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You searched for +publisher:"Virginia Tech" +contributor:("Etzkorn, Felicia A."). Showing records 1 – 30 of 35 total matches.

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Virginia Tech

1. Melin, Vanessa Estella. Neural tube defects in rodents caused by a tap water contaminant.

Degree: MS, Biomedical and Veterinary Sciences, 2011, Virginia Tech

 In May of 2006, the Hrubec group suddenly began to observe neural tube defects (NTDs) in embryos of untreated control mice. Unintentional exposure to a… (more)

Subjects/Keywords: tap water; neural tube defects

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APA (6th Edition):

Melin, V. E. (2011). Neural tube defects in rodents caused by a tap water contaminant. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/76879

Chicago Manual of Style (16th Edition):

Melin, Vanessa Estella. “Neural tube defects in rodents caused by a tap water contaminant.” 2011. Masters Thesis, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/76879.

MLA Handbook (7th Edition):

Melin, Vanessa Estella. “Neural tube defects in rodents caused by a tap water contaminant.” 2011. Web. 16 Sep 2019.

Vancouver:

Melin VE. Neural tube defects in rodents caused by a tap water contaminant. [Internet] [Masters thesis]. Virginia Tech; 2011. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/76879.

Council of Science Editors:

Melin VE. Neural tube defects in rodents caused by a tap water contaminant. [Masters Thesis]. Virginia Tech; 2011. Available from: http://hdl.handle.net/10919/76879


Virginia Tech

2. Congdon, Molly D. Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors.

Degree: PhD, Chemistry, 2016, Virginia Tech

 A variety of diseases including Alzheimer's disease, asthma, cancer, fibrosis, multiple sclerosis, and sickle cell disease have been associated with elevated levels of sphingosine-1-phosphate (S1P).… (more)

Subjects/Keywords: sphingosine; sphingosine kinase; sphingosine-1-phosphate; structure-activity relationship; molecular docking

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APA (6th Edition):

Congdon, M. D. (2016). Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/82129

Chicago Manual of Style (16th Edition):

Congdon, Molly D. “Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors.” 2016. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/82129.

MLA Handbook (7th Edition):

Congdon, Molly D. “Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors.” 2016. Web. 16 Sep 2019.

Vancouver:

Congdon MD. Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors. [Internet] [Doctoral dissertation]. Virginia Tech; 2016. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/82129.

Council of Science Editors:

Congdon MD. Structure Activity Relationship Studies on Isoform Selective Sphingosine Kinase Inhibitors. [Doctoral Dissertation]. Virginia Tech; 2016. Available from: http://hdl.handle.net/10919/82129


Virginia Tech

3. Wynn, Jessica Elaine. Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials.

Degree: PhD, Chemistry, 2016, Virginia Tech

 The interaction of the protein Rev with Rev Response Element (RRE) RNA is critical to the HIV-1 life cycle as this complex is required for… (more)

Subjects/Keywords: HIV-1 RRE RNA; Branched Peptide Library; Boron-Acridine; Antimicrobial Peptides; Unnatural Amino Acids

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APA (6th Edition):

Wynn, J. E. (2016). Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/82227

Chicago Manual of Style (16th Edition):

Wynn, Jessica Elaine. “Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials.” 2016. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/82227.

MLA Handbook (7th Edition):

Wynn, Jessica Elaine. “Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials.” 2016. Web. 16 Sep 2019.

Vancouver:

Wynn JE. Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials. [Internet] [Doctoral dissertation]. Virginia Tech; 2016. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/82227.

Council of Science Editors:

Wynn JE. Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials. [Doctoral Dissertation]. Virginia Tech; 2016. Available from: http://hdl.handle.net/10919/82227


Virginia Tech

4. Kwansa, Albert Lawrence. Molecular Dynamics and Mechanical Behavior of Collagen Type I and its Lysine/Hydroxylysine-derived Crosslinks.

Degree: PhD, Biomedical Engineering, 2013, Virginia Tech

 Collagen type I is an extracellular matrix (ECM) protein that affords tensile strength and biological scaffolding to numerous vertebrate and invertebrate tissues. This strength has… (more)

Subjects/Keywords: Fibril-forming; Fibrillar; Cross-link; Strain Energy; Elastic Modulus

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APA (6th Edition):

Kwansa, A. L. (2013). Molecular Dynamics and Mechanical Behavior of Collagen Type I and its Lysine/Hydroxylysine-derived Crosslinks. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/50933

Chicago Manual of Style (16th Edition):

Kwansa, Albert Lawrence. “Molecular Dynamics and Mechanical Behavior of Collagen Type I and its Lysine/Hydroxylysine-derived Crosslinks.” 2013. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/50933.

MLA Handbook (7th Edition):

Kwansa, Albert Lawrence. “Molecular Dynamics and Mechanical Behavior of Collagen Type I and its Lysine/Hydroxylysine-derived Crosslinks.” 2013. Web. 16 Sep 2019.

Vancouver:

Kwansa AL. Molecular Dynamics and Mechanical Behavior of Collagen Type I and its Lysine/Hydroxylysine-derived Crosslinks. [Internet] [Doctoral dissertation]. Virginia Tech; 2013. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/50933.

