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You searched for +publisher:"Vanderbilt University" +contributor:("Pampee P. Young, M.D., Ph.D."). One record found.

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Vanderbilt University

1. Zachman, Angela Laurie. Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease.

Degree: PhD, Biomedical Engineering, 2014, Vanderbilt University

Peripheral artery disease (PAD) is characterized by platelet activation and aggregation on arterial walls, resulting in vessel occlusion and ischemia. To treat PAD, it is desirable to have a high degree of angiogenesis to promote collateral blood vessel formation, with a low degree of inflammation to minimize plaque development. However, these two processes are intrinsically linked and difficult to uncouple. Therefore, the overarching goal of this research was to develop a biomaterial system that enables controlled, dual delivery of pro-angiogenic and anti-inflammatory peptides in minimally-invasive way. To achieve the goal, a peptide-loaded injectable scaffold system was developed and tested in a mouse model of PAD. In addition, the mechanism of peptide-mediated regulation of angiogenesis and inflammation was elucidated. By regulating pathways involved in inflammation and angiogenesis independently, this dual peptide-loaded injectable scaffold system may significantly improve recovery of ischemic tissues in patients with PAD. Advisors/Committee Members: Pampee P. Young, M.D., Ph.D. (committee member), Hak-Joon Sung, Ph.D. (chair), Craig L. Duvall, Ph.D. (committee member), Melissa C. Skala, Ph.D. (committee member), Scott A. Guelcher, Ph.D. (committee member).

Subjects/Keywords: inflammation; injectable polymer; atherosclerosis; peripheral artery disease; peptide; angiogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Zachman, A. L. (2014). Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-03312014-183105/ ;

Chicago Manual of Style (16th Edition):

Zachman, Angela Laurie. “Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed August 17, 2019. http://etd.library.vanderbilt.edu//available/etd-03312014-183105/ ;.

MLA Handbook (7th Edition):

Zachman, Angela Laurie. “Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease.” 2014. Web. 17 Aug 2019.

Vancouver:

Zachman AL. Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2019 Aug 17]. Available from: http://etd.library.vanderbilt.edu//available/etd-03312014-183105/ ;.

Council of Science Editors:

Zachman AL. Peptide-functionalized Polymers Regulating Angiogenesis and Inflammation in Peripheral Artery Disease. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://etd.library.vanderbilt.edu//available/etd-03312014-183105/ ;

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