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You searched for +publisher:"Virginia Tech" +contributor:("Santos, Webster L."). Showing records 1 – 22 of 22 total matches.

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Virginia Tech

1. Sun, Jing. Synthesis and Application of Boronic Acid Derivatives.

Degree: MS, Chemistry, 2010, Virginia Tech

 Boronic acids are attractive synthetic intermediates and have been shown to be effective as inhibitors of various enzymes. In this project, the overarching goal is… (more)

Subjects/Keywords: ?-Borylation; Boronic Acid Derivatives; Human ClpXP; Pinacolyl Boronic Ester Deprotection

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APA (6th Edition):

Sun, J. (2010). Synthesis and Application of Boronic Acid Derivatives. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77006

Chicago Manual of Style (16th Edition):

Sun, Jing. “Synthesis and Application of Boronic Acid Derivatives.” 2010. Masters Thesis, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/77006.

MLA Handbook (7th Edition):

Sun, Jing. “Synthesis and Application of Boronic Acid Derivatives.” 2010. Web. 20 Feb 2020.

Vancouver:

Sun J. Synthesis and Application of Boronic Acid Derivatives. [Internet] [Masters thesis]. Virginia Tech; 2010. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/77006.

Council of Science Editors:

Sun J. Synthesis and Application of Boronic Acid Derivatives. [Masters Thesis]. Virginia Tech; 2010. Available from: http://hdl.handle.net/10919/77006


Virginia Tech

2. Lu, Hao. Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles.

Degree: MS, Chemistry, 2011, Virginia Tech

 Different structures of non-viral cationic polymer delivery vehicles, including charge center type, molecular weight and degradability, could significantly affect toxicity, release of nucleic acid and… (more)

Subjects/Keywords: Guanidine; Biodegradable Polymer; Non-viral Nucleic Acid Delivery; Self-degradable

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APA (6th Edition):

Lu, H. (2011). Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/76760

Chicago Manual of Style (16th Edition):

Lu, Hao. “Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles.” 2011. Masters Thesis, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/76760.

MLA Handbook (7th Edition):

Lu, Hao. “Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles.” 2011. Web. 20 Feb 2020.

Vancouver:

Lu H. Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles. [Internet] [Masters thesis]. Virginia Tech; 2011. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/76760.

Council of Science Editors:

Lu H. Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles. [Masters Thesis]. Virginia Tech; 2011. Available from: http://hdl.handle.net/10919/76760


Virginia Tech

3. Congdon, Molly D. Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors.

Degree: PhD, Chemistry, 2016, Virginia Tech

 A variety of diseases including Alzheimer's disease, asthma, cancer, fibrosis, multiple sclerosis, and sickle cell disease have been associated with elevated levels of sphingosine-1-phosphate (S1P).… (more)

Subjects/Keywords: sphingosine; sphingosine kinase; sphingosine-1-phosphate; structure-activity relationship; molecular docking

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APA (6th Edition):

Congdon, M. D. (2016). Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/82129

Chicago Manual of Style (16th Edition):

Congdon, Molly D. “Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors.” 2016. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/82129.

MLA Handbook (7th Edition):

Congdon, Molly D. “Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors.” 2016. Web. 20 Feb 2020.

Vancouver:

Congdon MD. Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors. [Internet] [Doctoral dissertation]. Virginia Tech; 2016. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/82129.

Council of Science Editors:

Congdon MD. Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors. [Doctoral Dissertation]. Virginia Tech; 2016. Available from: http://hdl.handle.net/10919/82129


Virginia Tech

4. Nelson, Amanda Kay. Metal-Catalyzed Formation and Transformations of Carbon-Boron Bonds.

Degree: PhD, Chemistry, 2016, Virginia Tech

 Our research seeks new methods for functionalizing organic small molecules using organoboronic derivatives as a versatile handle for late-stage manipulations. Metal-catalyzed formation of new carbon-boron… (more)

Subjects/Keywords: borylation; diboration; conjugate addition; aqueous; copper; cross-coupling

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APA (6th Edition):

Nelson, A. K. (2016). Metal-Catalyzed Formation and Transformations of Carbon-Boron Bonds. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/83400

Chicago Manual of Style (16th Edition):

Nelson, Amanda Kay. “Metal-Catalyzed Formation and Transformations of Carbon-Boron Bonds.” 2016. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/83400.

