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You searched for +publisher:"Vanderbilt University" +contributor:("Joshua P. Fessel, MD, PhD"). One record found.

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Vanderbilt University

1. Bloodworth, Melissa Harintho. Regulation of Immune Responses during Airway Inflammation.

Degree: PhD, Microbiology and Immunology, 2017, Vanderbilt University

Allergic asthma is refractory to corticosteroid treatment in up to 10% of patients and often leads to hospital admissions caused by respiratory viral and/ or bacterial infections. In these studies, I found that: 1) STAT6 inhibited innate γδ17 cell immune responses. STAT6 suppression of γδ17 cell function may provide one explanation for why asthmatic patients have significantly greater risk for invasive bacterial disease, including pneumonia, than nonasthmatic subjects. 2) A GLP-1R agonist, an FDA-approved agent currently used for Type II Diabetes, attenuated the type 2 immune response to RSV and attenuates RSV illness. The current availability of GLP-1R agonists for human treatment highlights the clinical significance of these studies as this therapy could be immediately transferrable to RSV disease. 3) PGI2, an FDA-approved agent currently used for pulmonary hypertension, protected against autoimmunity; enhanced Treg stability and function; rendered T effector cells more susceptible to Treg- mediated suppression; and promoted iTreg differentiation. PGI2 may therefore represent a novel treatment strategy for diseases that result from Treg dysregulation. Advisors/Committee Members: Ray Stokes Peebles Jr., MD (committee member), Wonder Drake, MD (committee member), Joshua P. Fessel, MD, PhD (committee member), Amy S. Major, PhD (committee member), John V. Williams (committee member), David M. Aronoff, MD (Committee Chair).

Subjects/Keywords: type 2 immunity (Th2); gamma-delta 17 (γδ17) cells; STAT6; Klebsiella pneumoniae; glucagon-like peptide 1 (GLP-1); respiratory syncytial virus (RSV); phenome-wide association study (PheWAS); regulatory T cells (Tregs); prostacyclin (PGI2)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bloodworth, M. H. (2017). Regulation of Immune Responses during Airway Inflammation. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11246

Chicago Manual of Style (16th Edition):

Bloodworth, Melissa Harintho. “Regulation of Immune Responses during Airway Inflammation.” 2017. Doctoral Dissertation, Vanderbilt University. Accessed April 18, 2021. http://hdl.handle.net/1803/11246.

MLA Handbook (7th Edition):

Bloodworth, Melissa Harintho. “Regulation of Immune Responses during Airway Inflammation.” 2017. Web. 18 Apr 2021.

Vancouver:

Bloodworth MH. Regulation of Immune Responses during Airway Inflammation. [Internet] [Doctoral dissertation]. Vanderbilt University; 2017. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/1803/11246.

Council of Science Editors:

Bloodworth MH. Regulation of Immune Responses during Airway Inflammation. [Doctoral Dissertation]. Vanderbilt University; 2017. Available from: http://hdl.handle.net/1803/11246

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