Council of Science Editors:

Kwansa AL. Molecular Dynamics and Mechanical Behavior of Collagen Type I and its Lysine/Hydroxylysine-derived Crosslinks. [Doctoral Dissertation]. Virginia Tech; 2013. Available from: http://hdl.handle.net/10919/50933


Virginia Tech

5. Raje, Mithun. Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors.

Degree: PhD, Chemistry, 2012, Virginia Tech

 Sphingosine kinase (SphK) has emerged as an attractive target for cancer therapeutics due to its role in cell proliferation. SphK phosphorylates sphingosine to form sphingosine-1-phosphate… (more)

Subjects/Keywords: reductive amination; structure-activity relationships; guanidine inhibitors; sphingosine-1-phosphate; sphingosine kinase inhibitors

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APA (6th Edition):

Raje, M. (2012). Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77051

Chicago Manual of Style (16th Edition):

Raje, Mithun. “Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors.” 2012. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/77051.

MLA Handbook (7th Edition):

Raje, Mithun. “Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors.” 2012. Web. 16 Sep 2019.

Vancouver:

Raje M. Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/77051.

Council of Science Editors:

Raje M. Design, synthesis, and biological evaluation of selective sphingosine kinase inhibitors. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/77051


Virginia Tech

6. Crumpton, Jason. Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids.

Degree: PhD, Chemistry, 2012, Virginia Tech

 The utilization of click chemistry to perform inter- and intramolecular ligation on DNA has become ubiquitous in the literature. Advances in copper (I) stabilizing ligands… (more)

Subjects/Keywords: click chemistry; DNA; matrix; peptide sequencing; MALDI-MS

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APA (6th Edition):

Crumpton, J. (2012). Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77076

Chicago Manual of Style (16th Edition):

Crumpton, Jason. “Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids.” 2012. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/77076.

MLA Handbook (7th Edition):

Crumpton, Jason. “Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids.” 2012. Web. 16 Sep 2019.

Vancouver:

Crumpton J. Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/77076.

Council of Science Editors:

Crumpton J. Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/77076


Virginia Tech

7. Mercedes-Camacho, Ana Yokayra. Pin1: WW domain ligands, catalytic inhibitors, and the mechanism.

Degree: PhD, Biochemistry, 2011, Virginia Tech

 The peptidyl prolyl cis/trans isomerase, PPIase, has been the focus of numerous studies in the field of cell cycle regulation since proline-directed phosphorylation is an… (more)

Subjects/Keywords: PPIases; Pin1 inhibitors; WW domain ligands; and KIE; c-Myc; ELEBA

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APA (6th Edition):

Mercedes-Camacho, A. Y. (2011). Pin1: WW domain ligands, catalytic inhibitors, and the mechanism. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77093

Chicago Manual of Style (16th Edition):

Mercedes-Camacho, Ana Yokayra. “Pin1: WW domain ligands, catalytic inhibitors, and the mechanism.” 2011. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/77093.

MLA Handbook (7th Edition):

Mercedes-Camacho, Ana Yokayra. “Pin1: WW domain ligands, catalytic inhibitors, and the mechanism.” 2011. Web. 16 Sep 2019.

Vancouver:

Mercedes-Camacho AY. Pin1: WW domain ligands, catalytic inhibitors, and the mechanism. [Internet] [Doctoral dissertation]. Virginia Tech; 2011. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/77093.

Council of Science Editors:

Mercedes-Camacho AY. Pin1: WW domain ligands, catalytic inhibitors, and the mechanism. [Doctoral Dissertation]. Virginia Tech; 2011. Available from: http://hdl.handle.net/10919/77093


Virginia Tech

8. Bryson, David Irby. Targeting RNA Structures with Multivalent Branched Peptide Libraries.

Degree: PhD, Chemistry, 2012, Virginia Tech

 RNA is essential for the transfer of genetic information, as the central dogma of biology dictates. The role of RNA, however, is not limited to… (more)

Subjects/Keywords: High Throughput Screening; Combinatorial Libraries; Branched Peptides; Multivalency; Cell Permeable Peptides; and Boron; RNA; HIV-1; Medium-Sized Ligands

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APA (6th Edition):

Bryson, D. I. (2012). Targeting RNA Structures with Multivalent Branched Peptide Libraries. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77327

Chicago Manual of Style (16th Edition):

Bryson, David Irby. “Targeting RNA Structures with Multivalent Branched Peptide Libraries.” 2012. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/77327.

MLA Handbook (7th Edition):

Bryson, David Irby. “Targeting RNA Structures with Multivalent Branched Peptide Libraries.” 2012. Web. 16 Sep 2019.

Vancouver:

Bryson DI. Targeting RNA Structures with Multivalent Branched Peptide Libraries. [Internet] [Doctoral dissertation]. Virginia Tech; 2012. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/77327.

