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You searched for +publisher:"Vanderbilt University" +contributor:("Lawrence J. Marnett"). Showing records 1 – 27 of 27 total matches.

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Vanderbilt University

1. Adams, Nicholas Morgan. Development of Simple Methods for RNA Biomarker Extraction and Detection.

Degree: PhD, Chemical and Physical Biology, 2014, Vanderbilt University

 Simple and rapid methods for detecting RNA biomarkers from patient samples are especially desirable in settings with limited access to laboratory resources and trained personnel.… (more)

Subjects/Keywords: RNA extraction; RNA detection; low resource diagnostics; molecular biology; method development

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APA (6th Edition):

Adams, N. M. (2014). Development of Simple Methods for RNA Biomarker Extraction and Detection. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-03142014-153431/ ;

Chicago Manual of Style (16th Edition):

Adams, Nicholas Morgan. “Development of Simple Methods for RNA Biomarker Extraction and Detection.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu//available/etd-03142014-153431/ ;.

MLA Handbook (7th Edition):

Adams, Nicholas Morgan. “Development of Simple Methods for RNA Biomarker Extraction and Detection.” 2014. Web. 26 Sep 2018.

Vancouver:

Adams NM. Development of Simple Methods for RNA Biomarker Extraction and Detection. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu//available/etd-03142014-153431/ ;.

Council of Science Editors:

Adams NM. Development of Simple Methods for RNA Biomarker Extraction and Detection. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://etd.library.vanderbilt.edu//available/etd-03142014-153431/ ;


Vanderbilt University

2. Goodman, Michael Christopher. Investigations of the enzymatic mechanisms and inhibition of prostaglandin E2 biosynthesis.

Degree: PhD, Chemistry, 2018, Vanderbilt University

 Polyunsaturated fatty acids can be liberated from phospholipids in the membrane bilayer and enzymatically converted to oxygenated bioactive lipid compounds that contribute to the pathology,… (more)

Subjects/Keywords: prostaglandins; cyclooxygenase; Inflammation; enzyme kinetics

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APA (6th Edition):

Goodman, M. C. (2018). Investigations of the enzymatic mechanisms and inhibition of prostaglandin E2 biosynthesis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-03202018-132825/ ;

Chicago Manual of Style (16th Edition):

Goodman, Michael Christopher. “Investigations of the enzymatic mechanisms and inhibition of prostaglandin E2 biosynthesis.” 2018. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-03202018-132825/ ;.

MLA Handbook (7th Edition):

Goodman, Michael Christopher. “Investigations of the enzymatic mechanisms and inhibition of prostaglandin E2 biosynthesis.” 2018. Web. 26 Sep 2018.

Vancouver:

Goodman MC. Investigations of the enzymatic mechanisms and inhibition of prostaglandin E2 biosynthesis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2018. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-03202018-132825/ ;.

Council of Science Editors:

Goodman MC. Investigations of the enzymatic mechanisms and inhibition of prostaglandin E2 biosynthesis. [Doctoral Dissertation]. Vanderbilt University; 2018. Available from: http://etd.library.vanderbilt.edu/available/etd-03202018-132825/ ;


Vanderbilt University

3. Mitchener, Michelle Marie. A. Competition and allostery govern substrate selectivity of cyclooxygenase-2 B. Enzymatic oxidation of M1dG in the genome.

Degree: PhD, Chemistry, 2017, Vanderbilt University

 Part A: Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and its ester analog, 2-arachidonoylglycerol (2-AG), to prostaglandins (PGs) and prostaglandin glyceryl esters (PG-Gs), respectively. Although the… (more)

Subjects/Keywords: M1dG; chemical kinetics; endocannabinoids; cyclooxygenase-2; DNA adducts

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APA (6th Edition):

Mitchener, M. M. (2017). A. Competition and allostery govern substrate selectivity of cyclooxygenase-2 B. Enzymatic oxidation of M1dG in the genome. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-12042017-111654/ ;

Chicago Manual of Style (16th Edition):

Mitchener, Michelle Marie. “A. Competition and allostery govern substrate selectivity of cyclooxygenase-2 B. Enzymatic oxidation of M1dG in the genome.” 2017. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-12042017-111654/ ;.

MLA Handbook (7th Edition):

Mitchener, Michelle Marie. “A. Competition and allostery govern substrate selectivity of cyclooxygenase-2 B. Enzymatic oxidation of M1dG in the genome.” 2017. Web. 26 Sep 2018.

Vancouver:

Mitchener MM. A. Competition and allostery govern substrate selectivity of cyclooxygenase-2 B. Enzymatic oxidation of M1dG in the genome. [Internet] [Doctoral dissertation]. Vanderbilt University; 2017. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-12042017-111654/ ;.

Council of Science Editors:

Mitchener MM. A. Competition and allostery govern substrate selectivity of cyclooxygenase-2 B. Enzymatic oxidation of M1dG in the genome. [Doctoral Dissertation]. Vanderbilt University; 2017. Available from: http://etd.library.vanderbilt.edu/available/etd-12042017-111654/ ;


Vanderbilt University

4. Hermanson, Daniel John. Substrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects.

Degree: PhD, Chemistry, 2014, Vanderbilt University

 Substrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects. Daniel John Hermanson Dissertation under the direction of Professor Lawrence J. Marnett Cyclooxygenase-2… (more)

Subjects/Keywords: pain; anxiety; cyclooxygenase-2; endocannabinoids; inflammation; NSAIDs

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APA (6th Edition):

Hermanson, D. J. (2014). Substrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-03212014-154440/ ;

Chicago Manual of Style (16th Edition):

Hermanson, Daniel John. “Substrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu//available/etd-03212014-154440/ ;.

