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You searched for +publisher:"Vanderbilt University" +contributor:("Joseph S. Neimat"). Showing records 1 – 3 of 3 total matches.

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Vanderbilt University

1. Kumar, Kevin Krishan. Investigation of Neuronal Manganese Regulation in Physiology and Disease Using High Throughput Screening, Induced Pluripotent Stem Cells, and Chemical Biology Approaches.

Degree: PhD, Neuroscience, 2014, Vanderbilt University

URL: http://hdl.handle.net/1803/14021 

Manganese (Mn) is both an essential biological cofactor and neurotoxicant. Disruption of Mn biology in the basal ganglia has been implicated in the pathogenesis of neurodegenerative disorders, such as parkinsonism and Huntington’s disease (HD). However, beyond several non-selective transporters, little is known about the intracellular processes regulating neuronal Mn homeostasis. We hypothesized that small molecules that modulate intracellular Mn could provide insight into cell-level Mn regulatory mechanisms. We performed a high throughput screen of 40,167 small molecules for modifiers of cellular Mn content. Utilizing the identified small molecules, we tested for differential regulation of Mn handling in human floor-plate lineage dopaminergic neurons, a lineage especially vulnerable to environmental Mn exposure. We report differential Mn accumulation between developmental stages and stage-specific differences in the Mn-altering activity of individual small molecules, demonstrating cell-level regulation of Mn content across neuronal differentiation. In a parallel study, we sought to reveal any cellular metabolic phenotypes influenced by Mn exposure and/or the mutant HD genotype using an unbiased metabolomics approach. Our analysis revealed metabolic evidence of an interaction between the HD genotype and environmentally relevant Mn exposures in a striatal neural lineage. The metabolic phenotypes detected support existing hypotheses that changes in energetic processes underlie the pathogenesis of both HD and Mn neurotoxicity. Advisors/Committee Members: Aaron B. Bowman (committee member), Joseph S. Neimat (committee member), Michael Aschner (committee member), C. David Weaver (committee member), Daniel O. Claassen (committee member), Kevin C. Ess (Committee Chair).

Subjects/Keywords: High Throughput Screening; Manganese; Neurodegenerative diseases; Human Induced Pluripotent Stem Cells; Metabolomics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kumar, K. K. (2014). Investigation of Neuronal Manganese Regulation in Physiology and Disease Using High Throughput Screening, Induced Pluripotent Stem Cells, and Chemical Biology Approaches. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14021

Chicago Manual of Style (16th Edition):

Kumar, Kevin Krishan. “Investigation of Neuronal Manganese Regulation in Physiology and Disease Using High Throughput Screening, Induced Pluripotent Stem Cells, and Chemical Biology Approaches.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed January 15, 2021. http://hdl.handle.net/1803/14021.

MLA Handbook (7th Edition):

Kumar, Kevin Krishan. “Investigation of Neuronal Manganese Regulation in Physiology and Disease Using High Throughput Screening, Induced Pluripotent Stem Cells, and Chemical Biology Approaches.” 2014. Web. 15 Jan 2021.

Vancouver:

Kumar KK. Investigation of Neuronal Manganese Regulation in Physiology and Disease Using High Throughput Screening, Induced Pluripotent Stem Cells, and Chemical Biology Approaches. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1803/14021.

Council of Science Editors:

Kumar KK. Investigation of Neuronal Manganese Regulation in Physiology and Disease Using High Throughput Screening, Induced Pluripotent Stem Cells, and Chemical Biology Approaches. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://hdl.handle.net/1803/14021


Vanderbilt University

2. Comber, David Benjamin. Design and Control of Magnetic Resonance-Compatible, Pneumatic Actuators and Robotic Platforms for Steerable Needle Interventions.

Degree: PhD, Mechanical Engineering, 2015, Vanderbilt University

URL: http://hdl.handle.net/1803/14258 

This dissertation presents the design and validation of a robotic platform to control steerable needles under magnetic resonance imaging (MRI) guidance. The use of MRI to guide needle-based interventions provides clinicians with informative data, including excellent visualization of soft tissue, needle placement confirmation, and thermal dose monitoring. Additionally, the patient stands to benefit from the minimally-invasive and radiation-free nature of MRI-guided interventions. However, because the closed, narrow bore of high-field MRI scanners substantially limits clinician access to the patient during imaging, many interventions require the use of a compact robot to help deliver the needle to the target under MRI guidance. Such a robot must satisfy the challenging requirements of safety, precision, compactness, and magnetic resonance (MR)-compatibility. Numerous potential interventions have yet to be realized because the majority of MR-compatible robots reported to date were designed in an anatomy-specific way and are thus difficult to apply to other anatomical targets. Therefore, the goal of the work described herein is to develop a modular robotic platform to actuate concentric tube steerable needles, a class of continuum robot applicable to treatment of a broad range of anatomical structures. The design, fabrication, and control of two, multiple degree-of-freedom prototypes are described. To the author’s knowledge, the first prototype is the first fully-pneumatic MR-compatible robot to be reported for neurosurgical applications. The main contributions of the second prototype are hybrid pneumatic control for precise and intrinsically-safe operation, and novel designs of bellows actuators additively manufactured for compactness and hermetic sealing. To enable a novel, foramen ovale approach to epilepsy treatment using the modular MR-compatible robot, prototypes of a non-invasive head holder, a helical needle, and a radiofrequency ablation electrode are presented. Finally, the potential applicability of this non-invasive approach to a wide range of patients is explored. Designed using nonlinear optimization, curvilinear concentric tube needle trajectories are shown to accurately traverse the medial axis of the hippocampus for twenty different cases. The results herein collectively contribute robotic hardware and controls to help transform deep brain therapy from open surgery to a minimally-invasive procedure. Advisors/Committee Members: Michael Goldfarb (committee member), Joseph S. Neimat (committee member), William A. Grissom (committee member), Robert J. Webster (Committee Chair), Eric J. Barth (Committee Chair).

