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You searched for +publisher:"Virginia Commonwealth University" +contributor:("Dr. Shirley Taylor"). One record found.

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Virginia Commonwealth University

1. Burton, Elliot N. Functional Consequences of mtDNA Methylation on Mitochondrial Transcription Factor Binding and Transcription Initiation.

Degree: MS, Human Genetics, 2016, Virginia Commonwealth University

The role of cytosine modifications on nuclear transcription has been well characterized, but the function of DNA methylation in the mitochondrial genome has not been determined. Previous studies conducted by the Taylor laboratory have shown overexpression of the mitochondrial isoform of DNMT1 leads to strand-specific changes in gene expression. Here, we show that increased mtDNMT1 expression leads to an increase in the polycistronic transcript encoding the ND1 and Cox1 sequences. In order to understand the mechanistic basis of these changes, we investigated the effects of CpG methylation in the heavy strand promoter on transcription initiation and TFAM binding. Methylation was found to increase transcription initiation from HSP1 and result in larger TFAM:DNA complexes forming at lower protein concentrations. Our data suggest a functional role for cytosine methylation in the mitochondria, which we propose may have an effect on oxidative phosphorylation and cellular function. Advisors/Committee Members: Dr. Shirley Taylor.

Subjects/Keywords: Molecular Genetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Burton, E. N. (2016). Functional Consequences of mtDNA Methylation on Mitochondrial Transcription Factor Binding and Transcription Initiation. (Thesis). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/V0F1-ER74 ; https://scholarscompass.vcu.edu/etd/4185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Burton, Elliot N. “Functional Consequences of mtDNA Methylation on Mitochondrial Transcription Factor Binding and Transcription Initiation.” 2016. Thesis, Virginia Commonwealth University. Accessed July 10, 2020. https://doi.org/10.25772/V0F1-ER74 ; https://scholarscompass.vcu.edu/etd/4185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Burton, Elliot N. “Functional Consequences of mtDNA Methylation on Mitochondrial Transcription Factor Binding and Transcription Initiation.” 2016. Web. 10 Jul 2020.

Vancouver:

Burton EN. Functional Consequences of mtDNA Methylation on Mitochondrial Transcription Factor Binding and Transcription Initiation. [Internet] [Thesis]. Virginia Commonwealth University; 2016. [cited 2020 Jul 10]. Available from: https://doi.org/10.25772/V0F1-ER74 ; https://scholarscompass.vcu.edu/etd/4185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Burton EN. Functional Consequences of mtDNA Methylation on Mitochondrial Transcription Factor Binding and Transcription Initiation. [Thesis]. Virginia Commonwealth University; 2016. Available from: https://doi.org/10.25772/V0F1-ER74 ; https://scholarscompass.vcu.edu/etd/4185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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