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You searched for +publisher:"University of Wisconsin – Milwaukee" +contributor:("Karyn M. Frick"). One record found.

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University of Wisconsin – Milwaukee

1. Kim, Jae Kyoon. The Role of G-protein Coupled Estrogen Receptor (GPER/GPR30) in Hippocampal Memory and Cell Signaling in Female Mice.

Degree: MS, Psychology, 2014, University of Wisconsin – Milwaukee

The loss of estrogens at menopause significantly increases a woman's risk of memory loss and Alzheimer's disease because estrogens are essential trophic factors for the hippocampus. However, current hormone replacement therapies are not recommended to reduce age-related memory decline because of their adverse side effects. To develop better hormone replacement therapies, it is essential to understand the mechanisms through which estrogens regulate memory. Our laboratory has demonstrated that the ability of 17β-estradiol (E2) to enhance hippocampal memory depends on the rapid activation of extracellular-signal-regulated kinase (ERK), which occurs through activation of ERα and ERβ. The G-protein coupled estrogen receptor (GPER) is a novel membrane estrogen receptor, expressed in areas of the brain important for learning and memory such as the hippocampus. However, little is known about the role of dorsal hippocampal (DH) GPER in hippocampal memory consolidation and cell signaling. Here, the present study tested the roles of GPER in regulating hippocampal memory consolidation and cell signaling in young female mice. DH infusion of the GPER agonist, G-1, enhanced object recognition and spatial memory consolidation in ovariectomized female mice. DH infusion of the GPER antagonist, G-15, blocked the memory-enhancing effects of G-1, suggesting that GPER activation mimics the beneficial effects of E2 on hippocampal memory. Interestingly, however, G-1 did not increase ERK phosphorylation like E2, but instead significantly increased phosphorylation of the c-Jun N-terminal kinase (JNK) in the DH, suggesting that the molecular mechanisms underlying the memory-enhancing effects of GPER activation may differ from those of ERα and ERβ activation. Consistent with this notion, DH infusion of the JNK inhibitor, SP600125, blocked G-1-induced memory enhancement and JNK phosphorylation, whereas the ERK inhibitor, U0126, did not. Finally, we showed that DH infusion of SP600125 or G-15 did not prevent E2 from enhancing memory and activating ERK, demonstrating that the memory-enhancing effects of E2 are not dependent on JNK or GPER activation in the DH. These results indicate that GPER regulates memory independently from ERα and ERβ by activating JNK signaling, rather than ERK signaling. Together, the data suggest that GPER does not function as an estrogen receptor in the DH. As such, this study identifies GPER as a putative new target for reducing memory decline in menopausal women without the detrimental side effects of currently available treatment options Advisors/Committee Members: Karyn M. Frick.

Subjects/Keywords: Other Psychology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kim, J. K. (2014). The Role of G-protein Coupled Estrogen Receptor (GPER/GPR30) in Hippocampal Memory and Cell Signaling in Female Mice. (Thesis). University of Wisconsin – Milwaukee. Retrieved from https://dc.uwm.edu/etd/708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Kim, Jae Kyoon. “The Role of G-protein Coupled Estrogen Receptor (GPER/GPR30) in Hippocampal Memory and Cell Signaling in Female Mice.” 2014. Thesis, University of Wisconsin – Milwaukee. Accessed February 21, 2019. https://dc.uwm.edu/etd/708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Kim, Jae Kyoon. “The Role of G-protein Coupled Estrogen Receptor (GPER/GPR30) in Hippocampal Memory and Cell Signaling in Female Mice.” 2014. Web. 21 Feb 2019.

Vancouver:

Kim JK. The Role of G-protein Coupled Estrogen Receptor (GPER/GPR30) in Hippocampal Memory and Cell Signaling in Female Mice. [Internet] [Thesis]. University of Wisconsin – Milwaukee; 2014. [cited 2019 Feb 21]. Available from: https://dc.uwm.edu/etd/708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kim JK. The Role of G-protein Coupled Estrogen Receptor (GPER/GPR30) in Hippocampal Memory and Cell Signaling in Female Mice. [Thesis]. University of Wisconsin – Milwaukee; 2014. Available from: https://dc.uwm.edu/etd/708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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