MLA Handbook (7th Edition):

Nelson, Amanda Kay. “Metal-Catalyzed Formation and Transformations of Carbon-Boron Bonds.” 2016. Web. 20 Feb 2020.

Vancouver:

Nelson AK. Metal-Catalyzed Formation and Transformations of Carbon-Boron Bonds. [Internet] [Doctoral dissertation]. Virginia Tech; 2016. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/83400.

Council of Science Editors:

Nelson AK. Metal-Catalyzed Formation and Transformations of Carbon-Boron Bonds. [Doctoral Dissertation]. Virginia Tech; 2016. Available from: http://hdl.handle.net/10919/83400


Virginia Tech

5. Raje, Mithun. Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors.

Degree: PhD, Chemistry, 2012, Virginia Tech

 Sphingosine kinase (SphK) has emerged as an attractive target for cancer therapeutics due to its role in cell proliferation. SphK phosphorylates sphingosine to form sphingosine-1-phosphate… (more)

Subjects/Keywords: reductive amination; structure-activity relationships; guanidine inhibitors; sphingosine-1-phosphate; sphingosine kinase inhibitors

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APA (6th Edition):

Raje, M. (2012). Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77051

Chicago Manual of Style (16th Edition):

Raje, Mithun. “Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors.” 2012. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/77051.

MLA Handbook (7th Edition):

Raje, Mithun. “Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors.” 2012. Web. 20 Feb 2020.

Vancouver:

Raje M. Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/77051.

Council of Science Editors:

Raje M. Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/77051


Virginia Tech

6. Crumpton, Jason. Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids.

Degree: PhD, Chemistry, 2012, Virginia Tech

 The utilization of click chemistry to perform inter- and intramolecular ligation on DNA has become ubiquitous in the literature. Advances in copper (I) stabilizing ligands… (more)

Subjects/Keywords: click chemistry; DNA; matrix; peptide sequencing; MALDI-MS

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APA (6th Edition):

Crumpton, J. (2012). Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77076

Chicago Manual of Style (16th Edition):

Crumpton, Jason. “Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids.” 2012. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/77076.

MLA Handbook (7th Edition):

Crumpton, Jason. “Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids.” 2012. Web. 20 Feb 2020.

Vancouver:

Crumpton J. Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/77076.

Council of Science Editors:

Crumpton J. Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/77076


Virginia Tech

7. Lemkul, Justin Alan. Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention.

Degree: PhD, Biochemistry, 2012, Virginia Tech

 Alzheimer's disease is the leading cause of senile dementia in the elderly, and as life expectancy increases across the globe, incidence of the disease is… (more)

Subjects/Keywords: Neurodegeneration; Thermodynamics; Protein-lipid interactions; Free energy calculations; Simulations

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APA (6th Edition):

Lemkul, J. A. (2012). Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77318

Chicago Manual of Style (16th Edition):

Lemkul, Justin Alan. “Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention.” 2012. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/77318.

MLA Handbook (7th Edition):

Lemkul, Justin Alan. “Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention.” 2012. Web. 20 Feb 2020.

Vancouver:

Lemkul JA. Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/77318.

Council of Science Editors:

Lemkul JA. Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/77318


Virginia Tech

8. Bryson, David Irby. Targeting RNA Structures with Multivalent Branched Peptide Libraries.

Degree: PhD, Chemistry, 2012, Virginia Tech

 RNA is essential for the transfer of genetic information, as the central dogma of biology dictates. The role of RNA, however, is not limited to… (more)

Subjects/Keywords: High Throughput Screening; Combinatorial Libraries; Branched Peptides; Multivalency; Cell Permeable Peptides; and Boron; RNA; HIV-1; Medium-Sized Ligands

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APA (6th Edition):

Bryson, D. I. (2012). Targeting RNA Structures with Multivalent Branched Peptide Libraries. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77327

Chicago Manual of Style (16th Edition):

Bryson, David Irby. “Targeting RNA Structures with Multivalent Branched Peptide Libraries.” 2012. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/77327.

MLA Handbook (7th Edition):

Bryson, David Irby. “Targeting RNA Structures with Multivalent Branched Peptide Libraries.” 2012. Web. 20 Feb 2020.

Vancouver:

Bryson DI. Targeting RNA Structures with Multivalent Branched Peptide Libraries. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/77327.