Council of Science Editors:

Bryson DI. Targeting RNA Structures with Multivalent Branched Peptide Libraries. [Doctoral Dissertation]. Virginia Tech; 2012. Available from: http://hdl.handle.net/10919/77327


Virginia Tech

9. Deora, Nipa. Computational Studies of Protonated Cyclic Ethers and Benzylic Organolithium Compounds.

Degree: PhD, Chemistry, 2010, Virginia Tech

 Protonated epoxides feature prominently in organic chemistry as reactive intermediates. Gas-phase calculations studying the structure and ring-opening energetics of protonated ethylene oxide, propylene oxide and… (more)

Subjects/Keywords: potential-energy surface; basis-set; epoxide; liga

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APA (6th Edition):

Deora, N. (2010). Computational Studies of Protonated Cyclic Ethers and Benzylic Organolithium Compounds. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/27800

Chicago Manual of Style (16th Edition):

Deora, Nipa. “Computational Studies of Protonated Cyclic Ethers and Benzylic Organolithium Compounds.” 2010. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/27800.

MLA Handbook (7th Edition):

Deora, Nipa. “Computational Studies of Protonated Cyclic Ethers and Benzylic Organolithium Compounds.” 2010. Web. 16 Sep 2019.

Vancouver:

Deora N. Computational Studies of Protonated Cyclic Ethers and Benzylic Organolithium Compounds. [Internet] [Doctoral dissertation]. Virginia Tech; 2010. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/27800.

Council of Science Editors:

Deora N. Computational Studies of Protonated Cyclic Ethers and Benzylic Organolithium Compounds. [Doctoral Dissertation]. Virginia Tech; 2010. Available from: http://hdl.handle.net/10919/27800


Virginia Tech

10. Roth, Kristina Lynn. Development of Metal-based Nanomaterials for Biomedical Applications.

Degree: PhD, Chemistry, 2017, Virginia Tech

 New synthetic advances in the control of nanoparticle size and shape along with the development of new surface modifications facilitates the growing use of nanomaterials… (more)

Subjects/Keywords: gold nanoparticle; biomineralization; metal organic framework; external stimuli; drug delivery

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APA (6th Edition):

Roth, K. L. (2017). Development of Metal-based Nanomaterials for Biomedical Applications. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/85365

Chicago Manual of Style (16th Edition):

Roth, Kristina Lynn. “Development of Metal-based Nanomaterials for Biomedical Applications.” 2017. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/85365.

MLA Handbook (7th Edition):

Roth, Kristina Lynn. “Development of Metal-based Nanomaterials for Biomedical Applications.” 2017. Web. 16 Sep 2019.

Vancouver:

Roth KL. Development of Metal-based Nanomaterials for Biomedical Applications. [Internet] [Doctoral dissertation]. Virginia Tech; 2017. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/85365.

Council of Science Editors:

Roth KL. Development of Metal-based Nanomaterials for Biomedical Applications. [Doctoral Dissertation]. Virginia Tech; 2017. Available from: http://hdl.handle.net/10919/85365


Virginia Tech

11. Guo, Xi. The development and applications of unsymmetrical diboron compounds.

Degree: PhD, Chemistry, 2014, Virginia Tech

 Organoboron compounds have shown a wide variety of applications in both organic synthesis and the pharmaceutical field in the past decades. Transition metal-catalyzed boration of… (more)

Subjects/Keywords: diboron compounds; conjugate addition; diboration; o-nitrobenzyl ligands

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APA (6th Edition):

Guo, X. (2014). The development and applications of unsymmetrical diboron compounds. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/71393

Chicago Manual of Style (16th Edition):

Guo, Xi. “The development and applications of unsymmetrical diboron compounds.” 2014. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/71393.

MLA Handbook (7th Edition):

Guo, Xi. “The development and applications of unsymmetrical diboron compounds.” 2014. Web. 16 Sep 2019.

Vancouver:

Guo X. The development and applications of unsymmetrical diboron compounds. [Internet] [Doctoral dissertation]. Virginia Tech; 2014. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/71393.

Council of Science Editors:

Guo X. The development and applications of unsymmetrical diboron compounds. [Doctoral Dissertation]. Virginia Tech; 2014. Available from: http://hdl.handle.net/10919/71393

12. Richoux Jr, Gary Michael. Enantioselective Synthesis of Drug-like Molecules via Axially-Chiral Intermediates.

Degree: PhD, Chemistry, 2016, Virginia Tech

 The self-regeneration of stereocenters via stereolabile axially-chiral intermediates (SRSvSACI) is a synthetic strategy in which the configuration of a starting material, possessing only a single… (more)

Subjects/Keywords: Memory of Chirality; benzodiazepine; rearrangement; SRSvSACI

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APA (6th Edition):

Richoux Jr, G. M. (2016). Enantioselective Synthesis of Drug-like Molecules via Axially-Chiral Intermediates. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/71675

Chicago Manual of Style (16th Edition):

Richoux Jr, Gary Michael. “Enantioselective Synthesis of Drug-like Molecules via Axially-Chiral Intermediates.” 2016. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/71675.

MLA Handbook (7th Edition):

Richoux Jr, Gary Michael. “Enantioselective Synthesis of Drug-like Molecules via Axially-Chiral Intermediates.” 2016. Web. 16 Sep 2019.

Vancouver:

Richoux Jr GM. Enantioselective Synthesis of Drug-like Molecules via Axially-Chiral Intermediates. [Internet] [Doctoral dissertation]. Virginia Tech; 2016. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/71675.