MLA Handbook (7th Edition):

Hermanson, Daniel John. “Substrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects.” 2014. Web. 26 Sep 2018.

Vancouver:

Hermanson DJ. Substrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu//available/etd-03212014-154440/ ;.

Council of Science Editors:

Hermanson DJ. Substrate-selective Inhibition of Cyclooxygenase-2: Molecular Determinants, Probe Development, and In Vivo Effects. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://etd.library.vanderbilt.edu//available/etd-03212014-154440/ ;


Vanderbilt University

5. Camarillo, Jeannie Marie. Functional implications of electrophilic protein adducts.

Degree: PhD, Biochemistry, 2016, Vanderbilt University

 Oxidative stress is a contributing factor in a number of chronic diseases, including cancer, atherosclerosis, and neurodegenerative diseases. Lipid peroxidation that occurs during periods of… (more)

Subjects/Keywords: hydroxynonenal; lipid peroxidation; click chemistry; lipid electrophiles; oxononenal

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APA (6th Edition):

Camarillo, J. M. (2016). Functional implications of electrophilic protein adducts. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-11172016-083939/ ;

Chicago Manual of Style (16th Edition):

Camarillo, Jeannie Marie. “Functional implications of electrophilic protein adducts.” 2016. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-11172016-083939/ ;.

MLA Handbook (7th Edition):

Camarillo, Jeannie Marie. “Functional implications of electrophilic protein adducts.” 2016. Web. 26 Sep 2018.

Vancouver:

Camarillo JM. Functional implications of electrophilic protein adducts. [Internet] [Doctoral dissertation]. Vanderbilt University; 2016. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-11172016-083939/ ;.

Council of Science Editors:

Camarillo JM. Functional implications of electrophilic protein adducts. [Doctoral Dissertation]. Vanderbilt University; 2016. Available from: http://etd.library.vanderbilt.edu/available/etd-11172016-083939/ ;


Vanderbilt University

6. Hariri, Ghazal. Development, Optimization and Evaluation of Tumor-Specific Nanosponge Drug Delivery Systems as Chemotherapeutics.

Degree: PhD, Chemical and Physical Biology, 2014, Vanderbilt University

 Current chemotherapeutic treatments for cancer utilize systemic administration of cytotoxic drugs and produce many side effects in healthy tissues, making optimal treatment of cancer hard… (more)

Subjects/Keywords: cancer; chemotherapy; drug delivery; nanoparticles

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APA (6th Edition):

Hariri, G. (2014). Development, Optimization and Evaluation of Tumor-Specific Nanosponge Drug Delivery Systems as Chemotherapeutics. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-11242014-221103/ ;

Chicago Manual of Style (16th Edition):

Hariri, Ghazal. “Development, Optimization and Evaluation of Tumor-Specific Nanosponge Drug Delivery Systems as Chemotherapeutics.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu//available/etd-11242014-221103/ ;.

MLA Handbook (7th Edition):

Hariri, Ghazal. “Development, Optimization and Evaluation of Tumor-Specific Nanosponge Drug Delivery Systems as Chemotherapeutics.” 2014. Web. 26 Sep 2018.

Vancouver:

Hariri G. Development, Optimization and Evaluation of Tumor-Specific Nanosponge Drug Delivery Systems as Chemotherapeutics. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu//available/etd-11242014-221103/ ;.

Council of Science Editors:

Hariri G. Development, Optimization and Evaluation of Tumor-Specific Nanosponge Drug Delivery Systems as Chemotherapeutics. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://etd.library.vanderbilt.edu//available/etd-11242014-221103/ ;


Vanderbilt University

7. Beavers, William Norris. w-Alkynyl Fatty Acids: Surrogates to Study Protein Adduction by Endogenously Generated Lipid Electrophiles.

Degree: PhD, Chemistry, 2015, Vanderbilt University

 Polyunsaturated Fatty Acids (PUFAs) are oxidized both enzymatically and by autoxidation to many inflammatory signaling molecules, which have been detected in multiple disease states. Oxidized… (more)

Subjects/Keywords: lipid electrophiles; polyunsaturated fatty acid oxidation; inflammation; click chemistry; stable isotope labeling of amino acids in cell culture; protein adduction

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APA (6th Edition):

Beavers, W. N. (2015). w-Alkynyl Fatty Acids: Surrogates to Study Protein Adduction by Endogenously Generated Lipid Electrophiles. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-07142015-113929/ ;

Chicago Manual of Style (16th Edition):

Beavers, William Norris. “w-Alkynyl Fatty Acids: Surrogates to Study Protein Adduction by Endogenously Generated Lipid Electrophiles.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu//available/etd-07142015-113929/ ;.

MLA Handbook (7th Edition):

Beavers, William Norris. “w-Alkynyl Fatty Acids: Surrogates to Study Protein Adduction by Endogenously Generated Lipid Electrophiles.” 2015. Web. 26 Sep 2018.

Vancouver:

Beavers WN. w-Alkynyl Fatty Acids: Surrogates to Study Protein Adduction by Endogenously Generated Lipid Electrophiles. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu//available/etd-07142015-113929/ ;.

Council of Science Editors:

Beavers WN. w-Alkynyl Fatty Acids: Surrogates to Study Protein Adduction by Endogenously Generated Lipid Electrophiles. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://etd.library.vanderbilt.edu//available/etd-07142015-113929/ ;


Vanderbilt University

8. Samanta, Debangshu. Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer.

Degree: PhD, Cancer Biology, 2012, Vanderbilt University

 Inactivating mutations in TGF-©¬ receptors and Smad signal transducers that contribute to resistance to TGF-©¬, are associated with only very small number of NSCLC. The… (more)

Subjects/Keywords: Smoking; Lung cancer; Smad3; Chemoresistance

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APA (6th Edition):

Samanta, D. (2012). Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-04122012-114031/ ;

Chicago Manual of Style (16th Edition):

Samanta, Debangshu. “Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer.” 2012. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-04122012-114031/ ;.

