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You searched for +publisher:"University of Vermont" +contributor:("Landry, Christopher"). Showing records 1 – 2 of 2 total matches.

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University of Vermont

1. Miller, Brendon Mark. A Nanoparticle/enzyme System For The Simultaneous Detection And Decontamination Of Organophosphates.

Degree: PhD, Chemistry, 2016, University of Vermont

The need for a direct visual response system for the detection of organophosphorus compounds stems from the continued threat and use of these toxic agents in military and terrorist conflicts. The development of an enzyme-inhibitor triggered release system allows for direct visual detection with high specificity. Mesoporous silica nanoparticles (MSNs) have physical features that make them attractive as scaffolds for the construction of these systems, such as pore diameters (20-500 Á) that can be synthetically controlled, large surface areas (300-1500 m2g-1), large pore volumes, chemical inertness, stability at elevated temperatures, and surfaces that can be easily functionalized. In our studies, the dye Congo Red was loaded into the pores of MSNs, which were then capped by tethering an enzyme (organophosphorus hydrolase (OPH) or acetylcholinesterase (AChE)) to the external surfaces of MSNs through a competitive inhibitor (diethyl 4-aminobenzyl phosphonate (DEABP) or tacrine, respectively). OPH has been extensively studied for its ability to hydrolyze a wide range of organophosphorus compounds, rendering them non-toxic. AChE has been commonly used for organophosphate detection resulting from its sensitivity to phosphorylation. Upon addition of organophosphorus compounds to suspensions of the modified MSNs, the enzymes detached from the MSN surface, releasing the dye and providing a visual confirmation of organophosphate presence. Enzyme kinetics were studied using 31P NMR or UV-Visible spectroscopy; Congo Red release was also monitored by UV-Visible spectroscopy. The system was sensitive and specific for organophosphorus compounds both in phosphate-buffered saline and in human serum. The rate of dye release directly correlated with the rate of organophosphorus conversion for OPH and the rate of phosphorylation for AChE. Advisors/Committee Members: Christopher C. Landry, Christopher S. Francklyn.

Subjects/Keywords: Chemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Miller, B. M. (2016). A Nanoparticle/enzyme System For The Simultaneous Detection And Decontamination Of Organophosphates. (Doctoral Dissertation). University of Vermont. Retrieved from https://scholarworks.uvm.edu/graddis/576

Chicago Manual of Style (16th Edition):

Miller, Brendon Mark. “A Nanoparticle/enzyme System For The Simultaneous Detection And Decontamination Of Organophosphates.” 2016. Doctoral Dissertation, University of Vermont. Accessed November 17, 2019. https://scholarworks.uvm.edu/graddis/576.

MLA Handbook (7th Edition):

Miller, Brendon Mark. “A Nanoparticle/enzyme System For The Simultaneous Detection And Decontamination Of Organophosphates.” 2016. Web. 17 Nov 2019.

Vancouver:

Miller BM. A Nanoparticle/enzyme System For The Simultaneous Detection And Decontamination Of Organophosphates. [Internet] [Doctoral dissertation]. University of Vermont; 2016. [cited 2019 Nov 17]. Available from: https://scholarworks.uvm.edu/graddis/576.

Council of Science Editors:

Miller BM. A Nanoparticle/enzyme System For The Simultaneous Detection And Decontamination Of Organophosphates. [Doctoral Dissertation]. University of Vermont; 2016. Available from: https://scholarworks.uvm.edu/graddis/576


University of Vermont

2. Solberg, Sean. Synthesis and Characterization of New Mesoporous Materials and their Application in Catalysis and Adsorption.

Degree: PhD, Chemistry, 2008, University of Vermont

Materials chemistry represents a very broad, but extremely applicable field of study to everyday life. Since many of the useful applications of these ‘sponge-like’ porous materials are dependent on the amount of surface area, the development and use of highly-porous materials with tremendous surface areas significantly enhances the effectiveness of these materials. Examples of such traditional applications include adsorption, separation, and catalytic applications. The study of porous materials has brought the ability to accurately synthesize and modify these materials to meet specific application requirements. The field of porous materials has been traditionally dominated by many “natural” or traditionally inspired materials such as zeolites and porous carbon materials. Although very effective, these materials have very small pore-windows that prevent their application in all but very small molecule applications. This limitation drove the development of large pore-window materials in the 1990s, known as mesoporous materials. Mesoporous materials are defined by IUPAC as possessing pore-openings between 20 and 500 Å. This much broader size-range spurred the use of mesoporous materials into other applications, including large-molecule heterogeneous catalysis and biomedical applications. Chapter one of this dissertation presents an introduction to the field of mesoporous materials, with both silica based and carbon based materials covered. Chapter two and three cover the development of a new mesoporous/microporous silica material. The purpose of this material was to combines the advantages of both types of materials, namely the large pore-opening of mesoporous materials with the stability of a traditional microporous material. The combined material, named MMM-2, is doped with titanium heteroatoms for use in catalytic reactions. The chapter presents a thorough study of the synthesis and characterization of MMM-2 along with its application as a more effective catalysis in the oxidation of cyclohexene. Chapters four and five further extend the work on the MMM-2 materials by incorporating aluminum into the silica framework to form a solid acid-catalyst. Again, thorough treatment is given to the synthesis and characterization of this material. Al- MMM-2 is shown to possess unique structural properties relative to the pure mesoporous and microporous materials that it is related to. Moreover, Al-MMM-2 is shown to be more effective in acid-catalysis reactions as well as possessing improved structural stability upon the reuse of the material in successive reaction cycles. Chapters six and seven cover the use of the mesoporous material, APMS in the adsorption and delivery of DNA. APMS, which is spherically shaped, is shown to be an effective adsorbant of DNA into its internal pores with adsorption determined to be dependent on several factors such as the ionic environment, pore size, and surface characteristics. Finally, chapter eight covers the templated synthesis and characterization of a … Advisors/Committee Members: Landry, Christopher.

Subjects/Keywords: mesoporous; silica

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Solberg, S. (2008). Synthesis and Characterization of New Mesoporous Materials and their Application in Catalysis and Adsorption. (Doctoral Dissertation). University of Vermont. Retrieved from https://scholarworks.uvm.edu/graddis/219

Chicago Manual of Style (16th Edition):

Solberg, Sean. “Synthesis and Characterization of New Mesoporous Materials and their Application in Catalysis and Adsorption.” 2008. Doctoral Dissertation, University of Vermont. Accessed November 17, 2019. https://scholarworks.uvm.edu/graddis/219.

MLA Handbook (7th Edition):

Solberg, Sean. “Synthesis and Characterization of New Mesoporous Materials and their Application in Catalysis and Adsorption.” 2008. Web. 17 Nov 2019.

Vancouver:

Solberg S. Synthesis and Characterization of New Mesoporous Materials and their Application in Catalysis and Adsorption. [Internet] [Doctoral dissertation]. University of Vermont; 2008. [cited 2019 Nov 17]. Available from: https://scholarworks.uvm.edu/graddis/219.

Council of Science Editors:

Solberg S. Synthesis and Characterization of New Mesoporous Materials and their Application in Catalysis and Adsorption. [Doctoral Dissertation]. University of Vermont; 2008. Available from: https://scholarworks.uvm.edu/graddis/219

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