Council of Science Editors:

Richoux Jr GM. Enantioselective Synthesis of Drug-like Molecules via Axially-Chiral Intermediates. [Doctoral Dissertation]. Virginia Tech; 2016. Available from: http://hdl.handle.net/10919/71675

13. Camerino, Eugene. Fluoromethyl ketone prodrugs: Potential new insecticides towards Anopheles gambiae.

Degree: PhD, Chemistry, 2015, Virginia Tech

 Malaria continues to cause significant mortality in sub-Saharan Africa and elsewhere, and existing vector control measures are being threatened by growing resistance to pyrethroid insecticides.… (more)

Subjects/Keywords: Acetylcholinesterase; trifluoromethyl ketones; difluoromethyl ketones; fluoromethyl ketones; Anopheles gambiae; insecticide treated nets; malaria; pyrazoles; propoxur; insecticide resistance; oxime; oxime ether

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APA (6th Edition):

Camerino, E. (2015). Fluoromethyl ketone prodrugs: Potential new insecticides towards Anopheles gambiae. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/73771

Chicago Manual of Style (16th Edition):

Camerino, Eugene. “Fluoromethyl ketone prodrugs: Potential new insecticides towards Anopheles gambiae.” 2015. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/73771.

MLA Handbook (7th Edition):

Camerino, Eugene. “Fluoromethyl ketone prodrugs: Potential new insecticides towards Anopheles gambiae.” 2015. Web. 16 Sep 2019.

Vancouver:

Camerino E. Fluoromethyl ketone prodrugs: Potential new insecticides towards Anopheles gambiae. [Internet] [Doctoral dissertation]. Virginia Tech; 2015. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/73771.

Council of Science Editors:

Camerino E. Fluoromethyl ketone prodrugs: Potential new insecticides towards Anopheles gambiae. [Doctoral Dissertation]. Virginia Tech; 2015. Available from: http://hdl.handle.net/10919/73771


Virginia Tech

14. Parker, Rachael N. Protein Engineering for Biomedical Materials.

Degree: PhD, Chemistry, 2017, Virginia Tech

 The inherent design freedom of protein engineering and recombinant protein production enables specific tailoring of protein structure, function, and properties. Two areas of research where… (more)

Subjects/Keywords: Protein engineering; biomaterials; leucine-rich repeat; keratin

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APA (6th Edition):

Parker, R. N. (2017). Protein Engineering for Biomedical Materials. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77416

Chicago Manual of Style (16th Edition):

Parker, Rachael N. “Protein Engineering for Biomedical Materials.” 2017. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/77416.

MLA Handbook (7th Edition):

Parker, Rachael N. “Protein Engineering for Biomedical Materials.” 2017. Web. 16 Sep 2019.

Vancouver:

Parker RN. Protein Engineering for Biomedical Materials. [Internet] [Doctoral dissertation]. Virginia Tech; 2017. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/77416.

Council of Science Editors:

Parker RN. Protein Engineering for Biomedical Materials. [Doctoral Dissertation]. Virginia Tech; 2017. Available from: http://hdl.handle.net/10919/77416


Virginia Tech

15. McCord, Jennifer Phipps. Protein Engineering for Biomedicine and Beyond.

Degree: PhD, Chemistry, 2019, Virginia Tech

 Many applications in biomedicine, research, and industry require recognition agents with specificity and selectivity for their target. Protein engineering enables the design of scaffolds that… (more)

Subjects/Keywords: protein engineering; consensus design; repeat proteins; cellulose binding module; keratin

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APA (6th Edition):

McCord, J. P. (2019). Protein Engineering for Biomedicine and Beyond. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/90787

Chicago Manual of Style (16th Edition):

McCord, Jennifer Phipps. “Protein Engineering for Biomedicine and Beyond.” 2019. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/90787.

MLA Handbook (7th Edition):

McCord, Jennifer Phipps. “Protein Engineering for Biomedicine and Beyond.” 2019. Web. 16 Sep 2019.

Vancouver:

McCord JP. Protein Engineering for Biomedicine and Beyond. [Internet] [Doctoral dissertation]. Virginia Tech; 2019. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/90787.

Council of Science Editors:

McCord JP. Protein Engineering for Biomedicine and Beyond. [Doctoral Dissertation]. Virginia Tech; 2019. Available from: http://hdl.handle.net/10919/90787


Virginia Tech

16. Monceaux, Christopher Jon. Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides.

Degree: PhD, Chemistry, 2010, Virginia Tech

 In the scope of our BACE1 inhibitor project we used an originally designed microtiter plate-based screening to discover 4 triazole-linked reduced amide isosteres that showed… (more)

Subjects/Keywords: Fürst-Plattner (trans diaxial effect); epoxidation; epoxide opening; click-chemistry; diazotransfer; microtiter plate-based screening; reduced amide BACE1 inhibitors

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APA (6th Edition):

Monceaux, C. J. (2010). Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/30221

Chicago Manual of Style (16th Edition):

Monceaux, Christopher Jon. “Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides.” 2010. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/30221.

MLA Handbook (7th Edition):

Monceaux, Christopher Jon. “Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides.” 2010. Web. 16 Sep 2019.