MLA Handbook (7th Edition):

Samanta, Debangshu. “Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer.” 2012. Web. 26 Sep 2018.

Vancouver:

Samanta D. Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer. [Internet] [Doctoral dissertation]. Vanderbilt University; 2012. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-04122012-114031/ ;.

Council of Science Editors:

Samanta D. Long-term smoking-mediated downregulation of Smad3 induces tumorigenicity and carboplatin resistance in non-small cell lung cancer. [Doctoral Dissertation]. Vanderbilt University; 2012. Available from: http://etd.library.vanderbilt.edu/available/etd-04122012-114031/ ;


Vanderbilt University

9. Birmingham, William Ross. Bioretrosynthetic Construction of a Non-Natural Nucleoside Analog Biosynthetic Pathway.

Degree: PhD, Biochemistry, 2013, Vanderbilt University

 Engineered biocatalysts have become increasingly sought after as replacements for individual chemical synthetic steps. However, their implementation in multistep sequences as biosynthetic pathways has proven… (more)

Subjects/Keywords: directed evolution; retrograde evolution; bioretrosynthesis; dideoxyinosine; phosphopentomutase; ribokinase

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APA (6th Edition):

Birmingham, W. R. (2013). Bioretrosynthetic Construction of a Non-Natural Nucleoside Analog Biosynthetic Pathway. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-11212013-085213/ ;

Chicago Manual of Style (16th Edition):

Birmingham, William Ross. “Bioretrosynthetic Construction of a Non-Natural Nucleoside Analog Biosynthetic Pathway.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-11212013-085213/ ;.

MLA Handbook (7th Edition):

Birmingham, William Ross. “Bioretrosynthetic Construction of a Non-Natural Nucleoside Analog Biosynthetic Pathway.” 2013. Web. 26 Sep 2018.

Vancouver:

Birmingham WR. Bioretrosynthetic Construction of a Non-Natural Nucleoside Analog Biosynthetic Pathway. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-11212013-085213/ ;.

Council of Science Editors:

Birmingham WR. Bioretrosynthetic Construction of a Non-Natural Nucleoside Analog Biosynthetic Pathway. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://etd.library.vanderbilt.edu/available/etd-11212013-085213/ ;


Vanderbilt University

10. McCranie, Emilianne Karyl. Investigations of Orthosomycin Biosynthesis.

Degree: PhD, Chemistry, 2015, Vanderbilt University

 Orthosomycins are highly decorated oligosaccharides with potent activity against a variety of Gram-positive bacteria including methicillin-resistant staphylococci and vancomycin-resistant enterococci. The research in this dissertation… (more)

Subjects/Keywords: biosynthesis; orthosomycin; antibiotic biosynthesis; chemical biology; chemistry; biochemistry

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APA (6th Edition):

McCranie, E. K. (2015). Investigations of Orthosomycin Biosynthesis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-12152015-171255/ ;

Chicago Manual of Style (16th Edition):

McCranie, Emilianne Karyl. “Investigations of Orthosomycin Biosynthesis.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu//available/etd-12152015-171255/ ;.

MLA Handbook (7th Edition):

McCranie, Emilianne Karyl. “Investigations of Orthosomycin Biosynthesis.” 2015. Web. 26 Sep 2018.

Vancouver:

McCranie EK. Investigations of Orthosomycin Biosynthesis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu//available/etd-12152015-171255/ ;.

Council of Science Editors:

McCranie EK. Investigations of Orthosomycin Biosynthesis. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://etd.library.vanderbilt.edu//available/etd-12152015-171255/ ;


Vanderbilt University

11. Duggan, Kelsey Constance. Structural and Functional Analysis of Cyclooxygenase-2 Inhibition by Non-Steroidal Anti-Inflammatory Drugs.

Degree: PhD, Biochemistry, 2011, Vanderbilt University

 The cyclooxygenase enzymes (COX-1 and COX-2) catalyze the conversion arachidonic acid (AA) to prostaglandin H2 (PGH2), which is the precursor to biologically active prostanoids. The… (more)

Subjects/Keywords: naproxen; prostaglandins; cyclooxygenase; non-steroidal anti-inflammatory drugs

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APA (6th Edition):

Duggan, K. C. (2011). Structural and Functional Analysis of Cyclooxygenase-2 Inhibition by Non-Steroidal Anti-Inflammatory Drugs. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-01142011-132702/ ;

Chicago Manual of Style (16th Edition):

Duggan, Kelsey Constance. “Structural and Functional Analysis of Cyclooxygenase-2 Inhibition by Non-Steroidal Anti-Inflammatory Drugs.” 2011. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-01142011-132702/ ;.

MLA Handbook (7th Edition):

Duggan, Kelsey Constance. “Structural and Functional Analysis of Cyclooxygenase-2 Inhibition by Non-Steroidal Anti-Inflammatory Drugs.” 2011. Web. 26 Sep 2018.

Vancouver:

Duggan KC. Structural and Functional Analysis of Cyclooxygenase-2 Inhibition by Non-Steroidal Anti-Inflammatory Drugs. [Internet] [Doctoral dissertation]. Vanderbilt University; 2011. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-01142011-132702/ ;.