Subjects/Keywords: interventional mri; concentric tube robot; surgical robotics; actuator design; nonlinear control

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Comber, D. B. (2015). Design and Control of Magnetic Resonance-Compatible, Pneumatic Actuators and Robotic Platforms for Steerable Needle Interventions. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14258

Chicago Manual of Style (16th Edition):

Comber, David Benjamin. “Design and Control of Magnetic Resonance-Compatible, Pneumatic Actuators and Robotic Platforms for Steerable Needle Interventions.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed January 15, 2021. http://hdl.handle.net/1803/14258.

MLA Handbook (7th Edition):

Comber, David Benjamin. “Design and Control of Magnetic Resonance-Compatible, Pneumatic Actuators and Robotic Platforms for Steerable Needle Interventions.” 2015. Web. 15 Jan 2021.

Vancouver:

Comber DB. Design and Control of Magnetic Resonance-Compatible, Pneumatic Actuators and Robotic Platforms for Steerable Needle Interventions. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1803/14258.

Council of Science Editors:

Comber DB. Design and Control of Magnetic Resonance-Compatible, Pneumatic Actuators and Robotic Platforms for Steerable Needle Interventions. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/14258


Vanderbilt University

3. Pallavaram Srinivasan, Srivatsan. Standardizing indirect targeting and building electrophysiological maps for deep brain stimulation surgery after accounting for brain shift.

Degree: PhD, Electrical Engineering, 2010, Vanderbilt University

URL: http://hdl.handle.net/1803/13019 

Chronic Deep Brain Stimulation (DBS) has been a rapidly evolving area of neurotherapeutics since its initial introduction for the treatment of Parkinson’s disease and essential tremor in the 1990s. In the recent past, there has been active research to improve the outcome of the procedure as well as to make it more accessible to patients. This dissertation is broadly categorized into two parts. The first is motivated by a lack of standardization in the localization of popular anatomical landmarks used to indirectly localize as well as communicate stereotactic targets. Inter-surgeon variability in manually selecting these landmarks and its impact on target localization is shown to be substantial. A method based on non-rigid image registration is used for automatic prediction of the landmarks and its accuracy is shown to be sub-millimetric in both clinical and non-clinical settings. The second part is motivated by shortcomings and inaccuracies in existing methods to populate statistical atlases of electrophysiological data acquired intra-operatively during DBS surgeries. A Gaussian smoothed spherical shell kernel is proposed as an improvement over an existing method to model stimulation response in order to build accurate statistical maps. The effect of intra-operative brain shift on the creation of electrophysiological atlases is investigated and shown to be substantial. An approach to build low-shift atlases is proposed and statistical maps of stimulation response built using data from such an atlas are shown to correlate strongly with a statistical ground truth as well as with an anatomical atlas. Finally, in a preliminary study, it is shown that statistical maps of adverse effects combined with statistical maps of efficacious stimulation response could be clinically useful for post-operative programming assistance in DBS. Advisors/Committee Members: Dr. J. Michael Fitzpatrick (committee member), Dr. Joseph S. Neimat (committee member), Dr. Peter E. Konrad (committee member), Dr. Robert Bodenheimer (committee member), Dr. Benoit M. Dawant (Committee Chair).

Subjects/Keywords: non-rigid registration; statistical maps; pre-operative planning; intra-operative navigation or guidance; post-operative programming; electrophysiological atlases; Deep Brain Stimulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Pallavaram Srinivasan, S. (2010). Standardizing indirect targeting and building electrophysiological maps for deep brain stimulation surgery after accounting for brain shift. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13019

Chicago Manual of Style (16th Edition):

Pallavaram Srinivasan, Srivatsan. “Standardizing indirect targeting and building electrophysiological maps for deep brain stimulation surgery after accounting for brain shift.” 2010. Doctoral Dissertation, Vanderbilt University. Accessed January 15, 2021. http://hdl.handle.net/1803/13019.

MLA Handbook (7th Edition):

Pallavaram Srinivasan, Srivatsan. “Standardizing indirect targeting and building electrophysiological maps for deep brain stimulation surgery after accounting for brain shift.” 2010. Web. 15 Jan 2021.

Vancouver:

Pallavaram Srinivasan S. Standardizing indirect targeting and building electrophysiological maps for deep brain stimulation surgery after accounting for brain shift. [Internet] [Doctoral dissertation]. Vanderbilt University; 2010. [cited 2021 Jan 15]. Available from: http://hdl.handle.net/1803/13019.

Council of Science Editors:

Pallavaram Srinivasan S. Standardizing indirect targeting and building electrophysiological maps for deep brain stimulation surgery after accounting for brain shift. [Doctoral Dissertation]. Vanderbilt University; 2010. Available from: http://hdl.handle.net/1803/13019

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