Vancouver:

Monceaux CJ. Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides. [Internet] [Doctoral dissertation]. Virginia Tech; 2010. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/30221.

Council of Science Editors:

Monceaux CJ. Triazole-linked reduced amide isosteres: An approach for the fragment-based drug discovery of anti-Alzheimer's BACE1 inhibitors and NH-assisted Fürst-Plattner opening of cyclohexene oxides. [Doctoral Dissertation]. Virginia Tech; 2010. Available from: http://hdl.handle.net/10919/30221


Virginia Tech

17. Hartsel, Joshua Alan. Revisiting aryl N-methylcarbamate acetylcholinesterase inhibitors as potential insecticides to combat the malaria-transmitting mosquito, Anopheles gambiae.

Degree: PhD, Chemistry, 2011, Virginia Tech

 My graduate work focused on the syntheses and pharmacology of species-selective aryl methylcarbamate acetylcholinesterase inhibitors to combat the malaria-transmitting mosquito, Anopheles gambiae. We identified six… (more)

Subjects/Keywords: Anopheles gambiae; acetylcholinesterase; aryl carbamate; insecticide-treated nets; malaria; propoxur; species-selective inhibitors; terbam; tert-alkylphenol

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APA (6th Edition):

Hartsel, J. A. (2011). Revisiting aryl N-methylcarbamate acetylcholinesterase inhibitors as potential insecticides to combat the malaria-transmitting mosquito, Anopheles gambiae. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/73002

Chicago Manual of Style (16th Edition):

Hartsel, Joshua Alan. “Revisiting aryl N-methylcarbamate acetylcholinesterase inhibitors as potential insecticides to combat the malaria-transmitting mosquito, Anopheles gambiae.” 2011. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/73002.

MLA Handbook (7th Edition):

Hartsel, Joshua Alan. “Revisiting aryl N-methylcarbamate acetylcholinesterase inhibitors as potential insecticides to combat the malaria-transmitting mosquito, Anopheles gambiae.” 2011. Web. 16 Sep 2019.

Vancouver:

Hartsel JA. Revisiting aryl N-methylcarbamate acetylcholinesterase inhibitors as potential insecticides to combat the malaria-transmitting mosquito, Anopheles gambiae. [Internet] [Doctoral dissertation]. Virginia Tech; 2011. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/73002.

Council of Science Editors:

Hartsel JA. Revisiting aryl N-methylcarbamate acetylcholinesterase inhibitors as potential insecticides to combat the malaria-transmitting mosquito, Anopheles gambiae. [Doctoral Dissertation]. Virginia Tech; 2011. Available from: http://hdl.handle.net/10919/73002


Virginia Tech

18. Zhao, Jielu. Design, Syntheses and Biological Activities of Paclitaxel Analogs.

Degree: PhD, Chemistry, 2011, Virginia Tech

 The conformation of paclitaxel in the bound state on the protein has been proposed to be the T-taxol conformation, and paclitaxel analogs constrained to the… (more)

Subjects/Keywords: T-taxol; tubulin; bioactive conformation; microtubules; thiolated paclitaxel; gold nanoparticles; conformationally constrained paclitaxel; simplified paclitaxel

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APA (6th Edition):

Zhao, J. (2011). Design, Syntheses and Biological Activities of Paclitaxel Analogs. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77272

Chicago Manual of Style (16th Edition):

Zhao, Jielu. “Design, Syntheses and Biological Activities of Paclitaxel Analogs.” 2011. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/77272.

MLA Handbook (7th Edition):

Zhao, Jielu. “Design, Syntheses and Biological Activities of Paclitaxel Analogs.” 2011. Web. 16 Sep 2019.

Vancouver:

Zhao J. Design, Syntheses and Biological Activities of Paclitaxel Analogs. [Internet] [Doctoral dissertation]. Virginia Tech; 2011. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/77272.

Council of Science Editors:

Zhao J. Design, Syntheses and Biological Activities of Paclitaxel Analogs. [Doctoral Dissertation]. Virginia Tech; 2011. Available from: http://hdl.handle.net/10919/77272


Virginia Tech

19. Qi, Jun. Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs.

Degree: PhD, Chemistry, 2010, Virginia Tech

 Prostate cancer is the most common non-skin cancer for men in America. The androgen receptor exerts transcriptional activity and plays an important role for the… (more)

Subjects/Keywords: docetaxel; paclitaxel; taxol; tubulin binding conformation; fluorescence; discodermolide; microtubules; tubulin; androgen receptor; cyanonilutamide

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APA (6th Edition):

Qi, J. (2010). Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/37537

Chicago Manual of Style (16th Edition):

Qi, Jun. “Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs.” 2010. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/37537.

MLA Handbook (7th Edition):

Qi, Jun. “Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs.” 2010. Web. 16 Sep 2019.

Vancouver:

Qi J. Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs. [Internet] [Doctoral dissertation]. Virginia Tech; 2010. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/37537.