Council of Science Editors:

Duggan KC. Structural and Functional Analysis of Cyclooxygenase-2 Inhibition by Non-Steroidal Anti-Inflammatory Drugs. [Doctoral Dissertation]. Vanderbilt University; 2011. Available from: http://etd.library.vanderbilt.edu/available/etd-01142011-132702/ ;


Vanderbilt University

12. Kennedy, Jack Phillip. Synthesis and biological evaluation of dispyrin, synthesis and design of selective M4 muscarinic modulators, and exploration of the total synthesis of piperazimycin A.

Degree: PhD, Chemistry, 2010, Vanderbilt University

 The content described in detail in this dissertation covers natural product guided drug discovery, traditional hit-to-lead medicinal chemistry and advances in total synthesis. The synthesis… (more)

Subjects/Keywords: Total Synthesis; Medicinal Chemistry; Organic Chemistry; Drug Discovery

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APA (6th Edition):

Kennedy, J. P. (2010). Synthesis and biological evaluation of dispyrin, synthesis and design of selective M4 muscarinic modulators, and exploration of the total synthesis of piperazimycin A. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-07292010-140837/ ;

Chicago Manual of Style (16th Edition):

Kennedy, Jack Phillip. “Synthesis and biological evaluation of dispyrin, synthesis and design of selective M4 muscarinic modulators, and exploration of the total synthesis of piperazimycin A.” 2010. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-07292010-140837/ ;.

MLA Handbook (7th Edition):

Kennedy, Jack Phillip. “Synthesis and biological evaluation of dispyrin, synthesis and design of selective M4 muscarinic modulators, and exploration of the total synthesis of piperazimycin A.” 2010. Web. 26 Sep 2018.

Vancouver:

Kennedy JP. Synthesis and biological evaluation of dispyrin, synthesis and design of selective M4 muscarinic modulators, and exploration of the total synthesis of piperazimycin A. [Internet] [Doctoral dissertation]. Vanderbilt University; 2010. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-07292010-140837/ ;.

Council of Science Editors:

Kennedy JP. Synthesis and biological evaluation of dispyrin, synthesis and design of selective M4 muscarinic modulators, and exploration of the total synthesis of piperazimycin A. [Doctoral Dissertation]. Vanderbilt University; 2010. Available from: http://etd.library.vanderbilt.edu/available/etd-07292010-140837/ ;


Vanderbilt University

13. Chandra, Aroop. The application of new methods to the synthesis of constrained proline derivatives, (+)-serratezomine A, and hapalindoles A, G, I, and K.

Degree: PhD, Chemistry, 2011, Vanderbilt University

 The development of new chemical methods to tackle synthetic challenges is presented in this dissertation. Application of these methods has led to the completion of… (more)

Subjects/Keywords: (+)-serratezomine A; alkaloids; peptide conformation; hapalindole; ambiguine

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APA (6th Edition):

Chandra, A. (2011). The application of new methods to the synthesis of constrained proline derivatives, (+)-serratezomine A, and hapalindoles A, G, I, and K. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-03282011-182026/ ;

Chicago Manual of Style (16th Edition):

Chandra, Aroop. “The application of new methods to the synthesis of constrained proline derivatives, (+)-serratezomine A, and hapalindoles A, G, I, and K.” 2011. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-03282011-182026/ ;.

MLA Handbook (7th Edition):

Chandra, Aroop. “The application of new methods to the synthesis of constrained proline derivatives, (+)-serratezomine A, and hapalindoles A, G, I, and K.” 2011. Web. 26 Sep 2018.

Vancouver:

Chandra A. The application of new methods to the synthesis of constrained proline derivatives, (+)-serratezomine A, and hapalindoles A, G, I, and K. [Internet] [Doctoral dissertation]. Vanderbilt University; 2011. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-03282011-182026/ ;.

Council of Science Editors:

Chandra A. The application of new methods to the synthesis of constrained proline derivatives, (+)-serratezomine A, and hapalindoles A, G, I, and K. [Doctoral Dissertation]. Vanderbilt University; 2011. Available from: http://etd.library.vanderbilt.edu/available/etd-03282011-182026/ ;


Vanderbilt University

14. Musee, Joel. Determinants of cyclooxygenase-2-mediated oxidative metabolism of the endocannabinoid, 2-arachidonoyl glycerol, in vitro and ex vivo.

Degree: PhD, Biochemistry, 2011, Vanderbilt University

 DETERMINANTS OF CYCLOOXYGENASE-2-MEDIATED OXIDATIVE METABOLISM OF THE ENDOCANNABINOID, 2-ARACHIDONOYL GLYCEROL, IN VITRO AND EX VIVO Joel Musee Dissertation under the direction of Professor Lawrence J.… (more)

Subjects/Keywords: prostaglandins; PGHS; COX; endocannabinoid; 2-arachidonoyl glycerol; analgesia; pain

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APA (6th Edition):

Musee, J. (2011). Determinants of cyclooxygenase-2-mediated oxidative metabolism of the endocannabinoid, 2-arachidonoyl glycerol, in vitro and ex vivo. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-04012011-233806/ ;

Chicago Manual of Style (16th Edition):

Musee, Joel. “Determinants of cyclooxygenase-2-mediated oxidative metabolism of the endocannabinoid, 2-arachidonoyl glycerol, in vitro and ex vivo.” 2011. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-04012011-233806/ ;.

MLA Handbook (7th Edition):

Musee, Joel. “Determinants of cyclooxygenase-2-mediated oxidative metabolism of the endocannabinoid, 2-arachidonoyl glycerol, in vitro and ex vivo.” 2011. Web. 26 Sep 2018.

Vancouver:

Musee J. Determinants of cyclooxygenase-2-mediated oxidative metabolism of the endocannabinoid, 2-arachidonoyl glycerol, in vitro and ex vivo. [Internet] [Doctoral dissertation]. Vanderbilt University; 2011. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-04012011-233806/ ;.