Council of Science Editors:

Bryson DI. Targeting RNA Structures with Multivalent Branched Peptide Libraries. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/77327


Virginia Tech

9. Guo, Xi. The development and applications of unsymmetrical diboron compounds.

Degree: PhD, Chemistry, 2014, Virginia Tech

 Organoboron compounds have shown a wide variety of applications in both organic synthesis and the pharmaceutical field in the past decades. Transition metal-catalyzed boration of… (more)

Subjects/Keywords: diboron compounds; conjugate addition; diboration; o-nitrobenzyl ligands

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APA (6th Edition):

Guo, X. (2014). The development and applications of unsymmetrical diboron compounds. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/71393

Chicago Manual of Style (16th Edition):

Guo, Xi. “The development and applications of unsymmetrical diboron compounds.” 2014. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/71393.

MLA Handbook (7th Edition):

Guo, Xi. “The development and applications of unsymmetrical diboron compounds.” 2014. Web. 20 Feb 2020.

Vancouver:

Guo X. The development and applications of unsymmetrical diboron compounds. [Internet] [Doctoral dissertation]. Virginia Tech; 2014. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/71393.

Council of Science Editors:

Guo X. The development and applications of unsymmetrical diboron compounds. [Doctoral Dissertation]. Virginia Tech; 2014. Available from: http://hdl.handle.net/10919/71393


Virginia Tech

10. Thorpe, Steven Brandon. Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds.

Degree: PhD, Chemistry, 2012, Virginia Tech

 The first successful synthesis and isolation of a boronic acid was reported in 1860 by Frankland in the pursuit of novel organometallic compounds. For more… (more)

Subjects/Keywords: borylation; diboron reagent; boronic ester; conjugate addition; copper catalysis

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APA (6th Edition):

Thorpe, S. B. (2012). Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/26669

Chicago Manual of Style (16th Edition):

Thorpe, Steven Brandon. “Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds.” 2012. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/26669.

MLA Handbook (7th Edition):

Thorpe, Steven Brandon. “Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds.” 2012. Web. 20 Feb 2020.

Vancouver:

Thorpe SB. Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/26669.

Council of Science Editors:

Thorpe SB. Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/26669


Virginia Tech

11. Zhang, Wenyu. Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation.

Degree: PhD, Chemistry, 2014, Virginia Tech

 RNAs have gained significant attention in recent years because they can fold into well-defined secondary or tertiary structures. These three dimensional architectures provide interfaces for… (more)

Subjects/Keywords: HIV-1; TAR RNA; RRE RNA; Branched Peptide Library; High-throughput Screening; Branched Peptide Boronic Acids; Acridine Branched Peptides; Unnatural Amino Acids

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APA (6th Edition):

Zhang, W. (2014). Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/56731

Chicago Manual of Style (16th Edition):

Zhang, Wenyu. “Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation.” 2014. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/56731.

MLA Handbook (7th Edition):

Zhang, Wenyu. “Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation.” 2014. Web. 20 Feb 2020.

Vancouver:

Zhang W. Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation. [Internet] [Doctoral dissertation]. Virginia Tech; 2014. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/56731.

Council of Science Editors:

Zhang W. Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation. [Doctoral Dissertation]. Virginia Tech; 2014. Available from: http://hdl.handle.net/10919/56731

12. Childress, Elizabeth Saunders. Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers.

Degree: PhD, Chemistry, 2017, Virginia Tech

 Sphingosine 1-phosphate (S1P) is a cellular signaling molecule that has been implicated in a variety of diseases including cancer, fibrosis, Alzheimer's, and sickle cell disease.… (more)

Subjects/Keywords: Structure-Activity Relationship; Sphingosine Kinase; Sphingosine 1-Phosphate; Mitochondrial Uncoupler; Protonophore; Oxygen Consumption Rate

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APA (6th Edition):

Childress, E. S. (2017). Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/86662

Chicago Manual of Style (16th Edition):

Childress, Elizabeth Saunders. “Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers.” 2017. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/86662.

MLA Handbook (7th Edition):

Childress, Elizabeth Saunders. “Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers.” 2017. Web. 20 Feb 2020.

Vancouver:

Childress ES. Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers. [Internet] [Doctoral dissertation]. Virginia Tech; 2017. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/86662.