Council of Science Editors:

Qi J. Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs. [Doctoral Dissertation]. Virginia Tech; 2010. Available from: http://hdl.handle.net/10919/37537


Virginia Tech

20. Xu, Guoyan. Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism.

Degree: PhD, Chemistry, 2010, Virginia Tech

 An important role of Pin1 is to catalyze the cis-trans isomerization of pSer/Thr-Pro bonds; as such, it plays an important role in many cellular events… (more)

Subjects/Keywords: PPIase assay; inhibition; Pin1; anti-cancer drug target; transition-state analogues; ketoamides; ketones; reduced amides

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APA (6th Edition):

Xu, G. (2010). Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/37823

Chicago Manual of Style (16th Edition):

Xu, Guoyan. “Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism.” 2010. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/37823.

MLA Handbook (7th Edition):

Xu, Guoyan. “Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism.” 2010. Web. 16 Sep 2019.

Vancouver:

Xu G. Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism. [Internet] [Doctoral dissertation]. Virginia Tech; 2010. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/37823.

Council of Science Editors:

Xu G. Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism. [Doctoral Dissertation]. Virginia Tech; 2010. Available from: http://hdl.handle.net/10919/37823


Virginia Tech

21. Chen, Xingguo Ronald. Pin1 Catalytic and WW Domain Ligands.

Degree: PhD, Chemistry, 2011, Virginia Tech

 Pin1 is a peptidyl prolyl isomerase (PPIase) enzyme with two domains, the catalytic domain and the WW domain. Both domains specifically bind pSer/pThrâ Pro motifs.… (more)

Subjects/Keywords: Pin1; catalytic; WW domain; ligand; inhibition; mimic; conformation; phosphorylation; assay; ELEBA; combinatorial; library; solid-phase; synthesis; NMR; peptide

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APA (6th Edition):

Chen, X. R. (2011). Pin1 Catalytic and WW Domain Ligands. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/37824

Chicago Manual of Style (16th Edition):

Chen, Xingguo Ronald. “Pin1 Catalytic and WW Domain Ligands.” 2011. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/37824.

MLA Handbook (7th Edition):

Chen, Xingguo Ronald. “Pin1 Catalytic and WW Domain Ligands.” 2011. Web. 16 Sep 2019.

Vancouver:

Chen XR. Pin1 Catalytic and WW Domain Ligands. [Internet] [Doctoral dissertation]. Virginia Tech; 2011. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/37824.

Council of Science Editors:

Chen XR. Pin1 Catalytic and WW Domain Ligands. [Doctoral Dissertation]. Virginia Tech; 2011. Available from: http://hdl.handle.net/10919/37824


Virginia Tech

22. Actis, Marcelo. Synthesis, Characterization, Critical Micelle Concentration and Biological Activity of two-Headed Amphiphiles.

Degree: MS, Chemistry, 2008, Virginia Tech

 In this project, we synthesized a new homologous series of five long-chain, two-headed amphiphiles [2CAm13, 2CAm15, 2CAm17, 2CAm19, 2CAm21; CH3(CH2)n-1CONHC(CH3)(CH2CH2COOH)2, n = 13, 15, 17,… (more)

Subjects/Keywords: two-headed; di-carboxylato; amphiphile; critical micelle concentration; antimicrobial activity; MRSA; S. aureus

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APA (6th Edition):

Actis, M. (2008). Synthesis, Characterization, Critical Micelle Concentration and Biological Activity of two-Headed Amphiphiles. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/35774

Chicago Manual of Style (16th Edition):

Actis, Marcelo. “Synthesis, Characterization, Critical Micelle Concentration and Biological Activity of two-Headed Amphiphiles.” 2008. Masters Thesis, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/35774.

MLA Handbook (7th Edition):

Actis, Marcelo. “Synthesis, Characterization, Critical Micelle Concentration and Biological Activity of two-Headed Amphiphiles.” 2008. Web. 16 Sep 2019.

Vancouver:

Actis M. Synthesis, Characterization, Critical Micelle Concentration and Biological Activity of two-Headed Amphiphiles. [Internet] [Masters thesis]. Virginia Tech; 2008. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/35774.

Council of Science Editors:

Actis M. Synthesis, Characterization, Critical Micelle Concentration and Biological Activity of two-Headed Amphiphiles. [Masters Thesis]. Virginia Tech; 2008. Available from: http://hdl.handle.net/10919/35774


Virginia Tech

23. Adou, Eba. I. ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA. II. A SYNTHETIC APPROACH TO LUCILACTAENE.

Degree: PhD, Chemistry, 2005, Virginia Tech

 ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA AND A SYNTHETIC APPROACH TO LUCILACTAENE ABSTRACT Eba Adou As part of an International… (more)

Subjects/Keywords: Lucilactaene; Anticancer agents; Cytotoxicity assay; Indole alkaloids; p53 Tumor suppressor Gene; Physalins; Cardenolide glycosides; Diterpenoids; Cucurbitacins; Cell cycle; Cell cycle inhibitor

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APA (6th Edition):

Adou, E. (2005). I. ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA. II. A SYNTHETIC APPROACH TO LUCILACTAENE. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/29973

Chicago Manual of Style (16th Edition):

Adou, Eba. “I. ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA. II. A SYNTHETIC APPROACH TO LUCILACTAENE.” 2005. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/29973.