Council of Science Editors:

Musee J. Determinants of cyclooxygenase-2-mediated oxidative metabolism of the endocannabinoid, 2-arachidonoyl glycerol, in vitro and ex vivo. [Doctoral Dissertation]. Vanderbilt University; 2011. Available from: http://etd.library.vanderbilt.edu/available/etd-04012011-233806/ ;


Vanderbilt University

15. Hardy, Klarissa Dawniette. Formation and Metabolism of 15-Deoxy-{Delta}12,14-Prostaglandin J2 in Vivo.

Degree: PhD, Pharmacology, 2011, Vanderbilt University

 PHARMACOLOGY FORMATION AND METABOLISM OF 15-DEOXY-{Delta}12,14-PROSTAGLANDIN J2 IN VIVO KLARISSA D. HARDY Dissertation under the direction of Professor L. Jackson Roberts, II 15-Deoxy-{Delta}12,14-prostaglandin J2 (15-d-PGJ2)… (more)

Subjects/Keywords: prostaglandin; isoprotane; metabolism

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APA (6th Edition):

Hardy, K. D. (2011). Formation and Metabolism of 15-Deoxy-{Delta}12,14-Prostaglandin J2 in Vivo. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-03242011-105849/ ;

Chicago Manual of Style (16th Edition):

Hardy, Klarissa Dawniette. “Formation and Metabolism of 15-Deoxy-{Delta}12,14-Prostaglandin J2 in Vivo.” 2011. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-03242011-105849/ ;.

MLA Handbook (7th Edition):

Hardy, Klarissa Dawniette. “Formation and Metabolism of 15-Deoxy-{Delta}12,14-Prostaglandin J2 in Vivo.” 2011. Web. 26 Sep 2018.

Vancouver:

Hardy KD. Formation and Metabolism of 15-Deoxy-{Delta}12,14-Prostaglandin J2 in Vivo. [Internet] [Doctoral dissertation]. Vanderbilt University; 2011. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-03242011-105849/ ;.

Council of Science Editors:

Hardy KD. Formation and Metabolism of 15-Deoxy-{Delta}12,14-Prostaglandin J2 in Vivo. [Doctoral Dissertation]. Vanderbilt University; 2011. Available from: http://etd.library.vanderbilt.edu/available/etd-03242011-105849/ ;


Vanderbilt University

16. Knutson, Charles Gerhard Francesco. Oxidative metabolism of exocyclic DNA adducts.

Degree: PhD, Biochemistry, 2008, Vanderbilt University

 Multiple exocyclic DNA adducts arise from reactions of lipid and DNA peroxidation products with DNA bases. These endogenous lesions are mutagenic; therefore, monitoring adduct levels… (more)

Subjects/Keywords: biomarkers; biochemistry; cancer; lipid peroxidation; oxidative stress; DNA adducts; toxicology

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APA (6th Edition):

Knutson, C. G. F. (2008). Oxidative metabolism of exocyclic DNA adducts. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-03122008-133135/ ;

Chicago Manual of Style (16th Edition):

Knutson, Charles Gerhard Francesco. “Oxidative metabolism of exocyclic DNA adducts.” 2008. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-03122008-133135/ ;.

MLA Handbook (7th Edition):

Knutson, Charles Gerhard Francesco. “Oxidative metabolism of exocyclic DNA adducts.” 2008. Web. 26 Sep 2018.

Vancouver:

Knutson CGF. Oxidative metabolism of exocyclic DNA adducts. [Internet] [Doctoral dissertation]. Vanderbilt University; 2008. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-03122008-133135/ ;.

Council of Science Editors:

Knutson CGF. Oxidative metabolism of exocyclic DNA adducts. [Doctoral Dissertation]. Vanderbilt University; 2008. Available from: http://etd.library.vanderbilt.edu/available/etd-03122008-133135/ ;

17. Chumbler, Nicole Marie. Defining the Functions and Regulation of Clostridium difficile Toxins A and B Enzymatic Activities in Cellular Intoxication.

Degree: PhD, Chemical and Physical Biology, 2015, Vanderbilt University

 Clostridium difficile is a common nosocomial infection that encompasses a range of clinical symptoms from mild diarrhea to complicated pseudomembranous and fulminant colitis. C. difficile… (more)

Subjects/Keywords: cell death; apoptosis; ROS; necrosis; Clostricium difficile; toxin; autoprotease

…MARTX VRE Vancomycin resistant entercocci VU HTS Vanderbilt University High Throughput… 

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APA (6th Edition):

Chumbler, N. M. (2015). Defining the Functions and Regulation of Clostridium difficile Toxins A and B Enzymatic Activities in Cellular Intoxication. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-03252015-161121/ ;

Chicago Manual of Style (16th Edition):

Chumbler, Nicole Marie. “Defining the Functions and Regulation of Clostridium difficile Toxins A and B Enzymatic Activities in Cellular Intoxication.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu//available/etd-03252015-161121/ ;.

MLA Handbook (7th Edition):

Chumbler, Nicole Marie. “Defining the Functions and Regulation of Clostridium difficile Toxins A and B Enzymatic Activities in Cellular Intoxication.” 2015. Web. 26 Sep 2018.

Vancouver:

Chumbler NM. Defining the Functions and Regulation of Clostridium difficile Toxins A and B Enzymatic Activities in Cellular Intoxication. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu//available/etd-03252015-161121/ ;.

Council of Science Editors:

Chumbler NM. Defining the Functions and Regulation of Clostridium difficile Toxins A and B Enzymatic Activities in Cellular Intoxication. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://etd.library.vanderbilt.edu//available/etd-03252015-161121/ ;

18. Branch, Megan Christine. Exploring New Structural and Functional Space in the Glutathione Transferase Superfamily from Escherichia coli K-12.

