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You searched for +publisher:"Vanderbilt University" +contributor:("Dr. Leon Bellan"). Showing records 1 – 2 of 2 total matches.

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Vanderbilt University

1. Lee, Sue Hyun. Engineering Biomaterials-based Approaches for Better Angiogenesis.

Degree: PhD, Biomedical Engineering, 2016, Vanderbilt University

Tissue engineering promises to solve the ever-increasing organ donor shortage, as well as to provide personalized and customized cures for numerous life-threatening diseases and organ/tissue failures. While significant advances have been made in recent years, most tissue engineering applications face a common roadblock that holds them back from being translated in the clinic: the inability to engineer constructs that would support sufficient and rapid blood vessel formation (angiogenesis) upon implantation. Most tissues cannot survive nor function properly without elaborate blood vessel networks in place. Thus, the goal of this work is to modify and examine two commonly used biomaterials, polycaprolactone (PCL) and gelatin, that would enhance blood vessel formation in vitro and in vivo through different mechanisms. The first approach was to incorporate reactive oxygen species (ROS)-degradable peptide into PCL scaffolds that would allow better cell infiltration, which led to improved angiogenesis. In the second approach, by modifying gelatin to form a thermostable hydrogel, a novel interaction between gelatin hydrogel and mesenchymal stem cells (MSC) that drove MSC differentiation into blood vessel-forming endothelial cells was discovered and examined. This dissertation work is aimed at overcoming the common barrier for clinical translation of tissue engineering, and the findings and the resulting design principles can be applied in various tissue engineering applications to accelerate clinical translation. Advisors/Committee Members: Dr. Mark Does (chair), Dr. Todd Giorgio (committee member), Dr. Melissa Skala (committee member), Dr. Leon Bellan (committee member), Dr. David Bader (committee member).

Subjects/Keywords: Tissue Engineering; Stem Cell; Biomaterials

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lee, S. H. (2016). Engineering Biomaterials-based Approaches for Better Angiogenesis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-04112016-130804/ ;

Chicago Manual of Style (16th Edition):

Lee, Sue Hyun. “Engineering Biomaterials-based Approaches for Better Angiogenesis.” 2016. Doctoral Dissertation, Vanderbilt University. Accessed March 30, 2020. http://etd.library.vanderbilt.edu//available/etd-04112016-130804/ ;.

MLA Handbook (7th Edition):

Lee, Sue Hyun. “Engineering Biomaterials-based Approaches for Better Angiogenesis.” 2016. Web. 30 Mar 2020.

Vancouver:

Lee SH. Engineering Biomaterials-based Approaches for Better Angiogenesis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2016. [cited 2020 Mar 30]. Available from: http://etd.library.vanderbilt.edu//available/etd-04112016-130804/ ;.

Council of Science Editors:

Lee SH. Engineering Biomaterials-based Approaches for Better Angiogenesis. [Doctoral Dissertation]. Vanderbilt University; 2016. Available from: http://etd.library.vanderbilt.edu//available/etd-04112016-130804/ ;

2. Muralidharan, Nitin. Mechano-Electrochemistry for Advanced Energy Storage and Harvesting Devices.

Degree: PhD, Interdisciplinary Materials Science, 2018, Vanderbilt University

A fundamental perception in the energy storage community is that mechanical processes accompanying electrochemical processes are an unavoidable by-product. However, the coupling between mechanics and electrochemistry termed as the âmechano-electrochemical couplingâ is a powerful yet unexplored tool. Using principles of elastic strain engineering, we demonstrate controllable modulation of electrochemical parameters governing energy storage systems. Leveraging the shape memory properties of NiTi alloys, redox potentials and diffusion coefficient modulations for energy storage materials were achieved as a function of applied strain. Building off these principles, we developed electrochemical-mechanical energy harvesters for harnessing ambient mechanical energy at very low frequencies (<5 Hz), a regime where the conventional state-of the art piezoelectric and triboelectric energy harvesters have drastically reduced performances. We also highlight frequency tuning capabilities in this class of energy harvesters owing to the inherent differences in various battery electrode chemistries for use in human motion harvesting and sensing applications and multifunctional transient energy harvesting and storage devices. Additionally, to further illustrate the relationship between mechanical and electrochemical properties, we developed multifunctional structural supercapacitor and battery composites for use in load-bearing applications. Overall, these approaches provide paradigm shifting fundamental insights as well as create a framework for developing such multifunctional energy storage/harvesting architectures for a multitude of applications. Advisors/Committee Members: Dr. Cary Pint (chair), Dr. Douglas Adams (chair), Dr. Greg Walker (committee member), Dr. Rizia Bardhan (committee member), Dr. Leon Bellan (committee member), Dr. Piran Kidambi (committee member).

Subjects/Keywords: electrochemical mechanical coupling; energy harvesting; in-situ; strain; stress; mechanical processes; elastic strain engineering; strain setting; substrate strains; shapememory alloy; superelastic; multifunctional energy storage; transient energy harvesters; transient energy storage; pseudocapacitors; supercapacitors; load-bearing; structural; human motion harvesting; modulating electrochemistry; mechano-electrochemistry; advanced energy storage; advanced energy harvesting; low frequency energy harvesting; ambient energy harvesting; electrochemical-mechanical energy harvesting; Nitinol; battery mechanics; strain engineering; energy storage

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Muralidharan, N. (2018). Mechano-Electrochemistry for Advanced Energy Storage and Harvesting Devices. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu/available/etd-06142018-084514/ ;

Chicago Manual of Style (16th Edition):

Muralidharan, Nitin. “Mechano-Electrochemistry for Advanced Energy Storage and Harvesting Devices.” 2018. Doctoral Dissertation, Vanderbilt University. Accessed March 30, 2020. http://etd.library.vanderbilt.edu/available/etd-06142018-084514/ ;.

MLA Handbook (7th Edition):

Muralidharan, Nitin. “Mechano-Electrochemistry for Advanced Energy Storage and Harvesting Devices.” 2018. Web. 30 Mar 2020.

Vancouver:

Muralidharan N. Mechano-Electrochemistry for Advanced Energy Storage and Harvesting Devices. [Internet] [Doctoral dissertation]. Vanderbilt University; 2018. [cited 2020 Mar 30]. Available from: http://etd.library.vanderbilt.edu/available/etd-06142018-084514/ ;.

Council of Science Editors:

Muralidharan N. Mechano-Electrochemistry for Advanced Energy Storage and Harvesting Devices. [Doctoral Dissertation]. Vanderbilt University; 2018. Available from: http://etd.library.vanderbilt.edu/available/etd-06142018-084514/ ;

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