Council of Science Editors:

Childress ES. Structure-Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers. [Doctoral Dissertation]. Virginia Tech; 2017. Available from: http://hdl.handle.net/10919/86662

13. Snead, Russell Franklin. Development of Novel, Regioselective Borylation Protocols.

Degree: PhD, Chemistry, 2018, Virginia Tech

 Organoboron compounds are highly valued synthetic intermediates due to their diverse array of reactivity, which is often utilized in the synthesis of valuable organic molecules.… (more)

Subjects/Keywords: borylation; transition metal-catalyzed; transition metal-free; allenes; alkynamides

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APA (6th Edition):

Snead, R. F. (2018). Development of Novel, Regioselective Borylation Protocols. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/85003

Chicago Manual of Style (16th Edition):

Snead, Russell Franklin. “Development of Novel, Regioselective Borylation Protocols.” 2018. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/85003.

MLA Handbook (7th Edition):

Snead, Russell Franklin. “Development of Novel, Regioselective Borylation Protocols.” 2018. Web. 20 Feb 2020.

Vancouver:

Snead RF. Development of Novel, Regioselective Borylation Protocols. [Internet] [Doctoral dissertation]. Virginia Tech; 2018. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/85003.

Council of Science Editors:

Snead RF. Development of Novel, Regioselective Borylation Protocols. [Doctoral Dissertation]. Virginia Tech; 2018. Available from: http://hdl.handle.net/10919/85003


Virginia Tech

14. Patwardhan, Neeraj Narendra. Study of Synthesis, Reactions and Enantiomerization of Cα-Chiral Grignard Reagents.

Degree: PhD, Chemistry, 2012, Virginia Tech

 The development of chiral organometallics for asymmetric synthesis is a topic of significant research in the recent past. The most studied in this class are… (more)

Subjects/Keywords: enantiomerization; kinetics; chiral Grignard reagents; solvent effects; reaction order; ion-pair separation; entropy of activation; electrostriction; DFT calculations

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APA (6th Edition):

Patwardhan, N. N. (2012). Study of Synthesis, Reactions and Enantiomerization of Cα-Chiral Grignard Reagents. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/37814

Chicago Manual of Style (16th Edition):

Patwardhan, Neeraj Narendra. “Study of Synthesis, Reactions and Enantiomerization of Cα-Chiral Grignard Reagents.” 2012. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/37814.

MLA Handbook (7th Edition):

Patwardhan, Neeraj Narendra. “Study of Synthesis, Reactions and Enantiomerization of Cα-Chiral Grignard Reagents.” 2012. Web. 20 Feb 2020.

Vancouver:

Patwardhan NN. Study of Synthesis, Reactions and Enantiomerization of Cα-Chiral Grignard Reagents. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/37814.

Council of Science Editors:

Patwardhan NN. Study of Synthesis, Reactions and Enantiomerization of Cα-Chiral Grignard Reagents. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/37814


Virginia Tech

15. Wynn, Jessica Elaine. Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials.

Degree: PhD, Chemistry, 2016, Virginia Tech

 The interaction of the protein Rev with Rev Response Element (RRE) RNA is critical to the HIV-1 life cycle as this complex is required for… (more)

Subjects/Keywords: HIV-1 RRE RNA; Branched Peptide Library; Boron-Acridine; Antimicrobial Peptides; Unnatural Amino Acids

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APA (6th Edition):

Wynn, J. E. (2016). Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/82227

Chicago Manual of Style (16th Edition):

Wynn, Jessica Elaine. “Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials.” 2016. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/82227.

MLA Handbook (7th Edition):

Wynn, Jessica Elaine. “Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials.” 2016. Web. 20 Feb 2020.

Vancouver:

Wynn JE. Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials. [Internet] [Doctoral dissertation]. Virginia Tech; 2016. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/82227.

Council of Science Editors:

Wynn JE. Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials. [Doctoral Dissertation]. Virginia Tech; 2016. Available from: http://hdl.handle.net/10919/82227

16. Peck, Cheryl Lynne. Development of Transition Metal-Catalyzed Borylation Protocols using Symmetrical and Unsymmetrical Diboron Reagents.

Degree: PhD, Chemistry, 2017, Virginia Tech

 The versatility of organoboron compounds has been demonstrated by their use as synthetic intermediates and more recently in therapeutic applications since the FDA approval of… (more)

Subjects/Keywords: borylation; transition metal-catalyzed; conjugate addition; alkynes; diboron reagents

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APA (6th Edition):

Peck, C. L. (2017). Development of Transition Metal-Catalyzed Borylation Protocols using Symmetrical and Unsymmetrical Diboron Reagents. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/80343

Chicago Manual of Style (16th Edition):

Peck, Cheryl Lynne. “Development of Transition Metal-Catalyzed Borylation Protocols using Symmetrical and Unsymmetrical Diboron Reagents.” 2017. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/80343.