Degree: PhD, Biochemistry, 2011, Vanderbilt University

 Genome sequencing projects have revealed that glutathione (GSH) transferases are widely distributed in bacteria but most remain only as annotations in sequenced genomes. The goal… (more)

Subjects/Keywords: yfcg; assignment of enzyme function; escherichia coli; glutathione; glutathione transferase; e. coli; yghu; yqjG

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APA (6th Edition):

Branch, M. C. (2011). Exploring New Structural and Functional Space in the Glutathione Transferase Superfamily from Escherichia coli K-12. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-07012011-143800/ ;

Chicago Manual of Style (16th Edition):

Branch, Megan Christine. “Exploring New Structural and Functional Space in the Glutathione Transferase Superfamily from Escherichia coli K-12.” 2011. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu//available/etd-07012011-143800/ ;.

MLA Handbook (7th Edition):

Branch, Megan Christine. “Exploring New Structural and Functional Space in the Glutathione Transferase Superfamily from Escherichia coli K-12.” 2011. Web. 26 Sep 2018.

Vancouver:

Branch MC. Exploring New Structural and Functional Space in the Glutathione Transferase Superfamily from Escherichia coli K-12. [Internet] [Doctoral dissertation]. Vanderbilt University; 2011. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu//available/etd-07012011-143800/ ;.

Council of Science Editors:

Branch MC. Exploring New Structural and Functional Space in the Glutathione Transferase Superfamily from Escherichia coli K-12. [Doctoral Dissertation]. Vanderbilt University; 2011. Available from: http://etd.library.vanderbilt.edu//available/etd-07012011-143800/ ;

19. Sun, Xiaofei. Studying the role of endocannabinoid signaling in reproduction.

Degree: PhD, Pharmacology, 2010, Vanderbilt University

 Marijuana is the most commonly used illicit drug, and its major active component, Δ9-tetrahydrocannabinol (Δ9-THC) exert its functions by targeting cannabinoid receptors, CNR1 and CNR2.… (more)

Subjects/Keywords: Placentation; Uterus; Endocannabinoids; Testis; Reproduction

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APA (6th Edition):

Sun, X. (2010). Studying the role of endocannabinoid signaling in reproduction. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-07152010-141308/ ;

Chicago Manual of Style (16th Edition):

Sun, Xiaofei. “Studying the role of endocannabinoid signaling in reproduction.” 2010. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu//available/etd-07152010-141308/ ;.

MLA Handbook (7th Edition):

Sun, Xiaofei. “Studying the role of endocannabinoid signaling in reproduction.” 2010. Web. 26 Sep 2018.

Vancouver:

Sun X. Studying the role of endocannabinoid signaling in reproduction. [Internet] [Doctoral dissertation]. Vanderbilt University; 2010. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu//available/etd-07152010-141308/ ;.

Council of Science Editors:

Sun X. Studying the role of endocannabinoid signaling in reproduction. [Doctoral Dissertation]. Vanderbilt University; 2010. Available from: http://etd.library.vanderbilt.edu//available/etd-07152010-141308/ ;

20. Moth, Christopher Williams. Computational Analysis of Cyclooxygenase Inhibition: Energetics and Dynamics.

Degree: PhD, Chemistry, 2008, Vanderbilt University

 The cyclooxygenase (COX) enzyme catalyzes the bis-dioxygenation and cyclization of arachidonic acid to form prostaglandin H2, the common precursor of bioactive prostaglandins. The genome codes… (more)

Subjects/Keywords: molecular dynamics; quasiharmonic analysis; indomethacin amides; prostaglandin G2; enzyme dynamics; cyclooxygenase; Cyclooxygenases  – Inhibitors

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APA (6th Edition):

Moth, C. W. (2008). Computational Analysis of Cyclooxygenase Inhibition: Energetics and Dynamics. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-04112008-120250/ ;

Chicago Manual of Style (16th Edition):

Moth, Christopher Williams. “Computational Analysis of Cyclooxygenase Inhibition: Energetics and Dynamics.” 2008. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-04112008-120250/ ;.

MLA Handbook (7th Edition):

Moth, Christopher Williams. “Computational Analysis of Cyclooxygenase Inhibition: Energetics and Dynamics.” 2008. Web. 26 Sep 2018.

Vancouver:

Moth CW. Computational Analysis of Cyclooxygenase Inhibition: Energetics and Dynamics. [Internet] [Doctoral dissertation]. Vanderbilt University; 2008. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-04112008-120250/ ;.

Council of Science Editors:

Moth CW. Computational Analysis of Cyclooxygenase Inhibition: Energetics and Dynamics. [Doctoral Dissertation]. Vanderbilt University; 2008. Available from: http://etd.library.vanderbilt.edu/available/etd-04112008-120250/ ;

21. Lavieri, Robert Raymond. Synthesis, development and biochemical characterization of small molecule, isoform-selective phospholipase D inhibitors and photoactivatable probes.

Degree: PhD, Pharmacology, 2014, Vanderbilt University

 Phospholipase D (PLD) catalyzes the production of the lipid second messenger phosphatidic acid (PtdOH). PLD expression and/or enzymatic activity are both elevated in a variety… (more)

Subjects/Keywords: inhibitors; photoprobe; Phospholipase D; halopemide

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APA (6th Edition):

Lavieri, R. R. (2014). Synthesis, development and biochemical characterization of small molecule, isoform-selective phospholipase D inhibitors and photoactivatable probes. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-11052014-230853/ ;

Chicago Manual of Style (16th Edition):

Lavieri, Robert Raymond. “Synthesis, development and biochemical characterization of small molecule, isoform-selective phospholipase D inhibitors and photoactivatable probes.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-11052014-230853/ ;.

