manual of Style (16th Edition):

Crowley, Michael. “Novel inhibitors of lysine specific demethylase 1 as epigenetic modulators.” 2011. Masters Thesis, Wayne State University. Accessed December 12, 2019. https://digitalcommons.wayne.edu/oa_theses/132.

MLA Handbook (7th Edition):

Crowley, Michael. “Novel inhibitors of lysine specific demethylase 1 as epigenetic modulators.” 2011. Web. 12 Dec 2019.

Vancouver:

Crowley M. Novel inhibitors of lysine specific demethylase 1 as epigenetic modulators. [Internet] [Masters thesis]. Wayne State University; 2011. [cited 2019 Dec 12]. Available from: https://digitalcommons.wayne.edu/oa_theses/132.

Council of Science Editors:

Crowley M. Novel inhibitors of lysine specific demethylase 1 as epigenetic modulators. [Masters Thesis]. Wayne State University; 2011. Available from: https://digitalcommons.wayne.edu/oa_theses/132

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