MLA Handbook (7th Edition):

Peck, Cheryl Lynne. “Development of Transition Metal-Catalyzed Borylation Protocols using Symmetrical and Unsymmetrical Diboron Reagents.” 2017. Web. 20 Feb 2020.

Vancouver:

Peck CL. Development of Transition Metal-Catalyzed Borylation Protocols using Symmetrical and Unsymmetrical Diboron Reagents. [Internet] [Doctoral dissertation]. Virginia Tech; 2017. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/80343.

Council of Science Editors:

Peck CL. Development of Transition Metal-Catalyzed Borylation Protocols using Symmetrical and Unsymmetrical Diboron Reagents. [Doctoral Dissertation]. Virginia Tech; 2017. Available from: http://hdl.handle.net/10919/80343


Virginia Tech

17. Sun, Furong. Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry.

Degree: PhD, Chemistry, 2012, Virginia Tech

 Oomycetes, such as Phytophthora sojae, are plant pathogens that employ protein effectors that enter host cells to facilitate infection. Plants may overcome infection by recognizing… (more)

Subjects/Keywords: Phytophthora sojae; Protein-lipid interactions; Phosphatidylinositol 3-phosphate; Avirulence homolog-5

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APA (6th Edition):

Sun, F. (2012). Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/37657

Chicago Manual of Style (16th Edition):

Sun, Furong. “Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry.” 2012. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/37657.

MLA Handbook (7th Edition):

Sun, Furong. “Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry.” 2012. Web. 20 Feb 2020.

Vancouver:

Sun F. Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/37657.

Council of Science Editors:

Sun F. Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/37657


Virginia Tech

18. Monceaux, Christopher Jon. Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides.

Degree: PhD, Chemistry, 2010, Virginia Tech

 In the scope of our BACE1 inhibitor project we used an originally designed microtiter plate-based screening to discover 4 triazole-linked reduced amide isosteres that showed… (more)

Subjects/Keywords: Fürst-Plattner (trans diaxial effect); epoxidation; epoxide opening; click-chemistry; diazotransfer; microtiter plate-based screening; reduced amide BACE1 inhibitors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Monceaux, C. J. (2010). Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/30221

Chicago Manual of Style (16th Edition):

Monceaux, Christopher Jon. “Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides.” 2010. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/30221.

MLA Handbook (7th Edition):

Monceaux, Christopher Jon. “Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides.” 2010. Web. 20 Feb 2020.

Vancouver:

Monceaux CJ. Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides. [Internet] [Doctoral dissertation]. Virginia Tech; 2010. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/30221.

Council of Science Editors:

Monceaux CJ. Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides. [Doctoral Dissertation]. Virginia Tech; 2010. Available from: http://hdl.handle.net/10919/30221


Virginia Tech

19. Maisuria, Bhadreshkumar B. Synthesis, Characterization, Critical Micelle Concentration and Antimicrobial Activity of Two-headed Amphiphiles.

Degree: MS, Chemistry, 2009, Virginia Tech

 This project is about the synthesis of homologous series of two-headed, long-chain amphiphiles (the 2CCbn series, where n = 16, 18, 20, 22, 30, 5α-cholestan-3Ã… (more)

Subjects/Keywords: homologous; two-headed; di-carboxylato; amphiphile; critical micelle concentration; minimal inhibitory concentration; S. aureus; MRSA

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APA (6th Edition):

Maisuria, B. B. (2009). Synthesis, Characterization, Critical Micelle Concentration and Antimicrobial Activity of Two-headed Amphiphiles. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/34607

Chicago Manual of Style (16th Edition):

Maisuria, Bhadreshkumar B. “Synthesis, Characterization, Critical Micelle Concentration and Antimicrobial Activity of Two-headed Amphiphiles.” 2009. Masters Thesis, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/34607.

MLA Handbook (7th Edition):

Maisuria, Bhadreshkumar B. “Synthesis, Characterization, Critical Micelle Concentration and Antimicrobial Activity of Two-headed Amphiphiles.” 2009. Web. 20 Feb 2020.