MLA Handbook (7th Edition):

Lavieri, Robert Raymond. “Synthesis, development and biochemical characterization of small molecule, isoform-selective phospholipase D inhibitors and photoactivatable probes.” 2014. Web. 26 Sep 2018.

Vancouver:

Lavieri RR. Synthesis, development and biochemical characterization of small molecule, isoform-selective phospholipase D inhibitors and photoactivatable probes. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-11052014-230853/ ;.

Council of Science Editors:

Lavieri RR. Synthesis, development and biochemical characterization of small molecule, isoform-selective phospholipase D inhibitors and photoactivatable probes. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://etd.library.vanderbilt.edu/available/etd-11052014-230853/ ;

22. Brogan, John Trevor. Total Synthesis and Biological Evaluation of Alkaloid Natural Products (+)-7-Bromotrypargine and Phidianidines A & B and the Development of a Novel Class of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1.

Degree: PhD, Chemical and Physical Biology, 2013, Vanderbilt University

 The first total synthesis of (+)-7-bromotrypargine, a β-carboline alkaloid from Ancornia sp. was completed in 9 steps, 8 steps longest linear sequence, and 40% overall… (more)

Subjects/Keywords: opioid; H3; SERT; DAT; NET; natural product; alkaloid; mGlu1 PAM

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APA (6th Edition):

Brogan, J. T. (2013). Total Synthesis and Biological Evaluation of Alkaloid Natural Products (+)-7-Bromotrypargine and Phidianidines A & B and the Development of a Novel Class of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-07182013-112209/ ;

Chicago Manual of Style (16th Edition):

Brogan, John Trevor. “Total Synthesis and Biological Evaluation of Alkaloid Natural Products (+)-7-Bromotrypargine and Phidianidines A & B and the Development of a Novel Class of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-07182013-112209/ ;.

MLA Handbook (7th Edition):

Brogan, John Trevor. “Total Synthesis and Biological Evaluation of Alkaloid Natural Products (+)-7-Bromotrypargine and Phidianidines A & B and the Development of a Novel Class of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1.” 2013. Web. 26 Sep 2018.

Vancouver:

Brogan JT. Total Synthesis and Biological Evaluation of Alkaloid Natural Products (+)-7-Bromotrypargine and Phidianidines A & B and the Development of a Novel Class of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-07182013-112209/ ;.

Council of Science Editors:

Brogan JT. Total Synthesis and Biological Evaluation of Alkaloid Natural Products (+)-7-Bromotrypargine and Phidianidines A & B and the Development of a Novel Class of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://etd.library.vanderbilt.edu/available/etd-07182013-112209/ ;


Vanderbilt University

23. Velez-Cruz, Renier. DNA Lesions as Cellular Poisons of Topoisomerase II-alpha.

Degree: PhD, Biochemistry, 2005, Vanderbilt University

 Topoisomerase II is an essential enzyme that controls DNA topology. This enzyme generates a protein-linked DNA break as a catalytic intermediate. This intermediate, known as… (more)

Subjects/Keywords: DNA adducts; topoisomerases; DNA; DNA damage; DNA repair

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APA (6th Edition):

Velez-Cruz, R. (2005). DNA Lesions as Cellular Poisons of Topoisomerase II-alpha. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-10112005-183529/ ;

Chicago Manual of Style (16th Edition):

Velez-Cruz, Renier. “DNA Lesions as Cellular Poisons of Topoisomerase II-alpha.” 2005. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-10112005-183529/ ;.

MLA Handbook (7th Edition):

Velez-Cruz, Renier. “DNA Lesions as Cellular Poisons of Topoisomerase II-alpha.” 2005. Web. 26 Sep 2018.

Vancouver:

Velez-Cruz R. DNA Lesions as Cellular Poisons of Topoisomerase II-alpha. [Internet] [Doctoral dissertation]. Vanderbilt University; 2005. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-10112005-183529/ ;.

Council of Science Editors:

Velez-Cruz R. DNA Lesions as Cellular Poisons of Topoisomerase II-alpha. [Doctoral Dissertation]. Vanderbilt University; 2005. Available from: http://etd.library.vanderbilt.edu/available/etd-10112005-183529/ ;


Vanderbilt University

24. Rigsby, Rachel Pharris. Studies of a genomic fosfomycin resistance protein from Pseudomonas aeruginosa.

Degree: PhD, Chemistry, 2005, Vanderbilt University

 CHEMISTRY STUDIES OF A GENOMIC FOSFOMYCIN RESISTANCE PROTEIN FROM PSEUDOMONAS AERUGINOSA RACHEL PHARRIS RIGSBY Dissertation under the direction of Professor Richard N. Armstrong In the… (more)

Subjects/Keywords: antibiotic resistance; fosfomycin resistance

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APA (6th Edition):

Rigsby, R. P. (2005). Studies of a genomic fosfomycin resistance protein from Pseudomonas aeruginosa. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-06282005-084134/ ;

Chicago Manual of Style (16th Edition):

Rigsby, Rachel Pharris. “Studies of a genomic fosfomycin resistance protein from Pseudomonas aeruginosa.” 2005. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-06282005-084134/ ;.

MLA Handbook (7th Edition):

Rigsby, Rachel Pharris. “Studies of a genomic fosfomycin resistance protein from Pseudomonas aeruginosa.” 2005. Web. 26 Sep 2018.

Vancouver:

Rigsby RP. Studies of a genomic fosfomycin resistance protein from Pseudomonas aeruginosa. [Internet] [Doctoral dissertation]. Vanderbilt University; 2005. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-06282005-084134/ ;.