MLA Handbook (7th Edition):

Adou, Eba. “I. ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA. II. A SYNTHETIC APPROACH TO LUCILACTAENE.” 2005. Web. 16 Sep 2019.

Vancouver:

Adou E. I. ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA. II. A SYNTHETIC APPROACH TO LUCILACTAENE. [Internet] [Doctoral dissertation]. Virginia Tech; 2005. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/29973.

Council of Science Editors:

Adou E. I. ISOLATION AND CHARACTERIZATION OF BIOACTIVE COMPOUNDS FROM SURINAME AND MADAGASCAR FLORA. II. A SYNTHETIC APPROACH TO LUCILACTAENE. [Doctoral Dissertation]. Virginia Tech; 2005. Available from: http://hdl.handle.net/10919/29973


Virginia Tech

24. DeGuzman, Joseph Christopher. Memory of Chirality in 1,4-Benzodiazepin-2-ones.

Degree: PhD, Chemistry, 2006, Virginia Tech

 Memory of chirality (MOC) is an emerging strategy in asymmetric synthesis. It has been applied to enolate chemistry, reactions involving carbocation intermediates, and to radical… (more)

Subjects/Keywords: enolate; axial chirality; quaternary; racemization; benzodiazepine; conformer; Memory of chirality; enantiomeric excess; dynamic chirality

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APA (6th Edition):

DeGuzman, J. C. (2006). Memory of Chirality in 1,4-Benzodiazepin-2-ones. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/28079

Chicago Manual of Style (16th Edition):

DeGuzman, Joseph Christopher. “Memory of Chirality in 1,4-Benzodiazepin-2-ones.” 2006. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/28079.

MLA Handbook (7th Edition):

DeGuzman, Joseph Christopher. “Memory of Chirality in 1,4-Benzodiazepin-2-ones.” 2006. Web. 16 Sep 2019.

Vancouver:

DeGuzman JC. Memory of Chirality in 1,4-Benzodiazepin-2-ones. [Internet] [Doctoral dissertation]. Virginia Tech; 2006. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/28079.

Council of Science Editors:

DeGuzman JC. Memory of Chirality in 1,4-Benzodiazepin-2-ones. [Doctoral Dissertation]. Virginia Tech; 2006. Available from: http://hdl.handle.net/10919/28079


Virginia Tech

25. Dai, Nan. I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics.

Degree: PhD, Chemistry, 2008, Virginia Tech

 Collagen is one of the most important and abundant proteins in mammals. It consists of three left-handed PPII helixes coiled along a common axis to… (more)

Subjects/Keywords: helicity; HTH-turn mimic.; conformationally locked isostere; polypeptides; triple helix; stability; collagen; helix-turn-helix

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APA (6th Edition):

Dai, N. (2008). I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/28411

Chicago Manual of Style (16th Edition):

Dai, Nan. “I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics.” 2008. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/28411.

MLA Handbook (7th Edition):

Dai, Nan. “I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics.” 2008. Web. 16 Sep 2019.

Vancouver:

Dai N. I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics. [Internet] [Doctoral dissertation]. Virginia Tech; 2008. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/28411.

Council of Science Editors:

Dai N. I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics. [Doctoral Dissertation]. Virginia Tech; 2008. Available from: http://hdl.handle.net/10919/28411


Virginia Tech

26. Yang, Chao. Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs.

Degree: PhD, Chemistry, 2008, Virginia Tech

 Paclitaxel was isolated from the bark of Taxus brevifolia in the late 1960s. It exerts its biological effect by promoting tubulin polymerization and stabilizing the… (more)

Subjects/Keywords: tubulin-binding conformation; macrocyclic taxoids; T-taxol conformation; discodermolide; Taxol; drug targeting; thio-taxol

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APA (6th Edition):

Yang, C. (2008). Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/28942

Chicago Manual of Style (16th Edition):

Yang, Chao. “Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs.” 2008. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/28942.

MLA Handbook (7th Edition):

Yang, Chao. “Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs.” 2008. Web. 16 Sep 2019.

Vancouver:

Yang C. Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs. [Internet] [Doctoral dissertation]. Virginia Tech; 2008. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/28942.

Council of Science Editors:

Yang C. Syntheses and Bioactivities of Targeted and Conformationally Restrained Paclitaxel and Discodermolide Analogs. [Doctoral Dissertation]. Virginia Tech; 2008. Available from: http://hdl.handle.net/10919/28942


Virginia Tech

27. Yoder, Brent Jason. Isolation and Structure Elucidation of Cytotoxic Natural Products from the Rainforests of Madagascar and Suriname.

Degree: PhD, Chemistry, 2005, Virginia Tech

 As part of an ongoing investigation of new bioactive metabolites from rainforest flora, extracts from five different plants were determined to have interesting compounds that… (more)

Subjects/Keywords: bioorganic; plants; cancer; chemistry

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APA (6th Edition):

Yoder, B. J. (2005). Isolation and Structure Elucidation of Cytotoxic Natural Products from the Rainforests of Madagascar and Suriname. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/29756

Chicago Manual of Style (16th Edition):

Yoder, Brent Jason. “Isolation and Structure Elucidation of Cytotoxic Natural Products from the Rainforests of Madagascar and Suriname.” 2005. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/29756.