Vancouver:

Maisuria BB. Synthesis, Characterization, Critical Micelle Concentration and Antimicrobial Activity of Two-headed Amphiphiles. [Internet] [Masters thesis]. Virginia Tech; 2009. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/34607.

Council of Science Editors:

Maisuria BB. Synthesis, Characterization, Critical Micelle Concentration and Antimicrobial Activity of Two-headed Amphiphiles. [Masters Thesis]. Virginia Tech; 2009. Available from: http://hdl.handle.net/10919/34607


Virginia Tech

20. Perfetti, Michael Thomas. Diastereoselective α-Alkylation of Chiral β-Borylated Esters.

Degree: MS, Chemistry, 2009, Virginia Tech

 The use of boron in the synthesis and development of asymmetric methodologies and various biological and medicinal compounds has increased significantly over the last decade.… (more)

Subjects/Keywords: Diastereoselective α-alkylation; syn selective; 11B NMR; boron-"ate"; β-boronic ester

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Perfetti, M. T. (2009). Diastereoselective α-Alkylation of Chiral β-Borylated Esters. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/30820

Chicago Manual of Style (16th Edition):

Perfetti, Michael Thomas. “Diastereoselective α-Alkylation of Chiral β-Borylated Esters.” 2009. Masters Thesis, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/30820.

MLA Handbook (7th Edition):

Perfetti, Michael Thomas. “Diastereoselective α-Alkylation of Chiral β-Borylated Esters.” 2009. Web. 20 Feb 2020.

Vancouver:

Perfetti MT. Diastereoselective α-Alkylation of Chiral β-Borylated Esters. [Internet] [Masters thesis]. Virginia Tech; 2009. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/30820.

Council of Science Editors:

Perfetti MT. Diastereoselective α-Alkylation of Chiral β-Borylated Esters. [Masters Thesis]. Virginia Tech; 2009. Available from: http://hdl.handle.net/10919/30820


Virginia Tech

21. Hou, Yanpeng. Antiproliferative Natural Products from the Madagascar Rainforest.

Degree: PhD, Chemistry, 2009, Virginia Tech

 As part of an International Cooperative Biodiversity Groups (ICBG) program and a continuing search for anticancer natural products from the Madagascar rainforest, twenty extracts from… (more)

Subjects/Keywords: Chemistry; Natural Products; Biodiversity; Antiproliferative

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hou, Y. (2009). Antiproliferative Natural Products from the Madagascar Rainforest. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/39467

Chicago Manual of Style (16th Edition):

Hou, Yanpeng. “Antiproliferative Natural Products from the Madagascar Rainforest.” 2009. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/39467.

MLA Handbook (7th Edition):

Hou, Yanpeng. “Antiproliferative Natural Products from the Madagascar Rainforest.” 2009. Web. 20 Feb 2020.

Vancouver:

Hou Y. Antiproliferative Natural Products from the Madagascar Rainforest. [Internet] [Doctoral dissertation]. Virginia Tech; 2009. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/39467.

Council of Science Editors:

Hou Y. Antiproliferative Natural Products from the Madagascar Rainforest. [Doctoral Dissertation]. Virginia Tech; 2009. Available from: http://hdl.handle.net/10919/39467


Virginia Tech

22. Dai, Nan. I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics.

Degree: PhD, Chemistry, 2008, Virginia Tech

 Collagen is one of the most important and abundant proteins in mammals. It consists of three left-handed PPII helixes coiled along a common axis to… (more)

Subjects/Keywords: helicity; HTH-turn mimic.; conformationally locked isostere; polypeptides; triple helix; stability; collagen; helix-turn-helix

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Dai, N. (2008). I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/28411

Chicago Manual of Style (16th Edition):

Dai, Nan. “I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics.” 2008. Doctoral Dissertation, Virginia Tech. Accessed February 20, 2020. http://hdl.handle.net/10919/28411.

MLA Handbook (7th Edition):

Dai, Nan. “I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics.” 2008. Web. 20 Feb 2020.

Vancouver:

Dai N. I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics. [Internet] [Doctoral dissertation]. Virginia Tech; 2008. [cited 2020 Feb 20]. Available from: http://hdl.handle.net/10919/28411.

Council of Science Editors:

Dai N. I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics. [Doctoral Dissertation]. Virginia Tech; 2008. Available from: http://hdl.handle.net/10919/28411

.