Council of Science Editors:

Rigsby RP. Studies of a genomic fosfomycin resistance protein from Pseudomonas aeruginosa. [Doctoral Dissertation]. Vanderbilt University; 2005. Available from: http://etd.library.vanderbilt.edu/available/etd-06282005-084134/ ;


Vanderbilt University

25. McClendon, Amy Kathleen. Human Topoisomerases and DNA Geometry: Putting a Positive Twist on Enzyme Action.

Degree: PhD, Biochemistry, 2006, Vanderbilt University

 HUMAN TOPOISOMERASES AND DNA GEOMETRY: PUTTING A POSITIVE TWIST ON ENZYME ACTION AMY KATHLEEN MCCLENDON Topoisomerases play critical roles in maintaining DNA topology during cellular… (more)

Subjects/Keywords: anticancer drugs; DNA replication; DNA supercoiling; human topoisomerases

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APA (6th Edition):

McClendon, A. K. (2006). Human Topoisomerases and DNA Geometry: Putting a Positive Twist on Enzyme Action. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-03302006-090925/ ;

Chicago Manual of Style (16th Edition):

McClendon, Amy Kathleen. “Human Topoisomerases and DNA Geometry: Putting a Positive Twist on Enzyme Action.” 2006. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-03302006-090925/ ;.

MLA Handbook (7th Edition):

McClendon, Amy Kathleen. “Human Topoisomerases and DNA Geometry: Putting a Positive Twist on Enzyme Action.” 2006. Web. 26 Sep 2018.

Vancouver:

McClendon AK. Human Topoisomerases and DNA Geometry: Putting a Positive Twist on Enzyme Action. [Internet] [Doctoral dissertation]. Vanderbilt University; 2006. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-03302006-090925/ ;.

Council of Science Editors:

McClendon AK. Human Topoisomerases and DNA Geometry: Putting a Positive Twist on Enzyme Action. [Doctoral Dissertation]. Vanderbilt University; 2006. Available from: http://etd.library.vanderbilt.edu/available/etd-03302006-090925/ ;


Vanderbilt University

26. Thompson, Lawrence Casper. Dynamic, Structural, and Mechanistic Study of Glutathione Transferases.

Degree: PhD, Biochemistry, 2006, Vanderbilt University

 This project involved the investigation of both the dynamic features of the dimer interface of the Mu class GSH transferase rGSTM1-1, as well as, the… (more)

Subjects/Keywords: hcca isomerase; hydrogen-deuterium exchange mass spectrometry; glutathione cofactor; isomerization; glutathione binding; mechanistic enzymology; transient state kinetics; crystallography; naphthalene metabolism; Xenobiotics  – Metabolism; phase II enzymes; xenobiotic catabolism; kappa glutathione transferases; dimer stability; Glutathione transferase

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APA (6th Edition):

Thompson, L. C. (2006). Dynamic, Structural, and Mechanistic Study of Glutathione Transferases. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-06232006-122911/ ;

Chicago Manual of Style (16th Edition):

Thompson, Lawrence Casper. “Dynamic, Structural, and Mechanistic Study of Glutathione Transferases.” 2006. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-06232006-122911/ ;.

MLA Handbook (7th Edition):

Thompson, Lawrence Casper. “Dynamic, Structural, and Mechanistic Study of Glutathione Transferases.” 2006. Web. 26 Sep 2018.

Vancouver:

Thompson LC. Dynamic, Structural, and Mechanistic Study of Glutathione Transferases. [Internet] [Doctoral dissertation]. Vanderbilt University; 2006. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-06232006-122911/ ;.

Council of Science Editors:

Thompson LC. Dynamic, Structural, and Mechanistic Study of Glutathione Transferases. [Doctoral Dissertation]. Vanderbilt University; 2006. Available from: http://etd.library.vanderbilt.edu/available/etd-06232006-122911/ ;


Vanderbilt University

27. Cha, Yong I. Cyclooxygenase-1 derived prostaglandin E2 (PGE2) signaling in early development.

Degree: PhD, Cell and Developmental Biology, 2006, Vanderbilt University

 Prostaglandin G/H synthases (PGHS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze a key step in the synthesis of biologically active prostaglandins (PGs), the… (more)

Subjects/Keywords: cellular control mechanisms; development; cyclooxygenase; prostaglandin; zebrafish; cancer

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APA (6th Edition):

Cha, Y. I. (2006). Cyclooxygenase-1 derived prostaglandin E2 (PGE2) signaling in early development. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-03062006-135146/ ;

Chicago Manual of Style (16th Edition):

Cha, Yong I. “Cyclooxygenase-1 derived prostaglandin E2 (PGE2) signaling in early development.” 2006. Doctoral Dissertation, Vanderbilt University. Accessed September 26, 2018. http://etd.library.vanderbilt.edu/available/etd-03062006-135146/ ;.

MLA Handbook (7th Edition):

Cha, Yong I. “Cyclooxygenase-1 derived prostaglandin E2 (PGE2) signaling in early development.” 2006. Web. 26 Sep 2018.

Vancouver:

Cha YI. Cyclooxygenase-1 derived prostaglandin E2 (PGE2) signaling in early development. [Internet] [Doctoral dissertation]. Vanderbilt University; 2006. [cited 2018 Sep 26]. Available from: http://etd.library.vanderbilt.edu/available/etd-03062006-135146/ ;.

Council of Science Editors:

Cha YI. Cyclooxygenase-1 derived prostaglandin E2 (PGE2) signaling in early development. [Doctoral Dissertation]. Vanderbilt University; 2006. Available from: http://etd.library.vanderbilt.edu/available/etd-03062006-135146/ ;

.