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You searched for +publisher:"Vanderbilt University" +contributor:("Dr. Mark Does"). Showing records 1 – 2 of 2 total matches.

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Vanderbilt University

1. Lee, Sue Hyun. Engineering Biomaterials-based Approaches for Better Angiogenesis.

Degree: PhD, Biomedical Engineering, 2016, Vanderbilt University

Tissue engineering promises to solve the ever-increasing organ donor shortage, as well as to provide personalized and customized cures for numerous life-threatening diseases and organ/tissue failures. While significant advances have been made in recent years, most tissue engineering applications face a common roadblock that holds them back from being translated in the clinic: the inability to engineer constructs that would support sufficient and rapid blood vessel formation (angiogenesis) upon implantation. Most tissues cannot survive nor function properly without elaborate blood vessel networks in place. Thus, the goal of this work is to modify and examine two commonly used biomaterials, polycaprolactone (PCL) and gelatin, that would enhance blood vessel formation in vitro and in vivo through different mechanisms. The first approach was to incorporate reactive oxygen species (ROS)-degradable peptide into PCL scaffolds that would allow better cell infiltration, which led to improved angiogenesis. In the second approach, by modifying gelatin to form a thermostable hydrogel, a novel interaction between gelatin hydrogel and mesenchymal stem cells (MSC) that drove MSC differentiation into blood vessel-forming endothelial cells was discovered and examined. This dissertation work is aimed at overcoming the common barrier for clinical translation of tissue engineering, and the findings and the resulting design principles can be applied in various tissue engineering applications to accelerate clinical translation. Advisors/Committee Members: Dr. Mark Does (chair), Dr. Todd Giorgio (committee member), Dr. Melissa Skala (committee member), Dr. Leon Bellan (committee member), Dr. David Bader (committee member).

Subjects/Keywords: Tissue Engineering; Stem Cell; Biomaterials

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lee, S. H. (2016). Engineering Biomaterials-based Approaches for Better Angiogenesis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-04112016-130804/ ;

Chicago Manual of Style (16th Edition):

Lee, Sue Hyun. “Engineering Biomaterials-based Approaches for Better Angiogenesis.” 2016. Doctoral Dissertation, Vanderbilt University. Accessed December 05, 2019. http://etd.library.vanderbilt.edu//available/etd-04112016-130804/ ;.

MLA Handbook (7th Edition):

Lee, Sue Hyun. “Engineering Biomaterials-based Approaches for Better Angiogenesis.” 2016. Web. 05 Dec 2019.

Vancouver:

Lee SH. Engineering Biomaterials-based Approaches for Better Angiogenesis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2016. [cited 2019 Dec 05]. Available from: http://etd.library.vanderbilt.edu//available/etd-04112016-130804/ ;.

Council of Science Editors:

Lee SH. Engineering Biomaterials-based Approaches for Better Angiogenesis. [Doctoral Dissertation]. Vanderbilt University; 2016. Available from: http://etd.library.vanderbilt.edu//available/etd-04112016-130804/ ;


Vanderbilt University

2. Dula, Adrienne Nicole. Micro-anatomical characterization of central white matter using magnetic resonance imaging.

Degree: PhD, Biomedical Engineering, 2008, Vanderbilt University

Most magnetic resonance imaging techniques offer tissue contrast but provide limited information regarding the variation of the magnetic resonance signal that exists on a smaller scale. The magnetic resonance signal arising from a heterogeneous tissue, such as spinal cord white matter, is the sum of signals from each tissue compartment within the imaging voxel. Analysis of this signal can better characterize the micro-anatomical heterogeneity tissue, white matter in particular. Many questions remain with regard to the compartmental contributions for the various types of magnetic resonance imaging (MRI) contrast. This project utilizes a variety of in vitro studies as well as simulations to better characterize the contribution of different water compartments to conventional MRI methods. Such an understanding of the complex combination of the various relaxation and exchange properties is important in developing an anatomical basis for interpreting magnetization transfer and T2 weighted images, particularly with respect to myelination. Advisors/Committee Members: Bill Valentine (committee member), Adam Anderson (committee member), Dan Gochberg (committee member), Dr. Mark Does (chair), John Gore (committee member).

Subjects/Keywords: quantitative magnetization transfer; multiexponential T2; Spinal cord  – Magnetic resonance imaging; myelin; Myelination

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Dula, A. N. (2008). Micro-anatomical characterization of central white matter using magnetic resonance imaging. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-04172008-172151/ ;

Chicago Manual of Style (16th Edition):

Dula, Adrienne Nicole. “Micro-anatomical characterization of central white matter using magnetic resonance imaging.” 2008. Doctoral Dissertation, Vanderbilt University. Accessed December 05, 2019. http://etd.library.vanderbilt.edu/available/etd-04172008-172151/ ;.

MLA Handbook (7th Edition):

Dula, Adrienne Nicole. “Micro-anatomical characterization of central white matter using magnetic resonance imaging.” 2008. Web. 05 Dec 2019.

Vancouver:

Dula AN. Micro-anatomical characterization of central white matter using magnetic resonance imaging. [Internet] [Doctoral dissertation]. Vanderbilt University; 2008. [cited 2019 Dec 05]. Available from: http://etd.library.vanderbilt.edu/available/etd-04172008-172151/ ;.

Council of Science Editors:

Dula AN. Micro-anatomical characterization of central white matter using magnetic resonance imaging. [Doctoral Dissertation]. Vanderbilt University; 2008. Available from: http://etd.library.vanderbilt.edu/available/etd-04172008-172151/ ;

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