MLA Handbook (7th Edition):

Yoder, Brent Jason. “Isolation and Structure Elucidation of Cytotoxic Natural Products from the Rainforests of Madagascar and Suriname.” 2005. Web. 16 Sep 2019.

Vancouver:

Yoder BJ. Isolation and Structure Elucidation of Cytotoxic Natural Products from the Rainforests of Madagascar and Suriname. [Internet] [Doctoral dissertation]. Virginia Tech; 2005. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/29756.

Council of Science Editors:

Yoder BJ. Isolation and Structure Elucidation of Cytotoxic Natural Products from the Rainforests of Madagascar and Suriname. [Doctoral Dissertation]. Virginia Tech; 2005. Available from: http://hdl.handle.net/10919/29756


Virginia Tech

28. Wang, Xiaodong. Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors.

Degree: PhD, Chemistry, 2005, Virginia Tech

 Pin1 (protein interacting with NIMA 1) is a peptidyl-prolyl isomerase involved in mitosis. As a potential anti-cancer drug target, Pin1 interacts and regulates the activity… (more)

Subjects/Keywords: conformation; collagen; inhibition; assay; Ser-trans-Pro; Ser-cis-Pro; peptidomimetics; solid phase peptide synthesis; cell cycle; Pin1; isosteres; mimic

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APA (6th Edition):

Wang, X. (2005). Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/26625

Chicago Manual of Style (16th Edition):

Wang, Xiaodong. “Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors.” 2005. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/26625.

MLA Handbook (7th Edition):

Wang, Xiaodong. “Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors.” 2005. Web. 16 Sep 2019.

Vancouver:

Wang X. Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors. [Internet] [Doctoral dissertation]. Virginia Tech; 2005. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/26625.

Council of Science Editors:

Wang X. Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors. [Doctoral Dissertation]. Virginia Tech; 2005. Available from: http://hdl.handle.net/10919/26625


Virginia Tech

29. Williams, Larry D. Experimental and Computational Investigation of Tacrine-Based Inhibitors of Acetylcholinesterase.

Degree: PhD, Chemistry, 2008, Virginia Tech

 Acetylcholinesterase (AChE) terminates cholinergic neurotransmission by catalyzing the hydrolysis of the neurotransmitter acetylcholine (ACh). Inhibition of AChE has proven an effective treatment for the memory… (more)

Subjects/Keywords: bump-hole; density functional theory; acetylcholinesterase; coalescence; tacrine

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APA (6th Edition):

Williams, L. D. (2008). Experimental and Computational Investigation of Tacrine-Based Inhibitors of Acetylcholinesterase. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/29444

Chicago Manual of Style (16th Edition):

Williams, Larry D. “Experimental and Computational Investigation of Tacrine-Based Inhibitors of Acetylcholinesterase.” 2008. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/29444.

MLA Handbook (7th Edition):

Williams, Larry D. “Experimental and Computational Investigation of Tacrine-Based Inhibitors of Acetylcholinesterase.” 2008. Web. 16 Sep 2019.

Vancouver:

Williams LD. Experimental and Computational Investigation of Tacrine-Based Inhibitors of Acetylcholinesterase. [Internet] [Doctoral dissertation]. Virginia Tech; 2008. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/29444.

Council of Science Editors:

Williams LD. Experimental and Computational Investigation of Tacrine-Based Inhibitors of Acetylcholinesterase. [Doctoral Dissertation]. Virginia Tech; 2008. Available from: http://hdl.handle.net/10919/29444


Virginia Tech

30. Zhang, Yiqun. Stereochemistry of small molecules: Configurational and conformational control.

Degree: PhD, Chemistry, 2007, Virginia Tech

 Stereochemistry is important aspect of chemistry that customarily includes the study of the relative spatial arrangement of atoms within molecules (static stereochemistry), and the study… (more)

Subjects/Keywords: conformational control; chiral Grignard reagents; halogen-metal exchange; cyclopropylnitrile; configurational stability; 3-strain; allylic 1; syn-pentane interaction; nitrile aldol

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APA (6th Edition):

Zhang, Y. (2007). Stereochemistry of small molecules: Configurational and conformational control. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/26535

Chicago Manual of Style (16th Edition):

Zhang, Yiqun. “Stereochemistry of small molecules: Configurational and conformational control.” 2007. Doctoral Dissertation, Virginia Tech. Accessed September 16, 2019. http://hdl.handle.net/10919/26535.

MLA Handbook (7th Edition):

Zhang, Yiqun. “Stereochemistry of small molecules: Configurational and conformational control.” 2007. Web. 16 Sep 2019.

Vancouver:

Zhang Y. Stereochemistry of small molecules: Configurational and conformational control. [Internet] [Doctoral dissertation]. Virginia Tech; 2007. [cited 2019 Sep 16]. Available from: http://hdl.handle.net/10919/26535.

Council of Science Editors:

Zhang Y. Stereochemistry of small molecules: Configurational and conformational control. [Doctoral Dissertation]. Virginia Tech; 2007. Available from: http://hdl.handle.net/10919/26535

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